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| 1 | Closed-loop drip irrigation control using a hybrid wireless sensor and actuator network显示文摘In this research, a closed-loop drip irrigation control hybrid wireless sensor and actuator network (HWSAN) prototype were developed and deployed in a crop field for soil property precise measurement and precision irrigation in accordance with the measured soil property. The HWSAN was composed of a wireless sensor and actuator network (WSAN) used for in-field soil property monitoring and irrigation control and a laboratory supervising system. The WSAN included ten sensor nodes, five irrigation control nodes, a central node, a gateway and a cellular modem. The laboratory supervising system was formed by a web-server. The system could automatically sample soil properties including soil moisture, electrical conductivity, and nearsurface temperature at four different depths underground and transmit field data through cellular network to the web-server. Closed-loop control was achieved through the control nodes listening uploading packets from its paired sensor nodes to control drip irrigation. Results from the quality of service (QoS) evaluation included: the data packet transmission rate was 84.76%, data accuracy rate was greater than 97% and no in-field data transmission errors. | LI Zhen WANG Ning HONG TianSheng FRANZEN Aaron LI JiaNian | 2011 | Science China(Information Sciences)2011，54，3： | 7 |
| 2 | Melatonin enhances radiofrequency-induced NK antitumor immunity,causing cancer metabolism reprogramming and inhibition of multiple pulmonary tumor development显示文摘Surgery is the comm on treatme nt for early lung cancer with multiple pulm onary no dules,but it is often accompanied by the problem of significant malignancy of other nodules in non-therapeutic areas.In this study,we found that a combined treatment of local rad iofreq ue ncy ablati on(RFA)and melatonin(MLT)greatly improved clinical outcomes for early lung cancer patie nts with multiple pulmonary nodules by minimizing lung function injury and reducing the probability of malignant transformation or enlargement of nodules in non-ablated areas.Mechanically,as demonstrated in an associated mouse lung tumor model,RFA not only effectively remove treated tumors but also stimulate antitumor immunity,which could inhibit tumor growth in non-ablated areas.MLT enhanced RFA-stimulated NK activity and exerted synergistic antitumor effects with RFA.Transcriptomics and proteomics analyses of residual tumor tissues revealed enhanced oxidative phosphorylation and reduced acidification as well as hypoxia in the tumor microenvironment,which suggests reprogrammed tumor metabolism after combined treatment with RFA and MLT.Analysis of residual tumor further revealed the depressed activity of MAPK,NF-kappa B,Wnt,and Hedgehog pathways and upregulated P53 pathway in tumors,which was in line with the inhibited tumor growth.Combined RFA and MLT treatment also reversed the Warburg effect and decreased tumor malignancy.These findings thus demonstrated that combined treatment of RFA and MLT effectively inhibited the malignancy of non-ablated nodules and provided an innovative non-invasive strategy for treating early lung tumors with multiple pulmonary nodules.Trial registration:www.chictr.org.cn,identifier ChiCTR2100042695,http://gffzz62a03ee25e6f4a77hbfpncxk66vn66kn9.ffgz.tsg.suse.edu.cn/showproj.aspx?proj=120931. | Ming Li Bingjie Hao Menghuan Zhang Russel J.Reiter Shumeng Lin Tiansheng Zheng Xiangyun Chen Yanbei Ren Liduo Yue Baigenzhin Abay Guojie Chen Xiao Xu Yufeng Shi Lihong Fan | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 6 |
