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| 1 | Agriculture Green Development: a model for China and the world显示文摘Realizing sustainable development has become a global priority.This holds,in particular,for agriculture.Recently,the United Nations launched the Sustainable Development Goals(SDGs),and the Nineteenth National People’s Congress has delivered a national strategy for sustainable development in China—realizing green development.The overall objective of Agriculture Green Development(AGD)is to coordinate'green'with'development'to realize the transformation of current agriculture with high resource consumption and high environmental costs into a green agriculture and countryside with high productivity,high resource use efficiency and low environmental impact.This is a formidable task,requiring joint efforts of government,farmers,industry,educators and researchers.The innovative concept for AGD will focus on reconstructing the whole crop-animal production and food production-consumption system,with the emphasis on high thresholds for environmental standards and food quality as well as enhanced human well-being.This paper addresses the significance,challenges,framework,pathways and potential solutions for realizing AGD in China,and highlights the potential changes that will lead to a more sustainable agriculture in the future.Proposals include interdisciplinary innovations,whole food chain improvement and regional solutions.The implementation of AGD in China will provide important implications for the countries in developmental transition,and contribute to global sustainable development. | Jianbo SHEN Qichao ZHU Xiaoqiang JIAO Hao YING Hongliang WANG Xin WEN Wen XU Tingyu LI Wenfeng CONG Xuejun LIU Yong HOU Zhenling CUI Oene OENEMA William JDAVIES Fusuo ZHANG | 2020 | Frontiers of Agricultural Science and Engineering2020，7，1： | 18 |
| 2 | An experimental study of salt expansion in sodium saline soils under transient conditions显示文摘Salt expansion in sulfate saline soils that are widely distributed in northwestern China causes serious infrastructural damages under low-temperature conditions. However, the mechanism of salt expansion under low temperatures is not clear. In this study, we conducted a series of cooling experiments combined with salt crystallization to study this mechanism, and employed an ionic model to calculate the supersaturation ratio of the solution. During the experiments, the strength and the process of salt expansion were examined under different cooling rates and various crystal morphologies. The relationship between temperature and supersaturation ratio under transient conditions was also considered. Results indicate that the initial supersaturation ratio of a sodium sulfate solution is closely related to environmental conditions, and that this ratio decreases with slowing the cooling rates and stabilizing the crystal forms. Higher initial supersaturation ratios lead to an increased non-steady-state zone, resulting in less salt expansion. On the other hand, chloride ion content has a distinct influence on the crystallization supersaturation ratio of the sodium sulfate solution, and higher chloride ion content can inhibit salt expansion in sodium saline soils. These findings help explain salt expansion mechanisms in complex conditions such as seasonally frozen soils, and thus help search for improved methods of preventing salt expansion in sulfate saline soils. | WAN Xusheng YOU Zhemin WEN Haiyan William CROSSLEY | 2017 | Journal of Arid Land2017，9，6： | 9 |
| 3 | 以金属有机骨架为牺牲模板制备MnOx-CeO2及其催化氧化甲苯性能显示文摘以均苯三甲酸合铈-金属有机骨架(Ce BTC-MOF)作为模板制备系列不同Mn含量的Mn O_x-Ce O_2催化剂,用于甲苯催化氧化。应用X射线衍射(XRD)、N_2物理吸附-脱附、热重分析(TG)、元素分析(EA)、电感耦合等离子体发射光谱法(ICP-OES)、扫描电子显微镜(SEM)、透射电子显微镜(TEM)、程序升温还原(H_2-TPR)、X射线光电子能谱(XPS)、拉曼光谱(Raman)和紫外可见漫反射(UV-vis)等手段对催化剂进行了表征。结果表明,通过MOF模板法制备的复合氧化物具备棒状形貌、高度分散、高比表面积和纳米晶体颗粒等特征。Mn在引入MOF的过程中,一部分进入Ce O_2晶格形成固溶体,另一部分则分散在Ce O_2表面,且分散的Mn分为单层分散态和晶相态。其中,Ce O_2载体表面和Mn分散物之间的强相互作用是影响活性的重要因素。当表面分散的Mn低于单层分散阈值6.2%时,Mn以嵌入模型的形式与表面Ce O_2发生强相互作用,有效促进催化剂的还原从而提高活性;当表面分散的Mn超过单层分散阈值6.2%时,载体表面形成Mn_3O_4晶相结构,对活性无明显促进作用。 | 林雪婷 付名利 贺辉 吴军良 陈礼敏 叶代启 胡芸 王逸凡 WEN William | 2018 | 物理化学学报2018，34，6： | 7 |
