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| 1 | Protective effects of Jiayan Kangtai granules on autoimmune thyroiditis in a rat model by modulating Th17/Treg cell balance显示文摘OBJECTIVE: To investigate the protective effects of Jiayan Kangtai(JYKT) granules, consisting of 9 Chinese herbs, in a rat model of autoimmune thyroiditis(AIT), and the possible underlying mechanism.METHODS: Female Lewis rats(6-8 weeks) were randomly apportioned to 5 groups of 10, including a normal control. AIT was induced in the untreated AIT-model group, and rats treated subsequently with daily low, medium, or high dose JYKT granules. After 12 weeks, plasma levels of thyroid autoantibodies and morphological changes in the thyroid were detected by enzyme-linked immunosorbent assay and histological examination, respectively. The presence of interleukin(IL)-6,IL23 p19, and IL-2 in thyroid tissue was assessed by immunohistochemical staining. The percentages of T helper(Th)17 cells and regulatory T cells(Tregs) in the peripheral blood were analyzed by flow cytometry. Relevant levels of cytokines and proteins were examined via bead-based multiplex flow cytometry and ELISA, respectively. Expressions of genes and proteins regulated by Th17 cells and Tregs were shown by real-time PCR and Western blot.RESULTS: Compared to the control, AIT-model rats had higher plasma concentrations of thyroid autoantibodies. The high-dose JYKT rats showed significantly lower levels of thyroid autoantibodies compared with the AIT model group. Rats in the AIT-JYKT groups also had fewer thyroid lesions and less lymphocytic infiltration, a lower percentage of Th17 cells, and a higher percentage of Tregs, compared with the AIT-model. Rats given high-dose JYKT had a significantly lower Th17/Treg ratio compared with the AIT model. Differences in plasma cytokine concentrations and relevant gene and protein expressions in the spleens of JYKT-treated rats and the AIT group suggested an association between JYKT treatment and lower Th17 cell percentage and higher Treg activity.CONCLUSION: JYKT treatment appeared to be protective against AIT in rats, possibly via the regulation of the Th17 cell/Treg imbalance in AIT. | Hou Yi Wang Tieshan Guo Xiangyu Sun Wen Guo Xuan Wu Lili Qin Lingling Zhang Chengfei Liu Tonghua | 2018 | Journal of Traditional Chinese Medicine2018，38，3： | 9 |
| 2 | Parkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson's disease显示文摘 | Pingping Song Shanshan Li Hao Wu Ruize Gao Guanhua Rao Dongmei Wang Ziheng Chen Biao Ma Hongxia Wang Nan Sui Haiteng Deng Zhuohua Zhang Tieshan Tang Zheng Tan Zehan Han Tieyuan Lu Yushan Zhu Quan Chen | 2016 | Protein & Cell2016，7，2： | 8 |
| 3 | Slope safety control during mining below a landslide显示文摘The East Open Pits of Daye Iron Mine were closed in year 2000 and the ore beyond the pit limit was planned to be mined by underground ways. In order to facilitate the smooth transition to underground mining, hanging-wall ores in the old pits were scheduled to be mined. Xiangbishan pit is one of the four mining spots selected. In 1979 when the pit was mined to around 36 m a.s.l., a landside of around 70000 m3 occurred in its North Slope, leading to the closure of the pit. The pit was then backfilled to 60 m a.s.l. to maintain the slope stability. The hanging-wall ore to be mined is just located below the old slide, so whether the slide will be reactivated and how to control its deformation and stability are the key issues concerned. Based on geological investigation and numerical analysis, it was predicted that the slide would be reactivated and a control measure using the intact ore body as a retaining wall was thus suggested. During mining, displacements were monitored to assure safety. By July, 2003, 383000 tons of ore were successfully mined. Though the observed displacement reached 8795 mm, no major failure happened. The final slope is 110 m high with an angle of 70°. | MIN Hong1, DENG Jianhui1, WEI Jinbing1, ZHANG Qizhong2, ZOU Jiangang2 & ZHOU Zhibin2 1. Institute of Rock and Soil Mechanics, Chinese Academy of Sciences, Wuhan 430071, China 2. Daye Iron Mine of WISCO, Tieshan, Daye 435006, China | 2005 | Science China(Technological Sciences)2005，48，z1： | 5 |
