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| 1 | Review of the biological and engineering aspects of algae to fuels approach显示文摘Current biofuel production relies on limited arable lands on the earth,and is impossible to meet the biofuel demands.Oil producing algae are alternative biofuel feedstock with potential to meet the world’s ambitious goal to replace fossil fuels.This review provides an overview of the biological and engineering aspects in the production and processing technologies and recent advances in research and development in the algae to fuels approach.The article covers biology,selection and genetic modification of algae species and strains,production systems design,culture media and light management,harvest and dewatering,downstream processing,and environment and economic assessment.Despite the many advances made over several decades,commercialization of algal fuels remains challenging chiefly because of the techno-economic constraints.Technological breakthroughs in all major aspects must take place before commercial production of algal fuels becomes economically viable. | Paul Chen Min Min Yifeng Chen Liang Wang Yecong Li Qin Chen Chenguang Wang Yiqin Wan Xiaoquan Wang Yanling Cheng Shaobo Deng Kevin Hennessy Xiangyang Lin Yuhuan Liu Yingkuan Wang Blanca Martinez Roger Ruan | 2009 | International Journal of Agricultural and Biological Engineering2009，2，4： | 9 |
| 2 | Anti-fertility effect of levonorgestrel and quinestrol in Brandt’s voles(Lasiopodomys brandtii)显示文摘The combination of levonorgestrel and quinestrol(EP-1)has been shown to have anti-fertility effects on several wild rodents,but the mechanism underlying these effects is poorly understood.We investigated the effects of EP-1 and each of its components,levonorgestrel(P)and quinestrol(E),on the fertility of Brandt’s voles(Lasiopodomys brandtii)by using a gastric gavage method.The doses for EP-1,E and P were 1,0.34 and 0.66 mg/kg body weight,respectively.Male voles(n=98)were treated daily for 5 or 14 days,then the testes and epididymides were collected,weighed and examined histologically at 30(D30),60(D60)or 90(D90)days after the end of treatment.Four males were allowed to mate with normal females at D90.Female voles(n=75)were treated for 3 days and a further 3 days after a 7-day interval.The uteri and ovaries were weighed and examined histologically at 15(D15),30(D30)or 75(D75)days after the end of treatment.Each of three females were mated with fertile males at D30 and D75,respectively.Our results indicated that quinestrol(E)significantly decreased the sperm numbers in the testes as well as the weight of the testes and epididymides,with both of these tissues showing obvious structural abnormalities,and significantly reduced the litter size and the pup weight for females mated with males of the E treatment group.For female voles,treatment with E,P or EP-1 resulted in no marked influence on the fertility status.These data indicate that quinestrol(E)alone has a significant anti-fertility effect on male Brandt’s voles,but is ineffective in combination with levonorgestrel(P). | Meirong ZHAO Ming LIU Dong LI Xinrong WAN Lyn A.HINDS Yanling WANG Zhibin ZHANG | 2007 | Integrative Zoology2007，2，4： | 6 |
| 3 | Multivariate coupling mechanism of NOCTUIDAE moth wings' surface superhydrophobicity显示文摘The surface shape, structure, biomaterial and wettability of moth wings (10 NOCTUIDAE species) from the northeast region of China were qualitatively and quantitatively studied by means of a stereoscopic microscope, a scanning electronic microscope, fourier transform infrared spectroscopy(FT-IR) and the interface contact angle measurement. The observation shows that there are scales arranged like over-lapping tiles on the surface of the moth wings. The shapes of the scales are different between species. They overlap horizontally and there is particular space vertically in the direction of the wing veins. The surface of the scale is structured by micron-class grooves and nanometer-class vertical gibbosities. The biomaterial components of the moth wing scale are mostly made up of protein, lipids and chitin. The observation also shows that the contact angle for wings with scales is in the range from 144.8° to 152.9°, while that for those without scales is from 90.0° to 115.9°. It indicates that the surfaces of the wings with scales are more hydrophobic. According as Cassie model, the equation of wettability on the NOCTUIDAE moth wing surface is established and the hydrophobic mechanism is analyzed. It is concluded that the hydrophobicity of the moth wings is induced by the multivariate coupling of the shape, structures and biomaterial of the scales. | WANG XiaoJun CONG Qian ZHANG JianJun WAN YanLing | 2009 | Chinese Science Bulletin2009，54，4： | 5 |
| 4 | Baicalein inhibits nu- clear factor - B and apoptosis via c - FLIP and MAPK in d - GalN/LPS induced acute liver failure in murine models 显示文摘 | Yanling Wu Lihua Lian Ying Wan | 2010 | Chem Biol Interact2010，188，3： | 1 |
| 5 | Preparation and properties of in situ polymerized fiber-reinforced nylon composites 显示文摘 | Zheng Liyan Wang Yanling Wan Yizeng | 2002 | Journal of Materials Science2002，21，13： | 1 |
| 6 | Pathogenicity and immunogenicity of recombinant Tiantan Vaccinia Virus with deleted C12L and A53R genes显示文摘 | Kaifan Dai Ying Liu Mingjie Liu Jianqing Xu Wei Huang Xianggang Huang Lianxing Liu Yanmin Wan Yanling Hao Yiming Shao | 2008 | Vaccine2008，，39： | 1 |
| 7 | The impact of receptor-binding domain natural mutations on antibody recognition of SARS-CoV-2显示文摘Dear Editor,The ongoing COVID-19 pandemic has resulted in over 25.0 million confirmed cases and over 840,000 deaths globally.As the third severe respiratory disease outbreak caused by the coronavirus,COVID-19 has led to much larger infected populations and coverage of geographic areas than SARS and MERS.Such high prevalence of infection has raised significant concerns about the emergence and spread of escape variants,which may evade human immunity and eventually render candidate vaccines and antibody-based therapeutics ineffective.Indeed,some naturally mutated SARS-CoV or MERS-CoV strains from the sequential outbreaks were reported to resist neutralization by the antibodies isolated during the first outbreak1,2. | Cheng Li Xiaolong Tian Xiaodong Jia Jinkai Wan Lu Lu Shibo Jiang Fei Lan Yinying Lu Yanling Wu Tianlei Ying | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 0 |
| 8 | SARS-CoV-2 Nsp8 induces mitophagy by damaging mitochondria显示文摘Autophagy plays an important role in the interaction between viruses and host cells.SARS-CoV-2 infection can disrupt the autophagy process in target cells.However,the precise molecular mechanism is still unknown.In this study,we discovered that the Nsp8 of SARS-CoV-2 could cause an increasing accumulation of autophagosomes by preventing the fusion of autophagosomes and lysosomes.From further investigation,we found that Nsp8 was present on mitochondria and can damage mitochondria to initiate mitophagy.The results of experiments with immunofluorescence revealed that Nsp8 induced incomplete mitophagy.Moreover,both domains of Nsp8 orchestrated their function during Nsp8-induced mitophagy,in which the N-terminal domain colocalized with mitochondria and the C-terminal domain induced auto/mitophagy.This novel finding expands our understanding of the function of Nsp8 in promoting mitochondrial damage and inducing incomplete mitophagy,which helps us to understand the etiology of COVID-19 as well as open up new pathways for creating SARS-CoV-2 treatment methods. | Shan Zong Yan Wu Weiling Li Qiang You Qian Peng Chenghai Wang Pin Wan Tao Bai Yanling Ma Binlian Sun Jialu Qiao | 2023 | Virologica Sinica2023，38，4： | 0 |
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