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13篇 您的检索式:作者名="Tim Ross"
    题名 作者 年代 出处 被引量
1Gemcitabine-based or capecitabine-based chemoradiotherapy for locally advanced pancreatic cancer (SCALOP): a multicentre, randomised, phase 2 trial显示文摘Somnath Mukherjee Christopher N Hurt John Bridgewater Stephen Falk Sebastian Cummins Harpreet Wasan Tom Crosby Catherine Jephcott Rajarshi Roy Ganesh Radhakrishna Alec McDonald Ruby Ray George Joseph John Staffurth Ross A Abrams Gareth Griffiths Tim Maugh 2013Lancet Oncology2013,,4:4
2Reduced striatal volumes in Parkinson’s disease:a magnetic resonance imaging study显示文摘Background:The presence and extent of structural changes in the brain as a consequence of Parkinson’s disease(PD)is still poorly understood.Methods:High-resolution 3-tesla T1-weighted structural magnetic resonance images in sixty-five PD and 27 age-matched healthy control participants were examined.Putamen,caudate,and intracranial volumes were manually traced in the axial plane of 3D reconstructed images.Striatal nuclei volumes were normalized to intracranial volume for statistical comparison.Disease status was assessed using the Unified Parkinson’s Disease Rating Scale and Hoehn and Yahr scale.Cognitive status was assessed using global status tests and detailed neuropsychological testing.Results:Both caudate and putamen volumes were smaller in PD brains compared to controls after adjusting for age and gender.Caudate volumes were reduced by 11%(p=0.001)and putamen volumes by 8.1%(p=0.025).PD striatal volumes were not found to be significantly correlated with cognitive or motor decline.Conclusion:Small,but significant reductions in the volume of both the caudate and putamen occur in PD brains.These reductions are independent of the effects of age and gender,however the relation of these reductions to the functional loss of dopamine,which is characteristic of PD,remains unclear.Toni L Pitcher Tracy R Melzer Michael R MacAskill Charlotte F Graham Leslie Livingston Ross J Keenan Richard Watts John C Dalrymple-Alford Tim J Anderson 2012Translational Neurodegeneration2012,1,1:2
3Drug-induced tubulo-interstitial nephritis secondary to proton pump inhibitors:Experience from a single UK renal unit显示文摘Torpey N Barker Tim Ross C 2004Nephrol Dial Transplant2004,19,6:1
4Fidelity Score for ATR Performance Modeling显示文摘 Eugene Lavely Tim Ross 2005Proceedings of the SPIE Conference on Algorithms for Synthetic Aperture Radar Imagery Ⅻ2005,5808,043:1
