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| 1 | Role of the renin angiotensin system in diabetic nephropathy显示文摘Diabetic nephropathy has been the cause of lot of mor bidity and mortality in the diabetic population.The renin angiotensin system(RAS) is considered to be involved in most of the pathological processes that result in diabetic nephropathy.This system has var ious subsystems which contribute to the disease pat ho logy.One of these involves angiotensin Ⅱ(Ang Ⅱ) which shows in c reased activity during diabetic nephropathy.This causes hypertrophy of various renal cells and has a pres sor effect on arteriolar smooth muscle resulting in increas ed vascular pressure.Ang Ⅱ also induces inflamm ation,apoptosis,cell growth,migration and differentiation.Monocyte chemoattractant protein-1 production responsible for renal f ibrosis is also regulated by RAS.Polymorphism of angiotensin converting enzym e(ACE) and Angiotensinogen has been shown to have effects on RAS.Available treatment modalities have proven effective in controlling the progression of nephropathy.Various drugs(based on antagonism of RAS) are currently in the market and others are still under trial.Amongst the approved drugs,ACE inhibitors and ang iot ensin receptor blockers(ARBs) are widely used in clinical practice.ARBs are shown to be superior to ACE inhibitors in terms of reducing proteinuria but the combined role of ARBs with ACE inhibitors in diabetic nephropathy is under debate. | Tanuj Chawla Deepika Sharma Archana Singh | 2010 | World Journal of Diabetes2010，1，5： | 34 |
| 2 | Deposition of atmospheric pollutant and their chemical characterization in snow pit profile at Dokriani Glacier,Central Himalaya显示文摘The uncertainty in assessing the numerous atmospheric pollutants transported via wind from arid and semi-arid regions is affecting the glacial ecosystem. In our study area due to the complexity of the system, a prominent seasonal difference noticed among major ions(Ca^(2+), Mg^(2+), SO_4^(2-), and NO_3^-). There is a need for understanding the ions cycling as a whole and the directionality of the feedback loops in the system. Therefore, we provide an appraisal of our current hypothesis for seasonal difference in major ion concentration from snow samples for two corresponding years(2013 and 2015) at Dokriani Glacier. A systematic study of chemical compositionsin the shallow snow pit from Dokriani Glacier was undertaken for the pre-monsoon season to understand the cycling of major ions from atmosphere to solute acquisition process. The intimating connections of ions cycling in snow and its temporal behavior was observed and analyzed through various statistical tests. Among major ions, the SO_4^(2-)has the highest concentration among anions on an average considered as 14.21% in 2013 and 29.46% in 2015. On the other side Ca^(2+) is the dominant cation contributing 28.22% in 2013 and 15.3% in 2015 on average. The average ratio of Na+/Cl-was higher in 2013 whereas lower in 2015. The backward trajectory analysis suggests the possible sources of the ions transported from Central Asia through the Western Disturbance(WD) as a prominent source of winter precipitation mainly in the Central Himalaya. Ionicconcentration of Ca^(2+) in cations was highly dominated while in anion SO_4^(2-)played the major role. Factor analysis and correlation matrix suggested that, the precipitation chemistry is