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| 1 | A prospective, multicenter study of 1111 colorectal endoscopic submucosal dissections (with video)显示文摘 | Yutaka Saito Toshio Uraoka Yuichiro Yamaguchi Kinichi Hotta Naoto Sakamoto Hiroaki Ikematsu Masakatsu Fukuzawa Nozomu Kobayashi Junichirou Nasu Tomoki Michida Shigeaki Yoshida Hisatomo Ikehara Yosuke Otake Takeshi Nakajima Takahisa Matsuda Daizo Saito | 2010 | Gastrointestinal Endoscopy2010，，6： | 6 |
| 2 | Factors associated with complicated erosive esophagitis: A Japanese multicenter, prospective, cross-sectional study显示文摘AIM To assess the clinical characteristics of patients with complicated erosive esophagitis(EE) and their associated factors.METHODS This prospective, cross-sectional study included patients diagnosed with EE by upper gastrointestinal endoscopy between October 2014 and March 2015 at 106 Japanese hospitals. Data on medical history, general condition, gastrointestinal symptoms, lifestyle habits, comorbidities, and endoscopic findings were collected using a standard form to create a dedicated database. Logistic regression analysis was used to calculate adjusted odds ratios(aO R) and 95%CI for the association with complicated EE.RESULTS During the study period, 1749 patients diagnosed with EE, 38.3% of whom were prescribed proton pump inhibitors(PPIs) were included. Of them, 143(8.2%) had EE complications. Esophageal bleeding occurred in 84(4.8%) patients, esophageal strictures in 45(2.6%) patients, and 14(0.8%) patients experienced both. Multivariate analysis showed that increased age(a OR: 1.05; 95%CI: 1.03-1.08), concomitant use of psychotropic agents(a OR: 6.51; 95%CI: 3.01-13.61), and Los Angeles grades B(a OR: 2.69; 95%CI: 1.48-4.96), C(aO R: 15.38; 95%CI: 8.62-28.37), and D(aO R: 71.49; 95%CI: 37.47-142.01) were significantly associated with complications, whereas alcohol consumption 2-4 d/wk was negatively associated(a OR: 0.23; 95%CI: 0.06-0.61). Analyzing associated factors with each EE complication separately showed esophageal ulcer bleeding were associated with increased age(a OR: 1.05; 95%CI: 1.02-1.07) and Los Angeles grades B(aO R: 3.60; 95%CI: 1.52-8.50), C(a OR: 27.61; 95%CI: 12.34-61.80), and D(a OR: 119.09; 95%CI: 51.15-277.29), while esophageal strictures were associated with increased age(a OR: 1.07; 95%CI: 1.04-1.10), gastroesophageal reflux symptom(aO R: 2.51; 95%CI: 1.39-4.51), concomitantuse of psychotropic agents(a OR: 11.79; 95%CI: 5.06-27.48), Los Angeles grades C(aO R: 7.35; 95%CI: 3.32-16.25), and D(a OR: 20.34; 95%CI: 8.36-49.53) and long-segment Barrett's esophagus(a OR: 4.63; 95%CI: 1.64-13.05).CONCLUSION Aging and severe EE were common associated factors, although there were more associated factors in esophageal strictures than esophageal ulcer bleeding. Despite the availability and widespread use of PPIs, EE complications are likely to remain a problem in Japan owing to the aging population and high-stress society. | Masahiro Sakaguchi Noriaki Manabe Nobuo Ueki Jun Miwa Tomoki Inaba Norimasa Yoshida Kouichi Sakurai Masahiro Nakagawa Hajime Yamada Michiya Saito Koji Nakada Katsuhiko Iwakiri Takashi Joh Ken Haruma | 2017 | World Journal of Gastroenterology2017，23，2： | 3 |
| 3 | Management of gastric mucosa-associated lymphoid tissue lymphoma in patients with extra copies of the MALT1 gene显示文摘AIM To identify the clinical features of gastric mucosaassociated lymphoid tissue(MALT) lymphoma with extra copies of MALT1.METHODS This is a multi-centered,retrospective study. We reviewed 146 patients with MALT lymphoma in the stomach who underwent fluorescence in situ hybridization analysis for t(11;18) translocation. Patients were subdivided into patients without t(11;18) translocation or extra copies of MALT1(Group A,n = 88),patients with t(11;18) translocation(Group B,n = 27),and patients with extra copies of MALT1(Group C,n = 31). The clinical background,treatment,and outcomes of each group were investigated.RESULTS Groups A and C showed slight female predominance,whereas Group B showed slight male predominance. Mean ages and clinical stages at lymphoma diagnosis