|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Efficacy and safety of metformin and sitagliptin based triple antihyperglycemic therapy(STRATEGY):a multicenter,randomized,controlled,non-inferiority clinical trial显示文摘Despite the current guideline's recommendation of a timely stepwise intensification therapy,the 'clinical inertia',termed as the delayed treatment intensification,commonly exists in the real world,which may be partly due to the relatively little substantial evidence and no clear consensus regarding the efficacy and safety of triple oral agents in patients inadequately controlled with dual therapy.In this clinical trial performed in 237 centers in China,5,535 type 2 diabetic patients inadequately controlled by previous therapies were treated with a stable metformin/sitagliptin dual therapy for 20 weeks.The patients who did not reach the glycated hemoglobin A1c(HbA1c) goal were then further randomized into glimepiride,gliclazide,repaglinide,or acarbose group for an additional 24-week triple therapy.A mean HbAlc reduction of 0.85%was observed when sitagliptin was added to the patients inadequately controlled with metformin in 16 weeks.Further HbAlc reductions in the 24-week triple therapy stage were 0.65%in glimepiride group,0.70%in gliclazide group,0.61%in repaglinide group,and 0.45%in acarbose group.The non-inferiority criterion for primary hypotheses was met for gliclazide and repaglinide,but not for acarbose,compared with glimepiride,when added to metformin/sitagliptin dual therapy.The incidences of adverse events(AEs) were 29.2%in the dual therapy stage and30.3%in the triple therapy stage.Metformin/sitagliptin as baseline therapy,with the addition of a third oral antihyperglycemic agent,including glimepiride,gliclazide,repaglinide,or acarbose,was effective,safe and well-tolerated for achieving an HbAlc<7.0%goal in type 2 diabetic patients inadequately controlled with previous therapies.The timely augmentation of up to three oral antihyperglycemic agents is valid and of important clinical benefit to prevent patients from exposure to unnecessarily prolonged hyperglycemia. | Wen Xu Yiming Mu Jiajun Zhao Dalong Zhu Qiuhe Ji Zhiguang Zhou Bin Yao Anhua Mao Samuel S.Engel Bin Zhao Yan Bi Longyi Zeng Xingwu Ran Juming Lu Linong Ji Wenying Yang Weiping Jia Jianping Weng | 2017 | Science China(Life Sciences)2017，60，3： | 19 |
| 2 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 3 | Cigarette Smoking Increases Risk for Incident Metabolic Syndrome in Chinese Men—Shanghai Diabetes Study显示文摘Objective To determine whether smoking increases the risk for developing metabolic syndrome (MetS) in Chinese men.Methods A total of 693 men with no MetS at baseline were followed for 2.9‐5.5 years.Subjects were divided into nonsmokers,ex‐smokers,and current smokers according to baseline smoking status.Results After adjusting for age,education level,alcohol intake,fasting plasma insulin,HOMA‐IR index,and BMI at baseline and weight change,current smokers were dose‐dependently associated with increased risk for developing new MetS compared with nonsmokers.The odds ratio (OR) was 2.131 (95% CI,1.264,3.592;P<0.01) for the NCEPIII definition or 3.083 (95% CI,1.807,5.295;P<0.01) for the JCDCG definition of MetS.Ex‐smokers who had quit for ≥13 years significantly decreased the risk for developing new MetS defined by the JCDCG definition.Compared with nonsmokers,current smokers were significantly associated with increased incidence of hypertriglyceridemia and low HDL‐C.Conclusion Smoking is a risk factor for developing MetS in Chinese men after adjusting for age,education level,alcohol intake,fasting plasma insulin,HOMA‐IR,BMI,and weight change.This could be due to an increased incidence of dyslipidemia.Smoking cessation for >13 years decreased the risk for developing MetS defined by the JCDCG definition. | ZHU YunXia ZHANG MingLiang HOU XuHong LU JunXi PENG LiangPu GU HuiLin WANG Chen JIA WeiPing | 2011 | Biomedical and Environmental Sciences2011，24，5： | 13 |
