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| 1 | Enhanced efficiency of generating induced pluripotent stem (iPS) cells from human somatic cells by a combination of six transcription factors显示文摘 | Jing Liao Zhao Wu Ying Wang Lu Cheng Chun Cui Yuan Gao Taotao Chen Lingjun Rao Siye Chen Nannan Jia Huiming Dai Shunmei Xin Jiuhong Kang Gang Pei Lei Xiao | 2008 | Cell Research2008，18，5： | 61 |
| 2 | A critical role of IFNγ in priming MSC-mediated suppression of T cell proliferation through up-regulation of BT-H1显示文摘 | Huiming Sheng | 2008 | Cell Research2008，18，8： | 55 |
| 3 | Similarity criteria and coal-like material in coal and gas outburst physical simulation显示文摘 | Bo Zhao Guangcai Wen Haitao Sun Dongling Sun Huiming Yang Jie Cao Linchao Dai Bo Wang | 2018 | International Journal of Coal Science & Technology2018，5，2： | 17 |
| 4 | An ACC Oxidase Gene Essential for Cucumber Carpel Development显示文摘在植物的性决心产生便于 outcrossing 并且提高基因差异的单性的花。在黄瓜和甜瓜,乙烯支持心皮开发并且逮捕雄蕊开发。五性决心基因被识别了,包括四个编码在乙烯生合成催化限制率的步骤的 1-aminocyclopropane-1-carboxylate (ACC ) synthase,和抄写因素基因在甜瓜对应于孟德尔的地点 gynoecious 并且是女性的一个否定管理者的 CmWIP1。ACC oxidase (ACO ) 把 ACC 变换成乙烯;然而,它留下逃犯在黄瓜染色体的基因为性决心是它 ACO 并且怎么批评的 CmWIP1 镇压女花的开发。在这研究,我们在 ACO 基因发现了那个变化, CsACO2,在忍受仅仅男的花的黄瓜授与 androecy。变化破坏 CsACO2 的酶的活动,导致从射击尖端的 50% 更少的乙烯排放。CsACO2 在心皮 primordia 被表示,它的表示为性决心在关键阶段在女花与 CsACS11 的重叠了,大概提供为合适的 CsACS2 要求的足够的乙烯表示。CmACO3, CsACO2 的 ortholog,在心皮区域显示出一个类似的表示模式,建议 CsACO2/CmACO3 的保存功能。我们表明了那 CsWIP1, CmWIP1 的 ortholog,能直接绑 CsACO2 的倡导者并且镇压它的表示。一起拿,我们建议由 WIP1 抄写因素和 ACO 组成的一个大概保存的规章的模块在黄瓜和甜瓜控制单性的花开发。 | Huiming Chen Jinjing Sun Shuai Li Qingzhi Cui Huimin Zhang Fengjiao Xin Huaisong Wang Tao Lin Dongli Gao Shenhao Wang Xia Li Donghui Wang Zhonghua Zhang Zhihong Xu Sanwen Huang | 2016 | Molecular Plant2016，9，9： | 16 |
| 5 | Progress in the stratigraphy and geochronology of the Shuidonggou site,Ningxia,North China显示文摘In the past years we carried out further stratigraphy division in field and it is found that rich stone artifacts can be found in fluvial-shallow lake-alluvial sediments on the terrace Ⅱ of Biangou River, in Shuidonggou site, Ningxia and they are SDG1, 2 and 7. More luminescence and AMS 14C dating in laboratory show that Paleolithic culture develops during the Upper Paleolithic period with ages of 35―20 ka. The Paleolithic culture of SDG 1 is a little earlier than that of SDG 2 similar to SDG 7. The sandy sediments on terrace Ⅱ of Biangou River deposits in the past 72―18 ka, corresponding to Last Glacial. SDG2 has a stable sedimentary environment, resulting in the continuous stratigraphy, thickest deposits and rich environment and culture information, which can be regarded as the important and classic paleoanthropological section of Late Pleistocene in this region. | LIU DeCheng WANG XuLong GAO Xing XIA ZhengKai PEI ShuWen CHEN FuYou WANG HuiMing | 2009 | Chinese Science Bulletin2009，54，21： | 13 |
| 6 | On-board measurement of particle numbers and their size distribution from a light-duty diesel vehicle:Influences of VSP and altitude显示文摘In this study,the particle size-resolved distribution from a China-3 certificated light-duty diesel vehicle was measured by using a portable emission measurement system(PEMS).In order to examine the influences of vehicle specific power(VSP) and high-altitude operation,measurements were conducted at 8 constant speeds,which ranged from 10 to 80 km/hr at10 km/hr intervals,and two different high altitudes,namely 2200 and 3200 m.The results demonstrated that the numbers of particles in all size ranges decreased significantly as VSP increased when the test vehicle was running at lower speeds(< 20 km/hr),while at a moderate