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| 1 | Prevalence and virological profiles of hepatitis B infection in human immunodeficiency virus patients显示文摘AIM: To determine the prevalence of hepatitis B virus (HBV) in adult human immunodeficiency virus (HIV) patients with CD4+ T-cell count less than 500/mm 3 and without antiretroviral therapy; to describe different HBV-HIV coinfection virological profiles; and to search for factors associated with HBs antigen (HBsAg) presence in these HIV positive patients.METHODS: During four months (June through September 2006), 491 patients were received in four HIV positive monitoring clinical centers in Abidjan. Inclusion criteria: HIV-1 or HIV-1 and 2 positive patients, age ≥ 18 years, CD4+ T-cell count < 500/mL and formal and signed consent of the patient. Realized blood tests included HIV serology, CD4+ T-cell count, quantitative HIV RNA load and HBV serological markers, such as HBsAg and HBc antibody (anti-HBcAb). We performed HBeAg, anti-HBe antibody (anti-HBeAb), anti-HBc IgM and quantitative HBV DNA load in HBsAg positive patients. Anti-HBsAb had been tested in HIV patients with HBsAg negative and anti-HBcAb-positive. HBV DNA was also tested in 188 anti-HBcAb positive patients with HBsAg negative status and without anti-HBsAb. Univariate analysis (Pearsonχ 2 test or Fischer exact test) and multivariate analysis (backward step-wise selection logistic regression) were performed as statistical analysis. RESULTS: Mean age of 491 patients was 36 ± 8.68 years and 73.3% were female. Type-1 HIV was found in 97% and dual-type HIV (type 1 plus type 2) in 3%. World Health Organization (WHO) clinical stage was 1, 2, 3 and 4 respectively in 61 (12.4%), 233 (47.5%), 172 (35%) and 25 patients (5.1%). Median CD4+ T-cell count was 341/mm 3 (interquartile range: 221-470). One hundred and twelve patients had less than 200 CD4+ T-cell/mm 3 . Plasma HIV-1 RNA load was elevated (≥ 5 log 10 copies/mL) in 221 patients (45%). HBsAg and anti-HBcAb prevalence was respectively 13.4% and 72.9%. Of the 66 HBsAg positive patients, 22 were inactive HBV carriers (33.3%), 21 had HBeAg positive hepatitis (31.8%) and 20 had HBeAg negative hepatitis (30.3%). HBeAg and anti-HBeAb were indeterminate in 3 of them. Occult B infection prevalence (HBsAg negative, anti-HBcAb positive, anti-HBsAb negative and detectable HBV DNA) was 21.3%. Three parameters were significantly associated with the presence of HBsAg: male [odds ratio (OR): 2.2;P = 0.005; 95% confidence interval (CI): 1.3-3.8]; WHO stage 4 (OR: 3.2;P = 0.01;95% CI: 1.3-7.9); and aspartate aminotransferase (AST) level higher than the standard (OR: 1.9;P = 0.04; 95% CI: 1.02-3.8). CONCLUSION: HBV infection prevalence is high in HIV-positive patients. HBeAg positive chronic hepatitis and occult HBV infection are more frequent in HIVpositive patients than in HIV negative ones. Parameters associated with HBsAg positivity were male gender, AIDS status and increased AST level. | Koffi Alain Attia Serge Eholié Eugène Messou Christine Danel Sandrine Polneau Henri Chenal Thomas Toni Myreille Mbamy Catherine Seyler Naomi Wakasugi Thérèse N'dri-Yoman Xavier Anglaret | 2012 | World Journal of Hepatology2012，4，7： | 4 |
| 2 | The Treatment-Naive Microbiome in New-Onset Crohn’s Disease显示文摘 | Dirk Gevers Subra Kugathasan Lee A. Denson Yoshiki Vázquez-Baeza Will Van Treuren Boyu Ren Emma Schwager Dan Knights Se Jin Song Moran Yassour Xochitl C. Morgan Aleksandar D. Kostic Chengwei Luo Antonio González Daniel McDonald Yael Haberman Thomas Walter | 2014 | Cell Host & Microbe2014，，： | 3 |
