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| 1 | Hepatic schwannoma:Imaging findings on CT,MRI and contrast-enhanced ultrasonography显示文摘A primary benign schwannoma of the liver is extremely rare and is difficult to preoperatively discriminate from a malignant tumor.We compared the imaging and pathological findings,and examined the possibility of preoperatively diagnosing a benign liver schwannoma.A 72-year-old woman was admitted to our hospital because of a 4.6-cm mass in the liver.A malignant tumor was suspected,and a right hepatectomy was performed.After this,the diagnosis of a primary benign schwannoma of the liver was made through pathological examination.Contrast-enhanced ultrasonography(CEUS) with Sonazoid showed minute blood flows into the septum and solid areas of the tumor in the vascular phase;most likely due to increased arterial flow associated with infiltration of chronic inflammatory cells.In the postvascular phase,CEUS showed contrast defect of cystic areas and delayed enhancement of solid areas;most likely due to aggregation of siderophores.Because discriminating between a benign and malignant schwannoma of the liver is difficult,surgery is generally recommended.However,the two key findings from CEUS may be useful in discriminating ancient schwannoma by recognizing the hemorrhage involved in the secondary degeneration and aggregation of siderophores. | Yu Ota Kazunobu Aso Kenji Watanabe Takahiro Einama Koji Imai Hidenori Karasaki Ryuji Sudo Yosui Tamaki Mituyoshi Okada Yosihiko Tokusashi Toru Kono Naoyuki Miyokawa Masakazu Haneda Masahiko Taniguchi Hiroyuki Furukawa | 2012 | World Journal of Gastroenterology2012，18，35： | 11 |
| 2 | Inhibitory effect of angiotensinⅡreceptor antagonist on hepatic stellate cell activation in non-alcoholic steatohepatitis显示文摘AIM: To investigate the efficacy of angiotensinⅡreceptor antagonist on hepatic stellate cells (HSCs) activation in the patients with non-alcoholic steatohepatitis (NASH). METHODS: Seven patients with NASH were prescribed losartan, a selective angiotensinⅡtype 1 receptor antagonist (50 mg/d) for 48 wk. Liver biopsies were performed both at the entry and end of the study in all patients. Quiescent and activated HSCs were identified by double immunostaining using anti-p75 andα-smooth muscle actin antibodies, and the number of each phenotype was counted. Similarly, the liver specimens obtained from the eight patients with non-alcoholic fatty liver (NAFL) were also examined as controls. RESULTS: In NASH hepatic tissues, activated HSCs were dominantly distributed as compared with those in NAFL. The 48-wk losartan treatment induced a remarkable decrease in activated HSCs and a mild increase in quiescent phenotypes. CONCLUSION: Our data suggest the crucial involvement of HSCs in anti-fibrotic effect of angiotensinⅡreceptor antagonist on patients with NASH. | Shiro Yokohama Yoshihiko Tokusashi Kimihide Nakamura Yosui Tamaki Satoshi Okamoto Mituyoshi Okada Kazunobu Aso Takenao Hasegawa Masaru Aoshima Naoyuki Miyokawa Masakazu Haneda Masashi Yoneda | 2006 | World Journal of Gastroenterology2006，12，2： | 10 |
| 3 | Genetic classification of combined hepatocellular-cholangiocarcinoma显示文摘 | Hiroaki Fujii Xue Gong Zhu Toshiharu Matsumoto Mitsuhiro Inagaki Yoshihiko Tokusashi Naoyuki Miyokawa Toshio Fukusato Toshimasa Uekusa Tetsuya Takagaki Naomi Kadowaki Toshikazu Shirai | 2000 | Human Pathology2000，，9： | 1 |
| 4 | Hepatocytic cells form bile duct-like structures within a three-dimensional collagen gel matrix 显示文摘 | Nishikawa Y Tokusashi Y Kadohama T Nishimori H Ogawa K | 1996 | Exp Cell Res1996，223，2： | 1 |
| 5 | Thyroid-Stimulating Hormone Induces Interleukin-18 Gene Expression In FRTL-5 cells:Immunohistochemical Detection of Interleukin-18 in Autoimmune Thyroid Disease 显示文摘 | Takiyama Y Miyokawa N Tokusashi Y | 2002 | Thyroid2002，12，11： | 1 |
| 6 | Expression of NGF in hepatocellular carcinoma cells with its receptors in non - tumor cell components显示文摘 | Tokusashi Y Asai K Taruakawa S | 2005 | Int J Cancer2005，114，1： | 1 |
| 7 | Pylorus-preserving total pancreatectomy for an intraductal papillary-mucinous neoplasm of the pancreas显示文摘 | Mitsuhiro Inagaki Mitsuhiro Obara Shuichi Kino Junichi Goto Shigeki Suzuki Akira Ishizaki Satoshi Tanno Yutaka Kohgo Yoshihiko Tokusashi Naoyuki Miyokawa Shinichi Kasai | 2007 | Journal of Hepato-Biliary-Pancreatic Surgery2007，，3： | 1 |
| 8 | Expression of NGF in hepatocellular carcinoma cells with its receptors in non-tumor cell components显示文摘 | Tokusashi Y Asai K Tamakawa S | 2005 | Int J Cancer2005，114，1： | 1 |
| 9 | Expression of NGF in hepatocellular carcinoma cells with its receptors in non-tumor cell components 显示文摘 | Tokusashi Y Asai K Tamakawa S Yamamoto M Yoshie M Yaginuma Y Miyokawa N | 2005 | Int J Cancer2005，114，： | 1 |
| 10 | Intrahepatic trans-plantation of normal hepatocytes prevents Wilson’s disease in Long-Evans Cinnamon rats显示文摘 | Yoshida Y Tokusashi Y Lee GH | 1996 | Gastroenterology1996，111，6： | 1 |
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