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| 1 | Improved heterologous gene expression in Trichoderma reesei by cellobiohydrolase I gene (cbh1) promoter optimization显示文摘在 Trichoderma reesei 改进 heterologous 基因表达,一套最佳的人工的 cellobiohydrolase 我基因(cbh1 ) 倡导者被获得。到有三个潜在的葡萄糖抑压者结合部位的 -724 的从 -677 的区域被删除。包括 CCAAT 盒子和 Ace2 结合部位,然后,到修改 cbh1 倡导者的 -820 的从 -620 的区域反复被插入到修改 cbh1 倡导者,获得有拷贝数字的倡导者 2, 4,和 6。结果证明葡萄糖压抑效果被废除,当拷贝数字同时增加了,记者基因由这些多拷贝倡导者调整了的葡糖醛酸糖苷酶(gus ) 的表示水平显著地被提高。数据显示出使用倡导者的大诺言在细丝状的真菌增加 heterologous 基因表达的人工的修正策略并且为基因功能调查和紧张修正提供了一套可选的高表示的向量。 | Ti Liu Tianhong Wang Xian Li Xuan Liu | 2008 | Acta Biochimica et Biophysica Sinica2008，40，2： | 18 |
| 2 | Shanghai Score: A Prognostic and Adjuvant Treatment-evaluating System Constructed for Chinese Patients with Hepatocellular Carcinoma after Curative Resection显示文摘 | Hui-Chuan Sun Lu Xie Xin-Rong Yang Wei Li Jian Yu Xiao-Dong Zhu Yong Xia Ti Zhang Yang Xu Bo Hu Li-Ping Du Ling-Yao Zeng Jian Ouyang Wei Zhang Tian-Qiang Song Qiang Li Ying-Hong Shi Jian Zhou Shuang-Jian Qiu Qian Liu Yi-Xue Li Zhao-You Tang Yu Shyr Feng Shen Jia Fan | 2017 | Chinese Medical Journal2017，，22： | 15 |
| 3 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 4 | Acidichromism in the LB film of bolaform Schiff base显示文摘bolaform (BNC10 ) 并且领导单人赛(HNOA ) 包含 naphthyl 组的 amphiphilic Schiff 被设计,他们的 Langmuir Blodgett 电影被调查。两个都, LB 电影显示出 acidichromism,这被发现,即在或者分别地暴露这些电影到 HCl 和 NH3 气体之上的可逆变色。bolaform Schiff 电影能在 acidichromic 过程期间套住 NH3 气体,这进一步被发现。 | Mei Fang Yin Ti Feng Jiao Ming Hua Liu | 2007 | Chinese Chemical Letters2007，18，1： | 4 |
| 5 | Ethnic Differences in Body Mass Index and Prevalence of Obesity in School Children of Urumqi City, Xinjiang, China显示文摘To investigate the prevalence of obesity and distribution of body mass index (BMI) in school children of four ethnic groups in Urumqi, Xinjiang, China, Methods A total of 55 508 school children of Han, Hui, Uygur and Kazak nationalities aged 8-18 years were selected by a cluster sampling from a districts of Urumqi City for anthropometric measurement and demographic survey. Prevalence of obesity and overweight and distribution of body mass index (BMI) by gender, age, and nationality were analyzed and compared. Cutoff points of BMI for defining obesity and overweight were based on the proposal set by the Working Group on Obesity in China (WGOC) to assess age-, gender- and nationality-specific prevalence of obesity and overweight. Results Prevalence of obesity was 5.34%, 6.78%, 3.39 %, and 1.22% for boys and 2.61%, 1.83%, 1.78%, and 1.40% for girls of Han, Hui, Uygur and Kazak nationalities, respectively. Prevalence of obesity tended to decrease with age overall, whereas that of overweight increased with age in Han children. Conclusions Prevalence of obesity in school children in Urumqi varies with their nationalities and is lower than that of an average national level and a level of western countries. Obesity is more prevalent in boys than in girls of Urmuqi overall, which is just the opposite in Kazak children. Han boys and Hui girls have the highest prevalence of obesity and Kazak boys and girls have the lowest ones. Prevalence of obesity decreases with age, but that of overweight shows a different trend. | WEI-LI YAN YU-JIAN ZHENG JUN WU SHU-FENG CHEN XIAO-KAI TI LING LI XIAO-RUI LIU | 2006 | Biomedical and Environmental Sciences2006，19，6： | 3 |
