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| 1 | Liver transplantation and the management of progressive familial intrahepatic cholestasis in children显示文摘Progressive familial intrahepatic cholestasis(PFIC) is a constellation of inherited disorders that result in the impairment of bile flow through the liver that predominantly affects children. The accumulation of bile results in progressive liver damage, and if left untreated leads to end stage liver disease and death. Patients often present with worsening jaundice and pruritis within the first few years of life. Many of these patients will progress to end stage liver disease and require liver transplantation. The role and timing of liver transplantation still remains debated especially in the management of PFIC1. In those patients who are appropriately selected, liver transplantation offers an excellent survival benefit. Appropriate timing and selection of patients for liver transplantation will be discussed, and the short and long term management of patients post liver transplantation will also be described. | Ashley Mehl Humberto Bohorquez Maria-Stella Serrano Gretchen Galliano Trevor W Reichman | 2016 | World Journal of Transplantation2016，6，2： | 6 |
| 2 | Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy显示文摘BACKGROUND Intraductal papillary mucinous neoplasms(IPMNs)are non-invasive pancreatic precursor lesions that can potentially develop into invasive pancreatic ductal adenocarcinoma.Currently,the International Consensus Guidelines(ICG)for IPMNs provides the basis for evaluating suspected IPMNs on computed tomography(CT)imaging.Despite using the ICG,it remains challenging to accurately predict whether IPMNs harbor high grade or invasive disease which would warrant surgical resection.A supplementary quantitative radiological tool,radiomics,may improve diagnostic accuracy of radiological evaluation of IPMNs.We hypothesized that using CT whole lesion radiomics features in conjunction with the ICG could improve the diagnostic accuracy of predicting IPMN histology.AIM To evaluate whole lesion CT radiomic analysis of IPMNs for predicting malignant histology compared to International Consensus Guidelines.METHODS Fifty-one subjects who had pancreatic surgical resection at our institution with histology demonstrating IPMN and available preoperative CT imaging were included in this retrospective cohort.Whole lesion semi-automated segmentation was performed on each preoperative CT using Healthmyne software(Healthmyne,Madison,WI).Thirty-nine relevant radiomic features were extracted from each lesion on each available contrast phase.Univariate analysis of the 39 radiomics features was performed for each contrast phase and values were compared between malignant and benign IPMN groups using logistic regression.Conventional quantitative and qualitative CT measurements were also compared between groups,viaχ2(categorical)and Mann Whitney U(continuous)variables.RESULTS Twenty-nine subjects(15 males,age 71±9 years)with high grade or invasive tumor histology comprised the'malignant'cohort,while 22 subjects(11 males,age 70±7 years)with low grade tumor histology were included in the'benign'cohort.Radiomic analysis showed 18/39 precontrast,19/39 arterial phase,and 21/39 venous phase features differentiated malignant from benign IPMNs(P<0.05).Multivariate analysis including only ICG criteria yielded two significant variables:thickened and enhancing cyst wall and enhancing mural nodule<5 mm with an AUC(95%CI)of 0.817(0.709-0.926).Multivariable post contrast radiomics achieved an AUC(95%CI)of 0.87(0.767-0.974)for a model including arterial phase radiomics features and 0.834(0.716-0.953)for a model including venous phase radiomics features.Combined multivariable model including conventional variables and arterial phase radiomics features achieved an AUC(95%CI)of 0.93(0.85-1.0)with a 5-fold cross validation AUC of 0.90.CONCLUSION Multi-phase CT radiomics evaluation could play a role in improving predictive capability in diagnosing malignancy in IPMNs.Future larger studies may help determine the clinical significance of our findings. | Stuart L Polk Jung W Choi Melissa J McGettigan Trevor Rose Abraham Ahmed Jongphil Kim Kun Jiang Yoganand Balagurunathan Jin Qi Paola T Farah Alisha Rathi Jennifer B Permuth Daniel Jeong | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 3 | Using on-site liver 3-D reconstruction and volumetric calculations in split liver transplantation显示文摘BACKGROUND: Split liver transplantation increases the number of grafts available for transplantation. Pre-recovery assessment of liver graft volume is essential for selecting suitable recipients. The purpose of this study was to determine the ability and feasibility of constructing a 3-D model to aid in surgical planning and to predict graft weight prior to