|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Combining CLUE-S and SWAT Models to Forecast Land Use Change and Non-point Source Pollution Impact at a Watershed Scale in Liaoning Province, China显示文摘Non-point source(NPS) pollution has become a major source of water pollution. A combination of models would provide the necessary direction and approaches designed to control NPS pollution through land use planning. In this study, NPS pollution load was simulated in urban planning, historic trends and ecological protection land use scenarios based on the Conversion of Land Use and its Effect at Small regional extent(CLUE-S) and Soil and Water Assessment Tool(SWAT) models applied to Hunhe-Taizi River Watershed, Liaoning Province, China. Total nitrogen(TN) and total phosphorus(TP) were chosen as NPS pollution indices. The results of models validation showed that CLUE-S and SWAT models were suitable in the study area. NPS pollution mainly came from dry farmland, paddy, rural and urban areas. The spatial distribution of TN and TP exhibited the same trend in 57 sub-catchments. The TN and TP had the highest NPS pollution load in the western and central plains, which concentrated the urban area and farm land. The NPS pollution load would increase in the urban planning and historic trends scenarios, and would be even higher in the urban planning scenario. However, the NPS pollution load decreased in the ecological protection scenario. The differences observed in the three scenarios indicated that land use had a degree of impact on NPS pollution, which showed that scientific and ecologically sound construction could effectively reduce the NPS pollution load in a watershed. This study provides a scientific method for conducting NPS pollution research at the watershed scale, a scientific basis for non-point source pollution control, and a reference for related policy making. | LIU Miao LI Chunlin HU Yuanman SUN Fengyun XU Yanyan CHEN Tan | 2014 | Chinese Geographical Science2014，24，5： | 15 |
| 2 | Estimation of Ecological Water Requirements Based on Habitat Response to Water Level in Huanghe River Delta,China显示文摘In recent years,wetland ecological water requirements (EWRs) have been estimated by using hydrological and functional approaches,but those approaches have not yet been integrated for a whole ecosystem.This paper presents a new method for calculating wetland EWRs,which is based on the response of habitats to water level,and determines water level threshold through the functional integrity of habitats.Results show that in the Huanghe (Yellow) River Delta water levels between 5.0 m and 5.5 m are required to maintain the functional integrity of the wetland at a value higher than 0.7.One of the dominant plants in the delta,Phragmites australis,tolerates water level fluctuation of about ± 0.25 m without the change in wetland functional integrity.The minimum,optimum and maximum EWRs for the Huanghe River Delta are 9.42×106 m3,15.56×106 m3 and 24.12×106 m3 with water levels of 5.0 m,5.2 m and 5.5 m,corresponding to functional integrity indices of 0.70,0.84 and 0.72,respectively.A wetland restoration program has been performed,which aims to meet these EWRs in attempt to recover from losses of up to 98% in the delta's former wetland area. | CUI Baoshan HUA Yanyan WANG Chongfang LIAO Xiaolin TAN Xuejie TAO Wendong | 2010 | Chinese Geographical Science2010，20，4： | 7 |
| 3 | jadR* and jadR2 act synergistically to repress jadomycin biosynthesis显示文摘The biosynthesis of antibiotics is controlled by cascade regulation involving cluster-situated regulators (CSRs) and pleiotropic regulators. Three CSRs have been identified in the jadomycin biosynthetic gene cluster, including one OmpR-type activator (JadR1) and two TetR-like repressors (JadR* and JadR2). To examine their interactions in jadomycin biosynthesis, a series of mutants were generated and tested for jadomycin production. We noticed that jadomycin production in the jadR*-jadR2 double mutant was increased dramatically compared with either single mutant. Transcriptional analysis showed that jadR* and jadR2 act synergistically to repress jadomycin production by inhibiting the transcription of jadR1. Furthermore, jadR* and jadR2 reciprocally inhibit each other. The complex interactions among these three CSRs may provide clues for the activation of the jadomycin gene cluster, which would otherwise remain silent without stimulation from stress signals. | ZHANG YanYan ZOU ZhengZhong NIU GuoQing TAN HuaRong | 2013 | Science China(Life Sciences)2013，56，7： | 6 |