| 4 | The clinical association of programmed cell death protein 4(PDCD4) with solid tumors and its prognostic significance:a meta-analysis显示文摘Background: Programmed cell death protein 4(PDCD4) is a novel tumor suppressor protein involved in pro?grammed cell death. Its association with cancer progression has been observed in multiple tumor models, but evidence supporting its association with solid tumors in humans remains controversial. This study aimed to determine the clinical signiicance and prognostic value of PDCD4 in solid tumors.Methods: A systematic literature review was performed to retrieve publications with available clinical informa?tion and survival data. The eligibility of the selected articles was based on the criteria of the Dutch Cochrane Centre proposed by the Meta?analysis Of Observational Studies in Epidemiology group. Pooled odds ratios(ORs), hazard ratios(HRs), and 95% conidence intervals(CIs) for survival analysis were calculated. Publication bias was examined by Begg's and Egger's tests.Results: Clinical data of 2227 cancer patients with solid tumors from 23 studies were evaluated. PDCD4 expression was signiicantly associated with the diferentiation status of head and neck cancer(OR 4.25, 95% CI 1.87–9.66) and digestive system cancer(OR 2.87, 95% CI 1.84–4.48). Down?regulation of PDCD4 was signiicantly associated with short overall survival of patients with head and neck(HR: 3.44, 95% CI 2.38–4.98), breast(HR: 1.86, 95% CI 1.36–2.54), digestive system(HR: 2.12, 95% CI 1.75–2.56), and urinary system cancers(HR: 3.16, 95% CI 1.06–9.41).Conclusions: The current evidence suggests that PDCD4 down?regulation is involved in the progression of several types of solid tumor and is a potential marker for solid tumor prognoses. Its clinical usefulness should be conirmed by large?scale prospective studies. | John Zeng Hong Li Wei Gao Wai-Kuen Ho Wen Bin Lei William Ignace Wei Jimmy Yu-Wai Chan Thian-Sze Wong | 2016 | Chinese Journal of Cancer2016，35，12： | 7 |
| 5 | Total intravenous anesthesia for cesarean section in a pregnant woman with spinal muscular atrophy显示文摘Spinal muscular atrophy (SMA) is a genetic neuromuscular disorder characterized by progressive degeneration of the anterior horn cell leading to a lower motor neuron lesion.It is characterized by degeneration of alpha neurons in the anterior horn cells of the spinal cord leading to progressive muscle atrophy and premature death,usually from respiratory failure.1 There are four types according to the symptoms (Table 1). | Fang Qiwu Gao Guolan An Jianxiong Liu Caicai Qian Xiaoyan Wen Hui Wu Jianping Wang Yong Doris K.Cope John P. Williams | 2014 | Chinese Medical Journal2014，，18： | 3 |
| 6 | Fecal Incontinence in US Adults: Epidemiology and Risk Factors显示文摘 | William E. Whitehead Lori Borrud Patricia S. Goode Susan Meikle Elizabeth R. Mueller Ashok Tuteja Alison Weidner Milena Weinstein Wen Ye | 2009 | Gastroenterology2009，，2： | 2 |
| 7 | Fabrication of all-transparent polymer-based and encapsulated nanofluidic devices using nano-indentation lithography显示文摘In this paper,we describe a novel and simple process for the fabrication of all-transparent and encapsulated polymeric nanofluidic devices using nano-indentation lithography.First,a nanomechanical probe is used to‘scratch’nanoscale channels on polymethylmethacrylate(PMMA)substrates with sufficiently high hardness.Next,polydimethylsiloxane(PDMS)is used twice to duplicate the nanochannels onto PDMS substrates from the‘nano-scratched’PMMA substrates.A number of experiments are conducted to explore the relationships between the nano-indentation parameters and the nanochannel dimensions and to control the aspect ratio of the fabricated nanochannels.In addition,traditional photolithography combined with soft lithography is employed to fabricate microchannels on another PDMS‘cap’substrate.After manually aligning the substrates,all uncovered channels on two separate PDMS substrates are bonded to achieve a sealed and transparent nanofluidic device,which makes the dimensional transition from microscale to nanoscale feasible.The smallest