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| 1 | 烧结工艺使用气体燃料喷入技术减少CO_2排放显示文摘JFE钢铁公司开发了在烧结矿表面喷入含氢的气体燃料技术,可不增加焦粉配比,提高烧结矿质量。使用该技术,含氢气体可部分替代焦粉,使1200~1400℃的燃烧层变宽成为可能。通过X射线对多孔状的烧结饼进行CT检查与烧结锅试验,从理论到实践都证明了喷入燃料气体技术的使用效果。保持1200~1400℃的温度带,为生产高强度、高还原性的烧结矿至关重要,它能使合适的温度带变宽、液相率增加、提高1~5mm孔隙间的熔合并提升烧结矿强度。大于5mm的孔隙的烧结矿数量增多提高了料层的透气性,低温烧结工艺也抑制了铁矿石的自身熔化。而在未熔化的铁矿石中,小于1μm的微孔隙的存在也使烧结矿的还原性提高,从而改善烧结饼的孔隙结构,提高烧结矿质量。2009年1月,京浜1号烧结机应用了该技术,到目前为止工况稳定。结果,烧结工序的能源利用率大幅提升,减排CO2约6万t/a。 | Nobuyuki Oyama Yuji Iwami Satoshi Machida Takahide Higuchi Tetsuya Yamamoto Yushinori Watanabe Michitaka Sato Kanji Takeda Masakata Shimizu Koki Nishioka 何海良 | 2013 | 世界钢铁2013，，1： | 11 |
| 2 | Prognosis following transcatheter arterial embolization for 121 patients with unresectable hepatocellular carcinoma with or without a history of treatment显示文摘瞄准:回顾地为 HCC 后面的 transcatheter 与肝细胞癌(HCC ) 评估病人的预后与或没有治疗的历史动脉的 embolization (TAE ) 。方法:有在我们的医院里从 1992 ~ 2004 与 TAE 对待的 HCC 的 121 个病人在这研究被注册。84 个病人为 HCC 有治疗的历史,当时 37。在入口,有额外肝的转移的病人,门静脉肿瘤血栓,或孩子呸班的时候, C 被排除。当 HCC 的复发被提高的肿瘤标记,或 ultrasonography 或动态计算断层摄影术调查结果诊断时, TAE 被重复。结果:肿瘤尺寸更大,没有过去的治疗(P<0.01 ) ,肿瘤的数字是在病人的少数。然而,在节点转移(TNM ) 舞台或幸存在 2 个组之间评估的肿瘤没有差别。一个双性人 alpha-fetoprotein (法新社)(>100 ng/mL ) 的小叶片的肿瘤和高水平是与在有 HCC 的历史的病人的差的预后有关的因素。结论:预后追随者 TAE 在有或没有过去的治疗的 HCC 病人之间是类似的。在到一堂重复 TAE 功课的入口能改进预后以前, HCC 或周期性的 HCC 和获得的好本地人的早诊断对 HCC 控制。 | Atsushi Hiraoka Teru Kumagi Masashi Hirooka Takahide Uehara Kiyotaka Kurose Hidehito luchi Yoichi Hiasa Bunzo Matsuura Kojiro Michitaka Seishi Kumano Hiroaki Tanaka Yoshimasa Yamashita Norio Horiike Teruhito Mochizuki Morikazu Onji | 2006 | World Journal of Gastroenterology2006，12，13： | 9 |
| 3 | 植物病毒病发生威胁粮食作物稳产(译)显示文摘近年来我国水稻生产上病毒病频繁发生,已对部分地区水稻生产安全造成一定影响,目前在国家区试中已率先启动了水稻条纹叶枯病、水稻黑条矮缩病和南方水稻黑条矮缩病鉴定,本译文旨在介绍当前威胁和有潜在威胁的水稻为主的谷物病毒病生物学特性、传播流行规律、病毒带毒监测技术、病毒的基因功能及其与介体互作分子机制、抗病毒新材料的创制等方面的研究进展,为开展水稻病毒病抗性品种选育及病害防控技术开发相关研究提供参考借鉴。 | 曾波 兰莹 周彤 Nobuhiro S Takahide S Il-Ryong C | 2017 | 种子2017，36，10： | 2 |
| 4 | Phase 1 study of efatutazone, a novel oral peroxisome proliferator-activated receptor gamma agonist, in combination with FOLFIRI as second-line therapy in patients with metastatic colorectal cancer显示文摘 | Yoshito Komatsu Takayuki Yoshino Kentaro Yamazaki Satoshi Yuki Nozomu Machida Takahide Sasaki Ichinosuke Hyodo Yutaka Yachi Hiroshi Onuma Atsushi Ohtsu | 2014 | Investigational New Drugs2014，，3： | 2 |
| 5 | Efficacy of MK615 for the treatment of patients with liver disorders显示文摘AIM:To investigate the hepatoprotective effect of MK615,a Japanese apricot extract,in an animal model,and its clinical therapeutic effect.METHODS:Wistar rats were administered physiological saline(4 mL/kg) or MK615 solution(4 mL/kg) for 7 d.On the sixth d,acute hepatic injury was induced by administering a single intraperitoneal injection(ip) of D-galactosamine hydrochloride(D-GalN)(600 mg/kg).Plasma levels of alanine aminotransferase(ALT) and aspartate aminotransferase(AST) were determined,and liver tissues were used for histopathological analysis.Fifty-eight patients with liver disorders [hepatitis C(n = 40),non-alcoholic fatty liver