| 4 | Predictor-based neural dynamic surface control for distributed formation tracking of multiple marine surface vehicles with improved transient performance显示文摘In this paper, we investigate the distributed formation tracking problem of multiple marine surface vehicles with model uncertainty and time-varying ocean disturbances induced by wind, waves, and ocean currents. The objective is to achieve a collective tracking with a time-varying trajectory, which can only be accessed by a fraction of follower vehicles. A novel predictor-based neural dynamic surface control design approach is proposed to develop the distributed adaptive formation controllers. We use prediction errors, rather than tracking errors, to construct the neural adaptive laws, which enable the fast identification of the vehicle dynamics without incurring high-frequency oscillations in control signals. We establish the stability properties of the closed-loop network via Lyapunov analysis, and quantify the transient performance by deriving the truncated L2 norms of the derivatives of neural weights, which we demonstrate to be smaller than the classical neural dynamic surface control design approach. We also extend the above result to the distributed formation tracking using the relative position information of vehicles, and the advantage is that the velocity information of neighbors and leader are required. Finally, we give the comparative studies to illustrate the performance improvement of the proposed method. | Zhouhua PENG Dan WANG Tieshan LI | 2016 | Science China(Information Sciences)2016，59，9： | 5 |
| 5 | two-dimensional material functional devices enabled by direct laser fabrication显示文摘 | Tieshan YANG Han LIN Baohua JIA | 2018 | Frontiers of Optoelectronics2018，11，1： | 4 |
| 6 | Suburbanization and Subcentering of Population in Beijing Metropolitan Area:A Nonparametric Analysis显示文摘This study focuses on the suburbanization and subcentering of population and examines the nature of spatial restructuring in terms of the population distribution in the Beijing metropolitan area.Instead of the classic density function approach,we employ the nonparametric analysis to characterize the spatial pattern of population densities in the Beijing metropolitan area and identify the suburban subcenters.Our findings suggest that the population has spread with rapid urban growth in the Beijing metropolitan area,and the compact urban form has been replaced by a more dispersed polycentric spatial distribution.However,compared with the decentralization of western cities,the spatial extent of the decentralization of population in the Beijing metropolitan area is quite limited.The rapid growth of population in the near suburbs has expedited the sprawl of the central city,with a larger central agglomeration of population dominating the metropolitan area.In this sense,the spatial pattern of the Beijing metropolitan area is still characterized by the continuous compactness.However,our findings do provide the evidence that the city has been turning to a polycentric structure.We find significant population subcenters have emerged in the suburbs of Beijing since the 1980s.But the polycentricity emerged in the Beijing metropolitan area is very different by nature from that observed in Western cities.The subcenters emerged are adherent to the development scheme planned for the city,so it can be referred to as the so called 'planned polycentricity'. | SUN Tieshan HAN Zhenhai WANG Lanlan LI Guoping | 2012 | Chinese Geographical Science2012，22，4： | 3 |
| 7 | Effects of Industrial Relocation on Chinese Regional Economic Growth Disparities: Based on System Dynamics Modeling显示文摘The economic growth of China has led to increasing growth disparities between regions. Such disparities are uncontrolled and are severely negative symptoms in the process of economic development. On the basis of system dynamics(SD) modeling and the relationship between industrial relocation and regional economic growth, we construct a model of the interrelationship between the two aforementioned phenomena. The model is an effective and creative exploration for examining effects of industrial relocation on Chinese regional economic growth disparities. The SD model is employed in this study to build an inter-regional labor migration SD model, an inter-regional capital migration SD model, an intra-industry SD model, an intra-regional population SD model, and