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| 1 | An expert consensus on the evaluation and treatment of acute thoracolumbar spine and spinal cord injury in China显示文摘This is an expert consensus on the evaluation and treatment of thoracolumbar spinal injury,established from February 2009 to July 2010.The expert consensus consists mainly of six parts with a total of 54 recommendations including the overview(one item);pre-hospital care(one item);evaluation and diagnosis(13 items);treatment(23 items);prevention and treatment of major complications(12 items);and rehabilitation(four items).This is the first time that Chinese experts have published a consensus on spine and spinal cord injury.The expert consensus was established based on Delphi methods,literature analysis,and clinical experiences.Each recommendation is supported by and was interpreted using multi-level evidences.The level of agreement with the recommendation among the panel members was assessed as either low,moderate,or strong.Each panel member was asked to indicate his or her level of agreement on a 5-point scale,with '1' corresponding to neutrality and '5' representing maximum agreement.Scores were aggregated across the panel members and an arithmetic mean was calculated.This mean score was then translated into low,moderate,or strong.After all of the votes were collected and calculated,the results showed no low-level recommendations,10 moderate-level recommendations,and 44 strong-level recommendations.An expert consensus was reached and was recognized by Chinese spine surgeons.Wide-scale adoption of these recommendations is urgent in the management of acute thoracolumbar spine and spinal cord injury in a broader attempt to create a standard evaluation and treatment strategy for acute thoracolumbar spine and spinal cord injury in China. | Zhicheng Zhang Fang Li Tiansheng Sun | 2013 | Neural Regeneration Research2013，8，33： | 6 |
| 2 | Treadmill step training promotes spinal cord neural plasticity after incomplete spinal cord injury显示文摘A large body of evidence shows that spinal circuits are significantly affected by training,and that intrinsic circuits that drive locomotor tasks are located in lumbosacral spinal segments in rats with complete spinal cord transection.However,after incomplete lesions,the effect of treadmill training has been debated,which is likely because of the difficulty of separating spontaneous stepping from specific training-induced effects.In this study,rats with moderate spinal cord contusion were subjected to either step training on a treadmill or used in the model(control) group.The treadmill training began at day 7 post-injury and lasted 20 ± 10 minutes per day,5 days per week for 10 weeks.The speed of the treadmill was set to 3 m/min and was increased on a daily basis according to the tolerance of each rat.After 3 weeks of step training,the step training group exhibited a significantly greater improvement in the Basso,Beattie and Bresnahan score than the model group.The expression of growth-associated protein-43 in the spinal cord lesion site and the number of tyrosine hydroxylase-positive ventral neurons in the second lumbar spinal segment were greater in the step training group than in the model group at 11 weeks post-injury,while the levels of brain-derived neurotrophic factor protein in the spinal cord lesion site showed no difference between the two groups.These results suggest that treadmill training significantly improves functional recovery and neural plasticity after incomplete spinal cord injury. | Tiansheng Sun Chaoqun Ye Jun Wu Zhicheng Zhang Yanhua Cai Feng Yue | 2013 | Neural Regeneration Research2013，8，27： | 5 |
| 3 | Novel reaction route for dimethyl carbonate synthesis from CO2 and methanol显示文摘 | Zhao Tiansheng Han Yizhuo Sun Yuhan | 2000 | Fuel Processing Technology2000，62，： | 1 |
| 4 | Clinical study on management of spinal cord injury following cervical nonfracture dislocation by methylprednisolone of large dos显示文摘 | SUN TIANSHENG QING SHAOTING HUANG HONGYUN | 1997 | Chinese Journal of Surgery1997，35，12： | 1 |
| 5 | Novel reaction route for dimethyl carbonate synthesis from CO2 and methanol显示文摘 | Tiansheng Zhao Yizhuo Han yuhan Sun | 2000 | Fuel Processing Technology2000，62，： | 1 |
