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| 1 | Characteristics of gas-solid micro fluidized beds for thermochemical reaction analysis显示文摘Fuel conversion and clean energy reaction systems involve a variety of catalytic and non-catalytic gas-solid thermochemical reactions.A good understanding of the correct reaction mechanism and kinetics,as well as the profiles of reaction products,is of great significance to the development,design,and operation of such reaction systems.The micro fluidized bed reaction analysis provides an efficient and reliable method to acquire this essential information with low capital and operating costs,low energy consumption and enhanced safety.This paper provides an overview of the system and its characteristics for the micro fluidized bed reaction analyzer that has been well proven to be a reliable new approach as well as an instrument for characterizing various gas-solid thermochemical reactions. | Zhennan Han Junrong Yue Xi Zeng Jian Yu Fang Wang Shaozeng Sun Hong Yao Guangqian Luo Xuejing Liu Yining Sun Fu Ding Liangliang Fu Lei Shi Kangjun Wang Jiebin Yang Shaonan Wang Xueqing Chen Dingrong Bai Guangwen Xu | 2020 | Carbon Resources Conversion2020，3，1： | 6 |
| 2 | Flow modification associated with mangrove trees in a macro-tidal flat, southern China显示文摘Limited studies have investigated the modification of tidal currents by mangrove trees. In particular, the impacts of mangrove trees on a vertical velocity profile remain unclear. An automatic system is developed to observe the vertical velocity profiles within a mangrove forest composed of artificially introduced Kandelia obovata located on the Ximen Island, the southern Zhejiang Province. The results reveal low flow velocities throughout the vertical profile within the mangrove forest. The vertical profile shows an overall decrease of the velocity with an increasing height above the bed. This pattern is due to the vertical increase of the drag force by the trunks and tree canopies.In addition, the turbulent energy density also varies vertically, corresponding to the vertical structure of the mangrove trees. In comparison with the vertical structure of flows within bare mudflats(semi-logarithmic) and salt marshes(nearly J-shape), the mangrove trees are shown to have a considerable impact on the vertical velocity profile in different ways. | Yang Chang Yining Chen Yan Li | 2019 | Acta Oceanologica Sinica2019，38，2： | 6 |
| 3 | Fuzzy Torque Control of the Bionic Flexible Manipulator Actuated by Pneumatic Muscle Actuators显示文摘A bionic flexible manipulator driven by pneumatic muscle actuator(PMA)can better reflect the flexibility of the mechanism.Current research on PMA mainly focuses on the modeling and control strategy of the pneumatic manipulator system.Compared with traditional electro-hydraulic actuators,the structure of PMA is simple but possesses strong nonlinearity and flexibility,which leads to the difficulty in improving the control accuracy.In this paper,the configuration design of a bionic flexible manipulator is performed by human physiological map,the kinematic model of the mechanism is established,and the dynamics is analyzed by Lagrange method.A fuzzy torque control algorithm is designed based on the computed torque method,where the fuzzy control theory is applied.The hardware experimental system is established.Through the co-simulation contrast test on MATLAB and ADAMS,it is found that the fuzzy torque control algorithm has better tracking performance and higher tracking accuracy than the computed torque method,and is applied to the entity control test.The experimental results show that the fuzzy torque algorithm can better control the trajectory tracking movement of the bionic flexible manipulator.This research proposes a fuzzy torque control algorithm which can compensate the error more effectively,and possesses the preferred trajectory tracking performance. | Kai Liu Yining Chen Jiaqi Xu Yang Wu Yonghua Lu Dongbiao Zhao | 2019 | Chinese Journal of Mechanical Engineering2019，32，5： | 4 |