| 3 | An expert consensus on the evaluation and treatment of acute thoracolumbar spine and spinal cord injury in China显示文摘This is an expert consensus on the evaluation and treatment of thoracolumbar spinal injury,established from February 2009 to July 2010.The expert consensus consists mainly of six parts with a total of 54 recommendations including the overview(one item);pre-hospital care(one item);evaluation and diagnosis(13 items);treatment(23 items);prevention and treatment of major complications(12 items);and rehabilitation(four items).This is the first time that Chinese experts have published a consensus on spine and spinal cord injury.The expert consensus was established based on Delphi methods,literature analysis,and clinical experiences.Each recommendation is supported by and was interpreted using multi-level evidences.The level of agreement with the recommendation among the panel members was assessed as either low,moderate,or strong.Each panel member was asked to indicate his or her level of agreement on a 5-point scale,with '1' corresponding to neutrality and '5' representing maximum agreement.Scores were aggregated across the panel members and an arithmetic mean was calculated.This mean score was then translated into low,moderate,or strong.After all of the votes were collected and calculated,the results showed no low-level recommendations,10 moderate-level recommendations,and 44 strong-level recommendations.An expert consensus was reached and was recognized by Chinese spine surgeons.Wide-scale adoption of these recommendations is urgent in the management of acute thoracolumbar spine and spinal cord injury in a broader attempt to create a standard evaluation and treatment strategy for acute thoracolumbar spine and spinal cord injury in China. | Zhicheng Zhang Fang Li Tiansheng Sun | 2013 | Neural Regeneration Research2013，8，33： | 6 |
| 4 | Effect of transcutaneous electrical nerve stimulation at acupoints on patients with type 2 diabetes mellitus:a randomized controlled trial显示文摘OBJECTIVE:To examine whether transcutaneous electric nerve stimulation at acupoints(Acu-TENS)improved the biochemical and physical indices of patients with type 2 diabetes mellitus(T2DM).METHODS:Ninety subjects with T2DM were divided randomly into a control group(n = 30),aerobic exercise group(n- 30),or Acu-TENS group(n = 30).In addition to conventional diabetes drug treatment,patients in the Acu-TENS group received acupoint stimulation,the aerobic exercise group engaged in walking exercises,and the control group was given sham electrical stimulation.All groups were treated for 30 min for each session and five times a week for 2 months.The indices of glycosylated hemoglobin,2 h postprandial glucose,fasting serum insulin,triglyceride,total cholesterol,and body mass index were assessed at pre-treatment,post-treatment,and follow-up,which was 2 months after treatment.RESULTS:The indices of the control group were not changed(P > 0.05) at the three time points.At the pre-treatment measurement,there were significant differences(P > 0.05) in indices among the three groups.At post-treatment,each index of the two groups was lower than that of the control group(P < 0.05),and improved in comparison with the pre-treatment measurement(P < 0.05).In follow-up,each index of the aerobic exercise group and Acu-TENS group increased,but was still decreased compared with the pre-treatment value(P < 0.05),excluding body mass index.CONCLUSION:Acu-TENS could improve the state of patients with T2 DM and be used as a therapy in clinical application. | Wu Zhiyuan Yang Ming Jia Jie Wu Yi Huang Tiansheng Li Mingfen He Zhijie Guo Zhenzhen Leung Mason Chin Pang | 2015 | Journal of Traditional Chinese Medicine2015，35，2： | 5 |
| 5 | Microstructural evolution and tensile properties of low-carbon steel with martensitic microstructure during warm deforming and annealing显示文摘For preparing large-scale nano-grained and ultrafine-grained steel sheets by warm rolling and annealing,the effects of de- forming temperature on both the flow stress and the microstructure evolution of 09MnNiD steel with lath martensitic microstructure were studied by warm-compression test and transmission electron microscopy(TEM)observation.Thereafter,the steel with the lath martensitic structure was multi-pass warm-rolled and then annealed.TEM results indicate that nano-grained and ultrafine-grained steel sheets are formed by warm rolling at 400℃and annealing at 400-600℃.In comparison with the as-warm-rolled specimen,the tensile strength at room temperature changes a little when the rolled samples are annealed below 450℃,and the tensile strength is greatly lowered as the annealing temperature increases to above 550℃. | Yuwei Gao Tianfu Jing Guiying Qiao Jinku Yu Tiansheng Wang Qun Li Xinyu Song Shuqiang Wang Hong Gao | 2008 | Journal of University of Science and Technology Beijing2008，15，3： | 4 |
