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| 1 | Evaluation of VEGF gene polymorphisms and proliferative diabetic retinopathy in Mexican population显示文摘● AIM: To assess if the included vascular endothelial growth factor(VEGF) polymorphisms rs3025035, rs3025021 and rs2010963 are associated to proliferative retinopathy in a Mexican population with type 2 diabetes mellitus(T2DM).● METHODS: A case-control study was conducted in adult individuals with T2 DM associated to proliferative retinopathy or non-proliferative retinopathy from Oct. 2014 to Jun. 2015 from the Retina Department of the Asociation to Prevent Blindness in Mexico. The selected patients were adults with a diagnosis of T2 DM ≥5y. All subjects had a comprehensive ocular examination and the classification of the retinopathy severity was made considering the Early Treatment Diabetic Retinopathy Study(ETDRS) standardization protocols. Genomic DNA was extracted from whole fresh blood. All samples were genotyped by q PCR for selected VEGF polymorphisms. Hardy-Weinberg equilibrium was calculated by comparing Chi-square values between the expected and the observed values for genotype counts.● RESULTS: In total 142 individuals were enrolled, 71 individuals with T2 DM and associated proliferative retinopathy and 71 individuals with non-proliferative retinopathy. One-sided Fisher's exact test was performed for rs3025021[OR(95% CI)=0.44(0.08-2.2); P=0.25] and rs2010963 [OR(95% CI)=0.63(0.25-1.6); P=0.23]. The minor allelic frequencies obtained were 26% for rs3025021, 10% for rs3025035 and 61% for rs2010963. The pairwise linkage disequilibrium between the three SNP was assessed, and was as follows: rs3025021 vs rs3025035: D'=1.0, r^2=0.1043, P≤0.0001; rs3025021 vs rs2010963: D'=0.442, r^2=0.0446, P=0.149; rs3025035 vs rs2010963: D'=0.505, r^2=0.0214, P=0.142.● CONCLUSION: This is the first analysis involving VEGFA polymorphisms and proliferative diabetic retinopathy in a Mexican population. A major finding of the present study is that none of the polymorphisms studied was significantly associated with proliferative retinopathy. Based on these results, we can infer that different populations have different associations for the same polymorphisms. | Roberto Gonzalez-Salinas Maria C Garcia-Gutierrez Gerardo Garcia-Aguirre Virgilio Morales-Canton Raul Velez-Montoya Vidal R Soberon-Ventura Victoria Gonzalez Rodrigo Lechuga Pablo Garcia-Solis David G Garcia-Gutierrez Marco Vinicio Garcia-Solis Manuel Saenz de Viteri Juan C Solis-S | 2017 | International Journal of Ophthalmology(English edition)2017，10，1： | 12 |
| 2 | Multidisciplinary approach for patients with esophageal cancer显示文摘Patients with esophageal cancer have a poor prognosis because they often have no symptoms until their disease is advanced. There are no screening recommendations for patients unless they have Barrett's esophagitis or a significant family history of this disease. Often, esophageal cancer is not diagnosed until patients present with dysphagia, odynophagia, anemia or weight loss. When symptoms occur, the stage is often stage Ⅲ or greater. Treatment of patients with very early stage disease is fairly straight forward using only local treatment with surgical resection or endoscopic mucosal resection. The treatment of patients who have locally advanced esophageal cancer is more complex and controversial. Despite multiple trials, treatment recommendations are still unclear due to conflicting data. Sadly, much of our data is difficult to interpret due to many of the trials done have included very heterogeneous groups of patients both histologically as well as anatomically. Additionally, studies have been underpowered or stopped early due to poor accrual. In the United States, concurrent chemoradiotherapy prior to surgical resection has been accepted by many as standard of care in the locally advanced patient. Patients who have metastatic disease are treated palliatively. The aim of this article is to describe the multidisciplinary approach used by an established team at a single high volume center for esophageal cancer, and to review the literature which guides our treatment recommendations. | Victoria M Villaflor Marco E Allaix Bruce Minsky Fernando A Herbella Marco G Patti | 2012 | World Journal of Gastroenterology2012，18，46： | 9 |