| 4 | Sensitivity-enhanced surface plasmon resonance sensor utilizing a tungsten disulfide (WS_2) nanosheets overlayer显示文摘Tungsten disulfide(WS_2), as a representative layered transition metal dichalcogenide(TMDC) material, possesses important potential for applications in highly sensitive sensors. Here, a sensitivity-enhanced surface plasmon resonance(SPR) sensor with a metal film modified by an overlayer of WS_2 nanosheets is proposed and demonstrated. The SPR sensitivity is related to the thickness of the WS_2 overlayer, which can be tailored by coating a WS_2 ethanol suspension with different concentrations or by the number of times of repeated post-coating.Benefitting from its large surface area, high refractive index, and unique optoelectronic properties, the WS_2 nanosheet overlayer coated on the gold film significantly improves the sensing sensitivity. The highest sensitivity(up to 2459.3 nm∕RIU) in the experiment is achieved by coating the WS_2 suspension once. Compared to the case without a WS_2 overlayer, this result shows a sensitivity enhancement of 26.6%. The influence of the WS_2 nanosheet overlayer on the sensing performance improvement is analyzed and discussed. Moreover, the proposed WS_2 SPR sensor has a linear correlation coefficient of 99.76% in refractive index range of 1.333 to 1.360. Besides sensitivity enhancement, the WS_2 nanosheet overlayer is able to show additional advantages, such as protection of metal film from oxidation, tunability of the resonance wavelength region, biocompatibility, capability of vapor,and gas sensing. | HAO WANG HUI ZHANG JIANGLI DONG SHIQI HU WENGUO ZHU WENTAO QIU HUIHUI LU JIANHUI YU HEYUAN GUAN SHECHENG GAO ZHAOHUI LI WEIPING LIU MIAO HE JUN ZHANG ZHE CHEN YUNHAN LUO | 2018 | Photonics Research2018，6，6： | 8 |
| 5 | Heat shock protein 90 promotes RNA helicase DDX5 accumulation and exacerbates hepatocellular carcinoma by inhibiting autophagy显示文摘Objective:Hepatocellular carcinoma(HCC),the main type of liver cancer,has a high morbidity and mortality,and a poor prognosis.RNA helicase DDX5,which acts as a transcriptional co-regulator,is overexpressed in most malignant tumors and promotes cancer cell growth.Heat shock protein 90(HSP90)is an important molecular chaperone in the conformational maturation and stabilization of numerous proteins involved in cell growth or survival.Methods:DDX5 m RNA and protein expression in surgically resected HCC tissues from 24 Asian patients were detected by quantitative real-time PCR and Western blot,respectively.The interaction of DDX5-HSP90 was determined by molecular docking,immunoprecipitation,and laser scanning confocal microscopy.The autophagy signal was detected by Western blot.The cell functions and signaling pathways of DDX5 were determined in 2 HCC cell lines.Two different murine HCC xenograft models were used to determine the function of DDX5 and the therapeutic effect of an HSP90 inhibitor.Results:HSP90 interacted directly with DDX5 and inhibited DDX5 protein degradation in the AMPK/ULK1-regulated autophagy pathway.The subsequent accumulation of DDX5 protein induced the malignant phenotype of HCC by activating theβ-catenin signaling pathway.The silencing of DDX5 or treatment with HSP90 inhibitor both blocked in vivo tumor growth in a murine HCC xenograft model.High levels of HSP90 and DDX5 protein were associated with poor prognoses.Conclusions:HSP90 interacted with DDX5 protein and subsequently protected DDX5 protein from AMPK/ULK1-regulated autophagic degradation.DDX5 and HSP90 are therefore potential therapeutic targets for HCC. | Ting Zhang Xinrui Yang Wanping Xu Jing Wang Dawei Wu Zhixian Hong Shengxian Yuan Zhen Zeng Xiaodong Jia Shanshan Lu Rifaat Safadi Sen Han Zhihong Yang Leonard M.Neckers Suthat Liangpunsakul Weiping Zhou Yinying Lu | 2021 | Cancer Biology & Medicine2021，18，3： | 7 |
