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| 1 | A growing field: the regulation of axonal regeneration by Wnt signaling显示文摘The canonical Wnt/β-catenin pathway is a highly conserved signaling cascade that plays critical roles during embryogenesis. Wnt ligands regulate axonal extension, growth cone guidance and synaptogenesis throughout the developing central nervous system(CNS). Recently, studies in mammalian and fish model systems have demonstrated that Wnt/β-catenin signaling also promotes axonal regeneration in the adult optic nerve and spinal cord after injury, raising the possibility that Wnt could be developed as a therapeutic strategy. In this review, we summarize experimental evidence that reveals novel roles for Wnt signaling in the injured CNS, and discuss possible mechanisms by which Wnt ligands could overcome molecular barriers inhibiting axonal growth to promote regeneration. A central challenge in the neuroscience field is developing therapeutic strategies that induce robust axonal regeneration. Although adult axons have the capacity to respond to axonal guidance molecules after injury, there are several major obstacles for axonal growth, including extensive neuronal death, glial scars at the injury site, and lack of axonal guidance signals. Research in rodents demonstrated that activation of Wnt/β-catenin signaling in retinal neurons and radial glia induced neuronal survival and axonal growth, but that activation within reactive glia at the injury site promoted proliferation and glial scar formation. Studies in zebrafish spinal cord injury models confirm an axonal regenerative role for Wnt/β-catenin signaling and identified the cell types responsible. Additionally, in vitro and in vivo studies demonstrated that Wnt induces axonal and neurite growth through transcription-dependent effects of its central mediator β-catenin, potentially by inducing regeneration-promoting genes. Canonical Wnt signaling may also function through transcription-independent interactions of β-catenin with cytoskeletal elements, which could stabilize growing axons and control growth cone movement. Therefore, these studies suggest that Wnt-induced pathways responsible for regulating axonal growth during embryogenesis could be repurposed to promote axonal growth after injury. | Armando L. Garcia Adanna Udeh Karthik Kalahasty Abigail S. Hackam | 2018 | Neural Regeneration Research2018，13，1： | 10 |
| 2 | Screening of ethyl acetate extract of Bridelia micrantha for hepatoprotective and anti-oxidant activities on Wistar rats显示文摘Objective:To explore the hepatoprotective and anti-oxidant activities of the methanolic leaf extract of Bridelia micrantha(B.micrantha) on paracetamol induced liver damage in Wistar rats. Methods:Parameters were measured including alanine aminotransaminase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP),bilirubin and total protein.The anti-oxidant effects were studied using the 1,l-Diphenynl-2-Picrylhydrazyl(DPPH) and Ferric Reducing Antioxidant Power(FRAP) assay methods.Results:B.micrantha extract decreased the level of AST in the rats given PCM from(129.47±0.921) IU/L to(57.78±1.71) IU/L(P<0.05).This was lower than the value for Silymarin which was(59.92±1.41) IU/L.ALT concentration was reduced from (150.18±2.23) IU/L to(79.10±2.01) IU/L(P<0.05).ALP was reduced from(49.86±0.85) IU/L to(29.64±1.53) IU/L(P<0.05).Total bilirubin was reduced from(2.14±0.10 mg/dL) to(0.18±0.07) mg/dL (P<0.05) while total protein was increased from(4.26±0.30) mg/dL to(6.20±0.19) mg/dL(P<0.05). Concentrations ranging from 10 - 400μg/mL of B.micrantha were assayed for antioxidant activities.The DPPH assay showed 98%antioxidant activity at concentration of 400μg/mL. The FRAP values were 0.016,0.39,0.455,0.601 and 1.382μM at 10.50,100,200 and 400μg/ mL respectively.Conclusions:Results suggest that B.micrantha has hepatoprotective and anti oxidant potentials.However,further work involving fractionation needs to done to isolate the active compound responsible for the hepatoprotective activity. | Nwaehujor Chinaka O Udeh Nkeiruka E | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，10： | 4 |
| 3 | Antidiarrhoeal activity of leaf methanolic extract of Rauwolfia serpentina显示文摘Objective:To evaluate the antidiarrhoeal property of methanol extract of the leaves of Rauwolfia serpentina(R. serpentina) in experimental diarrhoea induced by castor oil in mice.Methods:Doses of 100, 200 and 400 mg/kgR. serpentinaleaf methanol extracts were administered to castor oil induced diarrhoea mice to determine its antidiarrhoeal activity.Results:All doses of the extract and the reference drug atropine sulphate(3 mg/kg, i.p.) produced a dose-dependent reduction in intestinal weight and fluid volume. The extracts also significantly reduced the intestinal transit in charcoal meal test when compared to diphenoxylate Hcl(5 mg/kg, p.o.).Conclusions:The results show that the extract of R. serpentin a leaves has a significant antidiarrhoeal activity and supports its traditional uses in herbal medicine. | Ezeigbo II Ezeja MI Madubuike KG Ifenkwe DC Ukweni IA Udeh NE Akomas SC | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，6： | 4 |