| 6 | Identification and Molecular Characterization of a Phytoplasma Associated with Pomegranate Fasciation Disease显示文摘To confirm phytoplasma infection,samples of pomegranate(Punica granatum L.)plants showing symptoms of fasciation were collected from an orchard located in Tai’an,Shandong Province,China.A fragment of approximately 1.2 kb was amplified with universal primers targeting the phytoplasma 16S r RNA gene from symptomatic pomegranate plants,while no fragment was obtained from healthy plants.The phytoplasma associated with the disease was designated as pomegranate fasciation(Po F).Two representative phytoplasma 16S r DNA gene sequences(Po F-Ch01 and Po F-Ch02)had 100%nucleotide sequence identity.The 16S r DNA sequence of Po F-Ch01 and Po F-Ch02 showed the highest similarity(99.6%)to that of‘P.granatum’phytoplasma isolate AY-PG,which belong to 16Sr I-B.Further phylogenetic analysis showed that Po F-Ch01 and Po F-Ch02 belonged to a cluster of 16Sr I subgroup members.In silico RFLP analysis indicated that Po F-Ch01 shared the highest similarity coefficient of 0.97 with reference strains of 16Sr I-B,M and N.Actual RFLP analysis of both enzymes Bst U I and Bfa I confirmed that of the virtual RFLP analysis.Combining these results,we concluded that Po F was a member of the‘Candidatus Phytoplasma asteris’group(16Sr I),and has very close relationship with 16Sr I-B subgroup. | GAOdb Rui WANG Jie ZHU Tiansheng JIA Xi LI Xiangdong | 2018 | Horticultural Plant Journal2018，4，1： | 3 |
| 7 | CPT1C-mediated fatty acid oxidation facilitates colorectal cancer cell proliferation and metastasis显示文摘Fatty acid oxidation(FAO)has been proven to be an accomplice in tumor progression.Carnitine palmitoyltransferase 1C(CPT1C),a rate-limiting enzyme in FAO,mainly functions to catalyze fatty acid carnitinylation and guarantee subsequent entry into the mitochondria for FAO in colorectal cancer(CRC).Gene expression data and clinical information extracted from The Cancer Genome Atlas(TCGA)database show significantly higher expression of CPT1C in patients with metastatic CRC(P=0.005).Moreover,overexpression of CPT1C is correlated with worse relapse-free survival in CRC(HR 2.1,P=0.0006),while no statistical significance is indicated for CPT1A and CPT1B.Further experiments demonstrate that downregulation of CPT1C expression leads to a decrease in the FAO rate,suppression of cell proliferation,cell cycle arrest and repression of cell migration in CRC,whereas opposite results are obtained when CPT1C is overexpressed.Furthermore,an FAO inhibitor almost completely reverses the enhanced cell proliferation and migration induced by CPT1C overexpression.In addition,analysis of TCGA data illustrates a positive association between CPT1C expression and HIF1αlevel,suggesting that CPT1C is a transcriptional target of HIF1α.In conclusion,CPT1C overexpression indicates poor relapse-free survival of patients with CRC,and CPT1C is transcriptionally activated by HIF1α,thereby promoting the proliferation and migration of CRC cells. | Jing Li Wanwei Zheng Jie Wu Jun Zhang Bin Lv Wenshuai Li Jie Liu Xin Zhang Tiansheng Huang Zhongguang Luo | 2023 | Acta Biochimica et Biophysica Sinica2023，55，8： | 1 |