speed(between 30 and 60 km/hr),the particle number was statistically insensitive to increase VSP.Under high-speed cruising conditions,the numbers of ultrafine particles and PM2.5were insensitive to changes in VSP,but the numbers of nanoparticles and PM10 surged considerably.An increase in the operational altitude of the test vehicle resulted in increased particle number emissions at low and high driving speeds;however,particle numbers obtained at moderate speeds decreased as altitude rose.When the test vehicle was running at moderate speeds,particle numbers measured at the two altitudes were very close,except for comparatively higher number concentrations of nanoparticles measured at 2200 m. | Jia Liu Yunshan Ge Xin Wang Lijun Hao Jianwei Tan Zihang Peng Chuanzhen Zhang Huiming Gong Ying Huang | 2017 | Journal of Environmental Sciences2017，29，7： | 12 |
| 7 | 间歇A/O+MBR工艺在猪场沼液处理中的应用显示文摘猪场沼液含有大量有机物、氮、磷等营养元素,可回用与农业生产,排放水体却可造成严重的环境污染。在农业回用无法消纳时,采用间歇A/O+MBR工艺进行处理,一次性投资少,运行管理简单,出水水质稳定,COD、BOD_5、NH_(3^-)N、TP、SS的平均去除率可达到94.07%、94.96%、84.12%、93.20%和98.45%,出水水质优于GB 18596-2001。 | 邱俊 徐晓云 吴志勇 吴志坚 张磊 余峰 Wang Huiming | 2016 | 水处理技术2016，42，5： | 11 |
| 8 | Low-threshold topological nanolasers based on the second-order corner state显示文摘Topological lasers are immune to imperfections and disorder.They have been recently demonstrated based on many kinds of robust edge states,which are mostly at the microscale.The realization of 2D on-chip topological nanolasers with a small footprint,a low threshold and high energy efficiency has yet to be explored.Here,we report the first experimental demonstration of a topological nanolaser with high performance in a 2D photonic crystal slab.A topological nanocavity is formed utilizing the Wannier-type 0D corner state.Lasing behaviour with a low threshold of approximately 1μW and a high spontaneous emission coupling factor of 0.25 is observed with quantum dots as the active material.Such performance is much better than that of topological edge lasers and comparable to that of conventional photonic crystal nanolasers.Our experimental demonstration of a low-threshold topological nanolaser will be of great significance to the development of topological nanophotonic circuitry for the manipulation of photons in classical and quantum regimes. | Weixuan Zhang Xin Xie Huiming Hao Jianchen Dang Shan Xiao Shushu Shi Haiqiao Ni Zhichuan Niu Can Wang Kuijuan Jin Xiangdong Zhang Xiulai Xu | 2020 | Light(Science & Applications)2020，9，1： | 10 |
| 9 | Introduction to Wireless Endogenous Security and Safety:Problems, Attributes, Structures and Functions显示文摘The information security and functional safety are fundamental issues of wireless communications sytems.The endogenous security principle based on Dynamic Heterogeneous Redundancy provides a direction for the development of wireless communication security and safety technology.This paper introduces the concept of wireless endogenous security from the following four aspects.First,we sorts out the endogenous security problems faced by the current wireless communications system,and then analyzes the endogenous security and safety attributes of the wireless channel.After that,the endogenous security and safety structure of the wireless communications system is given,and finally the applications of the existing wireless communication endogenous security and safety functions are listed. | Liang Jin Xiaoyan Hu Yangming Lou Zhou Zhong Xiaoli Sun Huiming Wang Jiangxing Wu | 2021 | China Communications2021，18，9： | 10 |
