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| 1 | Sediment resuspension in the Lake Taihu, China显示文摘In order to examine the intensity of surfi-cial sediment resuspension in Lake Taihu, a large shallow lake in eastern China, suspended sediment concentrations (SSCs) were measured on the basis of analysis of water samples collected using an in-novative multi-level water sampler. The results show that under calm weather conditions, the SSC is rela-tively homogenous through the entire water column. However, when strong winds occur, the SSC in the bottom layer is 1-2 orders of magnitude greater than in the surface layer; thus, in this case, the amount of total suspended matter in the water column cannot be estimated using the SSC values of the surface layer alone. Furthermore, the depth of disturbance, or the thickness of the sediment layer that is set in mo-tion by wind-wave induced currents, is of the order of 100 mm. | HU Chunhua HU Weiping ZHANG Fabing HU Zhixin LI Xianghua CHEN Yonggen | 2006 | Chinese Science Bulletin2006，51，6： | 26 |
| 2 | Laser-Assisted Reduction of Highly Conductive Circuits Based on Copper Nitrate for Flexible Printed Sensors显示文摘Stretchable electronic sensing devices are defining the path toward wearable electronics. High-performance flexible strain sensors attached on clothing or human skin are required for potential applications in the entertainment,health monitoring, and medical care sectors. In this work,conducting copper electrodes were fabricated onpolydimethylsiloxane as sensitive stretchable microsensors by integrating laser direct writing and transfer printing approaches. The copper electrode was reduced from copper salt using laser writing rather than the general approach of printing with pre-synthesized copper or copper oxide nanoparticles. An electrical resistivity of 96 l X cm was achieved on 40-lm-thick Cu electrodes on flexible substrates. The motion sensing functionality successfully demonstrated a high sensitivity and mechanical robustness.This in situ fabrication method leads to a path toward electronic devices on flexible substrates. | Shi Bai Shigang Zhang Weiping Zhou Delong Ma Ying Ma Pooran Joshi Anming Hu | 2017 | Nano-Micro Letters2017，9，4： | 10 |
| 3 | The synergistic effect of resveratrol in combination with cisplatin on apoptosis via modulating autophagy in A549 cells显示文摘几研究证明了有自然产品和化疗代理人的联合治疗能改进化疗代理人的 sensitivityand cytotoxicity。Resveratrol,一个自然产品,包括 antitumor andantiviral 活动,以及脉管的保护的效果有许多生物效果。这研究的目的是与 cisplatin 和涉及 A549 房间的潜在的 anticancer 机制在联合调查 resveratrol 的 synergistic anticancereffect。从数 Kit-8 和 isobolographic 分析的房间的 resultsobtained 表明了 resveratrol 和 cisplatin resultedin synergistic 的那联合在 A549 房间的细胞毒素的效果。从染色的 Hoechst 的结果,流动 cytometry 和西方的污点分析 suggestedthat resveratrol 提高了调停 cisplatin 的 apoptosis。同时, LC3-II 和 P62 层次和在有 cisplatin 的联合的 resveratrol 触发了的 autophagosomesuggested 的形成的变化 autophagy。更重要地,由 3-methyladeninemarkedly 禁止 autophagy 稀释了 resveratrol 和 cisplatin 的联合在 A549 房间引起的 apoptosis。一起拿,我们的 studyprovides resveratrol synergistically 与 cisplatin 相结合的第一条证据在 A549 房间经由 modulating autophagiccell 死亡导致 apoptosis。这些调查结果也帮助我们在肺癌症与 chemotherapyagents 在联合理解自然产品的角色。 | Song Hu Xiaolin Li Rongrong Xu Lingyun Ye Hui Kong Xiaoning Zeng Hong Wang Weiping Xie | 2016 | Acta Biochimica et Biophysica Sinica2016，48，6： | 9 |
| 4 | Sensitivity-enhanced surface plasmon resonance sensor utilizing a tungsten disulfide (WS_2) nanosheets overlayer显示文摘Tungsten disulfide(WS_2), as a representative layered transition metal dichalcogenide(TMDC) material, possesses important potential for applications in highly sensitive sensors. Here, a sensitivity-enhanced surface plasmon resonance(SPR) sensor with a metal film modified by an overlayer of WS_2 nanosheets is proposed and demonstrated. The SPR sensitivity is related to the thickness of the WS_2 overlayer, which can be tailored by coating a WS_2 ethanol suspension with different concentrations or by the number of times of repeated post-coating.Benefitting from its large surface area, high refractive index, and unique optoelectronic properties, the WS_2 nanosheet