| 4 | Antidiarrheal activity of Pterocarpus erinaceus methanol leaf extract in experimentally-induced diarrhea显示文摘Objective:To investigate the antidiarrheal activity of the methanol leaf extract of Pterocarpus erinaceus in vivo.Methods:The methanol leaf extract of Ptemcarpus erinaceus was evaluated using different doses(100,200 and 400 mg/kg body weight) orally for antidiarrheal activity using castor oil-induced diarrhea,charcoal meal transit lime and castor oil-induced enteropooling in different groups of albino Wistar mice.The activity of the extract at different doses were compared to diphenoxylate(3 mg/kg) and atropine sulphate(3 mg/kg) which were used as standard reference drugs and also to the distilled water administered negative control group of mice.Results:The extract at the doses used caused a significant(P< 0.01) reduction in the wet faeces passed by the mice in the castor oil-induced diarrhea,decreased the distance travelled by the charcoal meal by up to 54.8%and also caused a dose dependent and significant(P< 0.001) reduction in the intraluminal fluid accumulation in the castor oil-induced enteropooling. Conclusions:Our results indicate that Pterocarpits erinaceus extract produced significant antidiarrheal activity and the action may attribute to inhibition of gastrointestinal movement and fluid secretion. | Ezeja Maxwell I Ezeigbo Ihechiluru I Madubuike Kelechi G Udeh Nkiru E Ukweni Iheanacho A Akomas Stella C Ifenkwe Daniel C | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，2： | 3 |
| 5 | Dry eye disease:preva- lence,distribution and determinants in a hospital - based popula- tion显示文摘 | Onwubiko S N Eze B I Udeh N N | 2014 | Cont Lens Anterior Eye2014，37，3： | 1 |
| 6 | The 2-year cost-effectiveness of 3 options to treat lumbar spinal stenosispatients 显示文摘 | Udeh B L Costandi S Dalton JE | 2015 | Pain Pract2015，15，2： | 1 |
| 7 | Interleukin-1 receptor antago- nist reverses stroke-associated peripheral immune suppression显示文摘 | Smith CJ1 Emsley HC Udeh CT | 2012 | Cy- tokine2012，58，3： | 1 |
| 8 | High-glutathione containing yeast Saccharomyces cerevisiae: optimiTation of production显示文摘 | UDEH K O ACHREMOWICZ B | 1997 | Actamicrobial Pol1997，46，： | 1 |
| 9 | High glulathione containing yeast Saccharamyces cerevisiae : optimization of production 显示文摘 | Udeh K O Achremowicz B | 1997 | Acta Microbiol Pol1997，46，： | 1 |
| 10 | High-glutathione containing yeast :Optimizationof production显示文摘 | UDEH K O ACHREMOWICZ B | 1997 | Acta Microbiol Pol1997，46，1： | 1 |
| 11 | Pathogenic mechanisms of Trypanosoma evansi infections显示文摘 | Nathan Habila Mairo H. Inuwa Idowu A. Aimola Michael U. Udeh Emmanuel Haruna | 2011 | Research in Veterinary Science2011，，： | 1 |
| 12 | Severe methemoglobinemia on reexposure to benzocaine显示文摘 | Udeh C Bittikofer J Sum Ping S T | 2001 | J Clin Anesth2001，13，2： | 1 |
| 13 | Primary and secondary prevention of heart failure with statins显示文摘 | Udeh JA Ray JG | 2006 | Expert Rev Cardiovasc Ther2006，4，6： | 1 |
| 14 | lnterleukin l receptor an- tagonist reverses stroke-associated peripheral immune suppression 显示文摘 | Smith CJ Emsley HC Udeh CT | 2012 | Cytokine2012，58，3： | 1 |
| 15 | Transperineal versus transrectal prostate biopsy: Our findings in a tertiary health institution显示文摘 | E Udeh O Amu I Nnabugwu OFN Ozoemena | 2015 | Nigerian Journal of Clinical Practice2015，，1： | 1 |
| 16 | Primary and seconaary prevention of heart failure with stafins显示文摘 | UdeH JA Ray JG | 2006 | Expert Rev Cardiovasc Ther2006，4，6： | 1 |
| 17 | Interleukin-1 receptor antagonist reverses stroke-associated peripheral immune suppression 显示文摘 | Smith C J Emsley H C Udeh C T | 2012 | Cytokine2012，58，3： | 1 |
| 18 | High-glutathione containing yeast: optimization of production显示文摘 | Udeh K O Achremowicz B | 1997 | Acta Microbiol Pol1997，46，1： | 1 |
| 19 | Prineipal component analysis of body me- asurements in three strains of Broiler chicken显示文摘 | Udeh I Ogbu C C | 2011 | Science World Journal2011，6，2： | 1 |
| 20 | Transperineal versus transrectal prostate biopsy: our findings in a tertiary health institution显示文摘 | Udeh EI Ainu OC Nnabugwu II | 2015 | Niger J Clin Pract2015，18，1： | 1 |
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