| 6 | Assessment on alien herbicide-resistant gene flow among crucifers by sexual compatibility显示文摘Cross-pollination and high cross-compatibility are frequently found in many cruciferous plants, which im-plies that there might be potential risk of alien gene flow among crucifers. In this work, the alien glyphosate-resistant gene flow between GM (Genetically modified) rapeseed vari-ety Q3 (Brassica napus) and 6 varieties from 5 cruciferous species was assessed by sexual compatibility through aniline blue fluorescence observation, manual cross, mentor pollina-tion with the mixture pollen and DNA identification. The results indicated that the compatibility indices of two B. napus varieties, B. juncea var. multiceps Tsen et Lee and Chinese cabbage (B. chinensis) (as female) with Q3 (as male) were 16.15, 12.77, 2.345 and 0.85, respectively. F1 plants were examined by PCR and all of these samples were confirmed as positive. Crossing between Orychophragmus violaceus, Des-curainia sophia (as female) and Q3 (as male) expressed high cross-incompatibility. Fluorescence microscope observation indicated that growing of pollen tube terminated at the upper 1/3 part of the style of O. violaceus and on the stigma surface of D. sophia. The mentor plants were further analyzed by PCR and all were shown to be negative. Under the neighboring growth and natural pollination conditions, the rates of gene flow to two B. napus varieties were 2.3278% and 2.1487%, respectively, B. juncea var. multiceps Tsen et Lee and Chinese cabbage were 1.0157% and 0.9236%, re-spectively. No gene flow was observed in O. violaceus and D. sophia. Frequency of gene flow was highly correlated with sexual compatibility. Due to possible alien gene flow among crucifers, special consideration and care should be taken to grow GM rapeseed. | ZHAO Xiangxiang LU Weiping QI Cunkou PU Huiming XIA Qiuxia LU Dalei LIU Geshan WANG Youping | 2005 | Chinese Science Bulletin2005，50，15： | 6 |
| 7 | Ground motion attenuation of M_s8.0 Wenchuan earthquake显示文摘The great Ms8.0 Wenchuan earthquake has been the most destructive earthquake since 1949 in China. The earthquake occurred no more than half a year after the establishment of the National Strong Motion Observation Network System (NSMONS) of China; what is more, the epicenter was located in the area with dense strong motion observation stations so that a large number of strong motion records of the main shock were obtained. In this paper, 501 strong motion records from 167 observation stations are utilized to establish the ground motion attenuation relations in three directions in the range of fault distance less than 600 km. The result shows the difference of seismic motion attenuation in two horizontal directions is insignificant. It is the first time that strong-motion records are used to establish the ground motion attenuation relations of the MS8.0 earthquake in China. | Dawei Lu Jianwen Cui Xiaojun Li Weiping Lian | 2010 | Earthquake Science2010，23，1： | 5 |
| 8 | Application of moderate nitrogen levels alleviates yield loss and grain quality deterioration caused by post-silking heat stress in fresh waxy maize显示文摘High temperature(HT)during grain filling is one of the most important environmental factors limiting maize yield and grain quality.Nitrogen(N)fertilizer is essential for maintaining normal plant growth and defense against environmental stresses.The effects of three N rates and two temperature regimes on the grain yield and quality of fresh waxy maize were studied using the hybrids Suyunuo 5(SYN5)and Yunuo 7(YN7)as materials.N application rates were 1.5,4.5,and 7.5 g plant-1,representing low,moderate,and high N levels(LN,MN,and HN,respectively).Mean day/night temperatures during the grain filling of spring-and