overlayer coated on the gold film significantly improves the sensing sensitivity. The highest sensitivity(up to 2459.3 nm∕RIU) in the experiment is achieved by coating the WS_2 suspension once. Compared to the case without a WS_2 overlayer, this result shows a sensitivity enhancement of 26.6%. The influence of the WS_2 nanosheet overlayer on the sensing performance improvement is analyzed and discussed. Moreover, the proposed WS_2 SPR sensor has a linear correlation coefficient of 99.76% in refractive index range of 1.333 to 1.360. Besides sensitivity enhancement, the WS_2 nanosheet overlayer is able to show additional advantages, such as protection of metal film from oxidation, tunability of the resonance wavelength region, biocompatibility, capability of vapor,and gas sensing. | HAO WANG HUI ZHANG JIANGLI DONG SHIQI HU WENGUO ZHU WENTAO QIU HUIHUI LU JIANHUI YU HEYUAN GUAN SHECHENG GAO ZHAOHUI LI WEIPING LIU MIAO HE JUN ZHANG ZHE CHEN YUNHAN LUO | 2018 | Photonics Research2018，6，6： | 8 |
| 5 | Whole-exome sequencing identifies a novel INS mutation causative of maturity-onset diabetes of the young 10显示文摘 | Jing Yan Feng Jiang Rong Zhang Tongfu Xu Zhou Zhou Wei Ren Danfeng Peng Yong Liu Cheng Hu Weiping Jia | 2017 | Journal of Molecular Cell Biology2017，9，5： | 7 |
| 6 | Resveratrol reduces intracellular reactive oxygen species levels by inducing autophagy through the AMPK-mTOR pathway显示文摘Oxidative stress induced by free fatty acid aggravates endothelial injury,which leads to diabeti cardiovascular complications.Reduction of intracellular oxidative stress may attenuate these pathogeni processes.The dietary polyphenol resveratrol reportedly exerts potential protective effects against endothelia injury.This study determined whether resveratrol can reduce the palmitic acid (PA)-induced generation o reactive oxygen species (ROS)and further explored the underlying molecular mechanisms.We found tha resveratrol significantly reduced the PA-induced endothelial ROS levels in human aortic endothelial cells Resveratrol also induced endothelial cell autophagy,which mediated the effect of resveratrol on ROS reduction Resveratrol stimulated autophagy via the AMP-activated protein kinase (AMPK)-mTOR pathway.Taketogether,these data suggest that resveratrol prevents PA-induced intracellular ROS by autophagy regulation via the AMPK-mTOR pathway.Thus,the induction of autophagy by resveratrol may provide a novel therapeuti candidate for cardioprotection in metabolic syndrome. | Jun Song Yeping Huang Wenjian Zheng Jing Yan Min Cheng Ruxing Zhao Li Chen Cheng Hu Weiping Jia | 2018 | Frontiers of Medicine2018，12，6： | 7 |
| 7 | miRNAs in non-alcoholic fatty liver disease显示文摘 | Zhen He Cheng Hu Weiping Jia | 2016 | Frontiers of Medicine2016，10，4： | 7 |
| 8 | Complete three-dimensional coseismic displacements due to the 2021 Maduo earthquake in Qinghai Province,China from Sentinel-1 and ALOS-2 SAR images显示文摘On 22 nd May 2021(local time),an earthquake of M_(s)7.4 struck Maduo county in Qinghai Province,China.This was the largest earthquake in China since the 2008 Wenchuan earthquake.In this study,ascending/descending Sentinel-1 and advanced land observation satellite-2(ALOS-2)synthetic aperture radar(SAR)images were used to derive the three-dimensional(3-D)coseismic displacements of this earthquake.We used the differential interferometric SAR(In SAR,DIn SAR),pixel offset-tracking(POT),multiple aperture In SAR(MAI),and burst overlap interferometry(BOI)methods to derive the displacement observations along the line-of-sight(LOS)and azimuth directions.To accurately mitigate the effect of ionospheric delay on the ALOS-2 DIn SAR observations,a polynomial fitting method was proposed to optimize range-spectrum-split-derived ionospheric phases.In addition,the 3-D displacement field was obtained by a strain model and variance component estimation(SM-VCE)method based on the high-quality SAR displacement observations.Results indicated that a left-lateral fault slip with the largest horizontal displacement of up to 2.4 m dominated this earthquake,and the small-magnitude vertical