an intra-regional SD model which are based on realities in labor and capital flow from the view of industrial relocation. VENSIM software is utilized to perform a system simulation based on the data of the eastern, middle, and western regions from 2000 to 2010. Results show that industrial relocation gradually narrows the relative disparity in GDP among the three regions. Moreover, the absolute one is enlarged continuously. The absolute and relative disparities in per capita GDP among eastern, middle, and western regions generally exhibit decreasing trends. | WU Aizhi LI Guoping SUN Tieshan LIANG Yusheng | 2014 | Chinese Geographical Science2014，24，6： | 3 |
| 8 | Adaptive robust dissipative designs on straight path control for underactuated ships显示文摘An adaptive robust control algorithm for ship straight path control system in the presence of both modeling uncertainties and the bounded disturbances is proposed. Motivated by the backstepping approach, the algorithm is developed by using the dissipation theory, such that the resulting closed-loop system is both strictly dissipative and asymptotically adaptively stable for all admissible uncertainties. Also, it is able to steer an underactuated ship along a prescribed straight path with ultimate bounds under external disturbances induced by wave, wind and ocean current. When there are no disturbances, the straight path control can be implemented in a locally asymptotically stable manner. Simulation results on an ocean-going training ship ‘YULONG’ are presented to validate the effectiveness of the algorithm. | Li Tieshan Yang Yansheng Hong Biguang | 2006 | Journal of Systems Engineering and Electronics2006，17，1： | 3 |
| 9 | Path following control of underactuated ships based on nonswitch analytic model predictive control显示文摘A path following controller is developed for underactuated ships with only surge force and yaw moment available to follow a predefined path.The proposed controller is based on nonswitch analytic model predictive control.It is shown that the optimal control law for a nonlinear path following system with ill-defined relative degree is continuous and nonsingular.The problem of ill-defined relative degree is solved.The path-following ability of the nonlinear system is guaranteed.Numerical simulations are provided to demonstrate the effectiveness of the proposed control law. | Xiaofei WANG Zaojian ZOU Tieshan LI Weilin LUO | 2010 | 控制理论与应用(英文版)2010，8，4： | 3 |
| 10 | Containment control of multi-agent systems with nonvanishing disturbance via topology reconfiguration显示文摘Dear editor,Multi-agent systems(MASs)are ubiquitous in natural as well as artificial systems.Over the past several decades,an increasing number of researchers have devoted attention to distributed cooperative control problems of MASs such as mobile robots[1]and unmanned aircraft[2].Recently,different containment control problems with multiple leaders have arisen,including finite-time coordination[3,4],formation producing[5],and heterogeneous MASs[6].In previous studies,the objective of containment control has been to make the followers converge to the convex hull formed by the leaders[7,8].However,in real-world applications for containment control of MASs,disturbances from the environment make it more reasonable to change the aforementioned convex hull into its interior points because the followers sometimes are not allowed to converge to the boundaries. | Qihe SHAN Fei TENG Tieshan LI C.L.Philip CHEN | 2021 | Science China(Information Sciences)2021，64，7： | 2 |
| 11 | Review of Antiswing Control of Shipboard Cranes显示文摘Shipboard cranes are extensively utilized in numerous fields such as cargo transferring and offshore engineering.The control of shipboard cranes,especially the antiswing control of payloads,has attracted much research attention due to their typical underactuation characteristics and complicated dynamics.Through comparisons of the traditional land-fixed cranes,a brief review on modeling and dynamics analysis is presented to illustrate the tremendous challenges and difficulties in controller design for shipboard cranes.A comprehensive review and brief analysis of shipboard crane control strategies are further presented.Some future research directions are also put forward for reference.It is expected that the paper will be useful for improving existing control schemes and generating novel control approaches for shipboard crane systems. | Yuchi Cao Tieshan Li | 2020 | IEEE/CAA Journal of Automatica Sinica2020，7，2： | 2 |