an in situ division of the donor liver. METHODS: Over 11 months, 3-D volumetric reconstruction of 4 deceased donors was performed using Pathfinder Scout~? liver volumetric software. Demographic, laboratory, operative, perioperative and survival data for these patients along with donor demographic data were collected prospectively and analyzed retrospectively.RESULTS: The average predicted weight of the grafts from the adult donors obtained from an in situ split procedure were 1130 g(930-1458 g) for the extended right lobe donors and 312 g(222-396 g) for left lateral segment grafts. Actual adult graft weight was 92% of the predicted weight for both the extended right grafts and the left lateral segment grafts. The predicted and actual graft weights for the pediatric donors were 176 g and 210 g for the left lateral segment grafts and 308 g and 280 g for the extended right lobe grafts, respectively. All grafts were transplanted except for the right lobe from the pediatric donors due to the small graft weight.CONCLUSIONS: On-site volumetric assessment of donors provides useful information for the planning of an in situ split and for selection of recipients. This information may expand the donor pool to recipients previously felt to be unsuitable due to donor and/or recipient weight. | Trevor W Reichman Brittany Fiorello Ian Carmody Humberto Bohorquez Ari Cohen John Seal David Bruce George E Loss | 2016 | Hepatobiliary & Pancreatic Diseases International2016，15，6： | 2 |
| 4 | Characterization of a genetic resource collection for Miscanthua ( Saccharinae,Anddropogoneae, Poaceae) using AFLP and ISSR PCR显示文摘 | TREVOR R HODKINSON MARK W | 2002 | Annals of Botany2002，89，： | 1 |
| 5 | The kynurenine pathway as a therapeutic target in cognitive and neurodegenerative disorders显示文摘 | Trevor W Stone L Gail Darlington | 2013 | Br J Pharmacol2013，，6： | 1 |
| 6 | The Friday the thirteenth effect:myth or reality? 显示文摘 | Charnberlain Trevor W Cheung C Sherman Kwan Clarenee C Y | 1991 | Quarterly Journal of Business and Economics1991，30，20： | 1 |
| 7 | Recent advances in determining the pathogenesis of canine monocytic ehrlichiosis显示文摘 | Shimon H Trevor W Hylton B | 1999 | Journal of Clinical Microbiology1999，37，9： | 1 |
| 8 | Pfinder: real-time tracking of the human body显示文摘 | Christopher R W Ali A Trevor D | 1997 | IEEE Transactions on PAMI1997，19，7： | 1 |
| 9 | Changes in pore size distribution upon thermal cycling of TATB-based explosives measured by ultra-small angle X-Ray scattering显示文摘 | Trevor M W Tony van B Jonathan R I L | 2006 | Propellants Explosives Pyrotechnics2006，31，6： | 1 |
| 10 | Microbial Diversity and Community Structure of Post Disturbance Forest Soils as Determined by Sole-Carbon-Source-Utilization 显示文摘 | STADDON W J DUCHESNE L C TREVORS J T | 1997 | Microbial Ecology1997，34，2： | 1 |
| 11 | Cognitive enhancing effects of modafinil in healthy volunteers显示文摘 | Danielle C Turner1 Trevor W | 2003 | Psychopharmacology2003，165，3： | 1 |
| 12 | High performance liquid chromatography-visible spectroscopylectrospray ionization mass spectrometry methods for acrylic and polyester forensic fiber dye analysis 显示文摘 | LAUREN M P TREVOR A W RONALD F | 2006 | Journal of Forensic Science2006，51，4： | 1 |
| 13 | Putting a spin on the dorsal–ventral divide of the striatum显示文摘 | Pieter Voorn Louk J.M.J Vanderschuren Henk J Groenewegen Trevor W Robbins Cyriel M.A Pennartz | 2004 | Trends in Neurosciences2004，，8： | 1 |
| 14 | Interpretativereading:recognizing the unusual and inferring resistancemechanisms from resistance phenotypes显示文摘 | David M L Trevor G W and Kevin P S | 2001 | JAntimicrob Chemother2001，48，1： | 1 |
| 15 | Heparin and low- molecu- lar- weight heap显示文摘 | Elaine G Barbara M Trevor W | 2008 | Thromb Haemost2008，99，5： | 1 |
| 16 | Quantitative analysis of trace levels of geosmin and MIB in source and drinking water using headspace SPME 显示文摘 | Susan B W Brownlee B Trevor S I | 2000 | Wat Res2000，34，10： | 1 |
| 17 | Yield loss caused by Pratylenchus thornei on wheat in South Australia显示文摘 | Julie M Nicol Kerrie A Davies Trevor W Hancock | 1999 | Journal of Nematology1999，31，4： | 1 |
| 18 | Determination of polar compounds in rundle shale oil显示文摘 | Gary B Timothy G Trevor W | 1983 | Fuel1983，62，12： | 1 |
| 19 | Mercury in the aquatic environment:a review of factors affecting methylation显示文摘 | Susanne M U Trevor W T Svetlana A | 2001 | Critical reviews in environmental science and technology2001，31，3： | 1 |
| 20 | Everitt The effects of nucleus accumbens core and shell lesions on intravenous heroin self-administration and the acquisition of drug-seeking behaviour under a second-order schedule of heroin reinforcement received 显示文摘 | Hutcheson DM John A Parkinson Trevor W Bobbins Barry J | 2001 | Psychopharmacology2001，153，6： | 1 |
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