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| 1 | Ultrasound diagnosis of fetal limb wall syndrome显示文摘 | Li Fang Chert Bo Tang Qingxia | 2011 | Anhui medicine2011，15，02： | 1 |
| 2 | Concerted regulation on vertical orientation and film quality of two-dimensional ruddlesden-popper perovskite layer for efficient solar cells显示文摘Recently,the two-dimensional(2D)ruddlesden-popper(RPP)perovskite has been successfully attracting great attention owing to their excellent electronic property and superior ambient stability.But 2D perovskite solar cells(PVSCs)with insulating large cations show a worse performance than three-dimensional(3D)PVSCs in general because of the worse charge transportation.In this work,dimethyl sulfoxide(DMSO)and KI were incorporated simultaneously to produce a synergistic effect on both film quality and orientation of 2D perovskite.With this strategy,a cavity-free 2D perovskite film was formed with vertically oriented crystal,and high quality film was obtained with decreased defects and increased crystallinity.Besides,profitable multiple phases were obtained for better spontaneous carrier separation and transportation.The 2D PVSCs based on(PEA)2(MA)n−1PbnI3n+1(n=5)delivered a higher power conversion efficiency(PCE)of 13.4%.In addition,the perovskite with KI and DMSO contained more stable low-dimension phase at the bottom of perovskite film,which could act as a barrier to prevent moisture from further eroding internal perovskites.The optimized 2D PVSCs remained 90%of the PCE after being exposed in air(50%–60%humidity,room temperature)with a continuous illumination for 300 h. | Xianglan Tang Xueying Wang Ting Hu Qingxia Fu Xiaotian Hu Zengqi Huang Shuqin Xiao Yiwang Chen | 2020 | Science China Chemistry2020，63，11： | 1 |
| 3 | The relationship between treatment-induced hypertension and efficacy of anlotinib in recurrent or metastatic esophageal squamous cell carcinoma显示文摘Objective:In this post-hoc analysis,we evaluated anlotinib treatment-induced hypertension as a potential predictive factor of efficacy in esophageal squamous cell carcinoma(ESCC)patients.Methods:A total of 109 patients enrolled in the anlotinib group in a phase 2 trial were included.The tumor response was assessed by computed tomography at week 3,week 6,and then every 6 weeks until progressive disease was observed.The primary endpoint of the study was progression free survival(PFS).The secondary endpoints included overall survival(OS)and objective response rate(ORR).Results:In all patients,the median PFS was 3.02 months[95%confidence interval(CI):2.63–3.65 months]and the OS was 6.11 months(95%CI:4.40–7.79 months).The ORR was 7.34%(95%CI:3.22%–13.95%).A total of 59(54%)patients were diagnosed with treatment-induced hypertension(Group A),and the remaining patients(n=50,46%)were in Group B.Baseline prognostic factors were similar between the 2 groups.Patients in Group A had a longer PFS and OS and higher ORR.When stratifying patients using a previously known history of hypertension,treatment-induced hypertension was a predictor only for patients without previous hypertension,who had longer PFS[hazard ratio(HR):0.40,95%CI:0.24–0.68]and OS(HR:0.37,95%CI:0.21–0.67).Conclusions:We showed,for the first time,a correlation between treatment-induced hypertension and better prognoses in recurrent or metastatic ESCC patients treated with anlotinib,without a previously known history of hypertension.Treatment-induced hypertension may be a simple and low cost predictor for anlotinib antitumor efficacy in these patients,which may also reflect the intended target inhibition. | Yan Song Juxiang Xiao Wentao Fang Ping Lu Qingxia Fan Yongqian Shu Jifeng Feng Shu Zhang Yi Ba Yang Zhao Ying Liu Chunmei Bai Yuxian Bai Yong Tang Jie He Jing Huang | 2021 | Cancer Biology & Medicine2021，18，2： | 1 |
| 4 | Microbiome analysis reveals soil microbial community alteration with the effect of animal excretion contamination and altitude in Tibetan Plateau of China显示文摘The fertile forages in the Tibetan Plateau provide natural conditions for animal husbandry,whereas it is still unclear that whether animal excretion can result in the alteration of soil microbial community.Therefore,this study was performed to investigate the impact of animal excretion contamination and land altitude on the soil microbial community in different grazing areas of Tibetan Plateau.A total of 1160,190 high-quality valid sequences and 25,478 operational taxonomic units were achieved from 18 samples at three different altitude sites(Linzhi,Rikaze and Shannan).Here,we found excremental contamination did not alter the richness and diversity of soil microbial community,but it resulted in a significant alteration in the proportion of some bacteria.Specifically,the proportion of Proteobacteria in the LZa was obviously