| 4 | Application system and data description of the China Seismo-Electromagnetic Satellite显示文摘The China Seismo-Electromagnetic Satellite, launched into orbit from Jiuquan Satellite Launch Centre on February 2 nd, 2018, is China's first space satellite dedicated to geophysical exporation. The satellite carries eight scientific payloads including high-precision magnetometers to detect electromagnetic changes in space, in particular changes associated with global earthquake disasters. In order to encourage and facilitate use by geophysical scientists of data from the satellite's payloads, this paper introduces the application systems developed for the China Seismo-Electromagnetic Satellite by the Institute of Crustal Dynamics, China Earthquake Administration;these include platform construction, data classification, data storage, data format, and data access and acquisition. | JianPing Huang XuHui Shen XueMin Zhang HengXin Lu Qiao Tan Qiao Wang Rui Yan Wei Chu YanYan Yang DaPeng Liu Song Xu | 2018 | Earth and Planetary Physics2018，2，6： | 5 |
| 5 | A targeted sequencing approach to find novel pathogenic genes associated with sporadic aortic dissection显示文摘Aortic dissection(AD) is a heterogeneous genetic disease of the aorta with high mortality and poor prognosis. However, only few genetic causes of AD have been explored till date. After conducting a broad literature review focused on identifying potential pathogenic pathways, we designed a panel containing 152 AD-associated genes to conduct massively parallel targeted nextgeneration sequencing of 702 sporadic aortic dissection patients and 163 matched healthy controls. After validation by Sanger sequencing, we identified 21 definitely pathogenic and 635 likely pathogenic variants in 61.25%(430/702) of patients. In these patients, 34.88%(150/430) harbored more than one variant that was either definitely or likely to be pathogenic. Among the candidate genes, we identified 546 likely pathogenic variants in 47.72%(335/702) of patients. Importantly, we identified 94 lossof-function(LOF) variants in 45 genes in AD patients, but only five LOF variants in the controls(P=1.34×10^(-4)). With a burden test, we highlighted RNF213 as an important new gene for AD pathogenesis. We also performed transcriptome sequencing of human aorta tissues to evaluate the expression levels of these newly identified genes. Our study has compiled a comprehensive genetic map of sporadic AD in the Han Chinese population. We believe it will facilitate risk predicting and genetic diagnosis of this severe disease in the future. | Zongzhe Li Chengming Zhou Lun Tan Peng Chen Yanyan Cao Xianqing Li Jiangtao Yan Hesong Zeng Dao-Wu Wang Dao-Wen Wang | 2018 | Science China(Life Sciences)2018，61，12： | 4 |
| 6 | Variants of genes encoding collagens and matrix metalloproteinase system increased the risk of aortic dissection显示文摘Aortic dissection(AD) is a devastating,heterogeneous condition of aorta.The homeostasis between collagens and matrix metalloproteases(MMPs)/tissue inhibitors of MMPs(TIMPs) system in the extracellular matrix plays an important role for structure and functions of aorta.However,our knowledge on association between variants of genes in this system and pathogenesis of AD is very limited.We analyzed all yet known coding human genes of collagens(45 genes),MMPs/TIMPs(27genes) in 702 sporadic AD patients and in 163 matched healthy controls,by using massively targeted next-generation and Sanger sequencing.To define the pathogenesis of potential disease-causing candidate genes,we performed transcriptome sequencing and pedigree co-segregation analysis in some genes and generated Col5a2 knockout rats.We identified 257 pathogenic or likely pathogenic variants which involved 88.89%(64/72) genes in