| 6 | Does repair of spinal cord injury follow the evolutionary theory?显示文摘Lower vertebrates,such as fish and amphibians,and higher vertebrates in embryonic development can acquire complete regeneration of complex body structures,including the spinal cord,an important part of the central nervous system.However,with species evolution and development,this regenerative capacity gradually weakens and even disappears,but the cellular and molecular mechanisms remain poorly understood.We explored the differences in mechanisms of spinal cord regeneration capability between lower and higher vertebrates,investigated differences in their cellular and molecular mechanisms and between the spinal cord structures of lower vertebrates and mammals,such as rat and monkey,to search for theoretical evidence and therapeutic targets for nerve regeneration in human spinal cord. | Zhicheng Zhang Fang Li Tiansheng Sun | 2012 | Neural Regeneration Research2012，7，11： | 1 |
| 7 | The imbalance between regulatory and IL - 17 - secreting CD4 + T cells in multiple - trauma rat显示文摘 | DAI Heling SUN Tiansheng LIU Zhi | 2013 | Injury2013，44，11： | 1 |
| 8 | Filamentation initiated by Cas2 and its association with the acquisition process in cells显示文摘Cas1-and-Cas2-mediated new spacer acquisition is an essential process for bacterial adaptive immunity.The process is critical for the ecology of the oral microflora and oral health.Although molecular mechanisms for spacer acquisition are known,it has never been established if this process is associated with the morphological changes of bacteria.In this study,we demonstrated a novel Cas2-induced filamentation phenotype in E.coli that was regulated by co-expression of the Cas1 protein.A 30 amino acid motif at the carboxyl terminus of Cas2 is necessary for this function.By imaging analysis,we provided evidence to argue that Cas-induced filamentation is a step coupled with new spacer acquisition during which filaments are characterised by polyploidy with asymmetric cell division.This work may open new opportunities to investigate the adaptive immune response and microbial balance for oral health. | Lei Wang Xin Yu Mengjie Li Guiqin Sun Lin Zou Tiansheng Li Linlin Hou Yameng Guo Danfeng Shen Di Qu Xunjia Cheng Li Chen | 2019 | International Journal of Oral Science2019，11，4： | 0 |
| 9 | Proteomics profiling of colorectal cancer progression identifies PLOD2 as a potential therapeutic target显示文摘Dear editors,Colorectal cancer(CRC)is the second leading cause of cancer deaths in developed countries[1].The malignant transformation from small clumps to cancer takes about 10 years[2].This study aimed to characterize proteomic dynamics associated with CRC development and progres-sion,and identify novel therapeutic targets for intercepting the underlying oncogenic processes.We have optimized pressure cycling technology(PCT)coupled with data-independent acquisition mass spectrometry(DIA-MS)for robust and reproducible proteomic analysis of biopsy-level formalin-fixed paraffin-embedded(FFPE)tissues[3]. | Yingkuan Shao Kailun Xu Xi Zheng Biting Zhou Xiuli Zhang Lin Wang Yaoting Sun Dan Li Ting Chen Jian Wang Shaojun Yu Lifeng Sun Xiaoming Xu Shaozhi Dai Huanhuan Gao Guan Ruan Wei Liu Xue Cai Tiansheng Zhu Lina Qi Jiani Chen Wangxiong Hu Xingyue Weng Yi Zhu Xueping Xiang Zhiyuan Hu Jinfan Li Lirong Chen Jimin Shao Shu Zheng Tiannan Guo | 2022 | Cancer Communications2022，42，2： | 0 |
| 10 | Atomically precise gold nanoclusters for healthcare applications显示文摘The potential application of gold nanoparticles(GNPs)in biomedicine has been extensively reported.However,there is still too much puzzle about their real face and potential health risks in comparison with the commercial drug molecules.The emergence of atomically precise gold nanoclusters(APGNCs)provides the opportunity to address the puzzle due to their ultrasmall size,defined molecular formula,editable surface engineering,available structures and unique physicochemical properties including excellent biocompatibility,strong luminescence,enzyme-like activity and efficient renal clearance,et al.Recently,these advantages of APGNCs also endow them promising performances in healthcare such as bioimaging,drug delivery,antibacterial and cancer therapy.Especially,their clear composition and structures like the commercial drug molecules facilitate the study of their functions and the structure-activity relationship in healthcare,which is essential for the guided design of APGNC nanomedicine.Therefore,this review will focus the advantages and recent progress of APGNCs in health care and envision their prospects for the future. | Tiansheng Wei Congcong Mi Yan Sun Yining Chen Xiaoyang Hu Zibao Gan Xiuwen Zheng | 2023 | Biomedical Engineering Communications2023，2，4： | 0 |
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