summer-sown plants were 27.6/21.0°C and 28.6/20.0°C for ambient temperature(AT)and 35/21.0°C and 35/20.0°C for HT,respectively.On average,HT reduced kernel number,weight,yield,and moisture content by 29.8%,17.9%,38.7%,and 3.3%,respectively.Kernel number,weight,yield,moisture,and starch contents were highest under MN among the three N rates under both temperature regimes.HT reduced grain starch content at all N levels.HT increased grain protein content,which gradually increased with N rate.Mean starch granule size under MN was larger(10.9μm)than that under LN and HN(both 10.4μm)at AT.However,the mean size of starch granules was higher under LN(11.7μm)and lower under MN(11.2μm)at HT.Iodine binding capacity(IBC)was lowest under MN and highest under HN among the three N levels under both temperature regimes.In general,IBC at all N rates was increased by HT.Peak viscosity(PV)was gradually reduced with increasing N rate at AT.In comparison with LN,PV was increased by MN and decreased by HN at HT.Retrogradation percentage gradually increased with N rate at AT,but was lowest under MN among the three N rates at HT.LN+AT and MN+HT produced grain with high pasting viscosity and low retrogradation tendency.MN application could alleviate the negative effects of HT on the grain yield and quality of fresh waxy maize. | Jue Wang Pengxiao Fu Weiping Lu Dalei Lu | 2020 | The Crop Journal2020，8，6： | 5 |
| 9 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 10 | Genomic variants of genes associated with three horticultural traits in apple revealed by genome re-sequencing显示文摘The apple(Malus×domestica Borkh.)cultivar‘Su Shuai’exhibits greater disease resistance,shorter internodes and lighter fruit flavor compared with its parents‘Golden Delicious’and‘Indo’.To obtain a comprehensive overview of the sequence variation in these three horticultural traits,the genomes of‘Su Shuai’and‘Indo’were resequenced using next-generation sequencing and compared to the genome of‘Golden Delicious’.A wide range of genetic variations were detected,including 2454406 and 18749349 single nucleotide polymorphism(SNP)and 59547 and 50143 structural variants(SVs)in the‘Indo’and‘Su Shuai’genomes,respectively.Among the SVs in‘Su Shuai’,17 genes related to disease resistance,10 genes related to Gibberellin(GA)and 19 genes associated with fruit flavor were identified.The expression patterns of eight of the SV genes were examined using reverse transcription-quantitative polymerase chain reaction(RT-qPCR).The results of this study illustrate the genomic variation in these cultivars and provide evidence for a genetic basis for the horticultural traits of disease resistance,short internodes and lighter flavor exhibited in these cultivars.These results provide a genetic basis for the phenotypic characteristics of‘Su Shuai’and,as such,these SVs could serve as gene-specific molecular markers in maker-assisted breeding of apples. | Shijie Zhang Weiping Chen Lu Xin Zhihong Gao Yingjun Hou Xinyi Yu Zhen Zhang Shenchun Qu | 2014 | Horticulture Research2014，1，1： | 5 |
| 11 | Real-time digital image stabilization based on regional field image gray projection显示文摘Digital image stabilization technique plays important roles in video surveillance and object acquisition.Many useful electronic image stabilization algorithms have been studied.A real-time algorithm is proposed based on field image gray projection which enables the regional odd and even field image to be projected into x and y directions and thus to get the regional gray projection curves in x and y directions,respectively.For the odd field image channel,motion parameters can be estimated via iterative minimum absolute difference based on two successive field image regional gray projection curves.Then motion compensations can be obtained after using the Kalman filter method.Finally,the odd field image is adjusted