disease(n = 15),and autoimmune liver disease(n = 3)] were orally administered commercially available Misatol ME-containing MK615(13 g/d) daily for 12 wk.Blood and urine were sampled immediately before and 6 wk,12 wk,and 16 wk after the start of intake to measure various biochemical parameters.The percentage change in ALT and AST levels after 12 wk from the pre-intake baseline served as a primary endpoint.RESULTS:D-GalN effectively induced acute hepatic injury in the rats.At 48 h after the ip injection of D-GalN,the plasma levels of ALT(475.6 ± 191.5 IU/L vs 225.3 ± 194.2 IU/L,P < 0.05) and AST(1253.9 ± 223.4 IU/L vs 621.9 ± 478.2 IU/L,P < 0.05) in the MK615 group were significantly lower than the control group.Scattered single cell necrosis,loss of hepatocytes,and extensive inflammatory cell infiltration were observed in hepatic tissue samples collected from the control group.However,these findings were less pronounced in the group receiving MK615.At the end of the clinical study,serum ALT and AST levels were significantly decreased compared with pre-intake baseline levels from 103.5 ± 58.8 IU/L to 71.8 ± 39.3 IU/L(P < 0.05) and from 93.5 ± 55.6 IU/L to 65.5 ± 34.8 IU/L(P < 0.05),respectively.A reduction of ≥ 30% from the pre-study baseline ALT level was observed in 26(45%) of the 58 patients,while 25(43%) patients exhibited similar AST level reductions.The chronic hepatitis C group exhibited significant ALT and AST level reductions from 93.4 ± 51.1 IU/L to 64.6 ± 35.1 IU/L(P < 0.05) and from 94.2 ± 55.5 IU/L to 67.2 ± 35.6 IU/L(P < 0.05),respectively.A reduction of ≥ 30% from the pre-study baseline ALT level was observed in 20(50%) of the 40 patients.ALT levels in both the combined ursodeoxycholic acid(UDCA) treatment and the UDCA uncombined groups were significantly lower after Misatol ME administration.MK615 protected hepatocytes from D-GalN-induced cytotoxicity in rats.Misatol ME decreased elevated ALT and AST levels in patients with liver disorders.CONCLUSION:These results suggest that MK615 and Misatol ME are promising hepatoprotective agents for patients with liver disorders. | Atsushi Hokari Tomohisa Ishikawa Hisao Tajiri Takahide Matsuda Osamu Ishii Nobuyuki Matsumoto Chiaki Okuse Hideaki Takahashi Takeshi Kurihara Ko-ichi Kawahara Ikuro Maruyama Mikio Zeniya | 2012 | World Journal of Gastroenterology2012，18，31： | 2 |
| 6 | RuHCl( CO ) ( PPh3 ) 3 -catalyzed chemoselective transfer-hydrogenation of enones leading to saturated ketones 显示文摘 | Takahide D Fukuyama T Horiguchi J | 2006 | Synlett2006，，5： | 1 |
| 7 | Formation and characteristics of dynamic membrane for ultrafiltration of protein in binary protein system显示文摘 | Hideto M Takahide S Masaaki T | 1994 | J Membr Sci1994，92，： | 1 |
| 8 | Changes in serum cholesterol levels determine future risk of cardiovascular events in patients with acute coronary syndrome in the Japanese Coronary Artery Disease (JCAD) Study显示文摘 | Shota Fukuda Kenei Shimada Masatoshi Fujita Minoru Yoshiyama Junichi Yoshikawa Takahide Kohro Doubun Hayashi Tsutomu Yamazaki Ryozo Nagai | 2013 | Journal of Cardiology2013，，6： | 1 |