5Effects of mammalian in utero heat stress on adolescent body temperature显示文摘Jay S. Johnson Rebecca L. Boddicker M. Victoria Sanz-Fernandez Jason W. Ross Josh T. Selsby Matt C. Lucy Tim J. Safranski Rob P. Rhoads Lance H. Baumgard 2013International Journal of Hyperthermia2013,,7:1
6提交后更改预先制订的统计分析计划 这些计划是研究完整性的基础,但不是不可改变的显示文摘透明度和可重复性是证据生成和研究知识传播的两个基本原则1-2。研究人员提出问题,挑战结论,复制结果并仔细审查结果——这就是我们积累知识并帮助制订循证政策的方式。如果科学研究要作为能够对人类福祉产生重大影响的政策基础,科学的完整性、可靠性、可重复性和透明度至关重要3。Islam Nazrul Cole Tim J Ross Joseph S Feeney Timothy Loder Elizabeth 吴俣(译) 刘民(校) 2022英国医学杂志中文版2022,25,12:0
7Development and Validation of a High-Density SNP Genotyping Array for African Oil Palm显示文摘高密度的单个核苷酸多型性(SNP ) genotyping 数组是能在一张人口以内测量基因多型性的水平的强大的工具。为了为油开发一个整个染色体的 SNP 数组,藏在掌内, SNP 发现用深从 132 Elaeis guineensis 和属于 59 起源的 Elaeis oleifera 手掌导出的八个图书馆重新定序被执行,导致发现 >300 万通常认为的 SNP。在过滤的 SNP 以后, Illumina OP200K 特定的数组与 170 860 根成功的探针被造。聚类分析的 Phenetic 表明数组能以与家谱记录一致的一个方法在不同起源的手掌之间区分。染色体宽的连接不平衡为商业人口更慢慢地衰退了(在 r 2= 从 120 kb 在 r 2= 的 0.43 ~ 146 kb 0.50 ) 什么时候与半野的人口相比(在 r 2= 的 19.5 kb 0.22 ) 。基因固定印射比较半野、商业的人口识别了 321 选择扫。染色体宽的协会研究(GWAS ) 在 2 与壳厚度特点的复合基因部件联系了的染色体上检测了一座重要山峰(基于特点 shell-to-fruit;S/F %) 在 tenera 手掌。在一样的特点上一个 genomic 选择模型测试导致了好预言精确性(r = 0.65 ) 与 42% S/F % ,变化解释了。为油手掌的第一个高密度的 SNP genotyping 数组被开发了并且出现为在基因研究并且与为开发早特点预言弄短的潜力的使用柔韧繁殖的油手掌周期。Qi Bin Kwong Chee Keng Teh Ai Ling Ong Huey Ying Heng Heng Leng Lee Mohaimi Mohamed Joel Zi-Bin Low Sukganah Apparow Fook Tim Chew Sean Mayes Harikrishna Kulaveerasingam Martti Tammi David Ross Appleton 2016Molecular Plant2016,9,8:0
8隐忍的女首相显示文摘在以橡木和石材作为内饰的英国议会大厦的深处,特蕾莎·梅(Theresa May)静静地等待着她的命运,四周是一些积着灰尘的皮面装订议会记录册。1月15日下午7点半,在经过近两年的协商之后,这位英国首相终于把她的英国脱欧协议交由英国下议院投票表决,让议员们决定到底是接受还是否决。Tim Ross Kitty Donaldson Alex Morales 杨飞(译) 2019商业周刊(中文版)2019,0,5:0
9践行达不成协议的艺术显示文摘●法国总统埃马纽埃尔·马克龙誓言在本次法国G7峰会上实行'创新',但多边主义的时代已然落幕6月29日凌晨两点,曰本大阪,20国集团(G20)峰会谈判室里的官员们开始有人睡着。他们已经连轴转工作了两天,靠虾酱意大利面及其他难吃的无国界融合料理果腹。Tim Ross Gregory Viscusi Arne Delfs John Follain 李译(译) 2019商业周刊(中文版)2019,0,16:0
10地震层析成像及全息岩土成像岩土工程地质条件调查显示文摘在大型工程项目的设计、施工和维护阶段,复杂多变的地下岩土工程条件对大型建筑和土木工程产业带来的巨大挑战令人难以想象.具体而言,通过准确的现场勘察可以降低工程风险,改善施工作业,确保施工安全,延长隧道或建筑结构的使用寿命,防止超设计的浪费.显然,由于缺乏对地下岩土工程地质条件进行合理描述的手段,限制了工程现场地质条件的表征和岩土工程技术的发展.NSA大地工程有限公司成功地将地震层析成像及全息岩土成像技术应用于隧道工程和大型土木工程开挖领域.经复杂介质传播的记录地震信号是由折射、反射、散射、弥散等多类波形所组成,层析成像和全息成像是常用的利用信号波形变化来估计介质性质变化的位置和范围的反演技术.·岩石三维图像(Rock Vision3DTM)技术的基本原理是基于地震能量在不同种类介质中以不同的衰减率和速度传播.通常,与破碎或裂隙发育的岩土体或空洞条件相比,地震波在完整坚硬的介质中传播时,具有更高的传播速度和更低的衰减.·TRTTM技术的基本原理是利用了地震波在岩土体中传播过程中遇到具有不同震动特性的岩土区带间的界面时部分地震波能量将产生反射的特性.绝大多数地质结构异常及岩性变化,在地震信号可及的距离范围内,均可形成可探测的地震反射.文章介绍了上述技术的各种应用条件,分析了地震成像技术在隧道工程施工中所能提供的与隧道工程施工有关的岩土工程地质条件方面的准确信息.根据这些信息,工程建设者可以按期在预定计划内安全地完成工程施工.Ed Kase Tim Ross 2004现代隧道技术2004,41,z2:0