displacement with an alternating uplift/subsidence pattern along the fault trace was more concentrated in the near-fault regions.Comparison with the global navigation satellite system data indicated that the SM-VCE method can significantly improve the accuracy of the displacements compared to the classical weighted least squares method,and the incorporation of the BOI displacements can substantially benefit the accuracy of north-south displacement.In addition to the displacements,three coseismic strain invariants calculated based on the strain model parameters were also investigated.It was found that the eastern and western parts of the faults suffered more significant strains compared with the epicenter region. | Jihong LIU Jun HU Zhiwei LI Zhangfeng MA Lixin WU Weiping JIANG Guangcai FENG Jianjun ZHU | 2022 | Science China Earth Sciences2022，65，4： | 6 |
| 9 | Serum IL-1β and IL-18 correlate with ESR and CRP in multidrug-resistant tuberculosis patients显示文摘Dear Editor:The emergence of multidrug-resistant tuberculosis(MDR-TB)is bringing new challenges.MDR-TB is caused by Mycobacterium tuberculosis(M.tuberculosis)that is resistant to isoniazid and rifampicin,with or without resistance to other anti-tuberculosis drugs.Approximately 450,000 people developed MDR-TB worldwide in 2012 and an estimated 170,000 people died from the disease^([1]).Bacterial burden is not strictly correlated with disease progression,and several hallmarks of severe tuberculosis suggest that insufficiently | Yanli Wang Chunmei Hu Zailiang Wang Hui Kong Weiping Xie Hong Wang | 2015 | The Journal of Biomedical Research2015，29，5： | 6 |
| 10 | Altered intestinal microbiota associated with colorectal cancer显示文摘The gut microbiota plays an important role in the development and progression of colorectal cancer (CRC). To learn more about the dysbiosis of carcinogenesis, we assessed alterations in gut microbiota in patients with CRC. A total of 23 subjects were enrolled in this study: 9 had CRC (CRC group) and 14 had normal colons (normal group). The microbiome of the mucosal-luminal interface of each subject was sampled and analyzed using 16S rRNA gene amplicon sequencing. We also used Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt) to predict microbial functional profiles. The microbial composition of the mucosal lumen differed between the groups, and the presence of specific bacteria may serve as a potential biomarker for colorectal carcinogenesis. We identified a significant reduction in Eubacterium, which is a butyrate-producing genera of bacteria, and a significant increase in Devosia in the gut microbiota of CRC patients. Different levels of gut microflora in healthy and CRC samples were identified. The observed abundance of bacterial species belonging to Eubacterium and Devosia may serve as a promising biomarker for the early detection of CRC. | Hong Zhang Ying Chang Qingqing Zheng Rong Zhang Cheng Hu Weiping Jia | 2019 | Frontiers of Medicine2019，13，4： | 6 |
| 11 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 12 | Measurement of γ detector backgrounds in the energy range of 3-8 MeV at Jinping underground laboratory for nuclear astrophysics显示文摘The astrophysical reaction rate of the charged-particleinduced reaction is dominated by the cross section within the Gamow window.The total cross section σ(E)of a chargedparticle-induced reaction is known to drops steeply with decreasing energy owing to the Coulomb barrier in the entrance channel: | YangPing Shen Jun Su WeiPing Liu Gang Lian Lin Gan LvHua Qiao ShengQuan Yan Yong Zhou Qian Yue Zhi Zeng QingDong Hu YuHao Mi Wei Zhao | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，10： | 5 |
| 13 | A NEW DAMAGE MECHANICS BASED APPROACH TO FATIGUE LIFE PREDICTION AND ITS ENGINEERING APPLICATION显示文摘An approach based on continuum damage mechanics to fatigue life prediction for structures is proposed. A new fatigue damage evolution equation is developed, in which the parameters are obtained in a simple way with reference to the experimental results of fatigue tests on standard specimens. With the utilization of APDL language on the ANSYS platform, a finite element implementation is presented to perform coupling operation on damage evolution of material and stress redistribution. The fatigue lives of some notched specimens and a Pitch-change-link are predicted by using the above approach. The calculated results are validated with experimental data. | Fei Shen Weiping Hu Qingchun Meng Miao Zhang | 2015 | Acta Mechanica Solida Sinica2015，28，5： | 4 |