increased,whereas Gemmatimonadetes was significantly decreased as compared to LZe.Moreover,significant difference can also be observed in Verrucomicrobia between RKZe and RKZa.Remarkably,we also found that excremental contamination significantly decreased the abundance of some bacterial genera,such as Sphingopyxis,Polycyclovorans,Singulisphaera Cohnella,Polycyclovorans,Defluviicoccus,and Arthrobacter,which were closely related to soil health,pollutant degradation,and nutrient metabolism.Importantly,excremental contamination increased the proportion of harmful and beneficial bacteria in soil,such as the percentage of Acidibacter,Gemmatimonadaceae and Pajaroellobacter increased,while the ratio of Pontibacter,Flavisolibacter,Parasegetibacter,and Niastella decreased.Remarkably,soil samples collected from different altitude sites also displayed different soil microbial community structures.Our results demonstrated that excremental contamination could alter the soil microbial community structure and affect the normal function of the soil by affecting the proportion of harmful bacteria to beneficial bacteria.Moreover,this study can also provide a theoretical basis for the establishment of a supervision system for soil quality in Tibet. | Aoyun Li Yaping Wang Yajing Wang Hailong Dong Qingxia Wu Khalid Mehmood Zhenyu Chang Ying Li Yung-Fu Chang Lijun Shi Zhaoxin Tang Hui Zhang | 2021 | International Soil and Water Conservation Research2021，9，4： | 1 |
| 5 | Circulating Lipoproteins Mediate the Association Between Cardiovascular Risk Factors and Cognitive Decline:A Community‑Based Cohort Study显示文摘Cardiovascular health metrics are now widely recognized as modifable risk factors for cognitive decline and dementia.Metabolic perturbations might play roles in the linkage of cardiovascular diseases and dementia.Circulating metabolites profling by metabolomics may improve understanding of the potential mechanism by which cardiovascular risk factors contribute to cognitive decline.In a prospective community-based cohort in China(n=725),312 serum metabolic phenotypes were quantifed,and cardiovascular health score was calculated including smoking,exercise,sleep,diet,body mass index,blood pressure,and blood glucose.Cognitive function assessments were conducted in baseline and follow-up visits to identify longitudinal cognitive decline.A better cardiovascular health was signifcantly associated with lower risk of concentration decline and orientation decline(hazard ratio(HR):0.84–0.90;p<0.05).Apolipoprotein-A1,high-density lipoprotein(HDL)cholesterol,cholesterol ester,and phospholipid concentrations were signifcantly associated with a lower risk of longitudinal memory and orientation decline(p<0.05 and adjusted-p<0.20).Mediation analysis suggested that the negative association between health status and the risk of orientation decline was partly mediated by cholesterol ester and total lipids in HDL-2 and-3(proportion of mediation:7.68–8.21%,both p<0.05).Cardiovascular risk factors were associated with greater risks of cognitive decline,which were found to be mediated by circulating lipoproteins,particularly the medium-size HDL components.These fndings underscore the potential of utilizing lipoproteins as targets for early stage dementia screening and intervention. | Jialin Li Qingxia Huang Yingzhe Wang Mei Cui Kelin Xu Chen Suo Zhenqiu Liu Yanpeng An Li Jin Huiru Tang Xingdong Chen Yanfeng Jiang | 2024 | Phenomics2024，4，1： | 0 |
| 6 | Comment on:the tumour microenvironment shapes innate lymphoid cells in patients with hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is the fourth leading cause of cancer-related deaths worldwide(1).Resident immune cell populations within the liver,which is considered the largest immune organ,increase the pathological complexity of HCC(2).Innate lymphoid cells(ILCs),recently identified leukocytes,are a family of innate immune cells with similar characters to T lymphocytes.ILCs largely exist in intestinal mucosal tissue and regulate intestinal inflammation,mucosal defense,and tissue repair in gut disease processes(3).Unlike T cells,ILCs lack antigen-specific receptors;therefore,they cannot directly mediate antigen-specific responses(4).However,they can be activated by cytokines and/or natural cytotoxic receptors(such as NKp44)(5).ILCs are a highly heterogeneous cell population with high plasticity.Based on the expression of transcription factors and the production of different cytokines,ILCs can be divided into ILC1,ILC2,and ILC3,which are counterparts of the three main helper T cell subsets(Th1,Th2,and Th17)(6).Although ILCs can be detected in various tumor types,their specific contribution to tumor immunity is yet to be thoroughly elucidated. | Lixia Xu Qingxia Yang Ce Tang Ming Kuang | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 0 |
