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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Extracellular Ca2+stimulates the activation of mitogen-activated protein kinase and cell growth in human fibroblast显示文摘 | Shixia H Veronica M Justin M | | 0，，： | 1 |
| 3 | Excitotoxic damage,disrupted energy metabolism,and oxidative stress in the rat brain:antioxidant and neuroprotective effects of L-carnitine显示文摘 | DANIELA S A VERONICA P D C MARA N H M | 2008 | Jonrnal of Neurochemistry2008，105，： | 1 |
| 4 | High frequency hearing loss correlated with mutations in the GJB2 gene显示文摘 | Stephen A Wilcox Kerryn Saunders Amelia H Osborn Angela Arnold Julia Wunderlich Therese Kelly Veronica Collins Leah J Wilcox RJ McKinlay Gardner Maria Kamarinos Barbara Cone-Wesson Robert Williamson Hans-Henrik M. Dahl | 2000 | Human Genetics2000，，4： | 1 |
| 5 | Human cytomegalovirus infection leads to accumulation of geminin and inhibition of the licensing of cellar DNA replication 显示文摘 | Nilma B Veronica S Deborah H | 2003 | J Virol2003，77，4： | 1 |
| 6 | Effective induction of HIV-specific CTL by multi-epitope using gene gun in a combined vaccination regime显示文摘 | Tomas H Veronica C Neuman N | 1999 | vaccine1999，17，： | 1 |
| 7 | Human cytomegalovirus infection leads to accumulation of Geminin and inhibition of cellular DNA replication显示文摘 | Nilima B Veronica S Deborah H | 2003 | J Virol2003，77，4： | 1 |
| 8 | Accounting for spatial var-iability in field experim ents on tea Experim ental显示文摘 | PEIRIS T U S SAMITA S VERONICA W H D | 2008 | Agriculture2008，44，4： | 1 |
| 9 | The active badge location system显示文摘 | Roy W Andy H Veronica F | 1992 | ACM Transaction on Information Systems1992，10，1： | 1 |
| 10 | Olfactory responses of A naphes iole ( Hymenoptera : Mymaridae)to volatile signals derived from host habitats显示文摘 | Veronica M Walker A J Livy H W | 2005 | Journal of Insect Behavior2005，18，1： | 1 |
| 11 | The Hydration of Formic Acid显示文摘 | Paul E H Veronica V | 2002 | J Phys Chem A2002，106，： | 1 |
| 12 | Biocatalytic oxidation of fuel as an alternadve to biodesulfurization显示文摘 | Marcela A Raunel T Veronica H | 1998 | Fuel Processing Technology1998，57，： | 1 |
| 13 | Interactions of Acetobacter diazotrophicus with an amylolytie yeast in nitrogen-free batch culture显示文摘 | ENIO H C VERONICA M R ANA C G S JOHANNA D | 1993 | FEMS Microbiol Leters1993，106，： | 1 |
| 14 | High frequency hearing loss correlated with mutations in the GJB2 gene显示文摘 | Stephen A Wilcox Kerryn Saunders Amelia H Osborn Angela Arnold Julia Wunderlich Therese Kelly Veronica Collins Leah J Wilcox RJ McKinlay Gardner Maria Kamarinos Barbara Cone-Wesson Robert Williamson Hans-Henrik M. Dahl | 2000 | Human Genetics2000，，4： | 1 |
| 15 | Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family显示文摘 | Druey K M Kendall J B Veronica H K | 1996 | Nature1996，379，： | 1 |
| 16 | A consistent attentional bias for drug-related material in active cocaine users across word and picture versions of the emotional Stroop task 显示文摘 | Robert H Veronica D Hugh G | 2006 | Drug Alcohol Depend2006，81，： | 1 |
| 17 | Understanding families in their owncontext:schizophrenia and structural family therapy in Beijing显示文摘 | Lawrence H Y Veronica J P | 2002 | Journal of Family Therapy2002，24，3： | 1 |
| 18 | Human Cytomegalovirus Infection Leads to Accumulation of Geminin and Inhibition of Cellular DNA Replication显示文摘 | Nilima B Veronica S Deborah H | 2003 | Virol2003，77，4： | 1 |
| 19 | Factors influencing the career choices of African American collegians: Implications for minority teacher recruitment 显示文摘 | Veronica H Shipp | 1999 | The Journal of Negro Education1999，68，3： | 1 |
| 20 | Biocatalytic oxidation of fuel as an alternative to biodesulfurization 显示文摘 | Marcela A Raunel T Veronica H | 1998 | Fuel Processing Technology1998，57，： | 1 |
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