| 6 | Whole-body physiology-based pharmacokinetics of caspofungin for general patients, intensive care unit patients and hepatic insufficiency patients显示文摘Caspofungin 是抗真菌的代理人在病人为侵略 candidiasis 作为首要的治疗准许了与的 echinocandin 对到 azoles 的严重的病或最近的暴露中等。在这研究,我们开发了一个整个身体的基于生理学的 pharmacokinetics (WB-PBPK ) 模型预言 caspofungin 的 pharmacokinetics (PK ) ,并且与蒙特卡罗模拟(MCS ) 结合了在病人的不同类型优化 caspofungin 的临床的剂量政体。caspofungin 的一个 WB-PBPK 模型从一般病人,的 4 以前的试用与未加工的数据被造并且验证有孩子呸 B 的特别护理单位(ICU ) 病人,连续肾的代替治疗上的 ICU 病人,温和、中等的肝的 insuffciency (嗨) 病人。MCS 被用来在这些病人优化 caspofungin 的临床的剂量政体。90% 的价值被考虑是为完成最佳的实验治疗的最小的反应(CFR ) 的累积部分。WB-PBPK 模型的模仿的结果在对所有试用的观察价值的好同意。为有 caspofungin 70/50 mg 的将军和 ICU 病人, AUC 和 Cmax 随身体重量(BW ) 的增加被减少并且显示出大变化。MCS 证明所有一般病人不管 BW 完成了 CFR90% 。然而并非有更高的 BW (70 kg ) 的所有 ICU 病人能完成 CFR90% 。与在一般病人的标准剂量政体相比,在有孩子呸 B 的 ICU 病人的 caspofungin 70/35 mg 完成了显著地减少的 AUC 和 Cmax,但是获得了类似的 AUC 和 Cmax 在中等嗨有孩子呸 B 的病人。caspofungin 的 WB-PBPK 模型能正确地预言所有人口的 PK。有 MCS 的联合 WB-PBPK 模型能成功地在所有耐心的人口优化 caspofungin 的临床的剂量政体。 | Qian-ting YANG Ya-jing ZHAI Lu CHEN Tao ZHANG Yan YAN Ti MENG Lei-chao LIU Li-mei CHEN Xue WANG Ya- lin DONG | 2018 | Acta Pharmacologica Sinica2018，39，9： | 3 |
| 7 | Production of Embryogenic Callus and Plant Regeneration from Elite Guizhou Waxy Maize Inbred Lines显示文摘Immature embryos from three elite Guizhou waxy maize inbred lines (W21019, B7, and QCL5036) were evaluated for their ability of forming callus and regeneration into plants. Immature embryos harvested at different physiological stages were used as explants to initiate callus on N6 basal medium with 0-3.5 mg L-1 of 2,4-dichlorophenoxy acetic acid (2,4-D). The concentration of 2,4-D, physiological age of immature embryos and genotype had a significant effect (P<0.05) on the percentage of embryogenic callus formed. The optimum 2,4-D concentration for the initiation of embryogenic callus was varied among the waxy maize genotypes from 2.0 mg L-1 (B7 and QCL5036) to 3.0 mg L-1 (W21019). The shoots were generated from embryogenic callus which were transferred into the regeneration medium supplemented with 0-2.5 mg L-1 of 6-benzylaminopurine (6-BA). 6-BA in the medium significantly promoted the regeneration of embryogenic callus. Embryogenic size was also an important factor that affected regeneration capacity. 0.6-0.7 cm was proved to be the best size for regeneration from embryogenic callus and the mean number of shoots per primary callus in all genotypes achieved the highest number. The ability of the plant regeneration was also affected by genotype. W21019 had the highest number of shoots formed per primary embryogenic callus. With the optimum condition, the highest mean number of shoots per primary callus was up to 12.13, 5.73, and 3.33 in line W21019, B7, and QCL5036, respectively. The successful regeneration of the two inbred lines provides a basis for development of genetic transformation to improve priority traits such as enhanced insects and drought tolerance. | ZHONG De-yi ZHU You-yin LIU qian ZHOU ti ZHAO De-gang | 2011 | Agricultural Sciences in China2011，10，4： | 2 |
