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| 1 | Extremely well-differentiated adenocarcinoma of the stomach: Clinicopathological and immunohistochemical features显示文摘瞄准:否则作为极其区分得好的腺癌(EWDA ) 知道,子宫的宫颈的最小的偏差癌被它的良性的显微镜的外观与它的好攻击的行为相对照描绘。以便阐明 clinicopathological 特征和 EWDA 的胃的对应物的生物行为,用免疫组织化学,我们为联系 oncogene 的产品的表型的表示,增生的活动,和表示分析了九损害。方法:包括外科手术前的活体检视诊断, Clinicopathological 特征被考察。用免疫组织化学,在胃的损害把 p53 和 c-erbB-2 蛋白质的索引和表示标记的 Ki-67 被检测。结果:在中间的地点或上面第三个胃和水虫息似的宏观的特征胃的 EWDA 是特征的。尽管 9 损害中的 4 个显示出仅仅焦点的淋巴或静脉的侵略,淋巴节点转移不是现在,任何一个都没损害死于病人(吝啬的后续时期, 56 瞬间) 。EWDA 的所有 9 个盒子能被分类进胃的显型(5 损害) 和肠的显型(4 损害) 。以前的类似于的胃的小凹的上皮,颈部粘液细胞或幽门的腺,而是他们的乳突的结构经常被伸长,肿瘤房间和他们的原子核稍微更大并且更亢奋与正常上皮相比色彩。后者与最小的原子非典型和不规则的腺类似于肠的组织变形;二这些损害表明了完全的肠的显型,当二表明了不完全的肠的显型时。把索引标记的 Ki-67 是低的,任何一个都没盒子揭示 p53 和 c-erbB-2 蛋白质的在表示上。结论:不同于宫颈的最小的偏差癌,这些调查结果建议胃的 EWDA 是低档恶意的损害。这有利生物行为被把索引和 p53 或 c-erbB-2 蛋白质在表示上的缺乏标记的低 Ki-67 的数据支持。因为它到有肠的组织变形的正常胃粘膜或粘膜的相似, EWDA 经常被误诊。阻止如此的损害的错误诊断,临床、病理学的特征应该被考虑。 | Takashi Yao Takashi Utsunomiya Masafumi Oya Kenichi Nishiyama Masazumi Tsuneyoshi | 2006 | World Journal of Gastroenterology2006，12，16： | 16 |
| 2 | Impact of obesity on the surgical outcome following repeat hepatic resection in Japanese patients with recurrent hepatocellular carcinoma显示文摘AIM: To evaluate the impact of obesity on the posto- perative outcome after hepatic resection in patients with hepatocellular carcinoma (HCC). METHODS: Data from 328 consecutive patients with primary HCC and 60 patients with recurrent HCC were studied. We compared the surgical outcomes between the non-obese group (body mass index: BMI < 25 kg/m2) and the obese group (BMI ≥ 25 kg/m2). RESULTS: Following curative hepatectomy in patients with primary HCC, the incidence of postoperative complications and the long-term prognosis in the non- obese group (n = 240) were comparable to those in the obese group (n = 88). Among patients with recurrent HCC, the incidence of postoperative complications after repeat hepatectomy was not significantly different between the non-obese group (n = 44) and the obese group (n = 16). However, patients in the obese group showed a significantly poorer long-term prognosis than those in the non-obese group (P < 0.05, five-yearsurvival rate; 51.9% and 92.0%, respectively). CONCLUSION: Obesity alone may not have an adverse effect on the surgical outcomes of patients with primary HCC. However, greater caution seems to be required when planning a repeat hepatectomy for obese patients with recurrent HCC. | Tohru Utsunomiya Masahiro Okamoto Toshihumi Kameyama Ayumi Matsuyama Manabu Yamamoto Megumu Fujiwara Masaki Mori Shiomi Aimitsu Teruyoshi Ishida | 2008 | World Journal of Gastroenterology2008，14，10： | 10 |
| 3 | Commissioning of laser electron gamma beamline SLEGS at SSRF显示文摘The Shanghai Laser Electron Gamma Source(SLEGS)is a powerful gamma source that provides MeV gamma-ray beams for nuclear science and technology.It was developed as one of the 16 beamline stations in the Phase Ⅱ Project of the Shanghai Synchrotron Radiation Facility.The slant-scattering mode is for the first time systematically employed in laser Compton scattering at SLEGS to produce energy-tunable quasi-monoenergetic gamma-ray beams.The SLEGS officially completed its commissioning from July to December 2021.Gamma rays in the energy range of 0.25-21.7 MeV with a flux of 2.1×10^(4)-1.2×10^(7) photons/s and an energy spread of 2-15% were produced during the test.This paper reports the results from commissioning the SLEGS beamline. | Hong-Wei Wang Gong-Tao Fan Long-Xiang Liu Hang-Hua Xu Wen-Qing Shen Yu-Gang Ma Hiroaki Utsunomiya Long-Long Song Xi-Guang Cao Zi-Rui Hao Kai-Jie Chen Sheng Jin Yu-Xuan Yang Xin-Rong Hu Xin-Xiang Li Pan Kuang | 2022 | Nuclear Science and Techniques2022，33，7： | 8 |