collagens-MMPs/TIMPs system and accounted for 31.05%(218/702) sporadic AD patients.In them,84.86%patients(185/218) carried one variant,12.84%two variants and 2.30%more than two variants.Importantly,we identified 52 novel probably pathogenic loss-of-function(LOF) variants(20 nonsense,16 frameshift,14 splice sites,one stop-loss,one initiation codon) in 11.06%(50/452) AD patients,which were absent in 163controls(P=2.5×10^(-5)).Transcriptome sequencing revealed that identified variants induced dyshomeostasis in expression of collagens-TIMPs/MMPs systems.The Col5α2^(-/-) rats manifested growth retardation and aortic dysplasia.Our study provides a first comprehensive map of genetic alterations in collagens-MMPs/TIMPs system in sporadic AD patients and suggests that variants of these genes contribute largely to AD pathogenesis. | Zongzhe Li Chengming Zhou Lun Tan Peng Chen Yanyan Cao Chenze Li Xianqing Li Jiangtao Yan Hesong Zeng Dao-Wu Wang Dao-Wen Wang | 2017 | Science China(Life Sciences)2017，60，1： | 4 |
| 7 | LKB1 orchestrates dendritic cell metabolic quiescence and anti-tumor immunity显示文摘Den dritic cells(DCs)play a pivotal role in priming adaptive immunity.However,the in volveme nt of DCs in con trolling excessive and deleterious T cell responses remains poorly defined.Moreover,the metabolic dependenee and regulation of DC function are unclear.Here we show that LKB1 signaling in DCs functions as a brake to restrain excessive tumor-promoting regulatory T cell(Treg)and Th17 cell responses,thereby promoting protective anti-tumor immunity and maintaining proper immune homeostasis.LKB1 deficiency results in dysregulated metabolism and mTOR activation of DCs.Loss of LKB1 also leads to aberrant DC maturation and production of cytokines and immunoregulatory molecules.Blocking mTOR signaling in LKB1-deficient DCs partially rectifies the abno rmal phe no types of DC activation and Treg expansio n,whereas unc on trolled Th17 resp on ses depend upon IL-6-STAT3 signaling.By coordi nating metabolic and immune quiesce nee of DCs,LKB1 acts as a crucial signali ng hub in DCs to enforce protective anti-tumor immunity and normal immune homeostasis. | Yanyan Wang Xingrong Du Jun Wei Lingyun Long Haiyan Tan Cliff Guy Yogesh Dhungana Chenxi Qian Geoffrey Neale Yang-Xin Fu Jiyang Yu Junmin Peng Hongbo Chi | 2019 | Cell Research2019，29，5： | 3 |
| 8 | Bioinspired tungsten-copper composites with Bouligand-type architectures mimicking fish scales显示文摘The microscopic Bouligand-type architectures of fish scales demonstrate a notable efficiency in enhancing the damage tolerance of materials;nevertheless,it is challenging to reproduce in metals.Here bioinspired tungsten-copper composites with different Bouligand-type architectures mimicking fish scales were fabricated by infiltrating a copper melt into woven contextures of tungsten fibers.These composites exhibit a synergetic enhancement in both strength and ductility at room temperature along with an improved resistance to high-temperature oxidization.The strengths were interpreted by adapting the classical laminate theory to incorporate the characteristics of Bouligand-type architectures.In particular,under load the tungsten fibers can reorient adaptively within the copper matrix by their straightening,stretching,interfacial sliding with the matrix,and the cooperative kinking deformation of fiber grids,representing a successful implementation of the optimizing mechanisms of the Bouligand-type architectures to enhance strength and toughness.This study may serve to promote the development of new high-performance tungsten-copper composites for applications,e.g.,as electrical contacts or heat sinks,and offer a viable approach for constructing bioinspired architectures in metallic materials. | Yuan Zhang Guoqi Tan Mingyang Zhang Qin Yu Zengqian Liu Yanyan Liu Jian Zhang Da Jiao Faheng Wang Longchao Zhuo Zhefeng Zhang Robert O.Ritchie | 2022 | Journal of Materials Science & Technology2022，，1： | 3 |