| 10 | The High Energy X-ray telescope (HE) onboard the Insight-HXMT astronomy satellite显示文摘The Insight-Hard X-ray Modulation Telescope(Insight-HXMT) is a broadband X-ray and γ-ray(1-3000 ke V) astronomy satellite. One of its three main telescopes is the High Energy X-ray telescope(HE). The main detector plane of HE comprises 18 Na I(Tl)/Cs I(Na) phoswich detectors, where Na I(Tl) is used as the primary detector to measure ~ 20-250 ke V photons incident from the field of view(FOV) defined by collimators, and Cs I(Na) is used as the active shielding detector to Na I(Tl) by pulse shape discrimination. Additionally, Cs I(Na) is used as an omnidirectional γ-ray monitor. The HE collimators have a diverse FOV,i.e. 1.1°×5.7°(15 units), 5.7°×5.7°(2 units), and blocked(1 unit). Therefore, the combined FOV of HE is approximately5.7°×5.7°. Each HE detector has a diameter of 190 mm resulting in a total geometrical area of approximately 5100 cm2, and the energy resolution is ~15% at 60 ke V. For each recorded X-ray event by HE, the timing accuracy is less than 10 μs and the deadtime is less than 10 μs. HE is used for observing spectra and temporal variability of X-ray sources in the 20-250 ke V band either by pointing observations for known sources or scanning observations to unveil new sources. Additionally, HE is used for monitoring the γ-ray burst in 0.2-3 Me V band. This paper not only presents the design and performance of HE instruments but also reports results of the on-ground calibration experiments. | CongZhan Liu YiFei Zhang XuFang Li XueFeng Lu Zhi Chang ZhengWei Li AiMei Zhang YongJie Jin HuiMing Yu Zhao Zhang MinXue Fu YiBao Chen JianFeng Ji YuPeng Xu JingKang Deng RenCheng Shang GuoQing Liu FangJun Lu ShuangNan Zhang YongWei Dong TiPei Li Mei Wu YanGuo Li HuanYu Wang BoBing Wu YongJie Zhang Zhi Zhang ShaoLin Xiong Yuan Liu Shu Zhang HongWei Liu YiJung Yang Fan Zhang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 9 |
| 11 | Highly expressed BMP9/GDF2 in postnatal mouse liver and lungs may account for its pleiotropic effects on stem cell differentiation,angiogenesis,tumor growth and metabolism显示文摘Bone morphogenetic protein 9(BMP9)(or GDF2)was originally identified from fetal mouse liver cDNA libraries.Emerging evidence indicates BMP9 exerts diverse and pleiotropic functions during postnatal development and in maintaining tissue homeostasis.However,the expression landscape of BMP9 signaling during development and/or in adult tissues remains to be analyzed.Here,we conducted a comprehensive analysis of the expression landscape of BMP9 and its signaling mediators in postnatal mice.By analyzing mouse ENCODE transcriptome datasets we found Bmp9 was highly expressed in the liver and detectable in embryonic brain,adult lungs and adult placenta.We next conducted a comprehensive qPCR analysis of RNAs isolated from major mouse tissues/organs at various ages.We found that Bmp9 was highly expressed in the liver and lung tissues of young adult mice,but decreased in older mice.Interestingly,Bmp9 was only expressed at low to modest levels in developing bones.BMP9-associated TGFβ/BMPR type I receptor Alk1 was highly expressed in the adult lungs.Furthermore,the feedback inhibitor Smads Smad6 and Smad7 were widely expressed in mouse postnatal tissues.However,the BMP signaling antagonist noggin was highly expressed in fat and heart in the older age groups,as well as in kidney,liver and lungs in a biphasic fashion.Thus,our findings indicate that the circulating BMP9 produced in liver and lungs may account for its pleiotropic effects on postnatal tissues/organs although possible roles of BMP9 signaling in liver and lungs remain to be fully understood. | Wei Liu Zhongliang Deng Zongyue Zeng Jiaming Fan Yixiao Feng Xi Wang Daigui Cao Bo Zhang Lijuan Yang Bin Liu Mikhail Pakvasa William Wagstaff Xiaoxing Wu Huaxiu Luo Jing Zhang Meng Zhang Fang He Yukun Mao Huiming Ding Yongtao Zhang Changchun Niu Rex C.Haydon Hue H.Luu Jennifer Moriatis Wolf Michael J.Lee Wei Huang Tong-Chuan He Yulong Zou | 2020 | Genes & Diseases2020，7，2： | 9 |