according to the compensations.In the mean time,motion compensation is applied to the even field image channel with the odd field image gray projection curves of the current frame.By minimizing absolute difference between odd and even field image gray projection curves of the current frame,the inter-field motion parameters can be estimated.Therefore,the even field image can be adjusted by combining the inter-field motion parameters and the odd field compensations.Finally,the stabilized image sequence can be obtained by synthesizing the adjusted odd and even field images.Experimental results show that the proposed algorithm can run in real-time and have a good stabilization performance.In addition,image blurring can be improved. | Weiping Yang Zhilong Zhang Yan Zhang Xinping Lu Jicheng Li Zhiguang Shi | 2016 | Journal of Systems Engineering and Electronics2016，27，1： | 4 |
| 12 | Effects of shading after pollination on kernel filling and physicochemical quality traits of waxy maize显示文摘Understanding the effects of shading after pollination on kernel filling and physicochemical properties of waxy maize could improve kernel quality.Experiments were conducted to investigate the effects of shading(30% and 50% light deprivation,taken plants without shading as control) on kernel weight,size,and physicochemical properties during kernel development in 2013 and 2014 using two waxy maize varieties(Suyunuo 5 and Yunuo 7).Results indicated that shading reduced kernel filling rate and decreased kernel size and weight,and the influence was large under severe light deprivation conditions.The large reduction in kernel weight and volume of Suyunuo 5 in response to shading indicated that it was more sensitive to shading than Yunuo 7.Starch content was reduced and protein content was increased by shading,especially under severe shading after 22 days after pollination(DAP).The iodine binding capacity of Yunuo 7 was not affected by shading at fresh and maturity stages but was gradually decreased by shading at the newly formed stage,while the values for Suyunuo 5were decreased at 7 and 40 DAP only by moderate shading and were similar among three treatments at 22 DAP.Severe shading decreased crystallinity at all kernel development stages,whereas moderate shading decreased crystallinity at fresh stage and increased it at mature stage for Suyunuo 5.Crystallinity in Yunuo 7 was increased by shading at 7 DAP and decreased by shading at 40 DAP,whereas the value at 22 DAP was increased by moderate shading and reduced by severe shading,respectively.The average gelatinization temperatures at different stages were decreased by shading and showed no difference between two shading levels.The retrogradation percentage at 7 DAP for both varieties was increased by shading.The value at 22 DAP was increased by moderate shading for Suyunuo 5 and decreased by severe shading for Yunuo 7,respectively.The retrogradation percentage at 40 DAP was decreased by shading treatments for Suyunuo 5 and reduced only by moderate shading for Yunuo 7.Peak viscosity was decreased by shading at fresh stage for Yunuo 7 and at maturity for Suyunuo 5.In conclusion,shading after pollination inhibited kernel filling of waxy maize and reduced paste viscosity quality,but kernel retrograde quality,crystallinity and starch iodine binding capacity in response to shading were dependent on stage and variety. | Huan Yang Yanling Shi Renchao Xu Dalei Lu Weiping Lu | 2016 | The Crop Journal2016，4，3： | 4 |