| 4 | Computer Predictions and Experimental Verification of Residual Stresses and Distortion in Carburizing-Quenching of Steel显示文摘In this paper, the carburizing-quenching process of carbon steel is analyzed with computer simulation which is based on the metallo-thermo-mechanical theory and finite element analysis coupled temperature, phase transformation and stress/strain fields. The residual stresses and distortion of a steel cylinder during carburizing quenching process were predicted and compared with experimental data. From the prediction results, improvement of hardness and strength of the cylinder component in carburizing-quenching process was verified. | Dong- Ying Ju, Michiharu Narazaki , Hirofumi Kamisugi , Haruyoshi Hirano 1 . Department of Mechanical Engineering, Saitama Institute of Technology, Saitama, Japan 2 . Department of Mechanical Systems Engineering, Utsunomiya University, Utsunomiya, Japan 3 | 2000 | Journal of Shanghai Jiaotong university(Science)2000，5，1： | 4 |
| 5 | Regulation of catecholamine synthesis by Leptin显示文摘 | Shibuya I Utsunomiya K ToyohI-Ra Y | 2002 | Ann N Y Acad Sci2002，971，52： | 2 |
| 6 | Glycosylation engineering of therapeutic IgG antibodies: challenges for the safety, functionality and efficacy显示文摘IgG 的 Fc 区域的 Glycosylation 在安全和治疗学的抗体的临床的功效上有深刻影响。当复杂类型的 oligosaccharide 纳入了 Fc 的 Asn297 的 biantennary 为抗体受动器功能是必要的时,海藻糖和外部手臂的糖属于核心 heptasaccharide 产生结构的异质(glycoforms ) 展出唯一的生物活动。因此,有效、量的 glycan 分析技术为治疗学的抗体的发展和质量控制是日益重要的,并且 Fc 的 glycan 侧面作为批评优秀属性被认出。在过去的十年,我们 IgG-Fc 的结构 / 功能上的 glycosylation 的影响的理解通过 X 光检查结晶、原子的磁性的回声研究很快成长了,它为新奇抗体治疗学的设计提供可能性。而且,用基于 endoglycosidase 的 glycosynthases 的 chemoenzymatic glycoengineering 途径可以作为下一代的治疗学的抗体与理想的功能便于同类的 IgG glycoforms 的发展。因此, Fc glycans 是在精确药的时代的治疗学的 IgG 抗体的安全,功能,和功效的改进的肥沃的地面。 | Yusuke Mimura Toshihiko Katoh Radka Saldova Roisin O'Flaherty Tomonori Izumi Yuka Mimura-Kimura Toshiaki Utsunomiya Yoichi Mizukami Kenji Yamamoto Tsuneo Matsumoto Pauline M. Rudd | 2018 | Protein & Cell2018，9，1： | 2 |
| 7 | Pharmacological profile of hydroxy fasudil as a selective rho kinase inhibitor on ischemic brain damage显示文摘 | Shin-ichi Satoh Tatsuma Utsunomiya Kazuyuki Tsurui Teruki Kobayashi Ichiro Ikegaki Yasuo Sasaki Toshio Asano | 2001 | Life Sciences2001，，12： | 2 |
| 8 | Expression of survivin and bcl-2 in the normal human endometuium显示文摘 | Konno R Yamakawa H Utsunomiya H | 2000 | Mol Hum Reprod2000，6，6： | 2 |
