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| 1 | Diagnostic value of fluid attenuated inversion recovery versus T_2-weighted image in diffuse axonal injury显示文摘BACKGROUND:At present, the most common examination modality for diffuse axonal injury (DAI) is CT or MRI. However, both methods exhibit low sensitivity in the diagnosis of DAI lesions. OBJECTIVE: To investigate the value of fluid attenuated inversion recovery (FLAIR) in the clinical diagnosis of DAI, and to compare with T2-weighted images. DESIGN, TIME AND SETTING: This prospective study was based on imaging analysis, and was performed in the First Affiliated Hospital of Chongqing Medical University (Chongqing, China) between October 2002 and April 2004. PARTICIPANTS: Sixty-three patients with craniocerebral injury were admitted to the Department of Neurosurgery at the First Affiliated Hospital of Chongqing Medical University, including 50 males and 13 females. The patients were included in the experiment and were divided into DAI (n=24) and non-DAI (n=39) groups, according to the emergent CT findings and clinical manifestations. METHODS: Both groups underwent MR examinations, including axial and sagittal T1 weighted images (TR = 450 ms, TE = 8–9 ms), T2-weighted images (TR = 3 600 ms, TE = 100 ms), and FLAIR (TR = 10 000 ms, TI = 2 500 ms, TE = 40 ms), 8-mm thick and 2-mm wide, using a GE Sigma MRI device. MAIN OUTCOME MEASURES: The DAI diagnostic rate and lesion-detecting rate of T2-weighted images and FLAIR were determined. RESULTS: All 63 patients were included in the final analysis. The DAI diagnosis rates of FLAIR and T2-weighted images were 88% (21/24) and 62% (15/24), respectively, of which the difference was statistically significant (P < 0.05). T2-weighted images and FLAIR detected lesions located in the gray matter-white matter junction in parasagittal areas, the corpus callosum, deep periventricular white matter, basal ganglia, internal capsule, hippocampus, cerebellum, and brain stem, with a detailed amount of 123 and 256, respectively. FLAIR was significantly greater than T2-weighted images (P < 0.01). CONCLUSION: FLAIR is superior to T2-weighted images for improving the DAI diagnostic rate and lesion-detecting rate, as well as revealing the extent and severity of DAI. | Haijian Xia Xiaochuan Sun Wenyuan Tang Tianyou Luo Fajin Lu Weidong Fang Luping Zheng | 2008 | Neural Regeneration Research2008，3，8： | 3 |
| 2 | Evaluation of non-typical diffuse axonal injury by magnetic resonance techniques显示文摘Because diffuse axonal injury (DAI) lacks specific clinical manifestations, it is difficult to evaluate DAI using computer tomography or conventional magnetic resonance imaging (MRI). This study investigated the value of magnetic resonance techniques using fluid-attenuated inversion recovery (FLAIR) and proton magnetic resonance spectroscopy (1HMRS) for diagnosing DAI. The corpus callosum and basal nuclei were analyzed using morphological and functional imaging. Similar to the DAI group, the non-typical DAI group exhibited similar lesion characteristics on FLAIR, as well as post-injury neurochemical and molecular changes in the corpus callosum, as detected by 1HMRS. However, there were differences in degree and severity of injury. Compared to conventional MRI, FLAIR significantly increased lesion detection. 1HMRS determined biochemical metabolism changes in midline structures following DAI, which resulted in increased diagnosis of non-typical DAI, which displayed similar lesion distribution, morphology, and function as DAI. Thus, the experiment proved the value of FLAIR and 1HMRS in non-typical DAI. | Haijian Xia Xiaochuan Sun Zongduo Guo Weidong Fang Fajin Lü Haitao Wu Tianyou Luo Wenyuan Tang | 2010 | Neural Regeneration Research2010，5，17： | 3 |
| 3 | Debonding Patch Detection in FRP-Strengthened Materials with Fiber-Optic Interferometer显示文摘The interfacial debonding in fiber-reinforced plastic(FRP)strengthened repair material will affect the bonding strength and lead to failure of the repair without warning.Unfortunately the interfacial damage is normally invisible and often in the form of a patch rather than a through-width crack.Therefore,a debonding patch detection technique based on fiber optic interferometry is proposed.A quasi-impulse loading is applied with a rubberhead hammer and the total elongation of a surface-mounted optical fiber along the length of the repair material is measured as a function of load position.When a debonding patch is present,the induced sudden slope or sign change on the plot of fiber integral strain v.s.load position will reveal the extent and the location of the debonded area.The results of the study indicate that the proposed technique is applicable for debonding patch detection in repaired members under various support conditions. | Xu Ying Wang Dexiang Tang Tianyou Lu Miaomiao | 2017 | Transactions of Nanjing University of Aeronautics and Astronautics2017，34，3： | 1 |
