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| 1 | Applications of phototheranostic nanoagents in photodynamic therapy显示文摘Nanotherapeutics 在象癌症那样的疾病的治疗有一个增加的角色。在光力学的治疗(太平洋夏季时间) ,治疗学地不活跃的 photosensitizer 混合物被光有选择地激活生产能够杀死 diseased 房间和病原体的分子。一个 phototheranostic 代理人能为指向的交货,光成像和疾病的光力学的治疗与能力被定义为单个 nanoentity。恶意的房间,纸巾和微生物引起的 etiologic 代理人能被太平洋夏季时间有效地指向。光力学的治疗是 noninvasive,或最低限度地侵略,并且当健康织物的损坏被最小化,杀死的效果是局部性的,有很少副作用。癌症,粉刺和另外的疾病的各种各样的形式可以被对待。在里面 photosensitizers 的 vivo 功效被把他们纳入能够指向 diseased 地点的 nanostructures 进一步改进。如此的 photosensitizer-functionalized nanostructures,或 nanotherapeutics,为改进 phototheranostic 性能允许成像和治疗学的代理人的地点特定的交货。这评论在诊断和治疗探索 phototheranostic nanostructures 的潜在的应用。 | Jayeeta Bhaumik Amit Kumar Mittal Avik Banedee Yusuf Chisti Uttam Chand Banerjee | 2015 | Nano Research2015，8，5： | 8 |
| 2 | Gastro-retentive drug delivery systems and their in vivo success:A recent update显示文摘Gastro-retentive drug delivery system(GRDDS) has gained immense popularity in the field of oral drug delivery recently. It is a widely employed approach to retain the dosage form in the stomach for an extended period of time and release the drug slowly that can address many challenges associated with conventional oral delivery, including poor bioavailability.Different innovative approaches like magnetic field assisted gastro-retention, plug type swelling system, muco-adhesion technique, floating system with or without effervescence are being applied to fabricate GRDDS. Apart from in vitro characterization, successful GRDDS development demands well designed in vivo study to establish enhanced gastro-retention and prolonged drug release. Gama scintigraphy and MRI are popular techniques to evaluate in vivo gastric residence time. However, checking of their overall in-vivo efficacy still remains a major challenge for this kind of dosage form, especially in small animals like mice or rat.Reported in vivo studies with beagle dogs, rabbits, and human subjects are only a handful in spite of a large number of encouraging in vitro results. In spite of the many advantages,high subject variations in gastrointestinal physiological condition, effect of food, and variable rate of gastric emptying time are the challenges that limit the number of available GRDDS in the market. This review article highlights the in vivo works of GRDDS carried out in the recent past, including their limitations and challenges that need to be overcome in the near future. | Uttam Kumar Mandal Bappaditya Chatterjee Faria Gias Senjoti | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，5： | 3 |
| 3 | Long-term soil management effects on crop yields and soil quality in a dryland Alfisol显示文摘 | Sharma K L Uttam Kumar Mandal Srinivas K | 2005 | Soil and Tillage Research2005，83，： | 1 |
| 4 | 闪光对于减轻静脉置管痛的作用:一项前瞻性随机安慰剂对照研究显示文摘背景尽管静脉置管时的疼痛经常让人备受困扰,但通常都是在没有任何镇痛措施下进行静脉置管的。临床上曾尝试用一些药物和非药物方法来减轻静脉置管的疼痛,但结果各异。本研究拟评价一次闪光对于减轻静脉置管痛的效果。方法90例拟择期行腹腔镜胆囊切除术的ASAⅠ~Ⅱ级的成年患者(15~60岁),随机分为3组,每组30例,组1为对照组;组2为分散注意力组,即在非优势手的手背静脉进行置管前给患者照相而不使用闪光;组3为闪光组,静脉置管前照相并且使用闪光;在照相后立即使用18G的穿刺针进行静脉置管。结果每组均有2例患者首次静脉穿刺失败,在数据分析中即予以剔除,闪光组疼痛的发生率为50%(28例中14例发生),其他2组为100%(28例全部发生),通过视觉模拟评分评估的疼痛严重程度分散注意力组和闪光组显著低于对照组,而闪光组也显著低于分散注意力组。结论静脉置管前使用闪光是一种减轻疼痛的安全而简单有效的方法。 | Anil Agarwal GhanshvamYadav Devendra Gupta Manish Tandon Prabhat Kumar Singh Uttam Singh 吴志林(译) | 2009 | 麻醉与镇痛2009，，3： | 1 |
| 5 | Mapping of resistance to spot blotch disease caused by Bipolaris sorokiniana in spring wheat显示文摘 | UTTAM KUMAR ARUN K JOSHI SUNDEEP KUMAR | 2009 | Theor Appl Genet2009，，118： | 1 |
| 6 | Status of groundwater arsenic contamination in Bangladesh: A 14-year study report显示文摘 | Dipankar Chakraborti Mohammad Mahmudur Rahman Bhaskar Das Matthew Murrill Sankar Dey Subhas Chandra Mukherjee Ratan Kumar Dhar Bhajan Kumar Biswas Uttam Kumar Chowdhury Shibtosh Roy Shahariar Sorif Mohammad Selim Mahmuder Rahman Quazi Quamruzzaman | 2010 | Water Research2010，，19： | 1 |