| 14 | Quantifying hysteresis of atrazine desorption from a sandy loam soil显示文摘Batch experiments were carried out to investigate the effects of initial atrazine concentrations and consecutive desorption steps on the desorption characteristics of atrazine from a sandy loam soil.As initial atrazine concentration increased,the average percentage of atrazine desorption on the sandy loam soil ranged gradually from 23.1% to 38.5% after five consecutive desorption steps.The values of the Freundlich capacity parameter,kdes,derived from the initial concentration and time-dependent desorption isotherm were consistently higher than those associated with sorption.The opposite trend was observed only for the values of nonlinear parameter,ndes,from the initial concentration-dependent desorption isotherms.Atrazine hydrolysis to hydroxyatrazine and bound residue formation were mainly responsible for the observed hysteresis in its sorption and desorption isotherms.For the initial concentration-dependent desorption isotherms,as initial atrazine concentration increased,the values of hysteretic coefficients ω and λ decreased,and H values increased.However,the relationships between initial atrazine concentration and hysteretic coefficients were not pronounced for ω,H,or λ.For the time-dependent desorption isotherms,λ and H values increased as the atrazine desorption step proceeded.The correlation between hysteretic coefficient and desorption step was highly significant for λ (P < 0.0001),but not for H. | Jiancai Deng Xin Jiang Weiping Hu Liuming Hu | 2010 | Journal of Environmental Sciences2010，22，12： | 4 |
| 15 | A DAMAGE MECHANICS MODEL FOR FATIGUE LIFE PREDICTION OF FIBER REINFORCED POLYMER COMPOSITE LAMINA显示文摘A damage mechanics fatigue life prediction model for the fiber reinforced polymer lamina is established. The stiffness matrix of the lamina is derived by elastic constants of fiber and matrix. Two independent damage degrees of fiber and matrix are introduced to establish constitutive relations with damage. The damage driving forces and damage evolution equations for fiber and matrix are derived respectively. Fatigue tests on 0°and 90°unidirectional laminates are conducted respectively to identify parameters in damage evolution equations of fiber and matrix. The failure criterion of the lamina is presented. Finally, the life prediction model for lamina is proposed. | Wenjing Shi Weiping Hu Miao Zhang Qingchun Meng | 2011 | Acta Mechanica Solida Sinica2011，24，5： | 4 |
| 16 | A proposed direct measurement of cross section at Gamow window for key reaction 19F(p,α) 16O in Asymptotic Giant Branch stars with a planned accelerator in CJPL显示文摘In 2014, the National Natural Science Foundation of China(NSFC) approved the Jinping Underground Nuclear Astrophysics laboratory(JUNA) project, which aims at direct cross-section measurements of four key stellar nuclear reactions right down to the Gamow windows. In order to solve the observed fluorine overabundances in Asymptotic Giant Branch(AGB) stars, measuring the key ^(19)F( p,α)^(16)O reaction at effective burning energies(i.e., at Gamow window) is established as one of the scientific research sub-projects. The present paper describes this sub-project in details, including motivation, status, experimental setup, yield and background estimation, aboveground test, as well as other relevant reactions. | JianJun He ShiWei Xu ShaoBo Ma Jun Hu LiYong Zhang ChangBo Fu NingTao Zhang Gang Lian Jun Su YunJu Li ShengQuan Yan YangPing Shen SuQing Hou BaoLu Jia Tao Zhang XiaoPeng Zhang Bing Guo Shigeru Kubono WeiPing Liu | 2016 | Science China(Physics,Mechanics & Astronomy)2016，59，5： | 3 |