| 8 | Regulating the nanoscale intimacy of metal and acidic sites in Ru/γ-Al_(2)O_(3)for the selective conversions of lignin-derived phenols to jet fuels显示文摘Catalytic hydrodeoxygenation(HDO)of biomass-derived oxy-compounds to advanced hydrocarbon fuels usually requires bifunctional catalysts containing metals and acidic sites.The appropriate tuning of metal and/or acidic active sites at interfaces of bifunctional catalysts can significantly improve catalyst activity and product selectivity.Here,4-trifuoromethyl salicylic acid(TFMSA),as a hydrothermal stable organic acid,was employed to tailor the bifunctional interface of Ru/γ-Al_(2)O_(3)to enhance the catalytic performance on converting lignin-derived phenols to jet fuel range cycloalkanes.More than 80%phenol was converted into cyclohexane at 230°C for 1 h over Ru/γ-Al_(2)O_(3)modified by TFMSA,which was about three times higher than that over unmodified Ru/γ-Al_(2)O_(3).X-ray diffraction(XRD),Transmission electron microscope(TEM),H2 chemisorption,and energy dispersive X-ray spectroscopy(EDS)elemental mapping results indicated that Ru nanoparticles and TFMSA were well distributed onγ-Al_(2)O_(3),and a nanoscale intimacy between Ru and TFMSA was reached.Meanwhile,Fourier transform infrared spectroscopy after pyridine adsorption(Py-FT-IR)analysis proved that Brønsted acidic sites on the catalytic interfaces of TFMSA modified Ru/γ-Al_(2)O_(3)had been improved.Moreover,the kinetic and density functional theory(DFT)results suggested that the synergistic effects of adjacent Ru nanoparticles and acidic sites were crutial for promoting the rate-limiting conversion step of phenol HDO to cyclohexane. | Shanshuai Chen Weichen Wang Xue Li Puxiang Yan Wanying Han Tian Sheng Tiansheng Deng Wanbin Zhu Hongliang Wang | 2022 | Journal of Energy Chemistry2022，31，3： | 1 |
| 9 | Does repair of spinal cord injury follow the evolutionary theory?显示文摘Lower vertebrates,such as fish and amphibians,and higher vertebrates in embryonic development can acquire complete regeneration of complex body structures,including the spinal cord,an important part of the central nervous system.However,with species evolution and development,this regenerative capacity gradually weakens and even disappears,but the cellular and molecular mechanisms remain poorly understood.We explored the differences in mechanisms of spinal cord regeneration capability between lower and higher vertebrates,investigated differences in their cellular and molecular mechanisms and between the spinal cord structures of lower vertebrates and mammals,such as rat and monkey,to search for theoretical evidence and therapeutic targets for nerve regeneration in human spinal cord. | Zhicheng Zhang Fang Li Tiansheng Sun | 2012 | Neural Regeneration Research2012，7，11： | 1 |
| 10 | Evaluating the impact of insect community on pine caterpillar density in different stand conditions显示文摘 | Tiansheng Li Guofa Zhou Jian Wu | 1998 | Entomologyia Sinica1998，5，2： | 1 |
| 11 | Iron/copper promoted oxidative homo - coupling reaction of terminal alkynes using air as the oxi- dam显示文摘 | Xu Meng Chuanbin Li Baochun Han Tiansheng Wang Baohua Chen | 2010 | Tetrahedron2010，66，23： | 1 |
| 12 | IL4I1-driven AHR signature: a new avenue for cancer therapy显示文摘Aryl hydrocarbon receptor(AHR)was considered to be an important pan-tumor therapeutic target,but small molecule inhibitors targeting AHR target gene ID01 have failed in clinical trials.The recent paper published in Cell by Opitz et al.explained the failure of previous clinical trials and identified new therapeutic targets(Fig.1). | Zuli Wang Tiansheng Li Chao Mao Wenliang Liu Yongguang Tao | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 0 |
| 13 | Dimension Reduction Based on Sampling显示文摘Dimension reduction provides a powerful means of reducing the number of random variables under consideration.However,there were many similar tuples in large datasets,and before reducing the dimension of the dataset,we removed some similar tuples to retain the main information of the dataset while accelerating the dimension reduc-tion.Accordingly,we propose a dimension reduction technique based on biased sampling,a new procedure that incorporates features of both dimensional reduction and biased sampling to obtain a computationally efficient means of reducing the number of random variables under consid-eration.In this paper,we choose Principal Components Analysis(PCA)as the main dimensional reduction algorithm to study,and we show how this approach works. | Zhuping Li Donghua Yang Mengmeng Li Haifeng Guo Tiansheng Ye Hongzhi Wang | 2023 | 国际计算机前沿大会会议论文集2023，，1： | 0 |