| 7 | Impact of anthropogenic disturbance on species diversity and vegetation structure of a lowland tropical rainforest of eastern Himalaya, India显示文摘Impact of anthropogenic disturbance on species diversity and vegetation structure of a lowland tropical rainforest was studied in the foothills of Eastern Himalaya, India. Tree species richness,density, basal area and the diversity indices were found significantly(P<0.05) decreased with the increasing level of disturbances whereas, shrub density, basal area and herb density significantly increased with increasing disturbance level. In case of shrubs, Simpson's dominance index significantly(P<0.007) increased along the disturbance gradient,whereas Pielou's evenness index significantly(P<0.005) decreased with an increasing level of disturbance. Shannon-Weiner diversity index for herbs significantly(P<0.016) increased with increasing disturbance whereas, Simpson's dominance index was significantly(P<0.013) declined along the disturbance gradient. Results revealed that10-50 cm dbh classes constituted the highest stem density, and highest basal area was recorded in the >100 cm dbh class in all three sites. Density of the matured trees decreased with increasing DBH whereas, tree basal area tended to increase with increasing DBH in all three sites. Tree species richness was highest in the lower DBH classes.62.07% of the total tree species regenerated in the largely undisturbed site followed by 50% in the mildly disturbed and 26.32% in the highly disturbed site.The overall regeneration condition was found to be good in the largely undisturbed site. Mildly disturbed site exhibited fair regeneration and so was in the highly disturbed site. Discernable variations in species composition, diversity, regeneration and tree population structure revealed the impact of anthropogenic disturbances on rainforest vegetation dynamics. Higher degree of disturbance was furtherly found not only affecting species diversity but also promoting the growth of invasive weed species.Dominance of Hydnocarpus kurzii and Crypteronia paniculata in the highly disturbed site also indicated that these less-valued timber species may benefit from the vegetation mosaic produced by the disturbance; so differences in abundance of these species may be useful for bio-indication. Furthermore,present study suggests the need of adequate biodiversity conservation measures and adaptation of sustainable forest management approaches in disturbed areas of lowland tropical rainforest in the foothills of eastern Himalaya, India. | Anudip GOGOI Uttam Kumar SAHOO | 2018 | Journal of Mountain Science2018，15，11： | 1 |
| 8 | Mass distribution in the falling stream of burden materials显示文摘 | Samik NAG Mriganshu GUHA Subhashis KUNDU Subhash Kumar SINHA Uttam SINGH | 2008 | ISIJ International2008，48，9： | 1 |
| 9 | Reconstruction of chronic acromioclavicular joint disruption with artificial ligament prosthesis显示文摘Rockwood 类型 3 acromioclavicular 混乱的 ObjectiveManagement 是争论的一件事。我们起初应该采用保守或起作用的措施表示吗?它不是清楚的,但是大多数证据赞成保守管理。我们在场我们在管理长期的 Rockwood 类型 3 acromioclavicular 关节混乱的八个盒子的一个未来的系列通过手术对待的在场的这些病人 surgically.MethodsWe 的经验。coracoclavicular 系带的解剖重建被病人是的人工的编织聚酯系带 prosthesis.ResultsAll 做能从第 14 手术后的天的一般水准执行每日的活动。所有病人疼痛地感到了改进,与在平均视觉类似物规模从的减少外科手术前到 2.0 个点(范围 0-5 点) 的 6.5 个点(范围 3-9 点) ,从 59% ~ 91% 的经常的分数和美国肩膀和肘外科医生手术后地从 65 ~ 93 个点承担 20。改进或至少在中间的后续上仍然保持静止的这些结果,和没有恶化在人工的系带修复术的 46 months.ConclusionThis 期中考试结果分析的平均后续被记录是有修复术的第一如此的后续研究。我们的结果是令人鼓舞的并且认为这种相对新、容易可再现的技术的进一步的使用和评估正当。 | Devendra Kumar Chouhan Uttam Chand Saini Mandeep Singh Dhillon | 2013 | Chinese Journal of Traumatology2013，16，4： | 1 |
| 10 | Identification of a Cd accumulator Conyza canadensis显示文摘 | Shuhe Wei Qixing Zhou Uttam Kumar Saha Hong Xiao Yahu Hu Liping Ren Gu Ping | 2008 | Journal of Hazardous Materials2008，，1： | 1 |
| 11 | Colloid-facilitated Pb transport in two shooting-range soils in Florida显示文摘 | Xianqiang Yin Bin Gao Lena Q. Ma Uttam Kumar Saha Huimin Sun Guodong Wang | 2009 | Journal of Hazardous Materials2009，，： | 1 |