dimensions of the achievable nanochannels that we have demonstrated thus far are of~20 nm depth and~800 nm width,with lengths extendable beyond 100μm.Fluid flow experiments are performed to verify the reliability of the device.Two types of colloidal solution are used to visualize the fluid flow through the nanochannels,that is,ethanol is mixed with gold colloid or fluorescent dye(fluorescein isothiocyanate),and the flow rate and filling time of liquid in the nanochannels are estimated based on time-lapsed image data.The simplicity of the fabrication process,bio-compatibility of the polymer substrates,and optical transparency of the nanochannels for flow visualization are key characteristics of this approach that will be very useful for nanofluidic and biomolecular research applications in the future. | Cong Wu Tiffany G.Lin Zhikun Zhan Yi Li Steve C.H.Tung William C.Tang Wen J.Li | 2017 | Microsystems & Nanoengineering2017，3，1： | 2 |
| 8 | Pool boiling heat transfer of aqueous TiO2-based nanofluids显示文摘 | Dongsheng Wen Yulong Ding Richard Williams | 2006 | Journal of Enhanced Heat Transfer2006，13，3： | 1 |
| 9 | Pilot study of rosiglitazone therapy in women with breast cancer: effects of short-term therapy on tumor tissue and serum markers 显示文摘 | Yee LD Williams N Wen P | 2007 | Clin Cancer Res2007，13，1： | 1 |
| 10 | DFT‑Guided Design and Fabrication of Carbon‑Nitride‑Based Materials for Energy Storage Devices:A Review显示文摘Carbon nitrides(including CN,C2N,C3N,C3N4,C4N,and C5N)are a unique family of nitrogen-rich carbon materials with multiple beneficial properties in crystalline structures,morphologies,and electronic configurations.In this review,we provide a comprehensive review on these materials properties,theoretical advantages,the synthesis and modification strategies of different carbon nitride-based materials(CNBMs)and their application in existing and emerging rechargeable battery systems,such as lithium-ion batteries,sodium and potassium-ion batteries,lithium sulfur batteries,lithium oxygen batteries,lithium metal batteries,zinc-ion batteries,and solid-state batteries.The central theme of this review is to apply the theoretical and computational design to guide the experimental synthesis of CNBMs for energy storage,i.e.,facilitate the application of first-principle studies and density functional theory for electrode material design,synthesis,and characterization of different CNBMs for the aforementioned rechargeable batteries.At last,we conclude with the challenges,and prospects of CNBMs,and propose future perspectives and strategies for further advancement of CNBMs for rechargeable batteries. | David Adekoya Shangshu Qian Xingxing Gu William Wen Dongsheng Li Jianmin Ma Shanqing Zhang | 2021 | Nano-Micro Letters2021，13，1： | 1 |
| 11 | Condensed tannin concentration of rhizomatous and nonrhizomatous birdsfoot trefoil in grazed mixures and monocultures显示文摘 | Wen L Roberts C A Williams J E | 2003 | Crop Sci2003，43，： | 1 |
| 12 | Enhanced 1.54-μm photo-and electroluminescence based on a perfluorinated Er(Ⅲ) complex utilizing an iridium(Ⅲ) complex as a sensitizer显示文摘Advanced 1.5-μm emitting materials that can be used to fabricate electrically driven light-emitting devices have the potential for developing cost-effective light sources for integrated silicon photonics.Sensitized erbium(Er^(3+))in organic materials can give bright 1.5-μm luminescence and provide a route for realizing 1.5-μm organic light emitting diodes(OLEDs).However,the Er3+electroluminescence(EL)intensity needs to be further improved for device applications.Herein,an efficient 1.5-μm OLED made from a sensitized organic Er3+co-doped system is realized,where a“traditional”organic phosphorescent molecule with minimal triplet–triplet annihilation is used as a chromophore sensitizer.The chromophore provides efficient sensitization to a co-doped organic Er^(3+) complex with a perfluorinatedligand shell.The large volume can protect the Er^(3+) 1.5-μm luminescence from vibrational quenching.The average lifetime of the sensitized Er^(3+) 1.5-μm luminescence reaches ~0.86 ms,with a lifetime component of 2.65 ms,which is by far the longest Er^(3+) lifetime in a hydrogen-abundant organic environment and can even compete with that obtained in the fully fluorinated organic Er^(3+) system.The optimal sensitization enhances the Er^(3+) luminescence by a factor of 1600 even with a high concentration of the phosphorescent molecule,and bright 1.5-μm OLEDs are obtained. | Hong-Fei Li Xiao-Qi Liu Chen Lyu Jelena Gorbaciova Li-Li Wen Guo-Gang Shan Peter B.Wyatt Huan-Qing Ye William P.Gillin | 2020 | Light(Science & Applications)2020，9，1： | 1 |
