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| 1 | Acanthus ilicifolius plant extract prevents DNA alterations in a transplantable Ehrlich ascites carcinoma-bearing murine model显示文摘AIM: To investigate the chemopreventive efficacy of the Indian medicinal plant Acanthus ilicifolius L Acanthaceae in a transplantable Ehrlich ascites carcinoma (EAC)- bearing murine model. METHODS: Male Swiss albino mice were divided into four groups: Group A was the untreated normal control; Group B was the EAC control mice group that received serial, intraperitoneal (ip) inoculations of rapidly proliferating 2 x 105 viable EAC cells in 0.2 mL of sterile phosphate buffered saline; Group C was the plant extract-treated group that received the aqueous leaf extract (ALE) of the plant at a dose of 2.5 mg/kg body weight by single ip injections, once daily for 10, 20 and 30 consecutive days following tumour inoculation (ALE control); and Group D was the EAC + ALE- treatment group. The chemopreventive potential of the ALE was evaluated in a murine model by studying various biological parameters and genotoxic markers, such as tumour cell count, mean survival of the animals, haematological indices, hepatocellular histology, immunohistochemical expression of liver metallothionein (MT) protein, sister-chromatid exchanges (SCEs), and DNA alterations.RESULTS: Treatment of the EAC-bearing mice with the ALE significantly (P < 0.001) reduced viable tumour cell count by 68.34% (228.7 x 106 ± 0.53) when compared to EAC control mice (72.4 x 106 ± 0.49), and restored body and organ weights almost to the normal values. ALE administration also increased (P < 0.001) mean survival of the hosts from 35 ± 3.46 d in EAC control mice to 83 ± 2.69 d in EAC + ALE-treated mice. Haematological indices also showed marked improvement with administration of ALE in EAC-bearing animals. There was a significant increase in RBC count (P < 0.001), hemoglobin percent (P < 0.001), and haematocrit value (P < 0.001) from 4.3 ± 0.12, 6.4 ± 0.93, and 17.63 ± 0.72 respectively in EAC control mice to 7.1 ± 0.13, 12.1 ± 0.77, and 30.23 ± 0.57 respectively in EAC + ALE-treated group, along with concurrent decrement (P < 0.001) in WBC count from 18.8 ± 0.54 in EAC control to 8.4 ± 0.71 in EAC + ALE. Furthermore, treatment with ALE substantially improved hepatocellular architecture and no noticeable neoplastic lesions or foci of cellular alteration were observed. Daily administration of the ALE was found to limit liver MT expression, an important marker of cell proliferation with concomitant reduction in MT immunoreactivity (62.25 ± 2.58 vs 86.24 ± 5.69, P < 0.01). ALE was also potentially effective in reducing (P < 0.001) the frequency of SCEs from 14.94 ± 2.14 in EAC control to 5.12 ± 1.16 in EAC + ALE-treated group. Finally, in comparison to the EAC control, ALE was able to suppress in vivo DNA damage by abating the generations of ‘tailed’ DNA by 53.59% (98.65 ± 2.31 vs 45.06 ± 1.14, P < 0.001), and DNA single-strand breaks (SSBs) by 38.53% (3.14 ± 0.31 vs 1.93 ± 0.23, P < 0.01) in EAC-bearing murine liver. CONCLUSION: Our data indicate that, ALE is beneficial in restoring haematological and hepatic histological profiles and in lengthening the survival of the animals against the proliferation of ascites tumour in vivo. Finally, the chemopreventive efficacy of the ALE is manifested in limiting MT expression and in preventing DNA alterations in murine liver. The promising results of this study suggest further investigation into the chemopreventive mechanisms of the medicinal plant A. ilicifolius in vivo and in vitro. | Tridib Chakraborty Dipak Bhuniya Mary Chatterjee Mosiur Rahaman Dipak Singha Baidya Nath Chatterjee Subrata Datta Ajay Rana Kartick Samanta Sunil Srivastawa Sankar K Maitra Malay Chatterjee | 2007 | World Journal of Gastroenterology2007，13，48： | 2 |