| 13 | Nutrients and organic matter in the surface sediment of a submerged macrophyte zone in a eutrophic lake:Implications for lake management显示文摘Little is known about the distribution and risk levels of nutrients and organic matter(OM)in the surface sediment of shallow submerged macrophyte-dominated lakes.In the current study,sixty surface sediment samples were collected from Xukou Bay,a typical submerged macrophyte-dominated zone in Lake Taihu,China.A 60-day degradation experiment of Potamogeton malaianus,a dominant species in the bay,was done in the laboratory.The results demonstrated that the ranges of total nitrogen(TN)and total phosphorus(TP),alkali-hydrolyzable nitrogen(AN),available phosphorus(AP),and OM in the surface sediment of the bay were 262.2-2,979.6 mg/kg,41.2-728.7 mg/kg,8.6-150.0 mg/kg,4.4-36.4 mg/kg,and 3.7-50.2 g/kg,respectively.The spatial distributions of TN,OM,and AN concentrations showed similar trends:The highest concentrations were present in the northeastern and southwestern zones,while the TP and AP concentrations were high in the northeastern,central,and southwestern zones.The heterogeneity in the spatial distribution of nutrients and OM in the surface sediment of the bay was associated with aquatic vegetation and anthropogenic activities.The comprehensive risk index and organic nitrogen index revealed that the surface sediment was moderately,interactively contaminated by TN and TP and by organic nitrogen.TN and OM in the northeastern zone were mainly derived from endogenous residues due to the decomposition of aquatic plants,while TN in the southwestern zone was primarily derived from agricultural wastewater.Consequently,targeted measures should be implemented to reduce TN and OM in the surface sediment of macrophyte-dominated lakes. | Jiancai Deng Xin Lu Weiping Hu Zhihong Xu | 2022 | International Journal of Sediment Research2022，37，3： | 3 |
| 14 | Gene flow from genetically modified herbicide-resistant rapeseed to cruciferous weeds显示文摘性相容性在之间遗传上修改了(美国通用汽车公司)glyphosate 抵抗的油菜籽变化 Q3 (Brassica 马来麝 L.) 和 5 棵饰有十字架的杂草通过荧光显微镜学的观察被学习并且在用手的授粉以后跨富饶。结果显示了那 Q3 (同样男性) 与 Thlaspi arvense L. 高度不兼容, Capsella bursa-pastoris (L.) 苜蓿, Cardamine hirsuta L。并且 Rorippa palustris (L.) Besser (作为女性) 。荧光显微镜的观察显示出那成长在耻辱表面上或在风格的上面的 1/3 部分终止的花粉试管。然而, B。juncea x Q3 是兼容的,并且相容性索引是 1.65。在附近的生长和自然授粉条件下面,基因的率从 Q3 流动到 T。arvense, C。bursa-pastoris, C。多毛并且 R。palustris 都是 0,当它为 B 是 0.86% 时。juncea。这些结果显示处于在美国通用汽车公司油菜籽之间的基因流动的率有差别,基因流动的饰有十字架的野杂草。 | ZHAO Xiangxiang XIA Oiuxia LU Dalei LU Weiping QI Cunkou PU Huiming LIU Geshan ZHAO Jian WANG Youping | 2006 | Progress in Natural Science:Materials International2006，16，9： | 3 |
| 15 | Optimal Control of Slurry Pressure during Shield Tunnelling Based on Random Forest and Particle Swarm Optimization显示文摘The control of slurry pressure aiming to be consistent with the external water and earth pressure during shield tunnelling has great significance for face stability,especially in urban areas or underwater where the surrounding environment is very sensitive to the fluctuation of slurry pressure.In this study,an optimal control method for slurry pressure during shield tunnelling is developed,which is composed of an identifier and a controller.The established identifier based on the random forest(RF)can describe the complex non-linear relationship between slurry pressure and its influencing factors.The proposed controller based on particle swarm optimization(PSO)can optimize the key factor to precisely control the slurry pressure at the normal state of advancement.A data set from Tsinghua Yuan Tunnel in China was used to train the RF model and several performance measures like R2,RMSE,etc.,were employed to evaluate.Then,the hybrid RF-PSO control method is adopted to optimize the control of slurry pressure.The good agreement between optimized slurry pressure and expected values demonstrates a high identifying and control precision. | Weiping Luo Dajun Yuan Dalong Jin Ping Lu Jian Chen | 2021 | Computer Modeling in Engineering & Sciences2021，，7： | 3 |
