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| 1 | Exercise training in hypertension:Role of microRNAs显示文摘Hypertension is a complex disease that constitutes an important public health problem and demands many studies in order to understand the molecular mechanisms involving his pathophysiology. Therefore, an increasing number of studies have been conducted and new therapies are continually being discovered. In this context, exercise training has emerged as an important non-pharmacological therapy to treat hypertensive patients, minimizing the side effects of pharmacological therapies and frequently contributing to allow pharmacotherapy to be suspended. Several mechanisms have been associated with the pathogenesis of hypertension, such as hyperactivity of the sympathetic nervous system and renin-angiotensin aldosterone system,impaired endothelial nitric oxide production, increased oxygen-reactive species, vascular thickening and stiffening, cardiac hypertrophy, impaired angiogenesis, and sometimes genetic predisposition. With the advent of microRNAs(miRNAs), new insights have been added to the perspectives for the treatment of this disease, and exercise training has been shown to be able to modulate the miRNAs associated with it. Elucidation of the relationship between exercise training and miRNAs in the pathogenesis of hypertension is fundamental in order to understand how exercise modulates the cardiovascular system at genetic level. This can be promising even for the development of new drugs. This article is a review of how exercise training acts on hypertension by means of specific miRNAs in the heart, vascular system, and skeletal muscle. | Vander Josédas Neves Tiago Fernandes Fernanda Roberta Roque Ursula Paula RenóSoci Stéphano Freitas Soares Melo Edilamar Menezes de Oliveira | 2014 | World Journal of Cardiology2014，6，8： | 9 |
| 2 | Pseudomelanosis duodeni associated with chronic renal failure显示文摘Pseudomelanosis duodeni (PD) is a rare dark speckled appearance of the duodenum associated with gastrointestinal bleeding,hypertension,chronic heart failure,chronic renal failure and consumption of different drugs.We report four cases of PD associated with chronic renal failure admitted to the gastroenterology outpatient unit due to epigastric pain,nausea,melena and progressive reduction of hemoglobin index.Gastroduodenal endoscopy revealed erosions in the esophagus and stomach,with no active bleeding at the moment.In addition,the duodenal mucosa presented marked signs of melanosis;later confirmed by histopathological study.Even though PD is usually regarded as a benign condition,its pathogenesis and clinical significance is yet to be defined. | Marcia Henriques de Magalhes Costa Maria da Gloria Fernandes Pegado Cleber Vargas Maria Elizabeth C Castro Kalil Madi Tiago Nunes Cyrla Zaltman | 2012 | World Journal of Gastroenterology2012，18，12： | 2 |
| 3 | Integrated Platform for Production and Purification of Human Pluripotent Stem Cell-Derived Neural Precursors显示文摘 | Gon?alo M. C. Rodrigues Andreia F. S. Matos Tiago G. Fernandes Carlos A. V. Rodrigues Michael Peitz Simone Haupt Maria Margarida Diogo Oliver Brüstle Joaquim M. S. Cabral | 2014 | Stem Cell Reviews and Reports2014，，2： | 1 |
| 4 | Maintenance treatment of psoriasis with cyclosporine A: Comparison between continuous and weekend therapy显示文摘 | Iolanda Conde Fernandes Tiago Torres Manuela Selores | 2012 | Journal of the American Academy of Dermatology2012，，： | 1 |
| 5 | High-throughput cellular microarray platforms: applications in drug discovery, toxicology and stem cell research显示文摘 | Tiago G. Fernandes Maria Margarida Diogo Douglas S. Clark Jonathan S. Dordick Joaquim M.S. Cabral | 2009 | Trends in Biotechnology2009，，6： | 1 |
