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| 1 | Drug eluting biliary stents to decrease stent failure rates:Areview of the literature显示文摘Biliary stenting is clinically effective in relieving both malignant and non-malignant obstructions. However, there are high failure rates associated with tumor ingrowth and epithelial overgrowth as well as internally from biofilm development and subsequent clogging. Within the last decade, the use of prophylactic drug eluting stents as a means to reduce stent failure has been investigated. In this review we provide an overview of the current research on drug eluting biliary stents. While there is limited human trial data regarding the clinical benefit of drug eluting biliary stents in preventing stent obstruction, recent research suggests promise regarding their safety and potential efficacy. | Joseph Shatzel Jisoo Kim Kartik Sampath Sharjeel Syed Jennifer Saad Zilla H Hussain Kabir Mody J Marc Pipas Stuart Gordon Timothy Gardner Richard I Rothstein | 2016 | World Journal of Gastrointestinal Endoscopy2016,8,2: | 6 |
| 2 | Occlusion Rate and Complications of Plastic Biliary Stent Placement in Patients Undergoing Neoadjuvant Chemoradiotherapy for Pancreatic Cancer With Malignant Biliary Obstruction显示文摘 | Brian R. Boulay Timothy B. Gardner Stuart R. Gordon | 2010 | Journal of Clinical Gastroenterology2010,,: | 2 |
| 3 | MicroRNAs as diagnostic markers for pancreatic ductal adenocarcinoma and its precursor, pancreatic intraepithelial neoplasm显示文摘 | Yue Xue Ahmad N. Abou Tayoun Kristine M. Abo J. Marc Pipas Stuart R. Gordon Timothy B. Gardner Richard J. Barth Arief A. Suriawinata Gregory J. Tsongalis | 2013 | Cancer Genetics2013,,: | 2 |
| 4 | Endoscopic management of necrotizing pancreatitis显示文摘 | Timothy B. Gardner | 2012 | Gastrointestinal Endoscopy2012,,6: | 2 |
| 5 | Early Fluid Resuscitation Reduces Morbidity Among Patients With Acute Pancreatitis显示文摘 | Matthew G. Warndorf Jane T. Kurtzman Michael J. Bartel Mougnyan Cox Todd Mackenzie Sarah Robinson Paul R. Burchard Stuart R. Gordon Timothy B. Gardner | 2011 | Clinical Gastroenterology and Hepatology2011,,8: | 1 |
| 6 | Pilot study of a novel serum mRNA gene panel for diagnosis of acute septic arthritis显示文摘BACKGROUND Septic arthritis is an orthopedic emergency requiring immediate surgical intervention.Current diagnostic standard of care is an invasive joint aspiration.Aspirations provide information about the inflammatory cells in the sample within a few hours,but there is often ambiguity about whether the source is infectious(e.g.bacterial)or non-infectious(e.g.gout).Cultures can take days to result,so decisions about surgery are often made with incomplete data.Novel diagnostics are thus needed.The“Sepsis MetaScore”(SMS)is an 11-mRNA host immune blood signature that can distinguish between infectious and noninfectious acute inflammation.It has been validated in multiple cohorts across heterogeneous clinical settings.AIM To study whether the SMS holds diagnostic validity in determining the etiology of acute arthritis.METHODS We conducted a blinded,prospective,non-interventional clinical study of the SMS.All patients undergoing work-up for a septic primary joint were enrolled.Patients proceeded through the normal standard-of-care pathway,including joint aspiration and inflammatory labs[white blood cell(WBC),erythrocyte sedimentation rate(ESR),C-reactive protein(CRP)].Venous blood was also drawn into PAX gene RNA-stabilizing tubes and mRNAs were measured using Nano String nCounter?.SMS was calculated blinded to clinical results.RESULTS A total of 20 samples were included,of which 11 were infected based on aspiration or intra-operative cultures.The SMS had an area under the ROC curve(AUROC)of 0.87 for separating infectious from non-infectious conditions.For comparison,the AUROCs for ESR=0.58,CRP=0.6,and WBC=0.59.At 100%sensitivity for infection,the specificity of the SMS was 40%,meaning nearly half of non-septic patients could have been ruled out for further intervention.CONCLUSION In this pilot study,SMS showed a high level of diagnostic accuracy in predicting septic joints compared to other diagnostic biomarkers.This quick blood test could be an important tool for early,accurate identification of acute septic joints and need for emergent surgery,improving clinical care and healthcare spending. | Blake J Schultz Timothy Sweeney Malcolm R DeBaun Melissa Remmel Uros Midic Purvesh Khatri Michael J Gardner | 2019 | World Journal of Orthopedics2019,10,12: | 1 |