| 9 | An Efficient Content-Based Image Retrieval System Using kNN and Fuzzy Mathematical Algorithm显示文摘The implementation of content-based image retrieval(CBIR)mainly depends on two key technologies:image feature extraction and image feature matching.In this paper,we extract the color features based on Global Color Histogram(GCH)and texture features based on Gray Level Co-occurrence Matrix(GLCM).In order to obtain the effective and representative features of the image,we adopt the fuzzy mathematical algorithm in the process of color feature extraction and texture feature extraction respectively.And we combine the fuzzy color feature vector with the fuzzy texture feature vector to form the comprehensive fuzzy feature vector of the image according to a certain way.Image feature matching mainly depends on the similarity between two image feature vectors.In this paper,we propose a novel similarity measure method based on k-Nearest Neighbors(kNN)and fuzzy mathematical algorithm(SBkNNF).Finding out the k nearest neighborhood images of the query image from the image data set according to an appropriate similarity measure method.Using the k similarity values between the query image and its k neighborhood images to constitute the new k-dimensional fuzzy feature vector corresponding to the query image.And using the k similarity values between the retrieved image and the k neighborhood images of the query image to constitute the new k-dimensional fuzzy feature vector corresponding to the retrieved image.Calculating the similarity between the two kdimensional fuzzy feature vector according to a certain fuzzy similarity algorithm to measure the similarity between the query image and the retrieved image.Extensive experiments are carried out on three data sets:WANG data set,Corel-5k data set and Corel-10k data set.The experimental results show that the outperforming retrieval performance of our proposed CBIR system with the other CBIR systems. | Chunjing Wang Li Liu Yanyan Tan | 2020 | Computer Modeling in Engineering & Sciences2020，，9： | 2 |
| 10 | 电磁监测试验卫星及其初步成果显示文摘As the first satellite of the China national geophysical field observation series of stllite missions,the China Seismo--Electromagnetic Satellite(CSES)was designed upon an optimized CAST2000 platform for a sun synchronous orbit.Onboard CSES,there are total eight types of scientific payloads including the Search-coil Magnetometer,Electric Field Detector,High Precision Magnetometer,GNSS Occupation Receiver,Plasma Analyzer,Langmuir Probe,Energetic Particle Detector Package,and a Three-band Transmitter to individually acquire the global eletromagnetic field,elec-tromagnetic waves,ionospheric plasma parameters as well as energetic particles.Up to now,CSES has been operating normally in orbit for 2 years.By using the various sensor data acquired by CSES,we have achieved scientfic research in the areas of the global geomagnetic field modeling,space weather,earthquake event analysis,the Lithosphere-Atmo-sphere-lonosphere coupling mechanism and so on.. | SHEN Xuhui ZEREN Zhima YUAN Shigeng DAI Jianping HUANG Jianping ZHU Xinghong YANG Yanyan YAN Rui ZHAO Shufan LIU Dapeng ZHANG Zhenxia WANG Qiao CHU Wei LU Hengxin XU Song GUO Feng TAN Qiao LI Wenjing ZHOU Na | 2020 | Aerospace China2020，21，1： | 2 |
| 11 | Expression of CD147 and Lewis y antigen in ovarian cancer and their relationship to drug resistance显示文摘 | Jian Gao Zhenhua Hu Juanjuan Liu Dawo Liu Yanyan Wang Mingbo Cai Danye Zhang Mingzi Tan Bei Lin | 2014 | Medical Oncology2014，，5： | 2 |
| 12 | SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors显示文摘Muta nt isocitrate dehydrog en ase 1(mlDH1)drives tumorigenesis via produci ng on cometabolite R-2-hydroxyglutarate(R-2-HG)across various tumor types.However,mlDHl in hibitors appear only effective in hematological tumors.The therapeutic ben efit in solid tumors remains elusive,likely due to the complex tumor microenvironment.In this study,we discover that R-2-HG produced by IDH1-mutant tumor cells is preferentially imported into vascular endothelial cells and remodels mitochondrial respiration to promote tumor angiogenesis,conferring a therapeutic vulnerability in IDH1-mutant solid tumors.Mechanistically,SLC1 Alz a Na'-depe ndent glutamate tran sporter that is prefere ntially expressed in en dothelial cells,facilitates the in flux of R-2-HG from the tumor