| 2 | Rapid and selective oxidation of benzyl alcohols to aldehydes and ketones with novel vanadium polyoxometalate under solvent-free conditions显示文摘 | Anindita Dewan Tridib Sarma Utpal Bora Dilip K. Kakati | 2011 | Tetrahedron Letters2011，，20： | 2 |
| 3 | 蓝线前景黯淡:为什么公交运量显著增加而公交社区的蓝图没有实现显示文摘本文对于连接洛杉矶中心区与长滩中心区之间一条长约35公里的轨道交通路线(即蓝线,BlueLine)进行了分析研究。这条线路经过洛杉矶县一些最贫穷并且被人遗忘的社区。尽管当初线路建设的倡导者和地方政府进行了大量宣传并做出许诺,但这条线路并未能改善周边社区的经济环境。本文以蓝线作为范例,旨在了解内城区地铁站点周围现实存在的和已认识到的阻碍发展的因素。根据对政客、规划者、社区领导者和交通运输专家的一系列访谈所收集的信息,以及广泛细致的现场调查得来的分析数据,作者总结出影响内城地铁站点周边地区发展所缺少的先决条件。 | Anastasia Loukaitou-Sideris Tridib Banerjee 刘贤腾 | 2006 | 国外城市规划2006，21，2： | 2 |
| 4 | A Value-based Orientation to New Product Planning显示文摘 | Mazumdar Tridib | 1993 | Joumal of Consumer Marketing1993，10，1： | 1 |
| 5 | A Value-based Orientation to New Product Planning显示文摘 | Mazumdar Tridib | 1993 | The Journal of Consumer Marketing1993，10，1： | 1 |
| 6 | An investigation of reference price segments 显示文摘 | Mazumdar Tridib and Papatla Purushottam | 2000 | Journal of Marketing Research2000，37，2000： | 1 |
| 7 | Dynamic expression of miR- NAs across immature and adult stages of the malaria mosquito A- nopheles stephensi显示文摘 | Jain S Rana V Tridibes A | 2015 | Parasit Vectors2015，，8： | 1 |
| 8 | Indirect network externality effects on product attributes显示文摘 | Amiya Basu Tridib Mazumdar S P Raj | 2003 | Marketing Science2003，22，2： | 1 |
| 9 | The differential effects of online word - of - mouth and critics reviews on pre - release movie evaluation 显示文摘 | Anindita Chakravarty Yong Liu Tridib Mazumdar | 2010 | Journal of Interactive Marketing2010，24，： | 1 |
| 10 | The Future of Public Space:Beyond Invented Streets and Rein vented Places显示文摘 | Tridib Banerjee | 2001 | APA Journal2001，，： | 1 |
| 11 | A polyaniline-containing filter paper that acts as a sensor, acid, base, and endpoint indicator and also filters acids and bases显示文摘 | Dipak Dutta Tridib Kumar Sarma Devasish Chowdhury Arun Chattopadhyay | 2004 | Journal of Colloid And Interface Science2004，，1： | 1 |
| 12 | Ferrocene conjugated L-tryptophan copper(11) complexes of phenanthroline bases showing DNA pho-to-cleavage activity and cytotoxicity 显示文摘 | Tridib K G Balabhadrapatruni V S K C Mithun R | 2011 | Inorg Chem2011，50，： | 1 |
| 13 | Ferrocene-Co njugated 1-Tryptophan Copper(11) Complexes of Phenanthmline Bas es Showing DNA Photocleava-ge Activity and Cytotoxicity显示文摘 | Tridib K Goswami Chakravarthi B V S K Roy M | 2011 | Inorg anic chemistry2011，50，17： | 1 |
| 14 | Ferrocene-Conj- ugated Copper(11) Complexes of 1-Methionine and Phenanthroline Bases: Synthesis, Structure, and Photocytotoxic Activity显示文摘 | Tridib K Goswami Sudarshan Gadadhar | 2012 | Organome tallics2012，31，8： | 1 |
| 15 | Indirect network externality effects on product attributes显示文摘 | AMIYA B TRIDIB M RAJ S P | 2003 | Marketing Science2003，22，2： | 1 |
| 16 | Starch-mediated shape-selective synthesis of Au nanoparticles with tunable longitudinal plasmon resonance 显示文摘 | Tridib Kumar Sarma Arun C | 2004 | Langmuir2004，20，： | 1 |
| 17 | Loyalty Differences in the Use of Internal and External Reference Prices 显示文摘 | MAZUMDAR TRIDIB PURUSHOTTAM PAPATLA | 1995 | Marketing Letters1995，6，3： | 1 |
| 18 | The Future of Public Space:Beyond invented Streets and Reinvented Places显示文摘 | Tridib B | 2001 | APA Journal2001，100，3： | 1 |
| 19 | Bidding Strategies and Consumer Savings in NYOP Auctions显示文摘 | Mingyu Joo Tridib Mazumdar S.P. Raj | 2011 | Journal of Retailing2011，，： | 1 |
| 20 | The Future of Public Space: Beyond Invented Streets and Reinvented Places显示文摘 | Tridib Banerjee | 2001 | Journal of the American Planning Association2001，，1： | 1 |
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