| 9 | Role of bone marrow cells in the development of pancreatic fibrosis in a rat model of pancreatitis induced by a choline-deficient/ethionine-supplemented diet显示文摘 | Shingo Akita Koji Kubota Akira Kobayashi Ryosuke Misawa Akira Shimizu Takenari Nakata Takahide Yokoyama Masafumi Takahashi Shinichi Miyagawa | 2012 | Biochemical and Biophysical Research Communications2012，，4： | 1 |
| 10 | Radiofrequency ablation of hep- atocellular carcinoma:correlation between LTP after ablation and ablative margin显示文摘 | Takahide N Shigehiro K | 2007 | AJR2007，188，： | 1 |
| 11 | Intrahepatic distant recurrence after radiofrequency ablation for a single small hepatocellular carcinoma: Risk factors and patterns显示文摘 | Yusuke Okuwaki Takahide Nakazawa Akitaka Shibuya Koji Ono Hisashi Hidaka Masaaki Watanabe Shigehiro Kokubu Katsunori Saigenji | 2008 | Journal of Gastroenterology2008，，1： | 1 |
| 12 | Hyaluronan deficiency in tumor stroma impairs macrophage trafficking and tumor neovascu-larization 显示文摘 | Nonutaka K Seijim Takahide M | 2010 | AACR2010，70，： | 1 |
| 13 | High-speed optical DQPSK and FSK modulation using integrated Mach-Zehnder interferome- ters显示文摘 | TETSUYA K TAKAHIDE S TETSUYA M | 2006 | Optics Express2006，14，10： | 1 |
| 14 | Optimization of coke breeze sega'egation in sintering bed under high pisolite ore ratio 显示文摘 | MACHIDA Satoshi HIGUCHI Takahide OYAMA Nobuyuki | 2009 | ISIJ International2009，49，5： | 1 |
| 15 | Cationic organotin clusters for highly efficient alcohol acetylation catalysts显示文摘 | Durand Sandrine Sakamoto Katsumasa Fukuyama Takahide | 2000 | Organometallics2000，19，16： | 1 |
| 16 | Opti- mization of coke breeze segregation in sintering bed under high piso-lite ore ratio 显示文摘 | Maehida Satoshi Higuchi Takahide Oyama Nobuyuki et al | 2009 | ISIJ International2009，49，5： | 1 |
| 17 | Early increase in α-fetoprotein for predicting unfavorable clinical outcomes in patients with advanced hepatocellular carcinoma treated with sorafenib显示文摘 | Takahide Nakazawa Hisashi Hidaka Juichi Takada Yusuke Okuwaki Yoshiaki Tanaka Masaaki Watanabe Akitaka Shibuya Tsutomu Minamino Shigehiro Kokubu Wasaburo Koizumi | 2013 | European Journal of Gastroenterology & Hepatology2013，，6： | 1 |
| 18 | 尼可地尔在日本冠状动脉疾病研究(JCAD)中对冠状动脉疾病患者心血管事件的影响显示文摘(接1月下)在观察研究中,对照组和治疗组之间的协变量不能进行调整,因此药物作用结果可能存在偏差。不过,采用包含药物使用情况的协变量作为条件概率的倾向得分分析,可在2实验组间形成良好的协变量平衡,并减少这种类型的偏差。对每个病人的倾向评分可表明服药的可能性,使用多重逻辑回归分析方法进行计算。所有的临床特征和除尼可地尔以外的药物都用到本计算中。 | Shigeo Horinaka Akihisa Yabe Hiroshi Yagi Toshihiko Ishimitsu Tsutomu Yamazaki Shinya Suzuki Takahide Kohro Ryozo Nagai 陈浩(译) | 2016 | 首都食品与医药2016，0，4： | 1 |
| 19 | Sequence Comparison of the ORF7 Region of Transmissible Gastroenteritis Viru- ses Isolated in Japan显示文摘 | Takahide Taniguchi Rie Taniguehi | 2004 | Virol2004，66，： | 1 |
| 20 | Applications of pulse heating thermography and lock-in thermography to quantitative nondestructive evaluations显示文摘 | Takahide S Shiro K | 2002 | Infrared Physics & Technology2002，43，： | 1 |
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