| 4 | Cancer-associated adipocyte-derived G-CSF promotes breast cancer malignancy via Stat3 signaling显示文摘Adipocyte is the most predominant cell type in the tumor microenvironment of breast cancer and plays a pivotal role in cancer progression,yet the underlying mechanisms and functional mediators remain elusive.We isolated primary preadipocytes from mammary fat pads of human breast cancer patients and generated mature adipocytes and cancer-associated adipocytes(CAAs)in vitro.The CAAs exhibited significantly different gene expression profiles as assessed by transcriptome sequencing.One of the highly expressed genes in CAAs is granulocyte colony-stimulating factor(G-CSF).Treatment with recombinant human G-CSF protein or stable expression of human G-CSF in triple-negative breast cancer(TNBC)cell lines enhanced epithelial–mesenchymal transition,migration,and invasion of cancer cells,by activating Stat3.Accordantly,targeting G-CSF/Stat3 signaling with G-CSF-neutralizing antibody,a chemical inhibitor,or siRNAs for Stat3 could all abrogate CAA-or G-CSF-induced migration and invasion of breast cancer cells.The pro-invasive genes MMP2 and MMP9 were identified as target genes of G-CSF in TNBC cells.Furthermore,in human breast cancer tissues,elevated G-CSF expression in adipocytes is well correlated with activated Stat3 signal in cancer cells.Together,our results suggest a novel strategy to intervene with invasive breast cancers by targeting CAA-derived G-CSF. | Li Liu Yudong Wu Cheng Zhang Chong Zhou Yining Li Yi Zeng Chunbo Zhang Rong Li Daya Luo Lieliang Wang Long Zhang Shuo Tu Huan Deng Shiwen Luo Ye-Guang Chen Xiangyang Xiong Xiaohua Yan | 2020 | Journal of Molecular Cell Biology2020，12，9： | 4 |
| 5 | Berberine mitigates hepatic insulin resistance by enhancing mitochondrial architecture via the SIRT1/Opa1 signalling pathway显示文摘The aberrant changes of fussion/fission-related proteins can trigger mitochondrial dynamics imbalance,which cause mitochondrial dysfunctions and result insulin resistance(IR).However,the relationship between the inner mitochondrial membrane fusion protein optic atrophy 1(Opa1)and hepatic IR as well as the specific molecular mechanisms of signal transduction has not been fully elucidated.In this study,we explore whether abnormalities in the Opa1 cause hepatic IR and whether berberine(BBR)can prevent hepatic IR through the SIRT1/Opa1 signalling pathway.High-fat diet(HFD)-fed mice and db/db mice are used as animal models to study hepatic IR in vivo.IR,morphological changes,and mitochondrial injury of the liver are examined to explore the effects of BBR.SIRT1/Opa1 protein expression is determined to confirm whether the signalling pathway is damaged in the model animals and is involved in BBR treatment-mediated mitigation of hepatic IR.A palmitate(PA)-induced hepatocyte IR model is established in HepG2 cells in vitro.Opa1 silencing and SIRT1 overexpression are induced to verify whether Opa1 deficiency causes hepatocyte IR and whether SIRT1 improves this dysfunction.BBR treatment and SIRT1 silencing are employed to confirm that BBR can prevent hepatic IR by activating the SIRT1/Opa1 signalling pathway.Western blot analysis and JC-1 fluorescent staining results show that Opa1 deficiency causes an imbalance in mitochondrial fusion/fission and impairs insulin signalling in HepG2 cells.SIRT1 and BBR overexpression ameliorates PA-induced IR,increases Opa1,and improves mitochondrial function.SIRT1 silencing partly reverses the effects of BBR on HepG2 cells.SIRT1 and Opa1 expressions are downregulated in the animal models.BBR attenuates hepatic IR and enhances SIRT1/Opa1 signalling in db/db mice.In summary,Opa1 silencing-mediated mitochondrial fusion/fission imbalance could lead to hepatocyte IR.BBR may improve hepatic IR by regulating the SIRT1/Opa1 signalling pathway,and thus,it may be used to treat type-2 diabetes. | Jia Xu Yining Zhang Zhiyi Yu Yueqi Guan Yuqian Lv Meishuang Zhang Ming Zhang Li Chen Xiaoyan Lv Fengying Guan | 2022 | Acta Biochimica et Biophysica Sinica2022，54，10： | 3 |
