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| 1 | Notoginsenoside Ft1 acts as a TGR5 agonist but FXR antagonist to alleviate high fat diet-induced obesity and insulin resistance in mice显示文摘Obesity and its associated complications are highly related to a current public health crisis around the world.A growing body of evidence has indicated that G-protein coupled bile acid(BA) receptor TGR5(also known as Gpbar-1) is a potential drug target to treat obesity and associated metabolic disorders.We have identified notoginsenoside Ftl(Ftl) from Panax notoginseng as an agonist of TGR5 in vitro.However,the pharmacological effects of Ftl on diet-induced obese(DIO) mice and the underlying mechanisms are still elusive.Here we show that Ftl(100 mg/100 diet) increased adipose lipolysis,promoted fat browning in inguinal adipose tissue and induced glucagon-like peptide-1(GLP-1) secretion in the ileum of wild type but not Tgr5^(-/-) obese mice.In addition,Ftl elevated serum free and taurineconjugated bile acids(BAs) by antagonizing Fxr transcriptional activities in the ileum to activate Tgr5 in the adipose tissues.The metabolic benefits of Ftl were abolished in Cyp27 al^(-/-) mice which have much lower BA levels.These results identify Ftl as a single compound with opposite activities on two key BA receptors to alleviate high fat diet-induced obesity and insulin resistance in mice. | Lili Ding Qiaoling Yang Eryun Zhang Yangmeng Wang Siming Sun Yingbo Yang Tong Tian Zhengcai Ju Linshan Jiang Xunjiang Wang Zhengtao Wang Wendong Huang Li Yang | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 10 |
| 2 | Some key technics of drop tower experiment device of National Microgravity Laboratory (China) (NMLC)显示文摘Drop tower is an important ground based facility for microgravity science experiment. The technical performances of the drop tower NMLC are advanced compared with similar facilities in the US, Germany and Japan. The main components such as drop capsule, deceleration devices, release mechanism present its advantages and creativities. | ZHANG Xiaoqian 1 , YUAN Longgen 1 , WU Wendong 1 , TIAN Lanqiao 2 & YAO Kangzhuang 2 1. Institute of Engineering Thermophysics, Chinese Academy of Sciences, Beijing 100080, China 2. Institute of Mechanics, Chinese Academy of Sciences, Beijing 100080, China | 2005 | Science China(Technological Sciences)2005，48，3： | 4 |
| 3 | Investigation of Coal Fueled Chemical Looping Combustion Using Fe_3O_4 as Oxygen Carrier:Influence of Variables显示文摘Chemical-looping combustion (CLC) is a novel combustion technique with inherent CO2 separation.Magnetite (Fe3O4) was selected as the oxygen carrier.Shenhua coal (Inner Mongolia,China),straw coke and natural coke were used as fuels for this study.Influences of operation temperatures,coal to Fe3O4 mass ratios,and different kinds of fuels on the reduction characteristics of the oxygen carrier were investigated using an atmosphere thermogravimetric analyzer (TGA).Scanning electron microscopy (SEM) was used to analyse the characteristic of the solid residues.Experimental results shown that the reaction between the coal and the oxygen carrier become strong at a temperature of higher than 800℃.As the operation temperature rises,the reduction conversion rate increases.At the temperatures of 850oС,900℃,and 950℃,the reduction conversion rates were 37.1%,46.5%,and 54.1% respectively.However,SEM images show that at the temperature of higher than 950℃,the iron oxides become melted and sintered.The possible operation temperature should be kept around 900℃.When the mass ratios of coal to Fe3O4 were 5/95,10/90,15/85,and 20/80,the reduction conversion rates were 29.5%,40.8%,46.5%,and 46.6% respectively.With the increase of coal,the conversion rate goes up.But there exist an optimal ratio around 15/85.Comparisons based on different kinds of fuels show that the solid fuel with a higher volatile and a more developed pore structure is conducive to the reduction reactivity of the oxygen carrier. | Xiaoyan Sun Wenguo Xiang Sha Wang Wendong Tian Xiang Xu Yanji Xu Yunhan Xiao | 2010 | Journal of Thermal Science2010，19，3： | 3 |
