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| 1 | Passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts and assessment of clinical outcomes显示文摘AIM To assess for passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts(TIPS) and compare outcomes with maximally dilated TIPS.METHODS Polytetrafluoroethylene covered TIPS(Viatorr) from July 2002 to December 2013 were retrospectively reviewed at two hospitals in a single institution. Two hundred and thirty patients had TIPS maximally dilated to 10 mm(m TIPS), while 43 patients who were at increased risk for hepatic encephalopathy(HE), based on clinical evaluation or low pre-TIPS portosystemic gradient(PSG), had 10 mm TIPS sub-maximally dilated to 8 mm(sm TIPS). Group characteristics(age, gender, Model for End-Stage Liver Disease score, post-TIPS PSG and clinical outcomes were compared between groups, including clinical success(ascites or varices), primary patency,primary assisted patency, and severe post-TIPS HE. A subset of fourteen patients with sm TIPS underwent follow-up computed tomography imaging after TIPS creation, and were grouped based on time of imaging(< 6 mo and > 6 mo). Change in diameter and crosssectional area were measured with 3D imaging software to evaluate for passive expansion.RESULTS Patient characteristics were similar between the sm TIPS and m TIPS groups, except for pre-TIPS portosystemic gradient, which was lower in the sm TIPS group(19.4 mm Hg ± 6.8 vs 22.4 mm Hg ± 7.1, P = 0.01). Primary patency and primary assisted patency between sm TIPS and m TIPS was not significantly different(P = 0.64 and 0.55, respectively). Four of the 55 patients(7%) with sm TIPS required TIPS reduction for severe refractory HE, while this occurred in 6 of the 218 patients(3%) with m TIPS(P = 0.12). For the 14 patients with follow-up computed tomography(CT) imaging, the median imaging follow-up was 373 d. There was an increase in median TIPS diameter, median percent diameter change, median area, and median percent area change in patients with CT follow-up greater than 6 mo after TIPS placement compared to follow-up within 6 mo(8.45 mm, 5.58%, 56.04 mm^2, and 11.48%, respectively, P = 0.01).CONCLUSION Passive expansion of sm TIPS does occur but clinical outcomes of sm TIPS and m TIPS were similar. Sub-maximal dilation can prevent complications related to overshunting in select patients. | Michael C Hsu Charles N Weber S William Stavropoulos Timothy W Clark Scott O Trerotola Richard D Shlansky Goldberg Michael C Soulen Gregory J Nadolski | 2017 | World Journal of Hepatology2017，9，12： | 11 |
| 2 | Producer Services in the Urban Core and Suburbs of Phoenix, Arizona显示文摘 | Breanda'n O'hUallacha'in Timothy F Leslie | 2007 | Urban Studies2007，，8： | 1 |
| 3 | TiO2 photocatalysis for indoor air application:effects of humidity and trace contaminant levels on the oxidation rates of formaldehyde,toluene and 1,3-butadiene显示文摘 | TIMOTHY N O ROBERT T B | 1995 | Environmental Science & Technology1995，29，： | 1 |
| 4 | Toward transcriptional therapies for the failing heart: chemical screens to modulategenes显示文摘 | TIMOTHY A M ERIC N O | 2005 | J Clin Invest2005，115，： | 1 |
| 5 | A mathematical model for the bacterial oxidation of sulfide ore concentrate 显示文摘 | Soumitro N Donald D Timothy O | 1994 | Biotechnology and Bioengineering1994，43，4： | 1 |
| 6 | Governance of Red Tourism in China:Per spec t ive s on Power a nd Gu a n x i显示文摘 | S h e n g n a n(Na n c y) Z h a o D a l l e n J Timothy | 2015 | Tou r i smManagement2015，，2： | 1 |