| 9 | Synchronous rectal and esophageal cancer treated with chemotherapy followed by two-stage resection显示文摘We report a case of 61-year-old male who had synchronous advanced rectal cancer involving the urinary bladder massively associated with multiple liver metastases, and esophageal cancer successfully treated by neoadjuvant chemotherapy followed by two-stage resection. Although complete resection of each of the lesions was considered possible by performing anterior pelvic exenteration, liver resection, and esophagectomy, it might be impossible for the patient to endure the stress of all of these operative procedures at once. Therefore, we planned to perform staged treatment with prioritizing consideration. First, we instituted chemotherapy with the FOLFOX(oxaliplatin + fluorouracil + leucovorin) plus cetuximab regimen, which could adequately control both rectal and esophageal cancer. After 6 cycles of chemotherapy, high anterior resection combined with cystoprostatectomy and lateral segmentectomy plus partial hepatectomy was performed followed by staged esophagectomy with three-field lymph node dissection. It was possible to use oxaliplatin and cetuximab safely as neoadjuvant therapy not only for advanced rectal cancer but for esophageal cancer, and it was effective. | Setsuo Utsunomiya Keisuke Uehara Takuya Kurimoto Ken Hirose Masahide Fukaya Yu Takahashi Yoshiro Taguchi Keita Itatsu Masato Nagino | 2013 | World Journal of Clinical Cases2013，1，2： | 2 |
| 10 | Malignant Transformation Arising From Mature Cystic Teratoma of the Ovary: A Retrospective Study of 20 Cases显示文摘 | Michiko Sakuma Takeo Otsuki Kosuke Yoshinaga Hiroki Utsunomiya Satoru Nagase Tadao Takano Hitoshi Niikura Kiyoshi Ito Keiko Otomo Toru Tase Yoh Watanabe Nobuo Yaegashi | 2010 | International Journal of Gynecological Cancer2010，，5： | 2 |
| 11 | Elasto-Plastic Analysis of PC Girder with Corrugated Steel Web by an Efficient Beam Theory显示文摘 | Jean- Francois Bariant Tomoaki Utsunomiya Eiichi Watanabe | 2006 | Structure Engineering/Earthquake Engineering2006，，23： | 1 |
| 12 | Paclitaxel-platinum combination chemotherapy for advanced or recurrent ovarian clear cell adenocareinoma: a multicenter trial显示文摘 | Utsunomiya H Akahira J Tanno S | 2006 | Int J Gynecol Canc- er2006，16，1： | 1 |
| 13 | Expression of survivinand Bcl-2 in the normal human endometrium显示文摘 | Konno R Yaakawa H Utsunomiya H | 2000 | Mol Hum Re-prod2000，6，6： | 1 |
| 14 | Normal development of the pituitary galand: assessment with three-dimensional MR volometry 显示文摘 | Takano K Utsunomiya H Ono M | 1999 | AJNR1999，20，： | 1 |
| 15 | Active roller guide system for high-speed elevators显示文摘 | Utsunomiya K Okamoto K Yumura K | 2002 | Elevator World2002，50，4： | 1 |
| 16 | Neurophsiological and immunohistochemical studies on Guillain-Barre syndrome with IgG anti-GalNAc-GD1a antibodies-effects on neuromuscular transmission显示文摘 | Taguchi K Ren J Utsunomiya I | 2004 | Neurol Sci2004，225，12： | 1 |
| 17 | Aromatase in endometriosis and uterine leiomyomata 显示文摘 | Bulun SE Imir G Utsunomiya H | 2005 | J Steroid Biochem2005，95，： | 1 |
| 18 | Sphincter of Oddi Motility in Patients with Hepatolithiasis and Common Bile Duet Stones显示文摘 | Kuo K K Utsunomiya N Nabae T | 2000 | Dig Dis Sci2000，45，9： | 1 |
| 19 | Gas chromatography of race earth chela- tes of isobutyrylpivalylmethane 显示文摘 | Utsunomiya K | 1972 | Analytica Chimica Acta1972，59，1： | 1 |
| 20 | Gastrointestinal Stromal Tumors: Are They of Cajal Cell Origin?显示文摘 | Xiaojuan Wang Ichiro Mori Weihua Tang Hirotoshi Utsunomiya Misa Nakamura Yasushi Nakamura Genying Zhou Kennichi Kakudo | 2002 | Experimental and Molecular Pathology2002，，2： | 1 |
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