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17篇 您的检索式：作者名="Torsten E"

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		题名	作者	年代	出处	被引量
	1	Predictive value of Ki67 and p53 in locally advanced rectal cancer:Correlation with thymidylate synthase and histopathological tumor regression after neoadjuvant 5-FU-based chemoradiotherapy显示文摘AIM: To investigate the predictive value of Ki67 and p53 and their correlation with thymidylate synthase (TS) gene expression in a rectal cancer patient cohort treated according to a standardized recommended neoadjuvant treatment regimen.METHODS: Formalin fixed, paraffin embedded pre-therapeutical tumor biopsies (n = 22) and post-therapeutical resection specimens (n = 40) from patients with rectal adenocarcinoma (clinical UICC stage Ⅱ/Ⅲ) receiving standardized neoadjuvant 5-fluorouracil (5-FU) based chemoradiotherapy were studied for Ki67 and p53 expression by immunohistochemistry and correlated with TS mRNA expression by quantitative TaqMan real-time PCR after laser microdissection. The results were compared with histopathological tumor regression according to a standardized semiquantitative score grading system.RESULTS: Responders (patients with high tumor regression) showed a significantly lower Ki67 expression than non-responders in the pre-therapeutical tumor biopsies (81.2% vs 16.7%; P < 0.05) as well as in the post-therapeutical resection specimens (75.8% vs 14.3%; P < 0.01). High TS mRNA expression was significantly correlated with a high Ki67 index and low TS mRNA expression was significantly correlated with a low Ki67 index in the pre-therapeutical tumor biopsies (corr. coef. = 0.46; P < 0.01) as well as in the post-therapeutical resection specimens (corr. coef. = 0.40; P < 0.05). No significant association was found between p53 and TS mRNA expression or tumor regression.CONCLUSION: Ki67 has, like TS, predictive value in rectal cancer patients after neoadjuvant 5-FU based chemoradiotherapy. The close correlation between Ki67 and TS indicates that TS is involved in active cell cycle processes.	Christiane Jakob Torsten Liersch Wolfdietrich Meyer Heinz Becker Gustavo B Baretton Daniela E Aust	2008	World Journal of Gastroenterology2008，14，7：	29
	2	Early precipitation stages of aluminum alloys-the role of quenched-in vacancies显示文摘	Torsten E M Staab Matz Haaks Hartwig Modrow	2008	Applied Surface Science2008，，：	1
	3	Integrated dynamic aquaculture and wastewater treatment modelling for recirculating aquaculture systems显示文摘	Torsten E I Wik Bjorn T Linden Per I Wramner	2009	Aquaculture2009，287，34：	1
	4	Variations of the ^44Ca/^40Ca ratio in seawater during the past 24 million years: Evidence from δ44Ca and δ^18O values of Miocene phosphates显示文摘	Anne-Désirée S Peter S Torsten V	2003	Geochimica et Cosmochimica Acta2003，67，14：	1
	5	IGF-I has a direct proliferative effect in adult hippocampal progenitor cells显示文摘	Maria A.I ?berg N.David ?berg Theo D Palmer Ann-Marie Alborn Christine Carlsson-Skwirut Peter Bang Lars E Rosengren Torsten Olsson Fred H Gage Peter S Eriksson	2003	Molecular and Cellular Neuroscience2003，，1：	1
	6	Residual stresses in green bodies of steel powder after conventional and high speed compaction显示文摘	TORSTEN E PPETRI L	2002	Materials Science Forum2002，407，404：	1
	7	Integrated dynamic aquaculture and wastewater treatment modelling for recirculating aquaculture systems显示文摘	Torsten E I Wik B T Linden P I	2009	Aquaculture2009，287，34：	1
	8	Hamstring tendons regeneration after ACL reconstruction:an overview显示文摘	Vassilios SN Nicolas E Torsten W	2007	Knee Sorg Sports Traumatol Arthrosc2007，4，：	1
	9	Integrated dynamic aquaculture and wastewater treatment modelling for recirculating aquaculture systems显示文摘	Torsten E I Wik Bj?rn T Lindén Per I Wramner	2009	Aquaculture2009，287，34：	1
	10	Hamstring tendons regeneration after ACL reconstruction:an overview显示文摘	Vassilios SN Nicolas E Torsten W	2007	Knee Surg Sports Traumatol Arthrosc2007，5，4：	1
	11	Hamstring tendons regeneration after ACL reconstruction:an overview显示文摘	Vassilios SN Nicolas E Torsten W		0，，04：	1
	12	Long-time survival with HIV-related pulmonary arterial hypertension: a case report显示文摘	Serap Alp Renate Schlottmann Torsten T Bauer Wolfgang E Schmidt Andreas Bastian	2003	AIDS2003，，11：	1
	13	Biodiversity and seasonal variation of the cyano baterial assemblage in a rice paddy field in Fujian,China显示文摘	Song T Y Lotta M Torsten E	2005	FEMS Microbiology Ecology2005，54，1：	1
	14	Novel terpyridine-manganese (I I ) complexes and their potential to activatehydrogen peroxide显示文摘	W ieprecht Torsten Jun taoxia Uwe H e in z e t a l	2003	Journal of Molecular Catalysis A :Chem ical2003，203，：	1
	15	Mesopic vision in myopia corrected by photorefractive keratectomy, soft contact lenses, and spectacles显示文摘	Dahan E Torsten S Martin K	1997	Cataract Refractive Surg1997，23，：	1
	16	Hamsring tendons regernation after ACL reconstructiont an overview显示文摘	Vassilios SN Nicolas E Torsten W	2007	Knee Surg Sports Traumatol Arthrosc2007，5，4：	1
	17	显示文摘	Kazuaki C Torsten E Reichert Y	1999	Int J Cancer1999，82，：	1

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