| 8 | MicroRNA-27a/b regulates cellular cholesterol efflux, influx and esterification/hydrolysis in THP-1 macrophages显示文摘 | Min Zhang Jian-Feng Wu Wu-Jun Chen Shi-Lin Tang Zhong-Cheng Mo Yan-Yan Tang Yuan Li Jia-Lin Wang Xiang-Yu Liu Juan Peng Kong Chen Ping-Ping He Yun-Cheng Lv Xin-Ping Ouyang Feng Yao Deng-Pei Tang Francisco S. Cayabyab Da-Wei Zhang Xi-Long Zheng Guo-Ping Ti | 2014 | Atherosclerosis2014，，1： | 2 |
| 9 | Therapeutic effects of a novel tylophorine analog, NK‐007, on collagen‐induced arthritis through suppressing tumor necrosis factor α production and Th17 cell differentiation显示文摘 | Ti Wen Yangguang Li Meng Wu Xiaolin Sun Xiucong Bao Yuquan Lin Jianlei Hao Lin Han Guangchao Cao Ziwen Wang Yuxiu Liu Zhenzhou Wu Zhangyong Hong Puyue Wang Liqing Zhao Zhanguo Li Qingmin Wang Zhinan Yin | 2012 | Arthritis & Rheumatism2012，，9： | 2 |
| 10 | From glycerol to allyl alcohol: iron oxide catalyzed dehydration and consecutive hydrogen transfer显示文摘 | LIU Y Ti]YSi]Z H JIA CH J | 2010 | Chem Commun2010，46，8： | 1 |
| 11 | Molecular recognition and complexation thermodynamics of dye guest mole-cules by modified cyclodextrins and calixarenesulfonates显示文摘 | LIU Yu HAN Bao Hang CHEN Yun Ti | 2002 | J Phys Chem B2002，106，： | 1 |
| 12 | Urine sediment examination: a comparison of automated urinalysis systems and manual microsco py显示文摘 | Chien TI Kao JT Liu HL | 2007 | Clin Chim Aeta2007，384，12： | 1 |
| 13 | Transcrlptome analysis of the Asian honey bee Apis cerana cerana显示文摘 | Wang ZL Liu TI' Huang ZY eta/ | 2012 | PLoS One2012，7，04： | 1 |
| 14 | Degradation of high-methoxyl pectin by dynamic high pressure microfluidization and its mechanism显示文摘 | Jun Chen Rui-Hong Liang Wei Liu Cheng-Mei Liu Ti Li Zong-Cai Tu Jie Wan | 2011 | Food Hydrocolloids2011，，1： | 1 |
| 15 | Urine sediment examination= a comparison of automated urinalysis systems and manual microsco py显示文摘 | Chien TI Kao JT Liu HL et a| | 2007 | Clin Chim Acta2007，384，1： | 1 |
| 16 | A signal processing model for arterial spin labeling functional MRI显示文摘 | Liu TI' Wong EC | 2005 | Neuroimage2005，24，1： | 1 |
| 17 | The red-cell immune system显示文摘 | Siegel I Liu TI Gieicher N | 1981 | Lancet1981，，8246： | 1 |
| 18 | Medium-chain fatty acid nanoliposomes for easy energy supply显示文摘 | Wei Liu Wei-Lin Liu Cheng-Mei Liu Jian-Hua Liu Shui-Bing Yang Hui-Juan Zheng Han-Wu Lei Roger Ruan Ti Li Zong-Cai Tu Xin-Yong Song | 2011 | Nutrition2011，，6： | 1 |
| 19 | One family cluster of avian influenza A(HTNg) virus infection in Shandong, China显示文摘 | Ti Liu Zhenqiang Bi Xianiun Wang | 2014 | BMC Infectious Diseases2014，1498，： | 1 |
| 20 | Urine sediment examina- tion: a comparison of automated urinalysis systems and manual microscopy显示文摘 | Chien TI Kao JT Liu HL | 2007 | Clin Chim Acta2007，384，12： | 1 |
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