| 12 | Tree-ring-based annual precipitation reconstruction in Kalaqin, Inner Mongolia for the last 238 years显示文摘A tree-ring-width chronology of Pinus tabulaeformis from Kalaqin, Inner Mongolia was developed using modern dendroc hronological techniques. Based on the results of correlation function analysis, the total precipitation from the previous August to current July was reconstructed for 1771-2008 AD with an explained variance of 49.3%. The reconstruction correlated well with the dryness/wetness series derived from historical documents, as well as the precipitation reconstruction of the Chifeng-Weichang region. There were eight intervals with greater precipitation than the average (associated with the strong East Asian summer monsoon) and seven intervals lower than the average (weak monsoon). A power spectrum analysis showed that there were 120 a, 80 a, 8 a and 2 a periodicities. | LIU Yu WANG CaiYong HAO WenJun SONG HuiMing CAI QiuFang TIAN Hua SUN Bo Hans W. LINDERHOLM | 2011 | Chinese Science Bulletin2011，56，28： | 9 |
| 13 | WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells显示文摘POU 抄写因素 OCT4 不仅在维持 pluripotent 和房间而且幕作为通过基因剂量的一个房间命运决定因素完成的胚胎的茎(ES ) 的自我更新的状态起一个必要作用。然而,控制细胞内部的 OCT4 蛋白质水平的分子的机制留下逃犯。这里,我们报导那人的 WWP2, E3 ubiquitin (Ub ) 蛋白质 ligase,通过它的 WW 领域明确地与 OCT4 交往并且在 vitro 并且在 vivo 提高 OCT4 的 Ub 修正。我们首先证明在人的 ES 房间的内长的 OCT4 能被 Ub post-translationally 修改。而且,我们发现 WWP2 以一种剂量依赖者方式,和 WWP2 的活跃地点半胱氨酸残余通过 26S proteasome 支持了 OCT4 的降级在 OCT4 上为它的酶的活动和解朊的效果被要求。显著地,我们当 WWP2 表示是由特定的 RNA 干扰(RNAi ) 的 downregulated 时,内长的 OCT4 蛋白质水平显著地被提高的数据表演,建议那 WWP2 是为在人的 ES 房间维持合适的 OCT4 蛋白质水平的一个重要管理者。而且,北污点分析证明 WWP2 抄本在多样的人的织物 / 器官是广泛地在场的并且高度在无差别的人的 ES 房间表示了。然而,它的表示水平快速在区分的人的 ES 房间以后被减少,显示 WWP2 表示力量发展地被调整。我们的调查结果证明 WWP2 是在人的 ES 房间的 OCT4 蛋白质水平的一个重要管理者。 | Huiming Xu Weicheng Wang Chunliang Li Hongyao Yu Acong Yang Beibei Wang Ying Jin | 2009 | Cell Research2009，19，5： | 8 |
| 14 | A Constitutive Model of Granite Shear Creep under Moisture显示文摘Previous constitutive models of granite shear creep have two limitations:(1) although moisture greatly affects granite shear creep behavior, currently there are no constitutive models that include this factor;(2) there are also no models that include an acceleration stage. This paper presents an improved Burgers constitutive model with the addition of a damage parameter to characterize the moisture effect and uses a nonlinear relation equation between stress and strain for inclusion as the acceleration stage. The damage parameter is determined from granite creep experiment under four different moisture contents(0%, 0.22%, 0.49%, and 0.79%). The nonlinear relation equation is obtained by fitting a dataset of stain versus time under five different loading stages. To verify the presented model, a creep experiment was conducted on other granite samples and the results show that the model agrees well with the experimental observation data. | Xingang Wang Bin Hu Huiming Tang Xinli Hu Jiading Wang Lei Huang | 2016 | Journal of Earth Science2016，27，4： | 8 |
| 15 | Epidemiological serosurvey of Hepatitis B in China—Declining HBV prevalence due to Hepatitis B vaccination显示文摘 | Xiaofeng Liang Shengli Bi Weizhong Yang Longde Wang Gang Cui Fuqiang Cui Yong Zhang Jianhua Liu Xiaohong Gong Yuansheng Chen Fuzhen Wang Hui Zheng Feng Wang Jing Guo Zhiyuan Jia Jingchen Ma Huaqing Wang Huiming Luo Li Li Shuigao Jin Stephen C. Hadler Yu W | 2009 | Vaccine2009，，47： | 7 |