were not different between groups. Complete response was obtained in 61 patients in Group A(69.3%),22 in Group B(81.5%),and 21 in Group C(67.7%). Helicobacter pylori(H. pylori) eradication alone resulted in complete remission in 44 patients in Group A and 13 in Group C. In Group B,14 patients underwent radiotherapy alone,which resulted in lymphoma disappearance. Although the difference was not statistically significant,event-free survival in Group C tended to be inferior to that in Group A(P = 0.10).CONCLUSION Patients with t(11;18) translocation should be treated differently from others. Patients with extra copies of MALT1 could be initially treated with H. pylori eradication,similar to patients without t(11;18) translocation or extra copies of MALT1. | Masaya Iwamuro Ryuta Takenaka Masahiro Nakagawa Yuki Moritou Shunsuke Saito Shinichiro Hori Tomoki Inaba Yoshinari Kawai Tatsuya Toyokawa Takehiro Tanaka Tadashi Yoshino Hiroyuki Okada | 2017 | World Journal of Gastroenterology2017，23，33： | 3 |
| 4 | Adipose Tissue-Derived Mesenchymal Stem Cells Facilitate Hematopoiesis in Vitro and in Vivo显示文摘 | Norihiko Nakao Takayuki Nakayama Takashi Yahata Yukari Muguruma Shigeki Saito Yasuhiko Miyata Koji Yamamoto Tomoki Naoe | 2010 | The American Journal of Pathology2010，，2： | 1 |
| 5 | Genetic polymorphisms of IL17A and pri-microRNA-938, targeting IL17A 3′-UTR, influence susceptibility to gastric cancer显示文摘 | Tomiyasu Arisawa Tomomitsu Tahara Hisakazu Shiroeda Yasuhito Matsue Takahiro Minato Tomoe Nomura Hideto Yamada Ranji Hayashi Takashi Saito Kazuhiro Matsunaga Tomoki Fukuyama Nobuhiko Hayashi Toshimi Otsuka Atsushi Fukumura Masakatsu Nakamura Tomoyuki Shib | 2012 | Human Immunology2012，，7： | 1 |
| 6 | Genetic polymorphisms of SCN10A are associated with functional dyspepsia in Japanese subjects显示文摘 | Tomiyasu Arisawa Tomomitsu Tahara Hisakazu Shiroeda Takahiro Minato Yasuhiro Matsue Takashi Saito Tomoki Fukuyama Toshimi Otsuka Atsushi Fukumura Masakatsu Nakamura Tomoyuki Shibata | 2013 | Journal of Gastroenterology2013，，1： | 1 |
| 7 | Association between functional promoter polymorphisms of macrophage migration inhibitory factor (MIF) gene and ulcerative colitis in Japan显示文摘 | Hisakazu Shiroeda Tomomitsu Tahara Masakatsu Nakamura Tomoyuki Shibata Tomoe Nomura Hideto Yamada Ranji Hayashi Takashi Saito Masayoshi Yamada Tomoki Fukuyama Toshimi Otsuka Hirokazu Yano Kazuaki Ozaki Mutsumi Tsuchishima Mikihiro Tsutsumi Tomiyasu Arisaw | 2010 | Cytokine2010，，2： | 1 |
| 8 | 采用深度卷积神经网络对结肠镜影像进行自动解剖定位显示文摘背景:结肠镜能检出肿瘤、息肉和炎症性肠病等结直肠疾病。应用深度卷积神经网络(CNN)的计算机辅助诊断(CAD)系统在结肠镜检查中能够识别解剖部位,为内镜医生提供支持。本研究旨在建立一个应用CNN的CAD系统,以区分盲肠、升结肠、横结肠、降结肠、乙状结肠及直肠等解剖部位的内镜影像。方法:我们用包括9,995个结肠镜影像的训练组来建立CNN,并用5,121个独立的结肠镜影像来进行验证CNN的检测效能。验证组影像根据解剖部位分为七类:回肠末端、盲肠、升结肠至横结肠、降结肠至乙状结肠、直肠、肛门以及无法识别的部位。我们检测了2017年1-11月间单中心的结肠镜影像照片,评估内镜医生与CNN的诊断一致性。本研究主要结局指标是CNN判断内镜下解剖部位的灵敏度和特异度。结果:我们建立的CNN识别内镜下解剖部位的曲线下面积为:回肠末端0.979,盲肠0.940,升结肠至横结肠0.875,降结肠至乙状结肠,0.846,直肠0.835,肛门0.992。在验证过程中,CNN系统能准确识别66.6%的内镜下解剖部位。结论:我们建立了一个临床相关的新的CNN系统,该系统可识别结肠镜下的不同解剖部位,这是构建CAD系统的第一步,后者能给结肠镜检查提供质量保障。 | Hiroaki Saito Tetsuya Tanimoto Tsuyoshi Ozawa Soichiro Ishihara Mitsuhiro Fujishiro Satoki Shichijo Dai Hirasawa Tomoki Matsuda Yuma Endo Tomohiro Tada | 2021 | Gastroenterology Report2021，9，3： | 0 |
| 9 | A case of obstructive azoospermia secondary to genitourinary tract infection caused by a prostatic utricle cyst显示文摘Dear Editor,Obstructive azoospermia(OA)is defined as the absence of spermatozoa in the sediment of a centrifuged sample of ejaculate and is usually caused by an obstruction anywhere along the posttesticular tracts.OA is diagnosed in 20%–40%of men with azoospermia.Although OA may be acquired congenitally,such as in Young’s syndrome that presents with bilateral vas deferens abnormalities,it commonly develops as a sequela of prostatic and ejaculatory duct cysts,childhood inguinal hernias,epididymitis,and vasectomy. | Tomoki Saito Mitsuru Komeya Kimitsugu Usui Shinnosuke Kuroda Teppei Takeshima Kunitomo Takashima Mario Ikeda Yoshihito Kondo Yasushi Yumura | 2022 | Asian Journal of Andrology2022，24，5： | 0 |
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