| 12 | Discount pricing policy for deteriorating items under preservation technology cost and shortages显示文摘This paper presents an inventory model with a constant rate of deterioration of the product,and shortages are allowed at the end of the cycle.The stock-dependent and price-sensitive demand have been considered with a policy of providing price discount to uplift the market demand.Preservation technology is applied to preserve the items from deterioration.The objective of this model is to maximize the total profit function by finding the optimal replenishment time,the optimal preservation technology investment and the optimal quantity.Next,we have shown that the total profit is a concave function of the replenishment time and preservation technology cost.Discount in pricing may be offered at a time of festival,season breaks down,lockdown and clearance of stock,before introducing a new product with up-gradations,etc.Numerical examples and graphical analysis are provided to explain the model.The discount policy could help any business organizations for smooth running of the business and obtain respective optimal profit. | Anubhav Namdeo Uttam Kumar Khedlekar Priyanka Singh | 2020 | Journal of Management Analytics2020，7，4： | 1 |
| 13 | Changes in soil hydraulic conductivity, runoff, and soil loss due to irrigation with different types of saline–sodic water显示文摘 | Uttam Kumar Mandal A.K. Bhardwaj D.N. Warrington Dina Goldstein A. Bar Tal G.J. Levy | 2008 | Geoderma2008，，3： | 1 |
| 14 | Long-term soil management effects on crop yields and soil quality in a dryland Alfisol显示文摘 | K.L. Sharma Uttam Kumar Mandal K. Srinivas K.P.R. Vittal Biswapati Mandal J. Kusuma Grace V. Ramesh | 2004 | Soil & Tillage Research2004，，2： | 1 |
| 15 | Identification,isolation and characterization of new impurity in rabeprazole sodium显示文摘 | P Sreenivasa Rao Uttam Kumar Ray P Badarinadh Gupta | 2010 | J Pharm Biom Analysis2010，52，4： | 1 |
| 16 | Elemental variations in glacier cryoconites of Indian Himalaya and Spitsbergen,Arctic显示文摘Cryoconite samples were collected from two different climatic domains i.e.,the Sutri Dhaka glacier,western Himalaya India and Svalbard glaciers,the Spitsbergen,Arctic,to understand the elemental source and elemental deposition patterns.The data of geochemical analysis suggest that the Himalayan cryoconite samples accumulate higher concentrations as compared to the cryoconite samples of the Arctic glaciers.The concentration of lithophile elements(Cs,Li,Rb and U)was recorded higher in the cryoconite holes of the Himalayas,especially,in the lower to the higher parts of the glacier,whereas,lower concentrations were recorded in the Arctic samples.Chalcophile elements in the Himalayan cryoconites are enriched in As and Bi while the Arctic cryoconite samples show a higher concentration of Bi,Pb and As.The higher concentrations are responsible for influencing the ecosystem and in human health related issues.Siderophile elements(Co,Fe,Mn and Ni)show high concentrations in the Himalayan samples,whereas,the Arctic samples show minor variations and low elemental concentration in these elements,respectively.In addition,a few elements,such as Ag,Mg,and Ca show higher concentration in the Himalayan glacier samples.Ca also occurs in high concentrations in Arctic glacier samples.R-mode factor analysis of the Himalayas(Arctic)samples indicate that the elements are distributed in four(three)factors,explaining 89%(90%)of the variance in their elemental distribution.The Factor 1 suggests statistically significant positive loadings for most of the lithophile,chalcophile and siderophile elements of the 'Himalayan' and the Arctic cryoconite samples.The sample-wise factor score distribution shows a considerable variation in the sampling locations along the glaciers of both the regions.Factors 2 and 3,demonstrate insignificant loading for most of the elements,except statistically significant positive loading in some of the elements of the both,Himalayan and Arctic 'cryoconites'.The higher elemental concentration in the cryoconites of the Himalayan region may be an indicator of the natural processes and/or attributed to the rapid industrialization in the Asian countries. | Shiv Mohan Singh Kumar Avinash Parmanand Sharma Ravindra Uttam Mulik Ajay Kumar Upadhyay Rasik Ravindra | 2017 | Geoscience Frontiers2017，8，6： | 1 |