| 3 | Knockdown of β-catenin controls both apoptotic and autophagic cell death through LKB1/AMPK signaling in head and neck squamous cell carcinoma cell lines显示文摘 | Hyo Won Chang Yoon Se Lee Hae Yun Nam MyoungWol Han Hyo Jung Kim So Young Moon HyesungJeon Jung Je Park Thomas E. Carey Sung Eun Chang Seong Who Kim Sang Yoon Kim | 2012 | Cellular Signalling2012，，： | 2 |
| 4 | Accelerated apoptosis characterizes cyclosporine-associated interstitial fibrosis显示文摘 | Thomas SE Andoh TF Picher RH | 1998 | Kidney Int1998，53，： | 1 |
| 5 | Complete reversal of paraplegia after thoracic endovascular aortic repair in a patient with complicated acute aortic dissection using immediate cerebrospinal fluid drainage显示文摘 | Holger Eggebrecht Dirk B?se Thomas Gasser Jaroslav Benedik Petra Mummel Oliver Müller Philipp Kahlert Konstantinos Tsagakis Heinz G. Jakob Raimund Erbel | 2009 | Clinical Research in Cardiology2009，，12： | 1 |
| 6 | The Laboratory Rat as an Animal Model for Osteoporosis Research 显示文摘 | Lelovas PP Xanthos Tl' Thoma SE | 2008 | Comp Med2008，58，： | 1 |
| 7 | Burden of acute gastro-intestinal illness in Canada, 1999 - 2007:interim summary of NSAGIactivities 显示文摘 | Thomas MK Majowicz SE Pollari F | 2008 | Can Commun Dis Rep2008，34，5： | 1 |
| 8 | Scavanger recepter mediated adhension of microglia to β-amyloid fibrils显示文摘 | Hickman SE Thomas CA | 1996 | Nature1996，382，： | 1 |
| 9 | Association of genetic variation at the beta-fibrinogen gene locus and plasma fibrinogen levels;interaction between allele frequency of the G/A-455 polymorphism,age and smoking显示文摘 | Thomas AE Green FR Humphries SE | 1996 | Clin Genet1996，50，4： | 1 |
| 10 | Gli genes and limb development显示文摘 | Thomas Theil Susanne Kaesler Lars Grotewold Jens B?se U. Rüther | 1999 | Cell & Tissue Research1999，，1： | 1 |
| 11 | Toll‐like receptors 2 and 4 and the cryopyrin inflammasome in normal pregnancy and pre‐eclampsia显示文摘 | F Xie Y Hu SE Turvey LA Magee RM Brunham K‐C Choi M Krajden PCK Leung DM Money DM Patrick E Thomas P von Dadelszen | 2009 | BJOG: An International Journal of Obstetrics & Gy2009，，： | 1 |
| 12 | Scavenger receptormediated adhesion of microglia to β-amyloid fibrils显示文摘 | EI Khoury J Hichman SE Thomas CA | 1996 | Nature1996，382，： | 1 |
| 13 | Association of genetic variation at the beta fibrinogen gene locus and plasma fibrinogen levels: Interaction between allele frequency of the G/A- 455 pol- ymorphism, age and smoking显示文摘 | Thomas AE Green FR Humphries SE | 1996 | Clin Genet1996，50，： | 1 |
| 14 | Decreasing unplanned extubations:Utilization of the penn state children's Hospital sedation algorithm显示文摘 | Popernack ML Thomas NJ Lucking SE | | 0，，01： | 1 |
| 15 | The laboratory rat as an animal model for osteoparosis research 显示文摘 | Lelovas PP Xanthos TT Thoma SE | 2008 | Comp Med2008，58，5： | 1 |
| 16 | The laboratory rat as an animal model for osteoporosis research显示文摘 | Lelovas PP Xanthos TT Thoma SE | 2008 | Comp Med2008，58，5： | 1 |
| 17 | Conformal Coatings of Cyclized‐PAN for Mechanically Resilient Si nano‐Composite Anodes显示文摘 | Daniela Molina Piper Thomas A. Yersak Seoung‐Bum Son Seul Cham Kim Chan Soon Kang Kyu Hwan Oh Chunmei Ban Anne C. Dillon Se‐Hee Lee | 2013 | Adv. Energy Mater2013，，6： | 1 |
| 18 | Scavenger receptormediated adhesion of microglia to beta-amyloid fibrils 显示文摘 | El Khoury J Hickman SE Thomas CA | 1996 | Nature1996，382，6593： | 1 |
| 19 | Adsorptive membrane chromatography for purification of plasmid DNA 显示文摘 | Teeters MA Conrardy SE Thomas BL | 2003 | J Chromatogr A2003，989，1： | 1 |
| 20 | Design and structure-activity relationship of a new class of potent VEGF receptor tyrosine kinase inhibitors显示文摘 | Laurent FH Andrew P Thomas Craig J Elaine SE | 1999 | J Med Chem1999，42，： | 1 |
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