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| 1 | Single-photon computational 3D imaging at 45 km显示文摘Single-photon light detection and ranging(lidar)offers single-photon sensitivity and picosecond timing resolution,which is desirable for high-precision three-dimensional(3 D)imaging over long distances.Despite important progress,further extending the imaging range presents enormous challenges because only a few echo photons return and are mixed with strong noise.Here,we tackled these challenges by constructing a high-efficiency,low-noise coaxial single-photon lidar system and developing a long-range-tailored computational algorithm that provides high photon efficiency and good noise tolerance.Using this technique,we experimentally demonstrated active single-photon 3 D imaging at a distance of up to 45 km in an urban environment,with a low return-signal level of^1 photon per pixel.Our system is feasible for imaging at a few hundreds of kilometers by refining the setup,and thus represents a step towards low-power and high-resolution lidar over extra-long ranges. | ZHENG-PING LI XIN HUANG YUAN CAO BIN WANG YU-HUAI LI WEIJIE JIN CHAO YU JUN ZHANG QIANG ZHANG CHENG-ZHI PENG FEIHU XU AND JIAN-WEI PAN | 2020 | Photonics Research2020，8，9： | 24 |
| 2 | Thermal Influence of the Couette Flow in a Hydrostatic Spindle on the Machining Precision显示文摘Hydrostatic spindles are increasingly used in precision machine tools. Thermal error is the key factor affecting the machining accuracy of the spindle, and research has focused on spindle thermal errors through examination of the influence of the temperature distribution, thermal deformation and spindle mode. However, seldom has any research investigated the thermal effects of the associated Couette flow. To study the heat transfer mechanism in spindle systems, the criterion of the heat transfer direction according to the temperature distribution of the Couette flow at different temperatures is deduced. The method is able to deal accurately with the significant phenomena occurring at every place where thermal energy flowed in such a spindle system. The variation of the motion error induced by thermal effects on a machine work-table during machining is predicated by establishing the thermo-mechanical error model of the hydrostatic spindle for a high precision machine tool. The flow state and thermal behavior of a hydrostatic spindle is analyzed with the evaluated heat power and the coefficients of the convective heat transfer over outer surface of the spindle are calculated, and the thermal influence on the oil film stiffness is evaluated. Thermal drift of the spindle nose is measured with an inductance micrometer, the thermal deformation data 1.35 μm after running for 4 h is consistent with the value predicted by the finite element analysis's simulated result 1.28 μm, and this demonstrates that the simulation method is feasible. The thermal effects on the processing accuracy from the flow characteristics of the fluid inside the spindle are analyzed for the first time. | CHEN Dongju FAN Jinwei LI Haiyong WANG Xiaofeng ZHANG Feihu | 2013 | Chinese Journal of Mechanical Engineering2013，26，3： | 5 |
| 3 | Profiling of circular RNA N^(6)-methyladenosine in moso bamboo(Phyllostachys edulis)using nanopore-based direct RNA sequencing显示文摘N6-methyladenosine(m^(6)A)is a prevalent modification in messenger RNAs and circular RNAs that play important roles in regulating various aspects of RNA metabolism.However,the occurrence of the m^(6)A modification in plant circular RNAs has not been reported.A widely used method to identify m^(6)A modifications relies on m^(6)A-specific antibodies followed by next-generation sequencing of precipitated RNAs(MeRIP-Seq).However,one limitation of MeRIP-Seq is that it does not provide the precise location of m^(6)A at single-nucleotide resolution.Although more recent sequencing techniques such as Nanopore-based direct RNA sequencing(DRS)can overcome such limitations,the technology does not allow sequencing of circular RNAs,as these molecules lack a poly(A)tail.Here,we developed a novel method to detect the precise location of m^(6)A modifications in circular RNAs using Nanopore DRS.We first enriched our samples for circular RNAs,which we then fragmented and sequenced on the Nanopore platform with a customized protocol.Using this method,we identified 470 unique circular RNAs from DRS reads based on the back-spliced junction region.Among exonic circular RNAs,about 10%contained m^(6)A sites,which mainly occurred around acceptor and donor splice sites.This study demonstrates the utility of our antibody-independent method in identifying total and methylated circular RNAs using Nanopore DRS.This method has the additional advantage of providing the exact location of m^(6)A sites at single-base resolution in circular RNAs or linear transcripts from non-coding RNA without poly(A)tails. | Yongsheng Wang Huihui Wang Feihu Xi Huiyuan Wang Ximei Han Wentao Wei Hangxiao Zhang Qianyue Zhang Yushan Zheng Qiang Zhu Markus V.Kohnen Anireddy S.N.Reddy Lianfeng Gu | 2020 | Journal of Integrative Plant Biology2020，62，12： | 3 |