| 13 | Copper-cysteamine nanoparticle-mediated microwave dynamic therapy improves cancer treatment with induction of ferroptosis显示文摘Photodynamic Therapy(PDT)holds a great promise for cancer patients,however,due to the hypoxic characteristics of most solid tumors and the limited penetration depth of light in tissues,the extensive clinical application of PDT is limited.Herein,we report microwave induced copper-cysteamine(Cu-Cy)nanoparticles-based PDT as a promising cancer treatment to overcome cancer resistance in combination with ferroptosis.The treatment efficiency of Cu-Cy-mediated microwave dynamic therapy(MWDT)tested on HCT15 colorectal cancer(CRC)cells via cell titer-blue cell viability assay and live/dead assay reveal that Cu-Cy upon MW irradiation can effectively destroy HCT15 CRC cells with average IC-50 values of 20μg/mL.The cytotoxicity of Cu-Cy to tumor cells after MW stimulation can be alleviated by ferroptosis inhibitor.Furthermore,Cu-Cy mediated MWDT could deplete glutathione peroxide 4(GPX4)and enhance lipid peroxides(LPO)and malondialdehyde(MDA).Our findings demonstrate that MW-activated Cu-Cy killed CRC cells by inducing ferroptosis.The superior in vivo antitumor efficacy of the Cu-Cy was corroborated by a HCT15 tumor-bearing mice model.Immunohistochemical experiments showed that the GPX4 expression level in Cu-Cy+MW group was significantly lower than that in other groups.Overall,these findings demonstrate that Cu-Cy nanoparticles have a safe and promising clinical application prospect in MWDT for deep-seated tumors and effectively inhibit tumor cell proliferation by inducing ferroptosis,which provides a potential solution for cancer resistance. | Hui Zhou Zhongtao Liu Zijian Zhang Nil Kanatha Pandey Eric Amador William Nguyen Lalit Chudal Li Xiong Wei Chen Yu Wen | 2023 | Bioactive Materials2023，，6： | 1 |
| 14 | Pilot study of rosiglita- zone therapy in women with breast cancer : effects of short- term therapy on tumor tissue and serum markers 显示文摘 | Yee LD Williams N Wen P | 2007 | Clin Cancer Res2007，13，1： | 1 |
| 15 | Photoelectrochemical characterisation of TiO2 thin films derived from microwave hydrothermally processed nanocrystalline colloids显示文摘 | Wen William Jiang Dianlu | 2006 | Journal of Photochemistry & Photobiology A:Chemistry2006，179，3： | 1 |
| 16 | Synergistic interactions between sorafenib and everolimus in pancreatic cancer xenografts in mice显示文摘 | Dipti K. Pawaskar Robert M. Straubinger Gerald J. Fetterly Bonnie H. Hylander Elizabeth A. Repasky Wen W. Ma William J. Jusko | 2013 | Cancer Chemotherapy and Pharmacology2013，，5： | 1 |
| 17 | Early appraisal of China's huge and complex health - care reforms 显示文摘 | Winnie ehi - man Yip William Chsiao Wen Chen etc | 2012 | The lancet2012，379，3： | 1 |
| 18 | Fecal Incontinence in US Adults: Epidemiology and Risk Factors显示文摘 | William E. Whitehead Lori Borrud Patricia S. Goode Susan Meikle Elizabeth R. Mueller Ashok Tuteja Alison Weidner Milena Weinstein Wen Ye | 2009 | Gastroenterology2009，，2： | 1 |
| 19 | Usefulness of pulsed arterial spin labeling MR imaging in mesial temporal lobe epilepsy显示文摘 | Young-Min Lim Yong-Won Cho Sadat Shamim Jeffrey Solomon Rasmus Birn Wen Ming Luh William D. Gaillard Eva K. Ritzl William H. Theodore | 2008 | Epilepsy Research2008，，2： | 1 |
| 20 | Photo- electrochemical characterisation of TiOz thin films de- rived from microwave hydrothermally processed nano- crystalline colloids显示文摘 | Shanqing Zhang William Wen Dianlu Jiang | 2006 | Journal of Photochemistry and Photobiology A: Chemistry2006，179，3： | 1 |
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