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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 3 | Distribution of pericellular matrix molecules in the temporomandibular joint and their chondroprotective effects against inflammation显示文摘The objectives of this study were to(1) determine the distribution and synthesis of pericellular matrix(PCM) molecules(collagen VI, collagen IV and laminin) in rat temporomandibular joint(TMJ) and(2) investigate the effects of PCM molecules on chondrocytes against inflammation in osteoarthritis. Four zones(fibrous, proliferating, mature and hypertrophic) of condylar cartilage and three bands(anterior, intermediate and posterior) of disc were analysed by immunohistochemistry for the presence of PCM molecules in rat TMJs. Isolated chondrocytes were pre-treated with PCM molecules before being subjected to interleukin(IL)-1β treatment to stimulate inflammation. The responses of the chondrocytes were analysed using gene expression, nitric oxide release and matrix metalloproteinase(MMP)-13 production measures. Histomorphometric analyses revealed that the highest areal deposition of collagen VI(67.4%), collagen IV(45.7%) and laminin(52.4%) was in the proliferating zone of TMJ condylar cartilage. No significant difference in the distribution of PCM molecules was noted among the three bands of the TMJ disc. All three PCM molecules were expressed intracellularly by chondrocytes cultured in the monolayer. Among the PCM molecules, pre-treatment with collagen VI enhanced cellular proliferation, ameliorated IL-1β-induced MMP-3, MMP-9, MMP-13 and inducible nitric oxide synthase gene expression, and attenuated the downregulation of cartilage matrix genes, including collagen I, aggrecan and cartilage oligomeric matrix protein(COMP). Concurrently, collagen VI pretreatment inhibited nitric oxide and MMP-13 production. Our study demonstrates for the first time the distribution and role of PCM molecules, particularly collagen VI, in the protection of chondrocytes against inflammation. | Wern Cui Chu Shipin Zhang Timothy J Sng Yu Jie Ong Wen-Li Tan Vivien Y Ang Casper B Foldager Wei Seong Toh | 2017 | International Journal of Oral Science2017，9，1： | 5 |
| 4 | A Novel Strategy to Fabricate γ-Fe2O3-MWCNTs Hybrids with Selectively Ferromagnetic or Superparamagnetic Properties 显示文摘 | Fan X B Tan F Y Zhang G L | 2007 | Mater Sci & Eng A2007，45，： | 1 |
| 5 | A randomized, controlled study comparing minilaparotomy versus isobaric gasless laparoscopic assisted minilaparotomy myomectomy for removal of large uterine myomas: short-term outcomes 显示文摘 | Tan J Sun Y Zhong B | 2009 | Obstet Gynecol Reprod Bio12009，145，1： | 1 |
| 6 | Genetic bases of appearance quality of rice grains in Shanyou 63, an elite rice hybrid显示文摘 | Tan Y F Li J X Yu S B et a1 | 2000 | Theor Appl Genet2000，101，56： | 1 |
| 7 | Function of the SIRT1 protein deacetylase in cancer显示文摘 | Stunkel W Peh B K Tan Y C | 2007 | Biotechnol J2007，2，11： | 1 |
| 8 | Ionothermal synthesis,crystal structure,and properties of an anionic two-dimensional cadmium metal organic framework based on paddle wheel-like cluster显示文摘 | Tan B Xie Z L Huang X Y | 2011 | Inorganic Chemistry Communications2011，14，6： | 1 |
| 9 | Effects of natural and synthetic antioxi- dants on changes in refined, bleached, and deodorized palm olein during deep - fat frying of potato chips 显示文摘 | Man Y B Tan C P | 1999 | Journal of the American Oil Chemists'' Society1999，76，3： | 1 |
| 10 | Experimental observation of the quantum hall effect and Berry' s phase in graphene 显示文摘 | Zhang Y B Tan Y W | 2005 | Na*ure2005，438，7065： | 1 |
| 11 | Comparative binding of CrylAb and CrylF Bacillus thuringiensis toxins to brush border membrane proteins from Ostrinia nubilalis, Os- trinia furnacalis and Diatraea saccharalis (Lepidoptera: Crambidae) midgut tissue 显示文摘 | Tan S Y Cayabyab B F Alcantara E P | 2013 | Journal of Invertebrate Pathol- ogy2013，114，3： | 1 |
| 12 | Lipoprotein subfraction distribution in Chinese patients with non-insulin-dependent diabetes mellitus显示文摘 | Tan K C Shiu S W Chu B Y | 1999 | Clin Biochem1999，32，2： | 1 |
| 13 | Mesoporous Co3O4 nanowire arrays for lithium ion batteries with high capacity and rate capability显示文摘 | LI Y G TAN B WU Y | 2008 | Nano Letters2008，8，1： | 1 |
| 14 | Quantum-dot based nanoparticles for targeted silencing of HEPR2/neu gene via RNA interferenee 显示文摘 | Tan W B Jiang S Zhang Y | 2007 | Biomaterials2007，28，8： | 1 |
| 15 | Characterisation of vegetable oils by surface acoustic wave sensing electronic nose显示文摘 | GAN H L CHEMAN Y B TAN C P | 2005 | Food Chemistry2005，89，： | 1 |
| 16 | The three important traits for cooking and eating quality of rice grains are controlled by a single locus in an elite rice hybrid,Shan you 63显示文摘 | Tan Y F Li J X Yu S B | 1999 | Theor Apll Genet1999，99，： | 1 |
| 17 | Fabrication of CdSfilms with superhydrophobicity by the microwaveassisted chemical bath deposition 显示文摘 | Liu Y Tan T Wang B | 2008 | Journal ofColloid and Interface Science [ISSN 0021-9797]2008，320，2： | 1 |
| 18 | Core Structure Based Design of Organocatalytic-Cycloaddition Reactions:Highly Efficient and Stereocontrolled Syntheses of 3,3'-Pyrrolidonyl Spirooxindoles显示文摘 | Tan B Zeng X Long W W Y | 2012 | Chem Eur J2012，18，1： | 1 |
| 19 | An evaluation of color-spatial retrieval techniques for large image databases显示文摘 | Tan K L Ooi B C Yee C Y | | 0，，01： | 1 |
| 20 | Contributing knowledge to electronic knowledge repositories: an empirical investigation显示文摘 | KANKANHALLI A TAN B C Y WEI K K | 2005 | MIS Quarterly2005，29，1： | 1 |
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