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| 1 | Abnormal activation of the synuclein-gamma gene in hepatocellular carcinomas by epigenetic alteration.显示文摘 | Zhao W Liu H Liu W Wu Y Chen W Jiang B Zhou Y Xue R Luo C Wang L Jiang JD Liu J | 2006 | 中国生物学文摘2006，20，4： | 31 |
| 2 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 3 | Measurement and Prediction of Insertion Force for the Mosquito Fascicle Penetrating into Human Skin显示文摘Mosquitoes are exceptional in their ability to pierce into human skin with a natural ultimate painless microneedle, namedfascicle. Here the structure of the Aedes albopictus mosquito fascicle is obtained using a Scanning Electron Microscope (SEM),and the whole process of the fascicle inserting into human skin is observed using a high-speed video imaging technique. Directmeasurements of the insertion force for mosquito fascicle to penetrate into human skin are reported. Results show that themosquito uses a very low force (average 18 μN) to penetrate into the skin. This force is at least three orders of magnitude smallerthan the reported lowest insertion force for an artificial microneedle with an ultra sharp tip to insert into the human skin. In orderto understand the piercing mechanism of mosquito fascicle tip into human multilayer skin tissue, a numerical simulation isconducted to analyze the insertion process using a nonlinear finite element method. A good agreement occurs between thenumerical results and the experimental measurements. | X Q Kong C W Wu | 2009 | Journal of Bionic Engineering2009，6，2： | 12 |
| 4 | 男性迟发性性腺功能减退症的检查、治疗和监测:国际男科学会(ISA)、国际老年男性研究会(ISSAM)、欧洲泌尿外科学会(EAU)、欧洲泌尿外科学院(EAA)和美国男科学会(ASA)联合推荐显示文摘简介
人口学资料明确显示:老年人口占总人口的百分率正逐年增加。当前,有关老年男性雄激素缺乏的问题逐渐成为令人感兴趣、但又充满争议的世界性话题。已经有横向和纵向的研究资料表明,随着年龄增大,成年男子的雄激素水平逐渐降低, | Wang C Nieschlage E Swerdloff R Behre HM Hellstrom WJ Gooren LJ Kaufman JM Legros JJ Lunenfeld B Morales A Morley JE Schulman C Thompson IM Weidner W Wu FCW 伍学焱(翻译) | 2011 | 国际生殖健康/计划生育杂志2011，30，1： | 8 |
| 5 | 从660 km边界地形推断地球不连续的化学分层显示文摘板块构造学说是固体地.球科学的基石,刻画了岩石圈的基本运动学特征,而地幔对流理论则为理解板块运动提供了动力学基础。然而长期以来,地幔对流模式的研究一直存在巨大的争议,分玻主要集中于全见幔对流和上下他幔分层对流两个模式。近年来还有一些学者提出了地混合对流模式的猜想,即一些区域地幔分层对流、其他区域上下他做整体对流。已有研究表明,温度异帯及化学异常均可造成大尺度(1000km)和中等尺度(100km)的间斷面起伏。 | 张宝华 Wu W Ni S Irving J C | 2019 | 矿物岩石地球化学通报2019，38，3： | 6 |
| 6 | Mutation analysis of autosomal dominant polycystic kidney disease genes in Han Chinese显示文摘 | Zhang S Mei C Zhang D Dai B Tang B Sun T Zhao H Zhou Y Li L Wu Y Wang W Shen X Song J | 2005 | 第二军医大学学报2005，26，8： | 6 |
| 7 | Next generation patient-derived prostate cancer xenograft models显示文摘对为前列腺癌症的更有效的治疗学的途径有批评需要。然而,在这个区域的研究被缺乏严重妨碍了临床上相关,在疾病的 vivo 模型试验性。这评论特别地基于 patients’ 的 subrenal 囊 grafting 集中于前列腺癌症异种皮移植模型的发展;进 nonobese 糖尿病 / 严重的肿瘤组织联合了 immunodeficient (NOD/SCID ) 老鼠。这种技术允许可移植的、导出病人的癌症织物异种皮移植线的成功的开发从不仅好攻击变形,而且从局部性的前列腺癌症纸巾。异种皮移植被发现了保留原来的恶意的关键生物性质,包括组织病理学说、分子的特征,肿瘤异质,对雄激素脱离的反应和变形能力。因此,他们是高度临床上相关并且在细胞、分子的层次,为个性化的癌症治疗屏蔽的药和现出症状之前的潜的药为前列腺癌症前进的研究提供珍贵工具测试的功效;特别当模型的一块面板习惯于盖子时许多疾病。这些异种皮移植模型能因此被看作前列腺癌症的下一代的模型。 | Dong Lin Hui Xue Yuwei Wang Rebecca Wu Akira Watahiki Xin Dong Hongwei Cheng Alexander W Wyatt Colin C Collins Peter W Gout Yuzhuo Wang | 2014 | Asian Journal of Andrology2014，16，3： | 4 |
| 8 | Uterine biology in pigs and sheep显示文摘There is a dialogue between the developing conceptus (embryo-fetus and associated placental membranes) and maternal uterus which must be established during the peri-implantation period for pregnancy recognition signaling, implantation, regulation of gene expression by uterine epithelial and stromal cells, placentation and exchange of nutrients and gases. The uterus provide a microenvironment in which molecules secreted by uterine epithelia or transported into the uterine lumen represent histotroph required for growth and development of the conceptus and receptivity of the uterus to implantation. Pregnancy recognition signaling mechanisms sustain the functional lifespan of the corpora lutea (CL) which produce progesterone, the hormone of pregnancy essential for uterine functions that