| 17 | An Assessment of Yarsagumba(Ophiocordyceps sinensis) Collection in Dhorpatan Hunting Reserve, Nepal显示文摘Yarsagumba(Ophiocordyceps sinensis), an endemic species to the Himalayas and Tibetan Plateau, is one of the most valuable medicinal mushrooms in the world. In Nepal, it is distributed largely in isolated patches of alpine grasslands of 3,000-5,000 m elevation. Although it is reported from 27 northernmost districts of Nepal, the local distribution pattern of this species is largely unknown.Furthermore, the collection system and local management regime of this species are not well documented. We conducted a field survey at Dhorpatan Hunting Reserve(DHR) among the different stakeholders in January-June 2012 to assess collection sites, patterns and trends and to understand the management regime. We estimated that about 75 kg of Yarsagumba is collected every year from DHR and the amount has been declining since 2008. To manage the resource, locals have initiated regulating the collection by issuing permits, taxing to the collectors, and monitoring the activities of harvesters with the help of park authorities. The revenue generated at local level from the permits has been used for community developmental activities. | Barna Bahadur THAPA Saroj PANTHI Rajesh Kumar RAI Uttam Babu SHRESTHA Achyut ARYAL Sabina SHRESTHA Bhushan SHRESTHA | 2014 | Journal of Mountain Science2014，11，2： | 1 |
| 18 | Minimization of Phenols and Phenolic Compounds in Pulp and Paper Industries: Biological Approaches显示文摘 | Manoj Kumar Ghosh Uttam Kumar Ghosh Samit Kumar | 2011 | Journal of Chemistry and Chemical Engineering2011，5，7： | 1 |
| 19 | Mathematical model of zika virus dynamics with vector control and sensitivity analysis显示文摘In this paper,we have developed and analyzed a deterministic Zika model considering both vector and sexual transmission route with the effect of human awareness and vector control in the absence of disease induce death.To formulate the model,we assume that the Zika virus is being first transmitted to human by mosquito bite,and then it is being transmitted to his or her sexual partner.The system contains at most three equilibrium points among them one is the disease free and other two are endemic equilibrium points,exists under certain conditions.The theoretical analysis shows that the diseases-free equilibrium is locally and globally asymptotically stable if the basic reproduction number is less than one.Theatrically we have established that endemic equilibrium point which is locally asymptotically stable if the basic reproduction number is greater than one.The system exhibits backward bifurcation when the transmission probability per biting of susceptible mosquito with infected humans crosses the critical value.We estimate the model parameters and validate the model by fitting the model with the reported Zika infected human data from 1 to 36 week of 2016 Zika outbreak in Colombia.Furthermore,using the normalised forward sensitivity index method we have established that the model parameter mosquito biting rate,recruitment rate of mosquito,transmission probability per biting of Susceptible(infected)humans with infected(susceptible)mosquito,rate of awareness in host population,recovery rates of infected human are most sensitive parameters of the considered Zika model.Lastly,some conclusions are given to control the spreading of the Zika disease. | Sudhanshu Kumar Biswas Uttam Ghosh Susmita Sarkar | 2020 | Infectious Disease Modelling2020，5，1： | 1 |
| 20 | Colloid-facilitated Pb transport in two shooting-range soils in Florida显示文摘 | Xianqiang Yin Bin Gao Lena Q. Ma Uttam Kumar Saha Huimin Sun Guodong Wang | 2009 | Journal of Hazardous Materials2009，，1： | 1 |
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