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您的检索式：作者名="Tianying Gu"
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| 1 | Current progress and challenges in the design and development of a successful COVID-19 vaccine显示文摘The coronavirus disease 2019(COVID-19)pandemic,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is still a worldwide concern,with little to no sign of a decreasing trend.There is a general consensus that normal life will be hampered until a safe and effective vaccine strategy is available and globally administered.Numerous countries have accelerated the clinical trials process for the development of a successful COVID-19 treatment,with over 200 candidates presently available for testing against SARS-CoV-2.Here,we provide an overview of the COVID-19 vaccine candidates currently in development,discuss the scientific and practical challenges associated with COVID-19 vaccine design,and share the potential strategies that could be exploited for vaccine design success. | Tingting Li Tianying Zhang Ying Gu Shaowei Li Ningshao Xia | 2021 | Fundamental Research2021，1，2： | 1 |
| 2 | Development of the peanut precision fertilization control system based on threshold velocity algorithm显示文摘In view of the fact that the current ground wheel velocimetry of the peanut precision fertilizer control system cannot solve the phenomenon of ground wheel slippage,and signal interference and delay loss cannot be excluded by BeiDou positioning velocimetry,a set of peanut precision fertilizer control system was designed based on the threshold speed algorithm.The system used STM32F103ZET6 microcontroller as the main controller,and touch screen for setting the operating parameters such as operating width,fertilizer type,and fertilizer application amount.The threshold speed algorithm combined with BeiDou and ground wheel velocimetry was adopted to obtain the forward speed of the tractor and adjust the speed of the DC drive motor of the fertilizer applicator in real time to achieve precise fertilizer application.First,through the threshold speed algorithm test,the optimal value of the length N of the ground wheel speed measurement queue was determined as 3,and the threshold of the speed variation coefficient was set to 4.6%.Then,the response performance of the threshold speed algorithm was verified by comparative test with different fertilization amounts(40 kg/hm^(2),50 kg/hm^(2),60 kg/hm^(2),70 kg/hm^(2))under two speed acquisition methods of ground wheel speed measurement and threshold speed algorithm(combination of Beidou single-point speed and ground wheel speed measurement)in different operation speeds(3 km/h,4 km/h,5 km/h).The response performance test results showed that the average value of the velocimetry delay distance of the BeiDou single-point positioning velocimetry method was 0.58 m,while the average value of that with the threshold velocity algorithm was 0.27 m,which decreased by 0.31 m and indicated more accurate with the threshold velocity algorithm.The field comparison test for fertilizer application performance turned out an over 96.08%accuracy rate of fertilizer discharge by applied with the threshold speed algorithm,which effectively avoided the inaccurate fertilizer application caused by wheel slippage and raised the accuracy of fertilizer discharge by at least 1.2%compared with that of using the ground wheel velocimetry alone.The results showed that the threshold speed algorithm can meet the requirements of precise fertilizer application. | Yuqi Fan Yan Yu Shuqi Shang Tianying Gu Yanrui Hu Linsong Diao Ruchao Ge Xing Zhang | 2022 | International Journal of Agricultural and Biological Engineering2022，15，5： | 0 |
| 3 | Two antibodies show broad,synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD显示文摘Continual evolution of the severe acute respiratory syndrome coronavirus(SARS-CoV-2)virus has allowed for its gradual evasion of neutralizing antibodies(nAbs)produced in response to natural infection or vaccination.The rapid nature of these changes has incited a need for the development of superior broad nAbs(bnAbs)and/or the rational design of an antibody cocktail that can protect against the mutated virus strain.Here,we report two angiotensin-converting enzyme 2 competing nAbs—8H12 and 3E2—with synergistic neutralization but evaded by some Omicron subvariants.Cryo-electron microscopy reveals the two nAbs synergistic neutralizing virus through a rigorous pairing permitted by rearrangement of the 472-489 loop in the receptor-binding domain to avoid steric clashing.Bispecific antibodies based on these two nAbs tremendously extend the neutralizing breadth and restore neutralization against recent variants including currently dominant XBB.1.5.Together,these findings expand our understanding of the potential strategies for the neutralization of SARS-CoV-2 variants toward the design of broad-acting antibody therapeutics and vaccines. | Hui Sun Tingting Deng Yali Zhang Yanling Lin Yanan Jiang Yichao Jiang Yang Huang Shuo Song Lingyan Cui Tingting Li Hualong Xiong Miaolin Lan Liqin Liu Yu Li Qianjiao Fang Kunyu Yu Wenling Jiang Lizhi Zhou Yuqiong Que Tianying Zhang Quan Yuan Tong Cheng Zheng Zhang Hai Yu Jun Zhang Wenxin Luo Shaowei Li Qingbing Zheng Ying Gu Ningshao Xia | 2024 | Protein & Cell2024，15，2： | 0 |
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