mostly influenced by anthropogenic, crustal, and sea salt sources over the studied region. The elemental cycling through ocean, atmosphere and biosphere opens up new ways to understand the geochemical processes operating at the glacierized catchments of the Himalaya. Moreover, increasing the field-based studies in the coming decades would also have the certain advantage in overcoming the conceptual and computational geochemical modelling difficulties. | Shipika SUNDRIYAL Tanuj SHUKLA Lekhendra TRIPATHEE Dwarika Prashad DOBHAL Sameer Kumar TIWARI Uday BHAN | 2018 | Journal of Mountain Science2018，15，10： | 2 |
| 3 | mpaired flow-mediated vasodilatation in Asian Indians with erectile dysfunction显示文摘Endothelial 机能障碍是在冠的动脉疾病(CAD ) 和可勃起的机能障碍(编辑) 之间的要求的连接。臂的动脉调停流动的 vasodilatation (FMD ) 是为 endothelial 功能评价的一个非侵略的代理人标记。尽管有代表可观的全球 CAD 负担的亚洲印第安人,在这些病人的 FMD 和编辑上的数据正在缺乏。经历冠的 angiography 的 225 个病人, 72 %有的编辑(使用可勃起的功能(IIEF-5 ) 问询表的国际索引估计) ;编辑对中等在 61 % 严重;病人。编辑病人有严重、弥漫的 angiographic CAD,包含的很多冠的容器和更低的吝啬的臂的动脉 FMD 的更高的发生(6.40 % ± 4.60 %对 9.10 % ± 4.87 %, P< 0.001 ) 与 non-ED 病人相比。在 FMD 的进步减小与增加编辑的严厉被注意损害 FMD (≤ 5.5 %) 两次在编辑病人同样普通(52 %对 24 %没有编辑) 。有损害 FMD 的病人有更高的编辑流行(85 %对 62 %) 并且更低的吝啬的 IIEF-5 与正常 FMD 与那些相比得分。损害 FMD 是另外的风险因素的一个重要编辑预言者独立人士(机会比率, 2.33;95 %信心间隔:0.59-9.23;P=0.03 ) 。在 FMD 和编辑严厉之间的反的关联被观察(r=− 0.22;P=0.004 ) 。编辑在有 angiographically 记录的 CAD 的亚洲印第安人之中是普通的。有编辑的病人损害了独立于另外的风险因素的 FMD,建议那个 endothelial 机能障碍是内在的 pathophysiology。泌尿科医师和心脏病专家需要知道在编辑, CAD 和 endothelial 机能障碍之间的协会。 | Tanuj Bhatia Aditya Kapoor Jatinder Kumar Archana Sinha Priyadarshi Ranjan Sudeep Kumar Naveen Garg Satyendra-Tewari Aneesh Srivastava Rakesh Kapoor Pravin K Goel | 2013 | Asian Journal of Andrology2013，15，5： | 1 |
| 4 | Anion water in gypsum (CaSO4· 2H20) and hemihydrate (CaSO4 · 1/2H2 O) 显示文摘 | Pradip K M Tanuj K M | 2002 | Cem Coner Res2002，32，2： | 1 |
| 5 | Skeletal asymmetry 显示文摘 | Kanchan Tanuj Mohan Kumar TS Pradeep Kumar G | 2008 | Journal of Forensic and Legal Medicine2008，15，3： | 1 |
| 6 | Sexdifferences from fingerprint ridge density in Chinese andMalaysian population显示文摘 | C N Vinod Prateek Rastogi Tanuj Kanchan | 2010 | Forensic Science International2010，197，： | 1 |
| 7 | Sexdifferences from fingerprint ridge density in the Indianpopulation显示文摘 | V C Nayak Prateek Rastogi Tanuj Kanchan | 2010 | Journal of Forensic and Legal Medicine2010，17，： | 1 |
| 8 | Detecting molecular interactions that stabilize native bovine rhodopsin 显示文摘 | TANUJ SAPRA K PARK P S FILIPEK S | 2006 | J Mol Biol2006，358，1： | 1 |
| 9 | Ultrasound Biomicroscopy in Glaucoma显示文摘 | Tanuj Dada Ritu Gadia Ajay Sharma Parul Ichhpujani Shveta Jindal Bali Shibal Bhartiya Anita Panda | 2011 | Survey of Ophthalmology2011，，5： | 1 |
| 10 | Ocular surface evaluation in eyes with chronic glaucoma on long term topical antiglaucoma therapy显示文摘AIM: To evaluate ocular surface changes and its correlation with the central corneal subbasal nerve fibre layer in chronic glaucoma patients. METHODS: A prospective comparative study of ocular surface evaluation was performed in 50 eyes of 25 patients using two or more antiglaucoma medications for at least 6mo and 50 eyes of 25 normal subjects without any ocular problems as controls. The study parameters evaluated included visual acuity, intraocular pressure, ocular surface evaluation parameters [fluorescein break-up time(FTBUT), Schirmer's I test, ocular surface staining scores and ocular surface disease