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| 1 | Do ethnic and socio-economic inequalities in mortality vary by region in New Zealand? An application of hierarchical Bayesian modelling显示文摘 | Richardson Ken Blakely Tony Young Jim | 2009 | Social Science and Medicine2009，69，8： | 1 |
| 2 | Developmentof a scale to measure problem use of short message service :The SMS problem use diagnostic questionnaire显示文摘 | Brain Rutland Titman Sheets Tony Young | 2007 | CyberpsychologyBehavior2007，，10： | 1 |
| 3 | Exercise-induced endotoxemia:the effect of ascorbic acid supplementation显示文摘 | Tony Ashton Lan S Young Gareth W Davison | | 0，，05： | 1 |
| 4 | Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in hepatocellular carcinoma:the PLANET study显示文摘Intra-tumor heterogeneity(ITH) is a key challenge in cancer treatment, but previous studies have focused mainly on the genomic alterations without exploring phenotypic(transcriptomic and immune)heterogeneity. Using one of the largest prospective surgical cohorts for hepatocellular carcinoma(HCC)with multi-region sampling, we sequenced whole genomes and paired transcriptomes from 67 HCC patients(331 samples). We found that while genomic ITH was rather constant across stages, phenotypic ITH had a very different trajectory and quickly diversified in stage Ⅱ patients. Most strikingly, 30% of patients were found to contain more than one transcriptomic subtype within a single tumor. Such phenotypic ITH was found to be much more informative in predicting patient survival than genomic ITH and explains the poor efficacy of single-target systemic therapies in HCC. Taken together, we not only revealed an unprecedentedly dynamic landscape of phenotypic heterogeneity in HCC, but also highlighted the importance of studying phenotypic evolution across cancer types. | Weiwei Zhai Hannah Lai Neslihan Arife Kaya Jianbin Chen Hechuan Yang Bingxin Lu Jia Qi Lim Siming Ma Sin Chi Chew Khi Pin Chua Jacob Josiah Santiago Alvarez Pauline Jieqi Chen Mei Mei Chang Lingyan Wu Brian K.P.Goh Alexander Yaw-Fui Chung Chung Yip Chan Peng Chung Cheow Ser Yee Lee Juinn Huar Kam Alfred Wei-Chieh Kow Iyer Shridhar Ganpathi Rawisak Chanwat Jidapa Thammasiri Boon Koon Yoong Diana Bee-Lan Ong Vanessa H.de Villa Rouchelle D.Dela Cruz Tracy Jiezhen Loh Wei Keat Wan Zeng Zeng Anders Jacobsen Skanderup Yin Huei Pang Krishnakumar Madhavan Tony Kiat-Hon Lim Glenn Bonney Wei Qiang Leow Valerie Chew Yock Young Dan Wai Leong Tam Han Chong Toh Roger Sik-Yin Foo Pierce Kah-Hoe Chow | 2022 | National Science Review2022，9，3： | 1 |
| 5 | Poised Chromatin at the ZEB1 Promoter Enables Breast Cancer Cell Plasticity and Enhances Tumorigenicity显示文摘 | Christine L. Chaffer Nemanja D. Marjanovic Tony Lee George Bell Celina G. Kleer Ferenc Reinhardt Ana C. D’Alessio Richard A. Young Robert A. Weinberg | 2013 | Cell2013，，1： | 1 |
| 6 | Modulation of remifentanil-induced postinfusion hyperalgesia by the β-blocker propranolol in humans显示文摘 | Larry F. Chu Tony Cun Lynn K. Ngai Julie E. Kim Abigail K. Zamora Chelsea A. Young Martin S. Angst David J. Clark | 2012 | Pain2012，，5： | 1 |
| 7 | BIODIVERSITY AND CONSERVATION OF FRESHWATER FISH IN HONG KONG, CHINA显示文摘We surveyed the distribution, composition and diversity of freshwater fish in Hong Kong, China from 2002 to 2004. Sites surveyed were mainly streams, marshes and estuaries. There are ponds for aquaculture and reservoirs in Hong Kong but no large natural water bodies. From the 220 sites surveyed, 114 species of 37 families were found. Gobiidae (with 24 species) and Cyprinidae (21 species) were the dominant families. This survey has increased the number of freshwater fish species recorded in Hong Kong to 167. Among these, 71 (42.5%) are primary freshwater fish, 44 are brackish and 46 are vagrants. The remaining 6 species are diadromous. In Hong Kong, freshwater fish are conserved by a combination of measures. About 38% of Hong Kong’s land area is designated as country parks and/or special areas, and is managed for nature conservation and educational purposes. In addition, another 5% of land area is zoned for conservation in the statutory land use zoning system to protect them from development and incompatible land uses. Major development projects have to go through the statutory environmental impact assessment process to ensure that they will not have adverse impact as far as practicable. There are conservation action plans for important species. For example, captive-bred individuals of the endemic Hong Kong Paradise Fish Macropodus hongkongensis have been released to suitable and secure sites inside country parks and their populations are regularly monitored. Other measures such as wetland creation, restoration and enhancement programmes are also implemented for freshwater fish conservation. | VIRGINIA Laifun Lee MARIA Lauching Young TONY Kingtung Chan SAMUEL Kinsan Lam FRANCO Kwokyan Ng JULIA Wingyin Chan | 2006 | 水生生物学报2006，30，6： | 0 |
| 8 | Perceived and Measured Levels of Environmental Pollution:Interdisciplinary Research in the Subarctic Lowlands of Northeast European Russia显示文摘本文对地处俄罗斯欧洲东北部的乌萨盆地开展跨学科野外研究。将当地居民对环境问题的感知与利用化学和遥感图像技术分析环境污染及其影响的研究成果进行比较。通过对积雪、表土和地衣的化学测定,以及遥感技术和对湖水和沉积物的分析,表明20世纪30年代以来大规模的煤矿开采是导致英塔(Inta)和沃尔库塔(Vorkuta)地区环境污染的主要原因。沃尔库塔及其周边地区遭受了最严重的影响,湖水与表土金属沉积、碱化的现象明显,陆生地衣(驯鹿地衣)的金属元素与阳离子含量升高,植物群落也出现变化。虽然近年来该地区的煤矿产业出现襄退,但附近乌中斯克(Usinsk)石油天然气工业的发展极为迅猛。1994年鸟申斯克原油大量泄漏事件发生之后,当地居民的环保意识逐渐增强,与认为大气污染是主要环境威胁因素的沃尔库塔居民相比,对环境污染的认知与关注程度较高。研究表明,在沃尔库塔2540km的范围内,向空气中排放的有害气体和局部沉积的污染物主要来自于热电厂、煤矿和水泥厂的煤炭燃烧。沃尔库塔居民通过直接观察和亲身体验来评价大气污染问题,例如发现积雪变色,呼吸系统出现问题,这些感知过程是不易用科学知识来形成的。 | Tony R. Walker Joachim Otto Habeck Timo P. Karjalalnen Tarmo Virtanen Nadia Solovieva Viv Jones Peter Kuhry Vasily, I. Ponomarev Kari Mikkola Ari Nikula Elena Patova Peter D. Crittenden Scott D. Young Tim Ingold 刘媛(译) | 2006 | AMBIO-人类环境杂志2006，35，5： | 0 |
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