| 6 | Tendency for Evolution of High Myopia in 308 Chinese School Children from Xi'an City显示文摘Purpose: To observe the refractive status, especially the tendency for evolution of high myopia, in eyes of Chinese school children from Xi’an city.Methods: The study was conducted in 11514 eyes of the 5757students aged between 7~18 years in Xi’an city primary and high schools. The inclusion criterion was >-6D of the spherical equivalent refraction. The object ophthalmic examinations were done, included non-cycloplegic objective refraction, visual acuity, intraocular pressure, fundus evaluation by ophthalmologists and nurses with professional training. Specially designed questionnaires were filled in and the data were statistically analyzed with SPSS10.0.Results: Of 11514 eyes, the detection rate was 81.4%(9376eyes) for myopia and 5.3%(615 eyes) for high myopia. High myopia was found in 2.6%.(300 eyes).of right eyes, 2.7%(315 eyes) in left eyes, and 2.4%(275 eyes) were in boys and 2.9%(340 eyes) in girls. Among 12 school grades, the detection rates of high myopia increased significantly with student age, with 0.9% in the 1stgrade of primary school and12.5% in the 3rd year of senior middle school. The average refractive error of spherical equivalent refraction was(-7.43±1.29) D with 95% confidence interval(-7.54,-7.33). No significant differences were found between the right and left eyes or both genders. The distribution of myopic severity was lowest(-6D).in primary school students younger than 12 years,was higher(-8D) in junior middle school students older than13 years, and highest(-13D) in senior middle school students.Conclusion: A continuous growth was evident in the severity of high myopia throughout 12 years of primary and middle school except for the first year of primary school, with growth occurring in two transitional stages between the senior primary and junior middle school years, and between the junior and senior middle school years. The distribution of high myopia was lowest, at-6D, in primary school, increased to-8D in junior middle school, and progressed to-10D in senior middle school, indicating a high risk of development of pathologic myopia during the students’ later lifespan. The adolescent period of 13 to 18 years of age in middle school is a critical period for the development of pathological myopia over-8D. | Yanming Chen Yining Shi Le Yang | 2014 | Eye Science2014，29，1： | 3 |
| 7 | High reproducibility and sensitivity of bifacial copper nanowire array for detection of glucose显示文摘The ordered bifacial copper nanowire array(Cu BNWA) was synthesized by a template assisted electrochemical deposition method.The morphology and structure of the as-prepared samples were investigated by field emission scanning electron microscope(FESEM) and X-ray diffraction(XRD).The results show that the ordered Cu nanowire array with uniform geometrical dimensions covered both side of the Cu substrate.When used as the electrode for glucose detection,the minimum detectable concentration of glucose can be reached as low as 0.2 mM.Impressively,the sample still showed high sensitivity and stability for glucose detection after two months placement in ambient environment.These excellent performances of the Cu BNWA make it a promising non-enzyme glucose detection sensor for various applications. | Hanqing Zhang Yining Wang Xuesen Gao Zhuo Gao Yan Chen | 2017 | Progress in Natural Science:Materials International2017，27，3： | 2 |
| 8 | Spatial and temporal evolution of landfast ice near Zhongshan Station, East Antarctica, over an annual cycle in 2011/2012显示文摘Annual observations of first-year ice(FYI) and second-year ice(SYI) near Zhongshan Station, East Antarctica,were conducted for the first time from December 2011 to December 2012. Melt ponds appeared from early December 2011. Landfast ice partly broke in late January, 2012 after a strong cyclone. Open water was refrozen to form new ice cover in mid-February, and then FYI and SYI co-existed in March with a growth rate of 0.8 cm/d for FYI and a melting rate of 2.7 cm/d for SYI. This difference was due to the oceanic heat flux and the thickness of ice,with weaker heat flux through thicker ice. From May onward, FYI and SYI showed a similar growth by 0.5 cm/d.Their maximum thickness