| 3 | Heterogeneity in mouse spasmolytic polypeptide-expressing metaplasia lineages identifies markers of metaplastic progression显示文摘 | Victoria G Weis Josane F Sousa Bonnie J LaFleur Ki Taek Nam Jared A Weis Paul E Finke Nadia A Ameen James G Fox James R Goldenring | 2013 | Gut2013，，9： | 3 |
| 4 | The influence of post-harvest UV-C hormesis on lycopene, β-carotene, and phenolic content and antioxidant activity of breaker tomatoes显示文摘 | Sergio Bravo Javier García-Alonso Gala Martín-Pozuelo Victoria Gómez Marina Santaella Inmaculada Navarro-González María Jesús Periago | 2012 | Food Research International2012，，1： | 2 |
| 5 | Pain care显示文摘 | Victoria G | 2004 | Nurse Care North American2004，29，3： | 1 |
| 6 | Use of single point mutations in domain I of β2-glycoprotein I to determine fine antigenic specificity of antiphospholipid autoantibodies显示文摘 | Michael-Iverson G Reddel S Victoria EJ | 2002 | J Immunol2002，169，： | 1 |
| 7 | Atomic force microscopy investigation of human immunodeficiency virus (HIV) and HIV-infected lymphocytes显示文摘 | Kuznetsov Y G Victoria J G Robinson W E | 2003 | J Virol2003，77，11： | 1 |
| 8 | WooMapping of deletion and translocation breakpoints in 1@4 implicates the serine/ threonine kinase Akt3 in postnatal microcephaly and agenesis of the corpus callosum显示文摘 | Boland E Jill C S Victoria G | 2007 | Am J Hum Genet2007，81，2： | 1 |
| 9 | Strigolactone inhibition of shoot branching显示文摘 | Victoria G Soraya F Philip B | 2008 | Nature2008，455，： | 1 |
| 10 | pain care 显示文摘 | Victoria G | 1994 | Nurse Care North American1994，29，3： | 1 |
| 11 | Advances in understanding what we measure when detecting anticardiolipin autoantibodies显示文摘 | Michaelqverson G Victoria EJ Cockerill KA | 2004 | Clinica Chimica Acta2004，343，： | 1 |
| 12 | Increased inflammation in lysozyme M-deficient mice in response to Micrococcas luteus and its peptidoglycan显示文摘 | TOMAS G VICTORIA G HSIANG-I L | 2003 | Blood2003，101，9： | 1 |
| 13 | Dicaffeoyltartaric acid analogues inhibit human immunodeficiency virus type 1 ( HIV - 1 ) inte-grase and HIV - 1 replication at nontoxic concentrations 显示文摘 | REINKE R A KING P J VICTORIA J G | 2002 | J Med Chem2002，45，： | 1 |
| 14 | Pain care显示文摘 | Victoria G | 1994 | Nurse Care North American1994，29，3： | 1 |
| 15 | The Role of Brand Personality in Charitable Giving: An Assessment and Validation 显示文摘 | VENABLE B T ROSE G M VICTORIA D | 2005 | Journal of the Academy of Marketing Science2005，33，3： | 1 |
| 16 | Trace-based and geostatistical inversion of 3-D seismic data for thin-sand delineation- An application in San Jorge Basin, Argentina 显示文摘 | Torres- Verdin C Victoria M Merletti G | 1999 | The Leading Edge1999，，： | 1 |
| 17 | Pain care显示文摘 | Victoria G | 1994 | Nurse Care North American1994，29，3： | 1 |
| 18 | Pain care显示文摘 | Victoria G | 1994 | Nurse Care North American1994，29，3： | 1 |
| 19 | Ligand-dependent structural changes and limited pro- teolysis of Escherichia coli phosphofructokinase-2显示文摘 | RICARDO C VICTORIA G JENNIFER A | 2002 | Arch Bilchem Biophys2002，406，2： | 1 |
| 20 | Oxidativestress and inflammation,a link between chronickidney disease and cardiovascular disease 显示文摘 | Victoria C Marian G Soledad G | 2008 | Kid-ney Int2008，74，12： | 1 |
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