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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | 尿钠排泄、血压、心血管病与死亡率的关系:社区前瞻性流行病学队列研究显示文摘WHO建议人群钠摄人<2 g/d作为预防心血管病的措施之一,但这一目标在任何国家都没有实现。该建议主要基于短期血压试验的个体水平数据,没有来自随机试验或观察性研究的关于低钠摄入与降低心血管事件的数据。前瞻性城市农村流行病学研究目前正在21个国家进行。该文对其中18个国家的数据进行分析,其中包含了临床结果数据。 | Mente A O'Donnell M Rangarajan S McQueen M Dagenais G Wielgosz A Lear S Ah STL Wei L Diaz R Avezum A Lopez-Jaramillo P Lanas F Mony P Szuba A Iqbal R Yusuf R Mohammadifard N Khatib R Yusoff K Ismail N Gulec S Rosengren A Yusufali A Kruger L Tsolekile LP Chifamba J Dans A Alhabib KF Yeates K Teo K Yusuf S 刘莉 叶鹏 | 2018 | 中华高血压杂志2018，26，12： | 29 |
| 3 | Metabolic profiling analysis of a D-galactosamine/lipopolysaccharide- induced mouse model of fulminant hepatic failure显示文摘 | Feng, B Wu, SM Lv, S Liu, F Chen, HS Yan, XZ Li, Y Dong, FT Wei, L | 2007 | 中国生物学文摘2007，21，11： | 23 |
| 4 | Pulmonary infection control window in treatment of severe respiratory failure of chronic obstructive pulmonary diseases: a prospective, randomized controlled, multi-centred study显示文摘Background Early withdraw from invasive mechanical ventilation (MV) followed by noninvasive MV is a new strategy for changing modes of treatment. This study was conducted to estimate the feasibility and the efficacy of early extubation and sequential noninvasive MV commenced at beginning of pulmonary infection control window in patients with exacerbated hypercapnic respiratory failure caused by chronic obstructive pulmonary diseases (COPD). Methods A prospective, randomized controlled study was conducted in eleven teaching hospitals' respiratory or medical intensive care units in China. Ninety intubated COPD patients with severe hypercapnic respiratory failure triggered by pulmonary infection (pneumonia or purulent bronchitis) were involved in the study. When the pulmonary infection had been controlled by antibiotics and comprehensive therapy, the 'pulmonary infection control window (PIC window)' has been reached. Each case was randomly assigned to study group (extubation and noninvasive MV via facial mask immediately) or control group (invasive MV was received continuously after PIC window by using conventional weaning technique).Results Study group (n=47) and control group (n=43) had similar clinical characteristics initially and at the time of PIC window. Compared with control group, study group had shorter duration of invasive MV [(6.4±4.4) days vs (11.3±6.2) days, P=0.000], lower rate of ventilator associated pneumonia (VAP) (3/47 vs 12/43, P=0.014), fewer days in ICU [(12±8) days vs (16±11) days, P=0.047] and lower hospital mortality (1/47 vs 7/43, P=0.025).Conclusions In COPD patients requiring intubation and invasive MV for hypercapnic respiratory failure, which is exacerbated by pulmonary infection, early extubation followed by noninvasive MV initiated at the start of PIC window may decrease significantly the duration of invasive MV, the risk of VAP and hospital mortality. | Wang, C Zhan, QY Cao, ZX Wei, LQ Cheng, ZZ Liu, S Zhang, JL Chen, RC Luo, Q Niu, SF Zhu, L Wu, DW Fang, BM Wu, TH Wang, CZ Liu, YN | 2005 | Chinese Medical Journal2005，，19： | 6 |
| 5 | A hybrid rough-cut process planning for quality 显示文摘 | Chin K S Zheng L Y Wei L | 2003 | International Journal of Advanced Manufacturing Teehnology2003，22，910： | 2 |
| 6 | Simultaneous enhancement in strength and ductility by reinforcing magnesium with carbon nanotubes显示文摘 | GOH C S WEI J LEE L C | 2006 | Materials Science and Engineering A2006，423，12： | 1 |
| 7 | Assessment of frozen-ground conditions for engineering geology along the Qinghai-Tibet highway and railway, China显示文摘 | JIN H J WEI Z WANG S L | 2008 | Engineering Geology2008，101，34： | 1 |
| 8 | Neonatal intramuscpLar injection of plasmid DNA encoding GLP-1 reduces serum inspLin level and modifies skeletal muscle myosin heavy chain composition in aduLt rats显示文摘 | Wang L Guo F Wei S | 2010 | Physiol Res2010，59，4： | 1 |
| 9 | Routing protocols in vehicular AD HOC networks: a survey and future perspectives 显示文摘 | WEI Lin-yun CHEN Y S LEE S L | 2010 | Information Science and Engineering2010，26，3： | 1 |
| 10 | The effects of Xylazine and fentanyl on various hormones and motabolites in karakul sheep and blesbok显示文摘 | Maraisal A L Greene S A Wei A B | 1991 | J S Afr Vet Assoc1991，62，1： | 1 |
| 11 | Illinois process for preparation of soymilk显示文摘 | Nelson A I Steinberg M P Wei L S | 1976 | Food Sci1976，41，1： | 1 |
| 12 | Lead uptake, distribution,and effects in two dominants ahmar shm acrophytes, Spartinaalterniflora (Cordgrass) and Phragmites australis(commonreed) 显示文摘 | WINDHAM L WEIS J S WEIS P | 2001 | MarinePollut Bu112001，42，10： | 1 |
| 13 | Security and privacy aspects of low-cost radio frequency identification systems显示文摘 | Weis S A Sarma S E Rivest R L | 2004 | Security in Pervasive Computing2004，28，2： | 1 |
| 14 | Simultaneous control of acid gases and P AHs using a spray dryer combined with a fabric filter using different additives 显示文摘 | LIU Z S WEI MY LIN C L | 2002 | Journal of Hazardous Materials2002，91，13： | 1 |
| 15 | 查看详情显示文摘 | Wang G E Qin W P Zhang J S Zhang J S Wang Y Cao C Y Wang L L Wei G D Zhu P E Wu C E Kim Ryongjin | | 0，，： | 1 |
| 16 | Association of the interleukin-2 polymorphisms with interleukin-2 serum levels and risk of ha- sopharyngeal carcinoma显示文摘 | Wei Y S Lan Y Zhang L | 2010 | DNA Cell Biol2010，29，7： | 1 |
| 17 | Comeal biomecharvical effects:Small-incision lenticule extraction versus femtosecond laser-assisted laser in situ keratomileusis显示文摘 | Wu D Wang Y Zhang L Wei S Tang X | 2014 | J Cataract Refract Surg2014，40，6： | 1 |
| 18 | Activation of the phosphatidyli- nositol 3 - kinase/Aktsigaling pathway during porcine circovirus type 2 infection facilitates cell survival and viral replication 显示文摘 | WEI L ZHU S WANG J | 2012 | J Virol2012，86，13： | 1 |
| 19 | MMSE and MoCA in Parkinson's disease and dementia with Lewy bodies: a multicenter 1- year follow-up study 显示文摘 | Biundo R Weis L Bostantjopoulou S | 2016 | J Neural Transm (Vienna)2016，123，4： | 1 |
| 20 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
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