| 16 | Insulin resistance and the metabolism of branched-chain amino acids显示文摘Insulin resistance(IR)is a key pathological feature of metabolic syndrome and subsequently causes serious health problems with an increased risk of several common metabolic disorders.IR related metabolic disturbance is not restricted to carbohydrates but impacts global metabolic network.Branched-chain amino acids(BCAAs),namely valine,leucine and isoleucine,are among the nine essential amino acids,accounting for 35%of the essential amino acids in muscle proteins and 40%of the preformed amino acids required by mammals.The BCAAs are particularly responsive to the inhibitory insulin action on amino acid release by skeletal muscle and their metabolism is profoundly altered in insulin resistant conditions and/or insulin deficiency.Although increased circulating BCAA concentration in insulin resistant conditions has been noted for many years and BCAAs have been reported to be involved in the regulation of glucose homeostasis and body weight,it is only recently that BCAAs are found to be closely associated with IR.This review will focus on the recent findings on BCAAs from both epidemic and mechanistic studies. | Jingyi Lu Guoxiang Xie Weiping Jia Wei Jia | 2013 | Frontiers of Medicine2013，7，1： | 3 |
| 17 | Shallow Convolutional Neural Networks for Acoustic Scene Classification显示文摘最近,深神经的网络,它包括 convolutional 神经网络(CNN ) ,广泛地被用于声学的景色分类(ASC ) 。由一些简化 CNN 在深 CNN 上看了改进的事实激发了,例如视觉几何学组网(VGG 网) ,我们弄明白怎么与改进性能简化 VGG 网风格体系结构到浅 CNN。分享的马克斯和正规化也是的批申请了更好的精确性。与声学的场面和事件(DCASE ) 的察觉和分类上的一系列控制测试, 2016 数据设定,我们的浅 CNN 完成 6.7% 改进,并且把时间复杂性归结为 5% ,与 VGG 网风格 CNN 相比。 | LU Lu YANG Yuhong JIANG Yuzhi AI Haojun TU Weiping | 2018 | Wuhan University Journal of Natural Sciences2018，23，2： | 3 |
| 18 | Role of Toll-like receptors in microbiota-associated gastrointestinal cancer metastasis显示文摘 | Qi Lu Hao Ding Weiping Li | 2013 | Journal of Cancer Research and Therapeutics2013，，7： | 2 |
| 19 | Ultrahigh rate capability of 1D/2D polyaniline/titanium carbide(MXene)nanohybrid for advanced asymmetric supercapacitors显示文摘High energy density and enhanced rate capability are highly sought-after for supercapacitors in today's mobile world.In this work,polyaniline/titanium carbide(MXene)(PANI/Ti3C2Tx)nanohybrid is synthesized through a facile and cost-effective self-assembly of.one-dimensional(10)PANI nanofibers and two-dimensional(20)Ti3C2Tx nanosheets.PANl!Ti3C2Tx delivers greatly improved specific capacitance,ultrahigh rate capability(67%capacitance retention from 1 to 100 A·g^(-1))as well as good cycle stability.Electrochemical kinetic analysis reveals that PANI/Ti3C2Tx is featured with surface capacitance-dominated process and has a quasi-reversible kinetics at high scan rates,giving rise to an ultrahigh rate capability.By using PANl!Ti3C2Tx as positive electrode,an 1.8 V aqueous asymmetric supercapacitor(ASC)is successfully assembled,showing a maximum energy density of 50.8 Wh·kg^(-1)·(at 0.9 kW-kg-1)and a power density of 18 kW·kg^(-1)(at 26 Wh·kg^(-1)).Moreover,an 3.0 V organic ASC is also elaborately fabricated,·by using PANI/Ti3C2Tx,achieving an ultrahigh energy density of 67.2 Wh·kg^(-1)(at 1.5 kW·kg^(-1))and a power density of 30 kW·kg^(-1)·(at 26.8 Wh·kg^(-1)).The present work not only improves fundamental understanding of the structure-property relationship towards ultrahigh rate capability electrode materials,but also provides valuable guideline for the rational design of high-performance:energy storage devices with both high energy and power densities. | Jinhua Zhou Qi Kang Shuchi Xu Xiaoge Li Cong Liu Lu Ni Ningna Chen Chunliang Lu Xizhang Wang Luming Peng Xuefeng Guo Weiping Ding Wenhua Hou | 2022 | Nano Research2022，15，1： | 2 |
| 20 | Tim‐3/galectin‐9 signaling pathway mediates T‐cell dysfunction and predicts poor prognosis in patients with hepatitis B virus‐associated hepatocellular carcinoma显示文摘 | Hang Li Ke Wu Kaixiong Tao Libo Chen Qichang Zheng Xiaoming Lu Jun Liu Liang Shi Chuanqiao Liu Guobin Wang Weiping Zou | 2012 | Hepatology2012，，： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员