| 4 | Basic and clinical study of increased effect of partial anti-tumor agents by infusing sodium bicarbonate through target artery显示文摘Objective: To observe the influence of pH value on the proliferation of LAK cells and on the killing effect of rIL-2, IFN-ɑ2b, TNF-α, LAK cells and doxorubicin on malignant tumor cells, and investigate the possibility of increasing the efficacy of rIL-2 or IFN-ɑ2b and doxorubicin by infusing sodium bicarbonate (NaHCO3) through target arteries. Methods: Separating single nucleus cells from peripheral blood of healthy men, and observing the influence of pH on the activation of single nucleus cells by rIL-2. MTT assay was used to measure the killing effect of rIL-2, IFN-ɑ2b and TNF-α on 7404 cells and the increased effect of doxorubicin on rIL-2 and IFN-ɑ2b, the cytotoxity of LAK cells in different pH. Forty-two patients with advanced primary liver cancer were obtained by stratified random, NaHCO3, rIL-2/IFN-ɑ2b and doxorubicin were infused through target arteries. The efficacy was estimated after two cycles. Results: The conditions of pH 7.3 and pH 7.6 in vitro helped the proliferation of LAK cells and the killing effect of rIL-2, IFN-ɑ2b and LAK cells on 7404 cells. In the condition of pH 6.8 there was almost no killing effect for LAK cells. In the condition of pH 7.0, 7.2, 7.4 and 7.6, the killing rate of TNF-α to 7404 cells increased by degrees, and in pH 7.4 the killing effect was the optimum. After two cycles treatments in the 42 patients with advanced primary liver cancer, the response rate (CR+PR) was 88% (37/42). The median overall response and median overall survival were increased , and no complication associated with infusing sodium bicarbonate was observed. Conclusion: The killing effect of rIL-2, IFN-ɑ2b, TNF-α and doxorubicin on malignant tumor cells was enhanced by increasing the pH value. | Pingsheng Fan Shicun Wang Lin Xiu Jide Li Kehai Feng Feihu Chen Xinmin Lin Jiansheng Zhuang | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，1： | 3 |
| 5 | Ultrafast response of harmonic modelocked THz lasers显示文摘The use of fundamental modelocking to generate short terahertz(THz)pulses and THz frequency combs from semiconductor lasers has become a routine affair,using quantum cascade lasers(QCLs)as a gain medium.However,unlike classic laser diodes,no demonstrations of harmonic modelocking,active or passive,have been shown in THz QCLs,where multiple pulses per round trip are generated when the laser is modulated at the harmonics of the cavity’s fundamental round-trip frequency.Here,using time-resolved THz techniques,we show for the first time harmonic injection and mode-locking in which THz QCLs are modulated at the harmonics of the round-trip frequency.We demonstrate the generation of the harmonic electrical beatnote within a QCL,its injection locking to an active modulation and its direct translation to harmonic pulse generation using the unique ultrafast nature of our approach.Finally,we show indications of self-starting harmonic emission,i.e.,without external modulation,where the QCL operates exclusively on a harmonic(up to its 15th harmonic)of the round-trip frequency.This behaviour is supported by time-resolved simulations of induced gain and loss in the system and shows the importance of the electronic,as well as photonic,nature of QCLs.These results open up the prospect of passive harmonic modelocking and THz pulse generation,as well as the generation of low-noise microwave generation in the hundreds of GHz region. | Feihu Wang Valentino Pistore Michael Riesch Hanond Nong Pierre-Baptiste Vigneron Raffaele Colombelli Olivier Parillaud Juliette Mangeney Jerome Tignon Christian Jirauschek Sukhdeep S.Dhillon | 2020 | Light(Science & Applications)2020，9，1： | 3 |