11Antigen unmasking does not improve the visualization of phospholipase C zeta in human spermatozoa显示文摘Phospholipase C zeta(PLCζ)is a sperm-specific protein that triggers oocyte activation.The analysis of PLCζexpression in human spermatozoa can be used as a diagnostic marker for oocyte activation deficiency.Our laboratory has previously optimized a standard'in-house'assay to determine PLCζexpression in human spermatozoa.However,one study has suggested that an antigen unmasking method(AUM)would be more efficient in visualizing PLCζin human sperm.This study aimed to compare our established assay and AUM(involving HCl,acidic Tyrode's solution[AT],and heat).The mean relative fluorescence(RF)intensity of PLCζin frozen-thawed spermatozoa from fourteen fertile donors stained with the in-house method was significantly higher than three other AUM groups(in-house[mean±standard error of mean]:18.87±2.39 arbitrary units[a.u.]vs non-AUM:11.44±1.61 a.u.,AT-AUM:12.38±1.89 a.u.,and HCl-AUM:12.51±2.16 a.u.,P<0.05,one-way analysis of variance).The mean RF intensity of PLCζin AT-and HCl-treated spermatozoa from 12 infertile males was not significantly different from that of the non-AUM group.However,the in-house method resulted in the highest RF intensity(12.11±1.36 a.u.,P<0.01).Furthermore,specificity testing of antibody-antigen binding indicated that the in-house method showed more specific binding than spermatozoa treated by the AUM.In conclusion,our in-house method showed superior visualization and reliability than the AUM,thus supporting the continued use of our in-house assay for clinical research screening.Xin Meng Celine Jones Pedro Melo Caroline Ross Ginny Mounce Tim Child Kevin Coward 2022Asian Journal of Andrology2022,24,4:0
12如今的特雷莎·梅无路可退显示文摘加文·巴威尔(Gavin Barwell)每天都早早起床,穿上笔挺的西装,经过伦敦城前去唐宁街10号上班;他向把守着这座首相官邸的警察微笑致意,然后在办公桌上伏案奋战,全力阻止英国政府自己把自己搞得四分五裂。Tim Ross 微微 2017商业周刊(中文版)2017,,19:0
13一种用于递送酸度敏感大分子到小肠的简易且廉价的肠溶胶囊(英文)显示文摘目的:通过开展胃肠道远端释放药物的研究,以增加对肠道健康和发病机制的理解。创新点:本研究选择了13C醋酸钠作为同位素探针,通过收集和分析呼吸中的13CO2来非侵入测量其在小肠吸收的情况。这将提供胃排空率的信息及释放和吸收位点的指标。方法:在一系列体外和体内的猪实验中,评估了EUDRAGITL100-55和DRcaps两种胶囊的肠溶保护特性。结论:包覆有EUDRAGITL100-55的DRcaps具有增强的肠溶保护性能,特别是在体内。本研究增加了对猪胃排空的了解,同时也开始设计用于递送酸度敏感大分子到小肠的简易且廉价的肠溶胶囊。Darren S.MILLER Anne Michelle PARSONS John BRESL Paul HERDE Duc Minh PHAM Angel TAN Hung-yao HSU Clive A.PRESTIDGE Tim KUCHEL Rezaul BEGG Syed Mahfuzul AZIZ Ross N.BUTLER 2015Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2015,16,7:0
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