| 6 | Stem cell cultivation in bioreactors显示文摘 | Carlos A.V. Rodrigues Tiago G. Fernandes Maria Margarida Diogo Cláudia Lobato da Silva Joaquim M.S. Cabral | 2011 | Biotechnology Advances2011，，6： | 1 |
| 7 | Exercise trainingprevents the microvascular rarefaction in hypertension balancingangiogenic and apoptotic factors role of microRNAs 16, 21,and 126 显示文摘 | Tiago Fernandes Flavio C Magalhaes | 2012 | Hypertension2012，59，2： | 1 |
| 8 | Risk factors associated with inflammatory bowel disease: A multicenter case-control study in Brazil显示文摘BACKGROUND The etiology of inflammatory bowel disease(IBD)is unknown,but it is believed to be multifactorial.The hygiene hypothesis proposes that better hygiene conditions would lead to less infectious disease during childhood and favor the development of immune-mediated diseases.AIM To test the hygiene hypothesis in IBD by assessing the environmental risk factors associated with IBD development in different regions of Brazil with diverse socioeconomic development indices.METHODS A multicenter case-control study was carried out with 548 Crohn’s disease(CD)and 492 ulcerative colitis(UC)outpatients and 416 healthy controls,from six IBD centers within different Brazilian states at diverse socioeconomic development stages.A semi-structured questionnaire with 87 socioeconomic and environmental questions was applied.Logistic regression model was created to assess the odds ratio(OR)with P value and 95%confidence intervals(CI).RESULTS Predictive variables for both diseases(CD and UC)were women[odd ratios(OR)=1.31;OR=1.69],low monthly family income(OR=1.78;OR=1.57),lower number of cohabitants(OR=1.70;OR=1.60),absence of vaccination(OR=3.11;OR=2.51),previous history of bowel infections(OR=1.78;OR=1.49),and family history of IBD(OR=5.26;OR=3.33).Associated risk factors for CD were age(18-39 years)(OR=1.73),higher educational level(OR=2.22),absence of infectious childhood diseases(OR=1.99).The UC predictive variables were living in an urban area(OR=1.62),inadequate living conditions(OR=1.48)and former smokers(OR=3.36).Appendectomy was a risk factor for CD(OR=1.58)with inverse association with UC(OR=4.79).Consumption of treated and untreated water was associated with risk of CD(OR=1.38)and UC(OR=1.53),respectively.CONCLUSION This is the first examining environmental exposures as risk factors for inflammatory bowel disease in Brazil.Most of the variables associated with disease risk support the role of the hygiene hypothesis in IBD development. | Valéria Cristina Loureiro Salgado Ronir Raggio Luiz Neio Lucio Fernandes Boéchat Isabella Sued Leao Bianca do Carmo Schorr JoséMiguel Luz Parente Daniela Calado Lima Eduardo Santos Silveira Júnior Genoile Oliveira Santana Silva Neogélia Pereira Almeida Andrea Vieira Maria Luiza Queiroz de Bueno Júlio Maria Chebli érika Ruback Bertges Luísa Martins da Costa Brugnara Columbano Junqueira Neto Stefania Burjack Gabriel Campbell Luana Letiza Discacciati Joao Paulo Silva Cézar Tiago Nunes Gilaad G Kaplan Cyrla Zaltman | 2020 | World Journal of Gastroenterology2020，26，25： | 1 |
| 9 | Aerobic exercise reduces oxidative stress and improves vascular changes of small mesenteric and coronary arteries in hypertension显示文摘 | Fernanda R Roque Ana M Briones Ana B García‐Redondo María Galán Sonia Martínez‐Revelles Maria S Avenda?o Victoria Cachofeiro Tiago Fernandes Dalton V Vassallo Edilamar M Oliveira Mercedes Salaices | 2013 | Br J Pharmacol2013，，3： | 1 |
| 10 | The role of microRNA-208a in cardiac hypertrophy induced by aerobic physical training显示文摘 | URSULA PAULA RENO SOCI TIAGO FERNANDES KA LEIZU T ROSA | 2013 | Faseb J2013，27，： | 1 |
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