| 6 | Rainbow technique for multi-parameter measurement of absorbing cylinder显示文摘Rainbow refractometry is widely used to measure the radius and real part of refractive index of a cylinder.However,studies on the detection of imaginary part of the refractive index with rainbow technique were scarce.This paper presents a new method for simultaneously measuring the radius,real and imaginary part of the refractive index of a cylinder,on the basis of the Airy theory and the Bouguer theory.The rainbows produced by the illuminated cylinder at a capillary exit are captured by a CCD camera in a labscale system,and then processed by the proposed method.Experimental results showed that the radius,real and imaginary part of the refractive index can be accurately determined when the SNR(signal to noise ratio)of the ripple structure is sufficiently high.However,the SNR of the ripple structure gradually decreases with decreasing scattering intensity of the cylinder,leading to larger measurement errors of the radius and real part of the refractive index.The relative error of the imaginary part of the refractive index derived from the measurement errors of the radius and real part of the refractive index,is less than3.4%. | Feihu Song Chuanlong Xu Shimin Wang | 2013 | Particuology2013，11，2： | 2 |
| 7 | Determination of paraquat in water samples using a sensitive fluorescent probe titration method显示文摘Paraquat(PQ),a nonselective herbicide,is non-fluorescent in aqueous solutions.Thus,its determination through direct fluorescent methods is not feasible.The supramolecular inclusion interaction of PQ with cucurbit[7]uril was studied by a fluorescent probe titration method.Significant quenching of the fluorescence intensity of the cucurbit[7]uril-coptisine fluorescent probe was observed with the addition of PQ.A new fluorescent probe titration method with high selectivity and sensitivity at the ng/mL level was developed to determine PQ in aqueous solutions with good precision and accuracy based on the significant quenching of the supramolecular complex fluorescence intensity.The proposed method was successfully used in the determination of PQ in lake water,tap water,well water,and ditch water in an agricultural area,with recoveries of 96.73% to 105.77%.The fluorescence quenching values(F) showed a good linear relationship with PQ concentrations from 1.0 × 108 to 1.2× 105 mol/L with a detection limit of 3.35 × 109 mol/L.In addition,the interaction models of the supramolecular complexes formed between the host and the guest were established using theoretical calculations.The interaction mechanism between the cucurbit[7]uril and PQ was confirmed by 1 H NMR spectroscopy. | Feihu Yao Hailong Liu Guangquan Wang Liming Du Xiaofen Yin Yunlong Fu | 2013 | Journal of Environmental Sciences2013，25，6： | 2 |
| 8 | Viral vectored vaccines:design,development,preventive and therapeutic applications in human diseases显示文摘Human diseases,particularly infectious diseases and cancers,pose unprecedented challenges to public health security and the global economy.The development and distribution of novel prophylactic and therapeutic vaccines are the prioritized countermeasures of human disease.Among all vaccine platforms,viral vector vaccines offer distinguished advantages and represent prominent choices for pathogens that have hampered control efforts based on conventional vaccine approaches.Currently,viral vector vaccines remain one of the best strategies for induction of robust humoral and cellular immunity against human diseases.Numerous viruses of different families and origins,including vesicular stomatitis virus,rabies virus,parainfluenza virus,measles virus,Newcastle disease virus,influenza virus,adenovirus and poxvirus,are deemed to be prominent viral vectors that differ in structural characteristics,design strategy,antigen presentation capability,immunogenicity and protective efficacy.This review summarized the overall profile of the design strategies,progress in advance and steps taken to address barriers to the deployment of these viral vector vaccines,simultaneously highlighting their potential for mucosal delivery,therapeutic application in cancer as well as other key aspects concerning the rational application of these viral vector vaccines.Appropriate and accurate technological advances in viral vector vaccines would consolidate their position as a leading approach to accelerate breakthroughs in novel vaccines and facilitate a rapid response to public health emergencies. | Shen Wang Bo Liang Weiqi Wang Ling Li Na Feng Yongkun Zhao Tiecheng Wang Feihu Yan Songtao Yang Xianzhu Xia | 2023 | Signal Transduction and Targeted Therapy2023，8，5： | 1 |