reached 160.5 cm and 167.0 cm, respectively, in late October. Drillings showed variations of FYI thickness to be generally less than 1.0 cm, but variations were up to 33.0 cm for SYI in March,suggesting that the SYI bottom was particularly uneven. Snow distribution was strongly affected by wind and surface roughness, leading to large thickness differences in the different sites. Snow and ice thickness in Nella Fjord had a similar 'east thicker, west thinner' spatial distribution. Easterly prevailing wind and local topography led to this snow pattern. Superimposed ice induced by snow cover melting in summer thickened multi-year ice,causing it to be thicker than the snow-free SYI. The estimated monthly oceanic heat flux was ~30.0 W/m2 in March–May, reducing to ~10.0 W/m2 during July–October, and increasing to ~15.0 W/m2 in November. The seasonal change and mean value of 15.6 W/m2 was similar to the findings of previous research. The results can be used to further our understanding of landfast ice for climate change study and Chinese Antarctic Expedition services. | Jiechen Zhao Qinghua Yang Bin Cheng Matti Lepp?ranta Fengming Hui Surui Xie Meng Chen Yining Yu Zhongxiang Tian Ming Li Lin Zhang | 2019 | Acta Oceanologica Sinica2019，38，5： | 2 |
| 9 | Rotation Control of a 3-DOF Parallel Mechanism Driven by Pneumatic Muscle Actuators显示文摘The pneumatic muscle actuator(PMA)has many advantages,such as good flexibility,high power/weight ratio,but its nonlinearity makes it difficult to build a static mathematical model with high precision.A new method is proposed to establish the model of PMA.The concept of hybrid elastic modulus which is related to the static characteristic of PMA is put forward,and the energy conservation law is used to achieve the expression of the hybrid elastic modulus,which can be fitted out based on experimental data,and the model of PMA can be derived from this expression.At the same time,a 3-DOF parallel mechanism(a new bionic shoulder joint)driven by five PMAs is designed.This bionic shoulder joint adopts the structure of two antagonistic PMAs actualizing a rotation control and three PMAs controlling another two rotations to get better rotation characteristics.The kinematic and dynamic characteristics of the mechanism are analyzed and a new static model of PMA is used to control it.Experimental results demonstrate the effectiveness of this new static model. | LIU Kai CHEN Yining WU Yang XU Jiaqi WANG Yangwei GE Zhishang | 2019 | Transactions of Nanjing University of Aeronautics and Astronautics2019，36，2： | 2 |
| 10 | KLF2 inhibits TGF-β-mediated cancer cell motility in hepatocellular carcinoma显示文摘Feedback regulation plays a pivotal role in determining the intensity and duration of TGF-p signaling and subsequently affecting the pathophysiological roles of TGF-p,including those in liver malignancy.KLF2,a member of the Kruppel-like factor(KLF)fam ily transcription factors,has been implicated in impeding hepatocellular carcinoma(HCC)development.However,the underlying molecular mechanisms are not fully understood.In the present study,we found that TGF-p stimulates the expression of KLF2 gene in several HCC cell lines.KLF2 protein is able to inhibit TGF-p/Smad signaling in HCC cells as assessed by luciferase reporter assay.Further studies indicated that KLF2 inhibits the transcriptional activity of Smad2/3 and Smad4 and ameliorates TGF-p-induced target gene expression,therefore creating a novel negative feedback loop in TGFp signaling.Functionally,stably expression of KLF2 in HCCLM3 cells attenuated TGF-卜induced cancer cell motility in wound-healing and transwell assays by interfering with TGF-p-mediated upregulation of MMP2.Together,our results revealed that KLF2 protein has a tumor-suppressive function in HCC through a negative feedback loop over TGF-p signaling. | Yining Li Shuo Tu Yi Zeng Cheng Zhang Tian Deng Weicheng Luo Lingyan Lian Ling Chen Xiangyang Xiong Xiaohua Yan | 2020 | Acta Biochimica et Biophysica Sinica2020，52，5： | 2 |
| 11 | A novel method for preparation of nanocrystalline mtile TiO2 powders by liquid hydrolysis of TiCl4显示文摘 | LI Yuanzhi FAN Yining CHEN Yi | 2002 | J Mater Chem2002，12，： | 1 |