| 14 | Mechanistic understanding of the charge storage processes in FeF_(2) aggregates assembled with cylindrical nanoparticles as a cathode material for lithium-ion batteries by in situ magnetometry显示文摘Transition metal fluorides(TMFs)cathode materials have shown extraordinary promises for electrochemical energy storage,but the understanding of their electrochemical reaction mechanisms is still a matter of debate due to the complicated and continuous changing in the battery internal environment.Here,we design a novel iron fluoride(FeF_(2))aggregate assembled with cylindrical nanoparticles as cathode material to build FeF_(2) lithium-ion batteries(LIBs)and employ advanced in situ magnetometry to detect their intrinsic electronic structure during cycling in real time.The results show that FeF_(2) cannot be involved in complete conversion reactions when the FeF_(2) LIBs operate between the conventional voltage range of 1.0–4.0 V,and that the corresponding conversion ratio of FeF_(2) can be further estimated.Importantly,we first demonstrate that the spin-polarized surface capacitance exists in the FeF_(2) cathode by monitoring the magnetic responses over various voltage ranges.The research presents an original and insightful method to examine the conversion mechanism of TMFs and significantly provides an important reference for the future artificial design of energy systems based on spinpolarized surface capacitance. | Zhengqiang Hu Fengling Zhang Huanyu Liang Hao Zhang Huaizhi Wang Tiansheng Wang Renbin Liu Jie Liu Yadong Li Xiaotong Dong Lianyu Bao Zhuan Liang Yaqun Wang Shishen Yan Qiang Li Hongsen Li | 2022 | Carbon Energy2022，4，6： | 0 |
| 15 | Filamentation initiated by Cas2 and its association with the acquisition process in cells显示文摘Cas1-and-Cas2-mediated new spacer acquisition is an essential process for bacterial adaptive immunity.The process is critical for the ecology of the oral microflora and oral health.Although molecular mechanisms for spacer acquisition are known,it has never been established if this process is associated with the morphological changes of bacteria.In this study,we demonstrated a novel Cas2-induced filamentation phenotype in E.coli that was regulated by co-expression of the Cas1 protein.A 30 amino acid motif at the carboxyl terminus of Cas2 is necessary for this function.By imaging analysis,we provided evidence to argue that Cas-induced filamentation is a step coupled with new spacer acquisition during which filaments are characterised by polyploidy with asymmetric cell division.This work may open new opportunities to investigate the adaptive immune response and microbial balance for oral health. | Lei Wang Xin Yu Mengjie Li Guiqin Sun Lin Zou Tiansheng Li Linlin Hou Yameng Guo Danfeng Shen Di Qu Xunjia Cheng Li Chen | 2019 | International Journal of Oral Science2019，11，4： | 0 |
| 16 | Proteomics profiling of colorectal cancer progression identifies PLOD2 as a potential therapeutic target显示文摘Dear editors,Colorectal cancer(CRC)is the second leading cause of cancer deaths in developed countries[1].The malignant transformation from small clumps to cancer takes about 10 years[2].This study aimed to characterize proteomic dynamics associated with CRC development and progres-sion,and identify novel therapeutic targets for intercepting the underlying oncogenic processes.We have optimized pressure cycling technology(PCT)coupled with data-independent acquisition mass spectrometry(DIA-MS)for robust and reproducible proteomic analysis of biopsy-level formalin-fixed paraffin-embedded(FFPE)tissues[3]. | Yingkuan Shao Kailun Xu Xi Zheng Biting Zhou Xiuli Zhang Lin Wang Yaoting Sun Dan Li Ting Chen Jian Wang Shaojun Yu Lifeng Sun Xiaoming Xu Shaozhi Dai Huanhuan Gao Guan Ruan Wei Liu Xue Cai Tiansheng Zhu Lina Qi Jiani Chen Wangxiong Hu Xingyue Weng Yi Zhu Xueping Xiang Zhiyuan Hu Jinfan Li Lirong Chen Jimin Shao Shu Zheng Tiannan Guo | 2022 | Cancer Communications2022，42，2： | 0 |