| 4 | On-line principlecomponent analysis with application to process modeling 显示文摘 | Jian Tang Wen Yu Tianyou Chai Lijie Zhao | 2012 | Neurocomputing2012，82，1： | 1 |
| 5 | Predicting Mill Load Us- ing Partial Least Squares and Extreme Learning Machines 显示文摘 | Tang Jian Wang Dianhui Chai Tianyou | 2012 | Soft Computing2012，16，9： | 1 |
| 6 | DeceFL:a principled fully decentralized federated learning framework显示文摘Traditional machine learning relies on a centralized data pipeline for model training in various applications;however,data are inherently fragmented.Such a decentralized nature of databases presents the serious challenge for collaboration:sending all decentralized datasets to a central server raises serious privacy concerns.Although there has been a joint effort in tackling such a critical issue by proposing privacy-preserving machine learning frameworks,such as federated learning,most state-of-the-art frameworks are built still in a centralized way,in which a central client is needed for collecting and distributing model information(instead of data itself)from every other client,leading to high communication burden and high vulnerability when there exists a failure at or an attack on the central client.Here we propose a principled decentralized federated learning algorithm(DeceFL),which does not require a central client and relies only on local information transmission between clients and their neighbors,representing a fully decentralized learning framework.It has been further proven that every client reaches the global minimum with zero performance gap and achieves the same convergence rate O(1=T)(where T is the number of iterations in gradient descent)as centralized federated learning when the loss function is smooth and strongly convex.Finally,the proposed algorithm has been applied to a number of applications to illustrate its effectiveness for both convex and nonconvex loss functions,time-invariant and time-varying topologies,as well as IID and Non-IID of datasets,demonstrating its applicability to a wide range of real-world medical and industrial applications. | Ye Yuan Jun Liu Dou Jin Zuogong Yue Tao Yang Ruijuan Chen Maolin Wang Chuan Sun Lei Xu Feng Hua Yuqi Guo Xiuchuan Tang Xin He Xinlei Yi Dong Li Guanghui Wen Wenwu Yu Hai-Tao Zhang Tianyou Chai Shaochun Sui Han Ding | 2023 | National Science Open2023，2，1： | 1 |
| 7 | Clinical role of ^(18)F-FDG PET/CT-based simultaneous modulated accelerated radiotherapy treatment planning for locally advanced nasopharyngeal carcinoma显示文摘Objective The aim of this study was to compare the long-term local control, overall survival, and late toxicities of positron emission tomography/computed tomography(PET/CT)-guided dose escalation radiotherapy versus conventional radiotherapy in the concurrent chemoradiotherapy treatment of locally advanced nasopharyngeal carcinoma(NPC).Methods A total of 48 patients with stage III–IVa NPC were recruited and randomly administered PET/CTguided dose escalation chemoradiotherapy(group A) or conventional chemoradiotherapy(group B). The dose-escalation radiotherapy was performed using the simultaneous modulated accelerated radiotherapy technique at prescribed doses of 77 gray(Gy) in 32 fractions(f) to the gross target volume(GTV): planning target volume(PTV) 1 received 64 Gy/32 f, while PTV2 received 54.4 Gy/32 f. Patients in group B received uniform-dose intensity-modulated radiotherapy, PTV1 received 70 Gy/35 f and PTV2 received 58 Gy/29 f. Concurrent chemotherapy consisted of cisplatin [20 mg/m2 intravenous(IV) on days 1–4] and docetaxel(75 mg/m2 IV on days 1 and 8) administered during treatment weeks 1 and 4. All patients received 2–4 cycles of adjuvant chemotherapy of the same dose and drug regimen.Results The use of fluorine-18-fluorodeoxyglucose(^(18)F-FDG) PET/CT significantly reduced the treatment volume delineation of the GTV in 83.3%(20/24) of patients. The 5-year local recurrence-free survival rates of the two groups were 100% and 79.2%, respectively(P = 0.019). The 5-year disease free survival(DFS) rates were 95.8% and 75.0%, respectively(P = 0.018). The 5-year local progression-free survival and DFS rates were significantly different. The 5-year overall survival(OS) rates were 95.8% and 79.2%, respectively. Differences in OS improvement were insignificant(P = 0.079). Late toxicities were similar in the two groups. The most common late toxicities of the two arms were grade 1–2 skin dystrophy, xerostomia, subcutaneous fibrosis, and hearing loss. There were no cases of grade 4 late toxicity.Conclusion The use of ^(18)F-FDG PET/CT-guided dose escalation radiotherapy is well tolerated and can reduce local recurrence rates for patients with locally advanced NPC compared to conventional chemoradiotherapy. | Jianshe Wang Tianyou Tang Jing Xu Andrew Z.Wang Liang Li Junnian Zheng Longzhen Zhang | 2015 | Oncology and Translational Medicine2015，1，6： | 1 |