| 4 | Energy and Exergy Analysis of a Novel Efficient Combined Process by Hydrothermal Degradation and Superheated Steam Drying of Degradable Organic Wastes显示文摘This paper considers the combination of hydrothermal degradation(HTD)and superheated steam(SHS)drying indisposal and processing of degradable organic wastes in municipal solid wastes(MSW).In SHS drying, a fractionof dryer thermal energy input can be recovered and used to satisfy the heat requirement in maintaining the HTDoperating temperature.Both energy and exergy analysis are applied to the combined process.The analysis coversranges of dryer inlet temperatures of 202.38-234.19℃ and feed water content of 32.5-65%.Thermal energyanalysis shows that the combination of HTD and SHS drying can achieve thermal energy self-sufficiency(TES)by manipulating process variables.The exergy analysis indicates the location,type,and magnitude of the exergylosses during the whole process by applying the second law of thermodynamics. | Shuqing GUO Yunhan XIAO Wendong TIAN Zhedian ZHANG | 2006 | Journal of Thermal Science2006，15，3： | 2 |
| 5 | 2-14 Investigation of the Thermonuclear 18Ne(α, p)21Na Reaction Rate via Resonant Elastic Scattering of 21Na + p显示文摘A nuclear astrophysics experiment was performed at CRIB (CNS low-energy Radioactive-Ion Beam separator)on Mar. 2011. The goal of this experiment is to study the reaction rate of 18Ne(,p)21Na reaction, which mightbe a key breakout reaction from the hot CNO cycle to rp-process in X-ray burst and nova. Yet its reaction rate ispoorly known.Explosive hydrogen burning is thought to be the main source of energy generation and a source of nucleosynthesisin X-ray burst and nova[1;2]. For example, XRBs are characterized by a sudden increase of X-ray emission withinonly a few seconds to a total energy output of about 1040 ergs, which is observed to repeat with some regularity.The recurrence time for single bursts can range from hours to days at the typical temperature of 0.4~2 GK. Thebursts have been interpreted as being generated by thermonuclear runaway on the surface of a neutron star thataccretes H- and He-rich material from a less evolved companion star in a close binary system. As shown in Fig. 1,under its typical temperature, the hydrogen burning in X-ray burst occurs from the hot CNO cycle: | Zhang Liyong He Jianjun Xu Shiwei H.Yamaguchi S. Kubono Y.Wakabayashi Chen Size Hu Jun Ma Peng Y. Togano T. Hashimoto D. Kahl T. Teranishi Chen Ruofu Wang Hongwei Tian Wendong Guo Bing S. Hayakawa N. Iwasa T. Yamada T. Komatsubara | 2014 | IMP & HIRFL Annual Report2014，，1： | 2 |
| 6 | Origin of the finite nuclear spin and its effect in intermediate energy heavy ion collisions显示文摘The heavy-ion phase-space exploration (HIPSE) model is used to discuss the origin of the nuclear spin in intermediate energy heavy-ion collision (HIC).The spin of maximal projectile-like fragment is found to depend strongly on impact parameter of a reaction system,while it relates weakly to the collision violence.Some interesting multi-fragmentation phenomena related to the spin are shown.We also found that the excitation energy in the de-excitation stage plays a robust role at the de-excitation stage in HIC. | ZHANG Guoqiang CAO Xiguang FU Yao MA Yugang CAI Xiangzou WANG Hongwei FANG Deqing CHEN Jingen GUO Wei Tian Wendong LIU Guihua | 2012 | Nuclear Science and Techniques2012，23，1： | 2 |
| 7 | Bile acid signaling and bariatric surgery显示文摘The rapid worldwide rise in obesity rates over the past few decades imposes an urgent need to develop effective strategies for treating obesity and associated metabolic complications.Bariatric surgical procedures,such as Roux-en-Y gastric bypass(RYGB)and vertical sleeve gastrectomy(VSG),currently provide the most effective treatment for obesity and type 2 diabetes(T2D),as well as for non-alcoholic steatohepatitis(NASH).However,the underlying mechanisms of the beneficial effects of bariatric surgery remain elusive.Recent studies have identified bile acids as potential signaling molecules involved in the beneficial effects of bariatric surgery.This review focuses on the most recent studies on the roles of bile acids and bile acid receptors Farnesoid X receptor(FXR)and G protein-coupled bile acid receptor 5(TGR5)in bariatric surgery.We also discuss the possibility of modulating bile acid signaling as a pharmacological therapeutic approach to treating obesity and its associated metabolic complications. | Jingyan Tian Silvia Huang Siming Sun Lili Ding Eryun Zhang Yanjun Liu Wendong Huang | 2017 | Liver Research2017，1，4： | 2 |