| 9 | Genome-wide profiling of circular RNAs,alternative splicing,and R-loops in stem-differentiating xylem of Populus trichocarpa显示文摘Circular RNAs(circRNAs)are a recently dis-covered type of non‐coding RNA derived from pre‐mRNAs.R‐loops consist of a DNA:RNA hybrid andthe associated single‐stranded DNA.InArabi-dopsis thaliana,circRNA:DNA R‐loops regulatealternative splicing(AS)ofSEPALLATA3(SEP3).However,the occurrence and functions ofcircRNAs and R‐loops inPopulus trichocarpaarelargely unexplored.Here,we performed circRNA‐enriched sequencing in the stem‐differentiatingxylem(SDX)ofP.trichocarpaand identified 2,742distinct circRNAs,including circ‐CESA4,circ‐IRX7,and circ‐GUX1,which are generated from genesinvolved in cellulose,and hemicellulose biosyn-thesis,respectively.To investigate the roles ofcircRNAs in modulating alternative splicing(AS),we detected 7,836 AS events using PacBio Iso‐Seq and identified 634 circRNAs that overlappedwith 699 AS events.Furthermore,using DNA:RNAhybrid immunoprecipitation followed by se-quencing(DRIP‐seq),we identified 8,932 R‐looppeaks that overlapped with 181 circRNAs and 672AS events.Notably,several SDX‐related circRNAsoverlapped with R‐loop peaks,pointing to theirpossible roles in modulating AS in SDX.Indeed,overexpressing circ‐IRX7increased the levels ofR‐loop structures and decreased the frequency ofintron retention in linearIRX7transcripts.Thisstudy provides a valuable R‐loop atlas resourceand uncovers the interplay between circRNAs andAS in SDX ofP.trichocarpa. | Xuqing Liu Yubang Gao Jiakai Liao Miao Miao Kai Chen Feihu Xi Wentao Wei Huihui Wang Yongsheng Wang XiXu Anireddy S.N.Reddy Lianfeng Gu | 2021 | Journal of Integrative Plant Biology2021，63，7： | 1 |
| 10 | Nume- rical analysis on the effect of swirl ratios on swirl cham- ber combustion system of DI diesel engines 显示文摘 | Wei Shengli Wang Feihu Leng Xianyin | 2013 | Energy Conversion and Management2013，75，： | 1 |
| 11 | Recent pro- gress of cell-penetrating peptides as new carriers for intra-cellular cargo delivery 显示文摘 | Wang Feihu Wang Yun Zhang Xiao | 2014 | J Control Release2014，174，： | 1 |
| 12 | Establishment and Characterization of a High Metastatic Potential in the Peritoneum for Human Gastric Cancer by Orthotopic Tumor Cell Implantation显示文摘 | Feihu Bai Xinning Guo Li Yang Jun Wang Yongquan Shi Faming Zhang Huihong Zhai Yuanyuan Lu Huahong Xie Kaichun Wu Daiming Fan | 2007 | Digestive Diseases and Sciences2007，，6： | 1 |
| 13 | Reversal of Multidrug Resistance of Adriamycin-resistant Gastric Adenocarcinoma Cells Through the Up-regulation of DARPP-32显示文摘 | Liu Hong Yunping Zhao Jin Wang Ying Han Wei Guo Haifeng Jin Huihong Zhai Feihu Bai Xiaoyin Zhang Taidong Qiao Zhen Chen Daiming Fan | 2008 | Digestive Diseases and Sciences2008，，1： | 1 |
| 14 | Inhibition of acid-sensing ion channels by amiloride protects rat articular chondrocytes from acid-induced apoptosis through mitochondrial - mediated pathway显示文摘 | Chao Rong Feihu Chen Sheng Jiang Wei Hu Nian Wang Fanrong Wu | 2011 | 中国药理通讯2011，28，2： | 1 |
| 15 | Energy and exergy analysis of solar power tower plants显示文摘 | Chao Xu Zhifeng Wang Xin Li Feihu Sun | 2011 | Applied Thermal En- gineering2011，，31： | 1 |
| 16 | Properties of a general azimuth-elevation tracking angle formula for a heliostat with a mirror-pivot offset and other angular errors 显示文摘 | Guo Minghuan Sun Feihu Wang Zhifeng | 2013 | Solar Energy2013，96，： | 1 |
| 17 | Phage display selection of peptides that inhibit metastasis ability of gastric cancer cells with high liver-metastatic potential显示文摘 | Shengjuan Hu Xinning Guo Huahong Xie Yulei Du Yanglin Pan Yongquan Shi Jun Wang Liu Hong Shuang Han Dongtao Zhang Dawei Huang Kedong Zhang Feihu Bai Haiping Jiang Huihong Zhai Yongzhan Nie Kaichun Wu Daiming Fan | 2006 | Biochemical and Biophysical Research Communications2006，，4： | 1 |
| 18 | Preparation of high heat-resistant profile based on PVC/a-MSAN/ABS ternary blends 显示文摘 | Wang Xing Guo Shaoyun Yang Feihu | 2013 | Advanced Materials ILesearch2013，，： | 1 |
| 19 | Numerical analysis on the effect of swirl ratios on swirl chamber combustion system of DI diesel engines显示文摘 | WEI Shengli WANG Feihu LENG Xianyin | 2013 | Energy Conversion and Management2013，75，12： | 1 |
| 20 | A comparison of methods for multi-class support vector machines 显示文摘 | Li Huaqing Qi Feihu Wang Shaoyu | 2005 | Computational Science and Its Applications-ICCSA2005，，： | 1 |
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