| 7 | Southern Ocean iron enrichment experiment: Carbon cycling in high-and low-Si waters 显示文摘 | Coale K H Johnson K S Chavez F P Buesseler K O Barber R T Brzezinski M A Cochlan W P Millero F J Falkowski P G Bauer J E Wanninkhof R H Kudela R M Altabet M A Hales B E Takahashi T Landry M R Bidigare R R Wang Xiujun Chase Z Strutton P G Friederich G E Gorbunov M Y Lance V P Hilting A K Hiscock M R Demarest M Hiscock W T Sullivan K F Tanner S J Gordon R M Hunter C N Elrod V A Fitzwater S E Jones J L Tozzi S Koblizek M Roberts A E Herndon J Brewster J Ladizinsky N Smith G Cooper D Timothy D Brown S L Selph K E Sheridan C C Twining B S Johnson Z I | 2004 | Science2004，304，5669： | 1 |
| 8 | TiO2 photocatalysis for indoor air application:effects of humidity and trace contaminant levels on the oxidation rates of Formaldehyde,Toluene and 1,3-Butadiene显示文摘 | TIMOTHY N O ROBERT T B | 1995 | Environmental Science & Technology1995，29，： | 1 |
| 9 | Viscoelastic properties of human cortical bone tissue depend on gender and elastic modulus显示文摘 | Ziheng Wu Timothy C O Glen L N | 2012 | Journal of Orthopaedic Research2012，5，： | 1 |
| 10 | Silver-graphene nanoribbon composite catalyst for the oxygen reduction reaction in alkaline electrolyte显示文摘 | Danae J Davis Abdul-Rahman O Raji Timothy N Lambert | 2014 | 26 : 164-1702014，26，： | 1 |
| 11 | Direct comparison of nanoindentation and macroscopic measurements of bone viscoelasticity显示文摘 | Tara N S Jingzhou Zhang Timothy C O | 2011 | Journal of the Mechanical Behavior of Biomedical Material2011，4，： | 1 |
| 12 | Semicarbazide fo_mation in flour and bread 显示文摘 | GREGORY O N TIMOTHY H B GREGORY W D | 2008 | J Agric Food Chem2008，56，6： | 1 |
| 13 | Spatial Convergence and Spillovers in American Invention 显示文摘 | Breanda' n O' hUallacha' in and Timothy F Leslie | 2005 | Annas of the Association of American Geographers2005，95，4： | 1 |
| 14 | Evolution and Functional Impact of Rare Coding Variation from Deep Sequencing of Human Exomes显示文摘 | Jacob A. Tennessen Abigail W. Bigham Timothy D. O’Connor Wenqing Fu Eimear E. Kenny Simon Gravel Sean McGee Ron Do Xiaoming Liu Goo Jun Hyun Min Kang Daniel Jordan Suzanne M. Leal Stacey Gabriel Mark J. Rieder Goncalo Abecasis David Altshuler Deborah A. N | 2012 | Science2012，，6090： | 1 |
| 15 | Semicarbazide formation in flour and bread显示文摘 | Gregory O N Timothy H B Gregory W D | 2008 | Journal of Agricultural and Food Chemistry2008，56，6： | 1 |
| 16 | TiO2 photocatalysis for indoor air applications:effects of humidity and trace contaminant levels on the oxdation rates of formaldehyde,toluene, and 1,3-butadience显示文摘 | Timothy N O Miranda A I Ansar Z | 1995 | Enivronmental Science Technology1995，29，5： | 1 |
| 17 | A mathematical model for the bacterial oxidation of sulfide ore eoneentrate显示文摘 | Soumitro N Donald D and Timothy O | 1994 | Bioteehnolngy and Bioengineering1994，43，： | 1 |
| 18 | A mathematical model for the bacterial oxidation of sulfide ore concentrate显示文摘 | Soumitro N Donald D Timothy O | 1994 | Biotechnology and Bioengineering1994，43，： | 1 |
| 19 | Semicarbazide formation in flour and bread显示文摘 | Gregory O N Timothy H B Diachenko G W | 2008 | Journal of Agricultural and Food Chemistry2008，56，6： | 1 |
| 20 | Semicarbazide formation in fl our and bread显示文摘 | Gregory O N Timothy H B Diachenko G W | 2008 | Journal ofAgricultural and Food Chemistry2008，56，6： | 1 |
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