microenvironment into the endothelial cells as well as the intracellular trafficking of R-2-HG from cytoplasm to mitochondria.R-2-HG hijacks SLC1A1 to promote mitochondrial Na^(+)/Ca^(2+)exchange,which activates the mitochondrial respiratory chain and fuels vascular en dothelial cell migratio n in tumor an giogenesis.SLC1A1 deficiency in mice abolishes mlDHl-promoted tumor an giogenesis as well as the therapeutic benefit of mlDHl in hibitor in solid tumors.Moreover,we report that HH2301,a newly discovered mlDHl inhibitor,shows promising efficacy in treating IDH1-mutant cholangiocarcinoma in preclinical models.Together,we identify a new role of SLC1A1 as a gatekeeper of R-2-HG-mediated crosstalk between IDH1-mutant tumor cells and vascular en dothelial cells,and dem on strate the therapeutic potential of mlDHl in hibitors in treating IDH1-muta nt solid tumors via disrupting R-2-HG-promoted tumor angiogenesis. | Xiaomin Wang Ziqi Chen Jun Xu Shuai Tang Nan An Lei Jiang Yixiang Zhang Shaoying Zhang Qingli Zhang Yanyan Shen Shijie Chen Xiaojing Lan Ting Wang Linhui Zhai Siyuwei Cao Siqi Guo Yingluo Liu Aiwei Bi Yuehong Chen Xiameng Gai Yichen Duan Ying Zheng Yixian Fu Yize Li Liang Yuan Linjiang Tong Kun Mo Mingcheng Wang Shu-Hai Lin Minjia Tan Cheng Luo Yi Chen Jia Liu Qiansen Zhang Leping Li Min Huang | 2022 | Cell Research2022，32，7： | 2 |
| 13 | MOEA/D+ uniform Design: a New Version of MOEA/D for Optimization Problems with Manyobjectives 显示文摘 | Tan Yanyan Jiao Yongchang Li Hong | 2013 | Computers & Operations Research2013，40，6： | 1 |
| 14 | MOEA/D+ uniform design:a new version of MOEA/D for optimization problems with many objectives显示文摘 | TAN Yanyan JIAO Yongchang LI Hong | 2013 | Computers & Operations Research2013，40，6： | 1 |
| 15 | Existence and features of the myodural bridge in gentoo penguins:a morphological study显示文摘Recent studies have evidenced that the anatomical structure now known as the myodural bridge(MDB)connects the suboccipital musculature to the cervical spinal dura mater(SDM).In humans,the MDB passes through both the posterior atlanto-occipital and the posterior atlanto-axial interspaces.The existence of the MDB in various mammals,including flying birds(Rock pigeons and Gallus domesticus)has been previously validated.Gentoo penguins are the world's fastest diving birds.The present study was therefore carried out to investigate the existence and characteristics of the MDB in Gentoo penguin,a non-flying,marine bird that can dive.For this study,six Gentoo penguin specimens were dissected to observe the existence and composition of their MDB. | Cheng Chen Yu Shengbo Chi Yanyan Tan Guangyuan Yan Baocheng Zheng Nan Sui Hongjin | 2021 | 解剖学杂志2021，44，S01： | 1 |
| 16 | Expression of CD147 and Lewis y antigen in ovarian cancer and their relationship to drug resistance显示文摘 | Jian Gao Zhenhua Hu Juanjuan Liu Dawo Liu Yanyan Wang Mingbo Cai Danye Zhang Mingzi Tan Bei Lin | 2014 | Medical Oncology2014，，5： | 1 |
| 17 | Current Status and Main Scientific Results of In-flight CSES Mission显示文摘The CSES(China Seismo-Electromagnetic Satellite)is the electromagnetism satellite of China’s Zhangheng mission which is planned to launch a series of microsatellites within next 10 years in order to monitor the electromagnetic environment,gravitational field.The CSES 01 probe(also called ZH-1)was launched successfully on 2 February 2018,from the Jiuquan Satellite Launch Centre(China)and is expected to operate for 5 years in orbit.The second probe CSES 02 is going to be launched in 2022.The scientific objectives of CSES are to detect the electromagnetic field and waves,plasma and particles,for studying the seismic-associated disturbances.To meet the requirements of scientific objective,the satellite is designed to be in a sun-synchronous orbit with a high inclination of 97.4°at an altitude around 507 km.CSES carries nine scientific payloads including Search-coil magnetometer,Electric Field Detector,High precision Magnetometer,GNSS occultation Receiver,Plasma Analyzer,Langmuir Probe,two Energetic Particle Detectors(including an Italian one),and Tri-Band Transmitter.Up to now,CSES has been operating in orbit for 2 years with stable and reliable performance.By using all kinds of data acquired by CSES,we have undertaken a series of scientific researches in the field of global geomagnetic field re-building,the ionospheric variation environment,waves,and particle precipitations under disturbed space weather and earthquake activities,the Lithosphere-Atmosphere-Ionosphere coupling mechanism research and so on. | SHEN Xuhui ZEREN Zhima HUANG Jianping YANG Yanyan ZHAO Shufan YAN Rui ZHANG Zhenxia LIU Dapeng WANG Qiao CHU Wei LU Hengxin XU Song GUO Feng TAN Qiao LI Wenjing ZHOU Na SONG Fuxi | 2020 | 空间科学学报2020，40，5： | 1 |