| 8 | Highly efficient ultraviolet high-harmonic generation from epsilon-near-zero indium tin oxide films显示文摘High-harmonic generation in the ultraviolet region is promising for wireless technology used for communications and sensing. However, small high-order nonlinear coefficients prevent us from obtaining high conversion efficiency and functional photonic devices. Here, we show highly efficient ultraviolet harmonic generation extending to the fifth order directly from an epsilon-near-zero indium tin oxide(ITO) film. The real part of the annealed ITO films was designed to reach zero around 1050 nm, matching with the central wavelength of an Yb-based fiber laser, and the internal driving electric field was extremely enhanced. A high energy conversion efficiency of 10-4 and 10-6 for 257.5 nm(fourth-order) and 206 nm(fifth-order) ultraviolet harmonic generation was obtained,which is at least 2 orders of magnitude higher than early reports. Our results demonstrate a new route for overcoming the inefficiency problem and open up the possibilities of compact solid-state high-harmonic generation sources at nanoscale. | Wendong Tian Fei Liang Dazhi Lu Haohai Yu Huaijin Zhang | 2021 | Photonics Research2021，9，3： | 2 |
| 9 | Distributed Stepping Motor Control System显示文摘The beam diagnostic devices used at RIBLL are driven by stepper motors, which are controlled by I/O modules based on ISA-bus in an industrial computer. The disadvantages of such mode are that a large number of long cables are used and one computer to control is unsafe. We have developed a distributed stepping motor control system for the remote, local and centralized control of the stepping motors. RS-485 bus is used for the connection between the remote control unit and the local control units. The con... | Bai Jie, Chen Zhiqiang, Xiao Guoqing, Zhan Wenlong, Guo Zhongyan, Wang Meng, Sun Zhiyu Li Jiaxing, Tian Wendong, Wang Jiansong, Wang Wusheng, Mao Ruishi, Chen Zhiqiang Hu Zhcngguo, Chen Lixin and Li Ch | 2001 | IMP & HIRFL Annual Report2001，，1： | 1 |
| 10 | miR‐194 is a marker of hepatic epithelial cells and suppresses metastasis of liver cancer cells in mice显示文摘 | Zhipeng Meng Xianghui Fu Xiaosong Chen Samuel Zeng Yan Tian Richard Jove Rongzhen Xu Wendong Huang | 2010 | Hepatology2010，，6： | 1 |
| 11 | AI Enlightens Wireless Communication:Analyses,Solutions and Opportunities on CSI Feedback显示文摘In this paper,we give a systematic description of the 1st Wireless Communication Artificial Intelligence(AI)Competition(WAIC)which is hosted by IMT-2020(5G)Promotion Group 5G+AI Work Group.Firstly,the framework of full channel state information(F-CSI)feedback problem and its corresponding channel dataset are provided.Then the enhancing schemes for DL-based F-CSI feedback including i)channel data analysis and preprocessing,ii)neural network design and iii)quantization enhancement are elaborated.The final competition results composed of different enhancing schemes are presented.Based on the valuable experience of 1stWAIC,we also list some challenges and potential study areas for the design of AI-based wireless communication systems. | Han Xiao Zhiqin Wang Wenqiang Tian Xiaofeng Liu Wendong Liu Shi Jin Jia Shen Zhi Zhang Ning Yang | 2021 | China Communications2021，18，11： | 1 |
| 12 | Spatial Distribution of Mature Larvae of Obolodiplosis robiniae and Damage Regularity of Its First Generation Larvae on Leaves of Locust( Robinia pseudoacacia)显示文摘[Objective] The paper was to explore the population dynamics of Obolodiplosis robiniae( Haldemann).[Method] The spatial distribution of mature larvae of O.robiniae and the damage regularity of its first generation larvae on leaves of locust were studied in Fangshan District of Beijing City.[Result] The spatial distribution of mature larvae of O.robiniae in the forest was significantly higher than those in forest edge and periphery of forest edge.The attack of the first generation larvae was mainly concentrated in the lower part of tree crown.[Conclusion] The study provides theoretical basis for the effective control against O.robiniae. | Sun Jingshuang Cao Ning Tian Wendong Qu Haixue Xue Xinhua Tian Guihong | 2013 | Plant Diseases and Pests2013，4，4： | 0 |