| 16 | Assessment on alien herbicide-resistant gene flow among crucifers by sexual compatibility显示文摘Cross-pollination and high cross-compatibility are frequently found in many cruciferous plants, which im-plies that there might be potential risk of alien gene flow among crucifers. In this work, the alien glyphosate-resistant gene flow between GM (Genetically modified) rapeseed vari-ety Q3 (Brassica napus) and 6 varieties from 5 cruciferous species was assessed by sexual compatibility through aniline blue fluorescence observation, manual cross, mentor pollina-tion with the mixture pollen and DNA identification. The results indicated that the compatibility indices of two B. napus varieties, B. juncea var. multiceps Tsen et Lee and Chinese cabbage (B. chinensis) (as female) with Q3 (as male) were 16.15, 12.77, 2.345 and 0.85, respectively. F1 plants were examined by PCR and all of these samples were confirmed as positive. Crossing between Orychophragmus violaceus, Des-curainia sophia (as female) and Q3 (as male) expressed high cross-incompatibility. Fluorescence microscope observation indicated that growing of pollen tube terminated at the upper 1/3 part of the style of O. violaceus and on the stigma surface of D. sophia. The mentor plants were further analyzed by PCR and all were shown to be negative. Under the neighboring growth and natural pollination conditions, the rates of gene flow to two B. napus varieties were 2.3278% and 2.1487%, respectively, B. juncea var. multiceps Tsen et Lee and Chinese cabbage were 1.0157% and 0.9236%, re-spectively. No gene flow was observed in O. violaceus and D. sophia. Frequency of gene flow was highly correlated with sexual compatibility. Due to possible alien gene flow among crucifers, special consideration and care should be taken to grow GM rapeseed. | ZHAO Xiangxiang LU Weiping QI Cunkou PU Huiming XIA Qiuxia LU Dalei LIU Geshan WANG Youping | 2005 | Chinese Science Bulletin2005，50，15： | 6 |
| 17 | An ACCUMULATION AND REPLICATION OF CHLOROPLASTS 5 gene mutation confers light green peel in cucumber显示文摘The peel color of fruit is an important commercial trait in cucumber,but the underlying molecular basis is largely unknown.A mutant showing light green exocarp was discovered from ethyl methane sulfonate(EMS) mutagenized cucumber line 406 with dark green exocarp.Genetic analysis showed the mutant phenotype is conferred by a single recessive gene,here designated as lgp(light green peel).By re-sequencing of bulked segregants,we identified the candidate gene Csa7Go51430 encoding ACCUMULATION AND REPLICATION OF CHLOROPLASTS 5(ARC5) that plays a vital role in chloroplast division in Arabidopsis.A single nucleotide polymorphism(SNP) causing amino acid alteration in the conserved GTPase domain of Csa7G051430 showed co-segregation with the altered phenotype.Furthermore,the transient RNA interference of this gene resulted in reduced number and enlarged size of chloroplasts,which were also observed in the Igp mutant.This evidence supports that the non-synonymous SNP in Csa7G051430 is the causative mutation for the light green peel.This study provides a new allele for cucumber breeding for light green fruits and additional resource for the study of chloroplast development. | Qian Zhou Shenhao Wang Bowen Hu Huiming Chen Zhonghua Zhang Sanwen Huang | 2015 | Journal of Integrative Plant Biology2015，57，11： | 6 |