| 17 | A laser light scattering study of the interaction between human serum albumin and ampicillin sodium显示文摘The complexes formed by the interaction of human serum albumin and ampicillin sodium in aqueous solutions were investigated at 25 ± 0.1℃, ionic strength I = 0.085 mol·kg-1, pH 4.9, 5.8 and 7.4. The results of static light scattering have suggested that at pH 7.4, 5.8, 4.9, the molecular weight of the protein/drug complexes is 210,000 g·mol-1, 418,000 g·mol-1, 448,000 g·mol-1, re- spectively. The z-average root-mean-square radius of gyration and the second virial coefficients de- crease with pH decreasing. Dynamic light scattering provides information on diffusion coefficient and particle distributions of protein/drug complexes under different conditions, which suggests a broad hydrodynamic diameter range of scatters. The diffusion coefficients of the systems change with am- picillin sodium concentration and pH changing. | WANG Weiping TANG Jianghong PENG Xuhong HU Zhide CHEN Xingguo | 2006 | Science China Chemistry2006，49，4： | 3 |
| 18 | Bone marrow and the control of immunity显示文摘Bone marrow is thought to be a primary hematopoietic organ. However, accumulated evidences demonstrate that active function and trafficking of immune cells, including regulatory T cells, conventional T cells, B cells, dendritic cells, natural killer T (NKT) cells, neutrophils, myeloid-derived suppressor cells and mesenchymal stem cells, are observed in the bone marrow. Furthermore, bone marrow is a predetermined metastatic location for multiple human tumors. In this review, we discuss the immune network in the bone marrow. We suggest that bone marrow is an immune regulatory organ capable of fine tuning immunity and may be a potential therapeutic target for immunotherapy and immune vaccination. | Ende Zhao Huanbin Xu Lin Wang Ilona Kryczek Ke Wu Yu Hu Guobin Wang Weiping Zou | 2012 | Cellular & Molecular Immunology2012，9，1： | 3 |
| 19 | Nutrients and organic matter in the surface sediment of a submerged macrophyte zone in a eutrophic lake:Implications for lake management显示文摘Little is known about the distribution and risk levels of nutrients and organic matter(OM)in the surface sediment of shallow submerged macrophyte-dominated lakes.In the current study,sixty surface sediment samples were collected from Xukou Bay,a typical submerged macrophyte-dominated zone in Lake Taihu,China.A 60-day degradation experiment of Potamogeton malaianus,a dominant species in the bay,was done in the laboratory.The results demonstrated that the ranges of total nitrogen(TN)and total phosphorus(TP),alkali-hydrolyzable nitrogen(AN),available phosphorus(AP),and OM in the surface sediment of the bay were 262.2-2,979.6 mg/kg,41.2-728.7 mg/kg,8.6-150.0 mg/kg,4.4-36.4 mg/kg,and 3.7-50.2 g/kg,respectively.The spatial distributions of TN,OM,and AN concentrations showed similar trends:The highest concentrations were present in the northeastern and southwestern zones,while the TP and AP concentrations were high in the northeastern,central,and southwestern zones.The heterogeneity in the spatial distribution of nutrients and OM in the surface sediment of the bay was associated with aquatic vegetation and anthropogenic activities.The comprehensive risk index and organic nitrogen index revealed that the surface sediment was moderately,interactively contaminated by TN and TP and by organic nitrogen.TN and OM in the northeastern zone were mainly derived from endogenous residues due to the decomposition of aquatic plants,while TN in the southwestern zone was primarily derived from agricultural wastewater.Consequently,targeted measures should be implemented to reduce TN and OM in the surface sediment of macrophyte-dominated lakes. | Jiancai Deng Xin Lu Weiping Hu Zhihong Xu | 2022 | International Journal of Sediment Research2022，37，3： | 3 |
| 20 | Hydroformylation of 1-Octene over Nanotubular TiO2-supported Amorphous Co-B Catalysts显示文摘 | SHI Yukun HU Xiaojing ZHU Baolin ZHANG Shoumin HUANG Weiping | 2015 | Chemical Research in Chinese Universities2015，31，5： | 3 |
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