| 8 | PTBP2-Mediated Alternative Splicing of IRF9 Controls Tumor-Associated Monocyte/Macrophage Chemotaxis and Repolarization in Neuroblastoma Progression显示文摘The recurrence and metastasis of children with mediastinal neuroblastoma(NB)are also occurred after surgery,chemotherapy,or radiotherapy.Strategies targeting the tumor microenvironment have been reported to improve survival;however,thorough investigations of monocytes and tumor-associated macrophages(Mϕs)with specialized functions in NB are still lacking.Our data first demonstrated polypyrimidine tract binding protein 2(PTBP2)as a possible identifier in patients with mediastinal NB screened by proteomic profiling and that PTBP2 predicted good outcomes.Functional studies revealed that PTBP2 in NB cells induced the chemotactic activity and repolarization of tumor-associated monocytes and Mϕs,which,in turn,inhibited NB growth and dissemination.Mechanistically,PTBP2 prevents interferon regulatory factor 9 alternative splicing and upregulates signal transducers and activators of transcription 1 to stimulate C-C motif chemokine ligand 5(CCL5)and interferon-stimulated gene factor-dependent type I interferon secretion,to induce monocyte/Mϕs chemotaxis,and to sustain monocytes in a proinflammatory phenotype.Our study defined a critical event of PTBP2-induced monocytes/Mϕs in NB progression and revealed that RNA splicing occurred by PTBP2 benefits immune compartmentalization between NB cells and monocytes.This work revealed the pathological and biological role of PTBP2 in NB development and indicates that PTBP2-induced RNA splicing benefits immune compartmentalization and predicted a favorable prognosis in mediastinal NB. | Jue Tang Jing He Huiqin Guo Huiran Lin Meng Li Tianyou Yang Hai-Yun Wang Di Li Jiabin Liu Le Li Huimin Xia Zhenjian Zhuo Lei Miao | 2023 | Research2023，，3： | 0 |
| 9 | Effect of electron-withdrawing groups in conjugated bridges: molecular engineering of organic sensitizers for dyesensitized solar cells显示文摘在结合的桥牌作为一个辅助电子领受人包含 quinoxaline 或 benzoxadiazole 的四器官的 sensitizers 为敏化染料的太阳能电池(DSSC ) 被综合并且利用。不同撤退电子的一半的加入能显著地影响吸收系列,电子性质,界面的相互作用然后全面变换效率,这被发现。因此,辅助领受人的适当选择是重要的优化太阳能电池的光电的表演。在这些 sensitizers 之中, LI-44 基于显示出的太阳能电池最好的光电的表演:电线走火光电流密度(J 13.90 妈 / 厘米 2, 的 sc ) 开电路的 photovoltage (V 0.66 V 的 oc ) ,和 0.66 的一个 fill 因素(FF ) ,相应于在标准全球 AM 下面的 6.10% 的全面变换效率 1.5 个太阳的轻条件。 | Jie SHI Zhaofei CHAI Runli TANG Huiyang LI Hongwei HAN Tianyou PENG Qianqian LI Zhen LI | 2016 | Frontiers of Optoelectronics2016，9，1： | 0 |
| 10 | Epidemiological characteristics and clinical manifestations of pediatric patients with COVID-19 in China: A multicenter retrospective study显示文摘Importance:The Coronavirus disease 2019(COVID-19)global pandemic poses a considerable challenge for pediatricians.Objective:This study aimed to identify the epidemiological characteristics and clinical features of pediatric patients with COVID-19 in China.Methods:This multicenter retrospective study included pediatric patients from 46 hospitals in China,covering 12 provinces and two municipalities.Epidemiological,demographic,clinical,laboratory,treatment,and outcome data were analyzed.Results:In total,211 pediatric patients with COVID-19 were included in this study.The median age was 7.0 years(range:22 days to 18 years).Approximately 16.3%of the patients exhibited asymptomatic infections,23.0%had upper respiratory tract infections,and 60.7%had pneumonia,including two with severe pneumonia and one with critical illness.Approximately 78.7%of the pediatric patients occurred in familial clusters.The most three common symptoms or signs at onset in children with COVID-19 were fever(54.5%),cough(49.3%),and pharyngeal congestion(20.8%).Only 17.6%of the patients presented with decreased lymphocyte count,whereas 13.6%had increased lymphocyte count.Among the patients with pneumonia who exhibited abnormal chest computed tomography findings,18.2%(23/127)of the patients had no other symptoms.Generally,the chest radiographs showed abnormalities that affected both lungs(49.6%);ground-glass opacity(47.2%)was the most common manifestation.The cure and improvement rates were 86.7%(183/211)and 13.3%(28/211),respectively.Only one patient with an underlying condition received invasive mechanical ventilation;none of the patients died.Interpretation:Similar to adults,children of all age groups are susceptible to COVID-19.Fortunately,most pediatric patients have mild symptoms or remain asymptomatic,despite the high incidence of pneumonia.Decreased proportions of white blood cells and lymphocytes are less frequent in children than in adults. | Yan Bai Liwei Gao Xianfeng Wang Lili Zhong Jingfeng Li Shenggang Ding Yuejie Zheng Jun Liu Yuxia Cui Lina Wang Mingfeng Han Jun Liu Xinping Jiang Min Jiang Junhua Li Ning Chen Yunxiao Shang Hourong Zhou Yi Xu Gen Lu Xing Chen Jizhi Xu Qihong Fan Yu Tang Jiang Wu Cen Li Xiaoxiang Yang Chunxi Chen Yonghong Yang Gary Wing-Kin Wong Adong Shen Tianyou Wang Runming Jin Baoping Xu Kunling Shen | 2021 | Pediatric Investigation2021，5，3： | 0 |
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