| 13 | Experimental Study 18Ne(a,p)21Na of Key Astrophysical Reaction显示文摘 | Zhang Liyong He Jianjun Xu Shiwei H. Yamaguchi S. Kubono Y. Wakabayashi Chen Size Ma Peng Y. Togano T. Hashimoto D. Kahl T. Teranishi Chen Ruofu Wang Hongwei Tian Wendong Guo Bing S. Hayakawa N. Iwasa T. Yamada T. Komatsubara | 2011 | IMP & HIRFL Annual Report2011，，1： | 0 |
| 14 | A Semi-Supervised Topic Model Incorporating Sentiment and Dynamic Characteristic显示文摘With the rapid popularization of social applications, various kinds of social media have developed into an important platform for publishing information and expressing opinion. Detecting hidden topics from the huge amount of user-generated contents is of great commerce value and social significance. However traditional text analysis approachesonly focus on the statistical correlation between words, but ignore the sentiment tendency and the temporal properties which may have great effects on topic detection results. This paper proposed a Dynamic Sentiment-Topic(DST) model which can not only detect and track the dynamic topics but also analyze the shift of public's sentiment tendency towards certain topic.Expectation-Maximization algorithm was used in DST model to estimate the latent distribution, and we used Gibbs sampling method to sample new document set and update the hyper parameters and distributions.Experiments are conducted on a real dataset and the results show that DST model outperforms the existing algorithms in terms of topic detection and sentiment accuracy. | Lanshan Zhang Xi Ding Ye Tian Xiangyang Gong Wendong Wang | 2016 | China Communications2016，13，12： | 0 |
| 15 | 2 - 30 Progress in Analyzing RIBLL1 17F+p Experimental Data显示文摘 | He Jianjun Hu Jun Xu Shiwei Chen Zhiqiang Zhang Xueying Wang Jiansong Yu Xiangqing Li Long Zhang Liyong Yang Yanyun Ma Peng Wang Hongwei Tian Wendong Zhang Xueheng Su Jun Li Ertao Hu Zhengguo Guo Zhongyan Xu Xing Yuan Xiaohua Lu Wan Lei Xiangguo Yu Yuhong Tang Shuwen Ye Ruiping Chen Jinda Jin Shilun Du Chengming Wang Shitao Ma Junbing Liu Longxiang Bai Zhen Sun Zhiyu Li Xiangqing Zhang Yuhu Zhou Xiaohong Xu Hushan | 2010 | IMP & HIRFL Annual Report2010，，1： | 0 |
| 16 | A Study on Heat Transfer for Immersed Tube inInternally Circulating Fluidized Bed显示文摘INTRODUCTIONThemethodhowtodealwiththedomesticandindustrialwasteswithoutfurthercontaminationisoneofthemostimportantenvironmentalissues.Fluidizedbedcombustor(FBC)hasadvantagesofhighcombustionefficiency)lowpollution,convenienceinpreprocessingbeforefedin... | Tian Wendong Hao Jinhua Wei Xiaolin Li Jun Wu Dongyin ShengHongzhi(Institute of Mechanics, Chinese Academy of Sciences, Beijing 100080, China) | 1999 | Journal of Thermal Science1999，8，3： | 0 |
| 17 | Simulation of Photon Collection Efficiency in Scintillator of 4л Detector Array显示文摘SimulationofPhotonCollectionEfficiencyinScintillatorof4лDetectorArray￥TianWendong;LiSonglin;ZhuYongtai;XuHushanandWangQiInthe... | Tian Wendong Li Songlin Zhu Yongtai Xu Hushan and Wang Qi | 1996 | IMP & HIRFL Annual Report1996，，1： | 0 |
| 18 | Measurements of Reaction Cross Section and Fragment Momentum Distribution for Proton-rich Nucleus ^31Cl显示文摘 | Fang Deqing Ma Chunwang Fu Yaoa Ma Yugang Cai Xiangzhou Guo Wei Liu Guihua Shi Yu Tian Wendong Wang Hongwei Fan Ruirui Fu Fen Gao Hui Gao Qi Guo Wentao Han Jianlong Hu Zhengguo Huang Tianhen Jia Fei Lei Xiangguo Li Bo Sun Zhiyu Wang Meng Wang Jiansong Xiao Zhigang Xu Zhiguo Yao Xiangwu Zhang Hongbin Zhang Xueheng Zheng Chuan Xu Hushan Xiao Guoqing Zhan Wenlong | 2007 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2007，，1： | 0 |
| 19 | Investigation of Proton Resonant Properties in laNe via 17F+p and Its Astrophysical Implications for 14O(α,p)17F Stellar Reaction显示文摘 | Hu Jun He Jianjun Xu Shiwei Chen Zhiqiang Zhang Xueying Wang Jiansong Yu Xiangqing Li Long Zhang Liyong Yang Yanyun Ma Peng Wang Hongwei Tian Wendong Yuan Xiaohua Lu Wan Zhang Xueheng SuJun Li Ertao Hu Zhengguo Guo Zhongya n Xu Xing Lei Xiangguo Yu Yuhong Tang Shuwen Ye Ruiping Chen Jinda Jin Shilun Du Chengming Wang Shitao Ma Junbing Liu Longxiang Bai Zhen Sun Zhiyu Li Xiangqing Zhang Yuhu Zhou Xiaohong Xu Hushan | 2009 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2009，，1： | 0 |
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