| 7 | Direct endoscopic necrosectomy for the treatment of walled-off pancreatic necrosis: results from a multicenter U.S. series显示文摘 | Timothy B. Gardner Nayantara Coelho-Prabhu Stuart R. Gordon Andres Gelrud John T. Maple Georgios I. Papachristou Martin L. Freeman Mark D. Topazian Rajeev Attam Todd A. Mackenzie Todd H. Baron | 2011 | Gastrointestinal Endoscopy2011,,4: | 1 |
| 8 | Endoscopic Therapy of Necrotizing Pancreatitis and Pseudocysts显示文摘 | Jessica M. Fisher Timothy B. Gardner | 2013 | Gastrointestinal Endoscopy Clinics of North Americ2013,,: | 1 |
| 9 | Lactated Ringer’s Solution Reduces Systemic Inflammation Compared With Saline in Patients With Acute Pancreatitis显示文摘 | Bechien U. Wu James Q. Hwang Timothy H. Gardner Kathryn Repas Ryan Delee Song Yu Benjamin Smith Peter A. Banks Darwin L. Conwell | 2011 | Clinical Gastroenterology and Hepatology2011,,8: | 1 |
| 10 | Alcohol and Smoking as Risk Factors in an Epidemiology Study of Patients With Chronic Pancreatitis显示文摘 | Gregory A. Coté Dhiraj Yadav Adam Slivka Robert H. Hawes Michelle A. Anderson Frank R. Burton Randall E. Brand Peter A. Banks Michele D. Lewis James A. Disario Timothy B. Gardner Andres Gelrud Stephen T. Amann John Baillie Mary E. Money Michael O’Connell | 2011 | Clinical Gastroenterology and Hepatology2011,,3: | 1 |
| 11 | SCAI/ACC/AHA Expert Consensus Document: 2014 Update on Percutaneous Coronary Intervention Without On-Site Surgical Backup显示文摘 | Gregory J. Dehmer James C. Blankenship Mehmet Cilingiroglu James G. Dwyer Dmitriy N. Feldman Timothy J. Gardner Cindy L. Grines Mandeep Singh | 2014 | Circulation2014,,24: | 1 |
| 12 | Alcohol and Smoking as Risk Factors in an Epidemiology Study of Patients With Chronic Pancreatitis显示文摘 | Gregory A. Coté Dhiraj Yadav Adam Slivka Robert H. Hawes Michelle A. Anderson Frank R. Burton Randall E. Brand Peter A. Banks Michele D. Lewis James A. Disario Timothy B. Gardner Andres Gelrud Stephen T. Amann John Baillie Mary E. Money Michael O’Connell | 2011 | Clinical Gastroenterology and Hepatology2011,,3: | 1 |
| 13 | Wandering neuronal migration in the postnatal vertebrate forebrain显示文摘 | Benjamin B Scott Timothy Gardner Ni Ji | | 0,,04: | 1 |
| 14 | 1999 update: ACC/AHA guidelines for the management of patients with acute myocardial infarction显示文摘 | Thomas J Ryan Elliott M Antman Neil H Brooks Robert M Califf L.David Hillis Loren F Hiratzka Elliot Rapaport Barbara Riegel Richard O Russell Earl E Smith W.Douglas Weaver Raymond J Gibbons Joseph S Alpert Kim A Eagle Timothy J Gardner Arthur Garson Gabri | 1999 | Journal of the American College of Cardiology1999,,3: | 1 |
| 15 | The American Heart Association’s 2008 Statement of Principles for Healthcare Reform显示文摘 | Raymond J. Gibbons Daniel W. Jones Timothy J. Gardner Larry B. Goldstein James H. Moller Clyde W. Yancy | 2008 | Circulation2008,,21: | 1 |
| 16 | Gene Transfer of Hepatocyte Growth Factor Attenuates Postinfarction Heart Failure显示文摘 | Vasant Jayasankar Y. Joseph Woo Lawrence T. Bish Timothy J. Pirolli Subhasis Chatterjee Mark F. Berry Jeffrey Burdick Timothy J. Gardner H. Lee Sweeney | 2003 | Circulation: Journal of the American Heart Association ( Suppl II)2003,,10: | 1 |
| 17 | SCAI/ACC/AHA Expert Consensus Document: 2014 Update on Percutaneous Coronary Intervention Without On-Site Surgical Backup显示文摘 | Gregory J. Dehmer James C. Blankenship Mehmet Cilingiroglu James G. Dwyer Dmitriy N. Feldman Timothy J. Gardner Cindy L. Grines Mandeep Singh | 2014 | Journal of the American College of Cardiology2014,,: | 1 |
| 18 | Pathologic Features of Ulcerative Colitis in Patients With Primary Sclerosing Cholangitis: A Case-control Study显示文摘 | Mee Joo Paula Abreu-e-Lima Francis Farraye Timothy Smith Prabhakar Swaroop Laura Gardner Gregory Y. Lauwers Robert Daniel Odze | 2009 | The American Journal of Surgical Pathology2009,,6: | 1 |
| 19 | Optimal surgical management of severe ischemic mitral regurgitation: To repair or to replace?显示文摘 | Louis P. Perrault Alan J. Moskowitz Irving L. Kron Michael A. Acker Marissa A. Miller Keith A. Horvath Vinod H. Thourani Michael Argenziano David A. D’Alessandro Eugene H. Blackstone Claudia S. Moy Joseph P. Mathew Judy Hung Timothy J. Gardner Michael K. | 2012 | The Journal of Thoracic and Cardiovascular Surgery2012,,6: | 1 |
| 20 | Alcohol and Smoking as Risk Factors in an Epidemiology Study of Patients With Chronic Pancreatitis显示文摘 | Gregory A. Coté Dhiraj Yadav Adam Slivka Robert H. Hawes Michelle A. Anderson Frank R. Burton Randall E. Brand Peter A. Banks Michele D. Lewis James A. Disario Timothy B. Gardner Andres Gelrud Stephen T. Amann John Baillie Mary E. Money Michael O’Connell | 2011 | Clinical Gastroenterology and Hepatology2011,,3: | 1 |