| 17 | A LEGAL ANALYSIS OF THE PROVISIONS OF VOLUME CONTRACT UNDER ROTTERDAM RULES显示文摘新政体被介绍进鹿特丹的体积合同由美国代表团的建议统治,它以它的包括有利弊。自从服务合同的早形式成功地在美国,在交通贸易被使用了,我们将承认那这政体确实有它的活力。作者下文在鹿特丹规则集中于体积合同的包括,并且在美国然后它的申请的服务合同的优点介绍服务合同的来临的历史。而且,作者在规则因此分析关于体积合同的概念在鹿特丹规则,以及一些评论考虑体积合同的相关条款和条款。 | Xiaochen Yu Tiansheng Li | 2012 | Frontiers of Law in China-Selected Publications from Chinese Universities2012，7，4： | 0 |
| 18 | Biomimetic hydroxyapatite coating on the 3D-printed bioactive porous composite ceramic scaffolds promoted osteogenic differentiation via PI3K/AKT/mTOR signaling pathways and facilitated bone regeneration in vivo显示文摘The architecture and surface modifications have been regarded as effective methods to enhance the bi-ological response of biomaterials in bone tissue engineering.The porous architecture of the implanta-tion was essential conditions for bone regeneration.Meanwhile,the design of biomimetic hydroxyap-atite(HAp)coating on porous scaffolds was demonstrated to strengthen the bioactivity and stimulate osteogenesis.However,bioactive bio-ceramics such asβ-tricalcium phosphate(β-TCP)and calcium sili-cate(CS)with superior apatite-forming ability were reported to present better osteogenic activity than that of HAp.Hence in this study,3D-printed interconnected porous bioactive ceramicsβ-TCP/CS scaf-fold was fabricated and the biomimetic HAp apatite coating were constructed in situ via hydrothermal reaction,and the effects of HAp apatite layer on the fate of mouse bone mesenchymal stem cells(mBM-SCs)and the potential mechanisms were explored.The results indicated that HAp apatite coating en-hanced cell proliferation,alkaline phosphatase(ALP)activity,and osteogenic gene expression.Further-more,PI3K/AKT/mTOR signaling pathway is proved to have an important impact on cellular functions.The present results demonstrated that the key molecules of phosphatidylinositol 3-kinase(PI3K),protein kinase B(AKT)and mammalian target of rapamycin(mTOR)were activated after the biomimetic hydrox-yapatite coating were constructed on the 3D-printed ceramic scaffolds.Besides,the activated influence on the protein expression of Runx2 and BMP2 could be suppressed after the treatment of inhibitor HY-10358.In vivo studies showed that the constructed HAp coating promoted bone formation and strengthen the bone quality.These results suggest that biomimetic HAp coating constructed on the 3D-printed bioac-tive composite scaffolds could strengthen the bioactivity and the obtained biomimetic multi-structured scaffolds might be a potential alternative bone graft for bone regeneration. | Bizhi Tan Naru Zhao Wei Guo Fangli Huang Hao Hu Yan Chen Jungang Li Zemin Ling Zhiyuan Zou Rongcheng Hu Chun Liu Tiansheng Zheng Gang Wang Xiao Liu Yingjun Wang Xuenong Zou | 2023 | Journal of Materials Science & Technology2023，，5： | 0 |
| 19 | Promotion of liquid-to-solid phase transition of cGAS by Baicalein suppresses lung tumorigenesis显示文摘Dear Editor,Kras and p53 mutation are among the most common gene mutations in lung cancer,which has both the highest incidence and mortality rate among cancers.1 Kras/p53 mutation also causes mitochondrial dysfunction,which has been implicated to promote the inflammation-to-cancer transition.2 We established a lung adenocarcinoma model by using conditional alleles of KrasLSLG12D/p53flox/flox in mice3 to evaluate the effect of Baicalein(5,6,7-trihydroxyflavone),a principal component of Scutellaria baicalensis in traditional Chinese medicine,4 on the initiation and progression of lung cancer.Cre-mediated expression of KrasG12D and deletion of p53 caused obvious tumor lesions in the lung,which were strongly inhibited by the administration of Baicalein(Fig.1a,b and Supplementary Fig.1a,b),indicating that Baicalein is highly potent in inhibiting the progression of primary lung cancer. | Tiansheng Zheng Haipeng Liu Yifan Hong Yajuan Cao Qing Xia Chengge Qin Ming Li Russel J.Reiter Yidong Bai Lihong Fan | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 0 |
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