| 18 | Effect of CO_2 Gas on the Swelling and Tribological Behaviors of NBR Rubber in Water显示文摘The swelling and tribological behaviors of nitrile-butadience(NBR) rubbers with three acrylonitrile contents(N18,N26 and N41) in water with different CO_2 gas flows are investigated by immersion and wear experiments.The results show that the bubbles of CO_2 into water severely destroy the cross-linking network of rubber and form defects on the surface,such as cracks,holes and lamellar perks.These defects lead to an increase in the static and dynamic swelling increment.The dynamic swelling increment is almost three or four times larger than the static swelling increment.The hardness and wear resistance of rubbers in water with CO_2 gas remarkably decreases in contrast to that in water,and they gradually decrease with an increase in the gas flow in water.The bubbles of CO_2 decrease the steady frictional coefficient of rubber in water due to the presence of the gas in water lubricant film.The steady frictional coefficient in water with different CO_2 gas flow basically remains 0.1.N41 with high acrylonitrile content shows better swelling and wear resistances than N18 and N26 because of its dense molecular network. | Xiaoren Lv Shuyuan Song Huiming Wang Shijie Wang | 2015 | Journal of Materials Science & Technology2015，31，12： | 6 |
| 19 | Lateral Hypothalamic Area Glutamatergic Neurons and Their Projections to the Lateral Habenula Modulate the Anesthetic Potency of Isoflurane in Mice显示文摘The lateral hypothalamic area(LHA)plays a pivotal role in regulating consciousness transition,in which orexinergic neurons,GABAergic neurons,and melanin-concentrating hormone neurons are involved.Glutamatergic neurons have a large population in the LHA,but their anesthesia-related effect has not been explored.Here,we found that genetic ablation of LHA glutamatergic neurons shortened the induction time and prolonged the recovery time of isoflurane anesthesia in mice.In contrast,chemogenetic activation of LHA glutamatergic neurons increased the time to anesthesia and decreased the time to recovery.Optogenetic activation of LHA glutamatergic neurons during the maintenance of anesthesia reduced the burst suppression pattern of the electroencephalogram(EEG)and shifted EEG features to an arousal pattern.Photostimulation of LHA glutamatergic projections to the lateral habenula(LHb)also facilitated the emergence from anesthesia and the transition of anesthesia depth to a lighter level.Collectively,LHA glutamatergic neurons and their projections to the LHb regulate anesthetic potency and EEG features. | Shiyi Zhao Rui Li Huiming Li Sa Wang Xinxin Zhang Dan Wang Juan Guo Huihui Li Ao Li Tingting Tong Haixing Zhong Qianzi Yang Hailong Dong | 2021 | Neuroscience Bulletin2021，37，7： | 5 |
| 20 | Downregulation of CD4+CD25+ regulatory T cells may underlie enhanced Th1 immunity caused by immunization with activated autologous T cells显示文摘规章的 T 房间(Treg ) 在免疫系统动态平衡起重要作用,并且可以被压制涉及反肿瘤免疫的 Th1 免疫反应也涉及肿瘤免疫忍耐。我们以前报导了有稀释激活的自体同源的 T 房间的那免疫导致提高的反肿瘤免疫并且在调整 Th1 回答 invivo 上面。然而,内在的分子的机制很好没被理解。这里,我们证明 Tregfunction 是显著地, down 在老鼠调整了稀释激活的自体同源的 T 房间的那收到的免疫。我们发现那 Foxp3 表情从使免疫的老鼠在 CD4+CD25+ T 房间减少了。而且,从使免疫的老鼠获得的 CD4+CD25+Foxp3+ Treg 从天真的老鼠与那些相比展出了减少的免疫力的抑制能力。进一步的分析证明使免疫的鼠标的浆液包含 anti-CD25 抗体(大约 30 ng/ml, p<0.01 对控制) 的高水平。与在 Treg 的 down 规定的 anti-CD25 反应的一个角色一致,到天真的鼠标的从使免疫的鼠标的浆液的采纳转移在接受者鼠标在 Treg 人口和功能导致了重要减少。在使免疫的老鼠被触发 anti-CD25 反应能被 CD25 在激活的自体同源的 T 房间为免疫使用了的 ConA 被导致到高水平的事实解释。我们的结果第一次证明有稀释激活的自体同源的 T 房间的那免疫唤起 anti-CD25 抗体生产,它导致阻碍的 CD4+CD25+Foxp3+Treg 扩大和功能体内。我们建议那阻抑的 Treg 功能多半在使免疫的老鼠贡献提高的 Th1 反应并且是位于 boostedanti 肿瘤免疫下面的机制的至少部分。 | Qi Cao Li Wang Fang Du Huiming Sheng Yan Zhang Juanjuan Wu Baihua Shen TianweiShen Jingwu Zhang Dangsheng Li Ningli Li | 2007 | Cell Research2007，17，7： | 5 |
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