| 18 | Extracellular vesicles based electrochemical biosensors for detection of cancer cells:A review显示文摘Extracellular vesicles(EVs)derived from cancer cells are considered as ideal biomarker for liquid biopsy in cancer diagnosis,and are stable and abundant.Electrochemical methods for the detection of EVs are prefe rred over co nventional methods such as Western blotting and enzyme-linked immunosorbent assay for their high sensitivity and real-time detection.This article summaries studies proposing the electrochemical methods utilizing immunological and molecular methodologies for detecting EVs derived biomacromolecules such as miRNAs and transme mbrane protein for cancer diagnosis.Moreover,the electrochemical detection methods are compared and future prospects for the development of electrochemical methods for EVs detection are concluded. | Hui Xie Kaili Di Rongrong Huang Adeel Khan Yanyan Xia Hongpan Xu Chang Liu Tingting Tan Xinyu Tian Han Shen Nongyue He Zhiyang Li | 2020 | Chinese Chemical Letters2020，31，7： | 0 |
| 19 | A Multi-Objective Optimization Approach for Heat Exchanger Network in Process Industries显示文摘To simultaneously improve the quantity and quality of heat recovery in a heat exchanger network(HEN),this study conducts a theory analysis based on the first and second laws of thermodynamics.Under the premise of maximizing the heat recovery quantity of HEN,Ġdiss is used as an evaluation index to optimize the quality of heat recovery.Meanwhile,the total annual cost(TAC)is considered as another optimization objective to ensure the economic feasibility of the HEN.A superstructure-based multi-objective mixed integer non-linear programming approach is put forward to solve the trade-off between minimizingĠdiss and minimizing TAC.This allows for the optimum HEN structure to be obtained.A well-studied example is solved to highlight the benefits of the proposed method. | Tan Qiang Chen Yuting Xu Yanyan Ye Shuang Xiao Hao Huang Weiguang | 2022 | China Petroleum Processing & Petrochemical Technology2022，24，2： | 0 |
| 20 | Isomerization and bioaccessibility of cypermethrin and fenpropathrin in Pacific oyster during simulated digestion as influenced by domestic cooking methods显示文摘Pyrethroids can be ingested by humans through eating contaminated oysters,which is potentially harmful to health.This study aimed to investigate the effects of raw,steaming,and roasting on cypermethrin(CP)and fenpropathrin(FP)in oysters during simulated digestion.Results showed that the amount of released CP and FP was different from raw(CP:0.617μg·g−1,FP:0.266μg·g−1),steaming(CP:0.498μg·g−1,FP:0.660μg·g−1),and roasting(CP:1.186μg·g−1,FP:0.588μg·g−1)at the end of simulated digestion.The share of cis-CP and low-efficiency CP increased significantly(p<0.05),and the share of high-efficiency trans-CP did not maintain a high level for a long time during simulated digestion.The fluorimetric titration and isothermal titration calorimetry confirmed that CP and FP could spontaneously interact with oyster actin,and CP could bind with oyster actin more tightly than FP.This study reveals that cooking methods affect the binding capacity of CP and FP to oyster tissues and influence the changes of CP and FP in oysters during digestion.Furthermore,the current study provides a reference for assessing the potential harm of pyrethroids in oysters to consumers. | Hangtao Xie Yadan Jiao Tian Li Tuo Zhang Yanyan Zheng Yongkang Luo Yuqing Tan Chune Liu Hui Hong | 2023 | Food Innovation and Advances2023，2，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员