support implantation and placentation required for a successful outcome of pregnancy. It is within the peri-implantation period that most embryonic deaths occur due to deficiencies attributed to uterine functions or failure of the conceptus to develop appropriately, signal pregnancy recognition and/or undergo implantation and placentation. With proper placentation, the fetal fluids and fetal membranes each have unique functions to ensure hematotrophic and histotrophic nutrition in support of growth and development of the fetus. The endocrine status of the pregnant female and her nutritional status are critical for successful establishment and maintenance of pregnancy. This review addresses the complexity of key mechanisms that are characteristic of successful reproduction in sheep and pigs and gaps in knowledge that must be the subject of research in order to enhance fertility and reproductive health of livestock species. | Fuller W Bazer Gwonhwa Song Jinyoung Kim Kathrin A Dunlap Michael Carey Satterfield Gregory A Johnson Robert C Burghardt Guoyao Wu | 2012 | Journal of Animal Science and Biotechnology2012，3，3： | 3 |
| 9 | The Novel Mechanical Property of Tongue of a Woodpecker显示文摘Biomaterials such as bone,teeth,nacre and silk are known to have superior mechanical properties due to their specificnanocomposite structures.Here we report that the woodpecker’s tongue exhibits a novel strength and flexibility due to its specialcomposite micro/nanostructure.The tongue consists of a flexible cartilage-and-bone skeleton covered with a thin layer tissue ofhigh strength and elasticity.At the interface between the cartilage-and-bone skeleton and the tissue layer,there is a hierarchicalfiber-typed connection.It is this special design of the tongue that makes the woodpeckers efficient in catching the insects insidetrees.The special micro/nanostructures of the woodpecker’s tongue show us a potential method to enhance the interfacialconnection between soft and hard material layers for bio-inspired composite system designs. | P Zhou X Q Kong C W Wu Z Chen | 2009 | Journal of Bionic Engineering2009，6，3： | 3 |
| 10 | Transmission of digital signals by chaotic synchronization 显示文摘 | Wu C W Chua L O | 1993 | Int J Bifurcation Chaos1993，，3： | 2 |
| 11 | A unified framework for synchronization and control of dynamic systems 显示文摘 | Wu C W Chua L O | 1994 | Int J Bifurcation Chaos1994，，4： | 2 |
| 12 | A steganographic method for images by pixelvalue differencing 显示文摘 | WU D C Tsai W H | 2003 | Pattern Recognition Letters2003，24，910： | 1 |
| 13 | Targeting cell-impermeable prodrug activation to tumor microenvironment eradicates multiple drug-resistant neoplasms 显示文摘 | Wu W Luo Y Sun C | 2006 | Cancer Res2006，66，2： | 1 |
| 14 | Persistent organic pollutants in water and surface sedimentsof Taihu Lake, China and risk assessment 显示文摘 | Wang H Wang C X Wu W Z | 2003 | Chemosphere2003，50，： | 1 |
| 15 | Satellite observations of modulation of surface winds by typhoon-induced upper ocean cooling显示文摘 | LIN I I LIU W T WU C C | 2003 | Geophysical Research Letters2003，30，3： | 1 |
| 16 | Maneuvering target tracking with colored noise 显示文摘 | Wu W R Chang D C | 1996 | IEEE Transactions on Aerospace and Electronic Systems (S0018-9251)1996，32，4： | 1 |
| 17 | Tropical application of halcinonide cream reduces the severity and incidence of intraperitoneal adhesions in a rat model显示文摘 | Yao W Wu C X | 2002 | Am J Surg2002，184，1： | 1 |
| 18 | A survey and comparison of Petri net based deadlock prevention policies for flexible manufacturing systems显示文摘 | LI Z W ZHOU M C WU N Q | 2008 | IEEE Trans on Syst Man Cybern C Appl Reviews2008，38，2： | 1 |
| 19 | Evaluation on the wear,tension and fatigue behavior of various PVD coated materials显示文摘 | SU Y L WU C T KAO W H | 1998 | Materials Letters1998，35，34： | 1 |
| 20 | A cold-induciblecoactivator of nuclear receptor linked to adaptive thermogenesis显示文摘 | Puigserver P Wu Z Park C W | 1998 | Cell1998，92，： | 1 |
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