| 12 | 显示文摘 | WANG Zonghua LUO Guoan CHEN Jianfang XIAO Sufang WANG Yining | 2003 | Electrophoresis2003，24，24： | 1 |
| 13 | Structure and reactivity of ultrafine CE-MO oxide particles显示文摘 | WENXING KUANG YINING FAN YI CHEN | 2001 | Catalysis Today2001，68，： | 1 |
| 14 | Partial oxidation of toluene over ultrafine mixed Mo-based oxide particles 显示文摘 | Kuang Wenxing Fan Yining Chen Kaidong | 1999 | Journal of Catalysis1999，186，2： | 1 |
| 15 | Characterization and environmental applications of clay–biochar composites显示文摘 | Ying Yao Bin Gao June Fang Ming Zhang Hao Chen Yanmei Zhou Anne Elise Creamer Yining Sun Liuyan Yang | 2014 | Chemical Engineering Journal2014，，： | 1 |
| 16 | Use of oral anticoagulation among stroke patients with atrial fibrillation in C hina: the C hina QUEST ( Q uality evaluation of stroke care and treatment) registry study显示文摘 | Qingchun Gao Xian Fu Jade W. Wei Xiangyan Chen Yining Huang Jiguang Wang Craig S. Anderson Ka Sing Wong | 2011 | Int J Stroke2011，，3： | 1 |
| 17 | Investigating formate tolerance mechanisms in Saccharomyces cerevisiae and its application显示文摘Current global energy and environmental crisis have spurred efforts towards developing sustainable biotechnological solutions,such as utilizing CO_(2) and its derivatives as raw materials.Formate is an attractive onecarbon source due to its high solubility and low reduction potential.However,the regulatory mechanism of formate metabolism in yeast remains largely unexplored.This study employed adaptive laboratory evolution(ALE)to improve formate tolerance in Saccharomyces cerevisiae and characterized the underlying molecular mechanisms.The evolved strain was applied to produce free fatty acids(FFAs)under high concentration of formate with glucose addition.The results showed that the evolved strain achieved a FFAs titer of 250 mg/L.Overall,this study sheds light on the regulatory mechanism of formate tolerance and provides a platform for future studies under high concentrations of formate. | Kai Wang Yining Liu Zhuoheng Wu Yilu Wu Haoran Bi Yanhui Liu Meng Wang Biqiang Chen Jens Nielsen Zihe Liu Tianwei Tan | 2023 | Green Carbon2023，1，1： | 1 |
| 18 | FSIP1 enhances the therapeutic sensitivity to CDK4/6 inhibitors in triple-negative breast cancer patients by activating the Nanog pathway显示文摘CDK4/6 inhibitors are routinely recommended agents for the treatment of advanced HR+HER2-breast cancer.However,their therapeutic effectiveness in triple-negative breast cancer(TNBC)remains controversial.Here,we observed that the expression level of fibrous sheath interacting protein 1(FSIP1)could predict the treatment response of TNBC to CDK4/6 inhibitors.High FSIP1 expression level was related to a poor prognosis in TNBC,which was associated with the ability of FSIP1 to promote tumor cell proliferation.FSIP1 downregulation led to slowed tumor growth and reduced lung metastasis in TNBC.FSIP1knockout caused cell cycle arrest at the G0/G1 phase and reduced treatment sensitivity to CDK4/6 inhibitors by inactivating the Nanog/CCND1/CDK4/6 pathway.FSIP1 could form a complex with Nanog,protecting it from ubiquitination and degradation,which may facilitate the rapid cell cycle transition from G0/G1 to S phase and exhibit enhanced sensitivity to CDK4/6 inhibitors.Our findings suggest that TNBC patients with high FSIP1 expression levels may be suitable candidates for CDK4/6 inhibitor treatment. | Guanglei Chen Lisha Sun Xi Gu Liping Ai Jie Yang Zhan Zhang Pengjie Hou Yining Wang Xunyan Ou Xiaofan Jiang Xinbo Qiao Qingtian Ma Nan Niu Jinqi Xue Hao Zhang Yongliang Yang Caigang Liu | 2023 | Science China(Life Sciences)2023，66，12： | 1 |
| 19 | Preparation and performance of a core-shell carbon/sulfur material for lituium/sulfur battery显示文摘 | Wang Chong Chen Jiajia Shi Yining et aI | 2010 | Electrochi mActa2010，55，23： | 1 |
| 20 | A novel method for preparation of nanocrystalline futile TiO2 powders by liquid hydrolysis of TiCl4显示文摘 | Yuanzhi Li Yining Fan Yi Chen | 2002 | J Mater Chem2002，，12： | 1 |
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