index score(OSDI)], central corneal sensation(Cochet Bonnett aesthesiometer), central subbasal nerve fiber layer density(SBNFLD) by confocal microscopy. RESULTS: The mean values in the glaucoma cases and control groups respectively were as follows: OSDI score(35.89±16.07/6.02±3.84; P=0.001), Schirmer's I test score(7.63±2.64 mm/12.86±1.93 mm; P=0.001), FTBUT(9.44±2.76s/11.8±1.88s; P=0.001), corneal(5.7±2.33/1.1±0.58; P=0.001) and conjunctival staining score(5.06±1.94/0.84±0.46; P=0.001), corneal sensitivity(4.68±0.44/5.07±0.37; P=0.076), mean subbasal nerve fiber number(3.58±0.99/5.40±1.70; P=0.001), SBNFL length(1101.44±287.56 μm/1963.70±562.56 μm; P=0.001) and density(6883.94±1798.03 μm/mm^2/12 273.15±3516.04 μm/mm^2; P=0.001). Dry eye severity of level 2 and 3 was seen in 66% of glaucoma group. Corneal(R^2=0.86) and conjunctival staining(R^2=0.71) and OSDI score(R^2=0.67) showed statistically significant negative correlation with central corneal SBNFLD while FTBUT(R^2=0.84), corneal sensitivity(R^2=0.52) showed positive correlation to central corneal SBNFLD in the long term topical antiglaucoma medication group.CONCLUSION: Ocular surface changes and antiglaucoma therapy induced dry eye is found to be associated with decreased SBNFLD in eyes on long term topical antiglaucoma medications. | Manu Saini Murugesan Vanathi Tanuj Dada Tushar Agarwal Rebika Dhiman Sudarshan Khokhar | 2017 | International Journal of Ophthalmology(English edition)2017，10，6： | 1 |
| 11 | Menezes, et aL Methods of Choice in Completed Suicides: Gender Differences and Review of Literature显示文摘 | Tanuj Kanchan Anand Menon Ritesh G | 2009 | Journal of Forensic Science2009，，16： | 1 |
| 12 | Liver stem cells and hepatocellular carcinoma显示文摘 | Lopa M Tanuj B Joseph M | 2009 | Hepatology2009，49，1： | 1 |
| 13 | Index and ring finger ratio—A new sex determinant in south Indian population显示文摘 | Tanuj Kanchan G. Pradeep Kumar Ritesh G. Menezes | 2008 | Forensic Science International2008，，： | 1 |
| 14 | Ultrasound biomicroscopy in glaucoma显示文摘 | Tanuj D Ritu G Ajay S | 2011 | Surv Ophthalmol2011，56，7： | 1 |
| 15 | Impact of initial topical medical therapy on short-term quality of life in newly diagnosed patients with primary glaucoma显示文摘 | Vishal Arora Shveta Bali Sanjeev Gupta Praveen Vashisht Tushar Agarwal Vishnubhatla Sreenivas Tanuj Dada | 2015 | Indian Journal of Ophthalmology2015，，6： | 1 |
| 16 | Comparing Outcomes of Enucleation and Evisceration显示文摘 | Tanuj Nakra Guy J. Ben Simon Raymond S. Douglas Robert M. Schwarcz John D. McCann Robert A. Goldberg | 2006 | Ophthalmology2006，，12： | 1 |
| 17 | Left Ventricular Remodeling after Late Revascularization Correlates with Baseline Viability显示文摘 | Pravin K Tanuj B Aditya K | 2014 | Tex Heart Inst J2014，41，4： | 1 |
| 18 | Comparison of fibrin clot adhesion to dentine conditioned with citric acid, tetracycline, and ethylene diamine tetra acetic acid: an in vitro scanning electron microscopic study显示文摘 | Tanuj M Aparna R | 2012 | J Indian Soc Periodontol2012，16，3： | 1 |
| 19 | Ultrasound biomicroscopy in glaucoma显示文摘 | Tanuj D Ritu G Ajay S | 2011 | Surv Ophthalmol2011，56，： | 1 |
| 20 | Evaluation of corneal biomechanical properties follow- ing penetrating keratoplasty using ocular response analyzer 显示文摘 | MURUGESAN V BYPAREDDY R KUMAR M TANUJ D ANI- TA P | 2014 | Indian J Ophthalmol2014，62，4： | 1 |
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