| 7 | Sequentially releasing self-healing hydrogel fabricated with TGFβ3-microspheres and bFGF to facilitate rat alveolar bone defect repair显示文摘Resorption and loss of alveolar bone leads to oral dysfunction and loss of natural or implant teeth. Biomimetic delivery of growth factors based on stem cell recruitment and osteogenic differentiation, as the key steps in natural alveolar bone regenerative process, has been an area of intense research in recent years. A mesoporous self-healing hydrogel(DFH) with basic fibroblast growth factor(bFGF) entrapment and transforming growth factor β3(TGFβ3)-loaded chitosan microspheres(CMs) was developed. The formulation was optimized by multiple tests of self-healing, in-bottle inversion, SEM, rheological, swelling rate and in vitro degradation. In vitro tubule formation assays, cell migration assays, and osteogenic differentiation assays confirmed the ability of DFH to promote blood vessels, recruit stem cells, and promote osteogenic differentiation. The optimum DFH formula is 0.05 ml 4ArmPEG-DF(20%) added to 1 ml CsGlu(2%) containing bFGF(80 ng) and TGFβ3-microspheres(5 mg). The results of in vitro release studied by Elisa kit, indicated an 95% release of b FGF in7 d and long-term sustained release of TGFβ3. For alveolar defects rat models, the expression levels of CD29 and CD45, the bone volume fraction, trabecular number, and trabecular thickness of new bone monitored by Micro-CT in DFH treatment groups were significantly higher than others(*P < 0.05, vs Model). HE and Masson staining show the same results.In conclusion, DFH is a design of bionic alveolar remodelling microenvironment, that is in early time microvessels formed by b FGF provide nutritious to recruited endogenous stem cells, then TGFβ3 slowly released speed up the process of new bones formation to common facilitate rat alveolar defect repair. The DFH with higher regenerative efficiency dovetails nicely with great demand due to the requirement of complicated biological processes. | Fenglin Yu Dezhi Geng Zhanpeng Kuang Shiyi Huang Yating Cheng Yini Chen Fang Leng Yu Bei Yueping Zhao Qingxia Tang Yadong Huang Qi Xiang | 2022 | Asian Journal of Pharmaceutical Sciences2022，17，3： | 0 |
| 8 | Simultaneously quantifying hundreds of acylcarnitines in multiple biological matrices within ten minutes using ultrahigh-performance liquid-chromatography and tandem mass spectrometry显示文摘Acylcarnitines are metabolic intermediates of fatty acids and branched-chain amino acids having vital biofunctions and pathophysiological significances. Here, we developed a high-throughput method for quantifying hundreds of acylcarnitines in one run using ultrahigh performance liquid chromatography and tandem mass spectrometry (UPLC-MS/MS). This enabled simultaneous quantification of 1136 acylcarnitines (C0–C26) within 10-min with good sensitivity (limit of detection < 0.7 fmol), linearity (correlation coefficient > 0.992), accuracy (relative error < 20%), precision (coefficient of variation (CV), CV < 15%), stability (CV < 15%), and inter-technician consistency (CV < 20%, n = 6). We also established a quantitative structure-retention relationship (goodness of fit > 0.998) for predicting retention time (tR) of acylcarnitines with no standards and built a database of their multiple reaction monitoring parameters (tR, ion-pairs, and collision energy). Furthermore, we quantified 514 acylcarnitines in human plasma and urine, mouse kidney, liver, heart, lung, and muscle. This provides a rapid method for quantifying acylcarnitines in multiple biological matrices. | Jingxian Zhang Qinsheng Chen Lianglong Zhang Biru Shi Men Yu Qingxia Huang Huiru Tang | 2024 | Journal of Pharmaceutical Analysis2024，14，1： | 0 |
| 9 | Comprehensive biological function analysis of lncRNAs in hepatocellular carcinoma显示文摘Thousands of long non-coding RNAs(lncRNAs)have been discovered in human genomes by gene chip,next-generation sequencing,and/or other methods in recent years,which represent a significant subset of the universal genes involved in a wide range of biological functions.An abnormal expression of lncRNAs is associated with the growth,invasion,and metastasis of various types of human cancers,including hepatocellular carcinoma(HCC),which is an aggressive,highly malignant,and invasive tumor,and a poor prognosis in China.With a more in-depth understanding of lncRNA research for HCC and the emergence of new moleculartargeted therapies,the diagnosis,treatment,and prognosis of HCC will be considerably improved.Therefore,this review is expected to provide recommendations and directions for future lncRNA research for HCC. | Dan Wang Fengjiao Chen Tao Zeng Qingxia Tang Bing Chen Ling Chen Yan Dong Xiaosong Li | 2021 | Genes & Diseases2021，8，2： | 0 |
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