| 12 | A DSC Approach to Robust Adaptive NN Tracking Control for Strict-feedback Nonlinear Systems显示文摘 | Tieshan Li Dan Wang Gang Feng | 2010 | IEEE Transactions on Systems Man and Cybernetics- Part B: Cybernetics2010，40，3： | 1 |
| 13 | A DSC Approach to Robust Adaptive NN Tracking Control for Strict Feed- back Nonlinear Systems显示文摘 | Li Tieshan Wang Dan Feng Gang | 2009 | IEEE Transactions on Systems Man and Cybernetics2009，40，3： | 1 |
| 14 | Study on Stress-strain Model of Metallic Materials with Shot Peening Residual Stress 显示文摘 | Zhang Tieshan Hu Jing Wu Jinshui | 2012 | Advaneed MaterialsResearch2012，，： | 1 |
| 15 | The new sideway of CNTF sig-nal transduction pathway显示文摘The action of ciliary neurotrophic factor (CNTF) on intercellular free Ca2+ concentrations [Ca2+]1 induced by glutamate (Glu) in primary cultured hippocampal neurons were detected with Fura2/AM, a Ca2+-sensitive fluorophore. and the morphological influence of G-protein on it was ob-jected. Glu could induce rapid increase of [Ca2+]1 in hippo-campal neurons. CNTF had no significant action on [Ca2+]1 in resting hippocampal neurons. However, after incubation of CNTF for 5 min, the increase of [Ca2+]1 in hippocampal neurons rapidly induced by Glu was inhibited. Pretussis toxin (PTX)-sensitive G protein could block the action. These results indicate that a new non-genomic rapid sideway might exist in the upper stream of CNTF signal transduction pathway, which was related to Ca2+ signal transduction. | YAN Jin HE Cheng LU Changlin WANG Chenghai BAO Xuan TANG Tieshan HUANG Xiuying SUN Fangzhen | 2001 | Chinese Science Bulletin2001，46，6： | 1 |
| 16 | A DSC approach to robust adaptive NN tracking control for strict-feedback nonlinear systems显示文摘 | LI Tieshan WANG Dan FENG Gang TONG Shaocheng | | 0，，： | 1 |
| 17 | Adaptive fuzzy output feedback control of MIMO nonlinear uncertain systems with time-varying delays and unknown backlash- like hysteresis显示文摘 | Li Yongming Tong Shaocheng Li Tieshan | 2012 | Neurocomputing2012，93，18： | 1 |
| 18 | Adaptive fuzzy output feedback control of nonlinear uncertain systems with unknown backlash-like hysteresis based on modular design显示文摘 | Li Yongming Tong Shaocheng Li Tieshan | 2013 | Neural Computing and Applications2013，23，1： | 1 |
| 19 | Adaptive median threshold algorithm used in FDIS of DSSS receivers显示文摘For direct sequence spread spectrum(DSSS) receivers, the capability of rejecting narrow-band interference can be significantly improved by a process of frequency-domain interference suppression(FDIS).The key issue of this process is how to determine a threshold to eliminate interference in the frequency domain,which has been extensively studied.However,these previous methods are tedious or very complex.A simple and efficient algorithm based on medians is proposed.The elimination threshold is only related to the median by a scale factor,which can be obtained by the numerical analysis.Simulation results show that the algorithm provides excellent narrow-band interference suppression while only slightly degrading the signal-to-noise ratio(SNR).A one-pass algorithm using logarithmic segmentation is further derived to estimate medians with low computational complexity. Finally,the FDIS is implemented in a field programmable gate array(FPGA) of Xilinx.Experiments are carried out by connecting the FDIS FPGA to a DSSS receiver,and the results show that the receiver has an effective countermeasure for a 60 dB interference-to-signal ratio(ISR). | Weijun Yang Chaojie Zhang Xiaojun Jin Zhonghe Jin Tieshan Yuan | 2013 | Journal of Systems Engineering and Electronics2013，24，1： | 1 |
| 20 | Isolation and complete genome sequence of a novel virulent mycobacteriophage, CASbig显示文摘Dear Editor,Bacteriophages are powerful tools for investigating and manipulating their hosts(Fernandes et al.,2014).This holds particularly true for mycobacteriophages,which have facilitated the development of mycobacterial genetic systems and have generated tools for the | Tieshan Teng Junping Yu Hang Yang Hongping Wei | 2015 | Virologica Sinica2015，30，1： | 1 |
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