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| 1 | Preliminary investigation of seismic damage to two steel space structures during the 2013 Lushan earthquake显示文摘Severe damage to steel space structures is rarely reported when compared to other structural systems damaged during past major earthquakes around the world.Two gymnasiums of steel space structures in downtown Lushan County that were damaged during the 2013 M7.0 Lushan earthquake in China were investigated and the observations are summarized in this paper.Typical damage to these two steel space structures ranges from moderate to severe.Moderate damage includes global buckling and dislocation of bolted connections of truss members,and inelastic elongation of anchor bolts and sliding of pedestal plates of supports.Severe damage includes member fracture caused by local buckling,and fracture failure of anchor bolts and welds.The distribution of structural damage to these two structures is described in detail and future research opportunities are suggested. | Dai Junwu Qu Zhe Zhang Chenxiao Weng Xuran | 2013 | Earthquake Engineering and Engineering Vibration2013，12，3： | 11 |
| 2 | Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection显示文摘Structural principles underlying the composition and synergistic mechanisms of protective monoclonal antibody cocktails are poorly defined.Here,we exploited antibody cooperativity to develop a therapeutic antibody cocktail against SARS-CoV-2.On the basis of our previously identified humanized cross-neutralizing antibody H014,we systematically an a lyzed a fully human n aive antibody library and rationally identified a potent neutralizing antibody partner,P17,which confers effective protection in animal model.Cryo-EM studies dissected the nature of the P17 epitope,which is SARS-CoV-2 specific and distinctly different from that of HOI4.High-resolution structure of the SARS-CoV-2 spike in complex with HOM and P17,together with functional investigations revealed that in a two-antibody cocktail,synergistic neutralization was achieved by S1 shielding and conformational locking,thereby blocking receptor attachment and viral membrane fusion,conferring high potency as well as robustness against viral mutation escape.Furthermore,cluster analysis identified a hypothetical 3rd antibody partner for further reinforcing the cocktail as pan-SARS-CoVs therapeutics. | Hangping Yao Yao Sun Yong-Qiang Deng Nan Wang Yongcong Tan Na-Na Zhang Xiao-Feng Li Chao Kong Yan-Peng Xuc Qi Chen Tian-Shu Cao Hui Zhao Xintian Yan Lei Cao Zhe Lv Dandan Zhu Rui Feng Nanping Wu Wenhai Zhang Yuhao Hu Keda Chen Rong-Rong Zhang Qingyu Lv Shihui Sun Yunhua Zhou Run Yan Guan Yang Xinglu Chanjuan Liu Xiangyun Lu Linfang Cheng Hongying Qiu Xing-Yao Huang Tianhao Weng Danrong Shi Weidong Jiang Junbin Shao Lei Wang Jie Zhang Tao Jiang Guojun Lang Cheng-Feng Qinc Lanjuan Li Xiangxi Wang | 2021 | Cell Research2021，31，1： | 5 |
| 3 | Effect of herb-partitioned moxibustion on dopamine levels and dopamine receptor 1 expression in the colon and central nervous system in rats with Crohn’s disease显示文摘OBJECTIVE:To observe the effect of herb-partitioned moxibustion at the Tianshu (ST 25) and Qihai (CV 6) acupoints in rats with Crohn's disease,and explore the underlying mechanism from dopamine (DA) and dopamine receptor 1 (D1 R) in the colon,spinal dorsal horn and hypothalamus.METHODS:The rats were randomly divided into the normal,model (CD),herb-partitioned moxibustion (Mox) and mesalazine (Mesa) groups.Damage in the colons was scored and observed by hematoxylin and eosin staining.DA and D1R protein expression in the colonic mucosa were detected by immunohistochemistry.The concentrations of DA and D1R in the spinal dorsal horn and hypothalamus were measured by enzyme-linked immunosorbent assay,and D1R mRNA expression was evaluated by quantitative real-time polymerase chain reaction.RESULTS:In the colon,compared with the normal group,DA,D1 R protein expressions and D1 R mRNA expression were significantly higher in the model group,while decreased in the Mox group and the Mesa group.In the spinal dorsal horn and hypothalamus,compared with the normal group,the concentrations of DA and D1 R,and the D1R mRNA expressions were significantly higher in the model group,and decreased in the Mox group and the Mesa group.CONCLUSION:Herb-partitioned moxibustion at the Tianshu (ST 25) and Qihai (CV 6) acupoints relieved ulceration in CD rats,the underlying mechanism maybe relative with the regulation of DA and D1R in the colon,spinal dorsal horn and hypothalamus by moxibustion. | Lu Yuan Zheng Handan Lü Tingting Ma Zhe Wu Huangan Xu Manwen Weng Zhijun Feng Hui Zhang Fang Ding Guanghong Wu Luyi Liu Huirong | 2019 | Journal of Traditional Chinese Medicine2019，39，3： | 3 |
| 4 | Application of imputation methods to genomic selection in Chinese Holstein cattle显示文摘Missing genotypes are a common feature of high density SNP datasets obtained using SNP chip technology and this is likely to decrease the accuracy of genomic selection. This problem can be circumvented by imputing the missing genotypes with estimated genotypes. When implementing imputation, the criteria used for SNP data quality control and whether to perform imputation before or after data quality control need to consider. In this paper, we compared six strategies of imputation and quality control using different imputation methods, different quality control criteria and by changing the order of imputation and quality control, against a real dataset of milk production traits in Chinese Holstein cattle. The results demonstrated that, no matter what imputation method and quality control criteria were used, strategies with imputation before quality control performed better than strategies with imputation after quality control in terms of accuracy of genomic selection. The different imputation methods and quality control criteria did not significantly influence the accuracy of genomic selection. We concluded that performing imputation before quality control could increase the accuracy of genomic selection, especially when the rate of missing genotypes is high and the reference population is small. | Ziqing Weng Zhe Zhang Xiangdong Ding Weixuan Fu Peipei Ma Chonglong Wang Qin Zhang | 2012 | Journal of Animal Science and Biotechnology2012，3，1： | 2 |
| 5 | Repurposing econazole as a pharmacological autophagy inhibitor to treat pancreatic ductal adenocarcinoma显示文摘Pancreatic ductal adenocarcinoma(PDAC)is characterized by the highest mortality among carcinomas.The pathogenesis of PDAC requires elevated autophagy,inhibition of which using hydroxychloroquine has shown promise.However,current realization is impeded by its suboptimal use and unpredictable toxicity.Attempts to identify novel autophagy-modulating agents from already approved drugs offer a rapid and accessible approach.Here,using a patient-derived organoid model,we performed a comparative analysis of therapeutic responses among various antimalarial/fungal/parasitic/viral agents,through which econazole(ECON),an antifungal compound,emerged as the top candidate.Further testing in cell-line and xenograft models of PDAC validated this activity,which occurred as a direct consequence of dysfunctional autophagy.More specifically,ECON boosted autophagy initiation but blocked lysosome biogenesis.RNA sequencing analysis revealed that this autophagic induction was largely attributed to the altered expression of activation transcription factor 3(ATF3).Increased nuclear import of ATF3 and its transcriptional repression of inhibitor of differentiation-1(ID-1)led to inactivation of the AKT/mammalian target of rapamycin(m TOR)pathway,thus giving rise to autophagosome accumulation in PDAC cells.The magnitude of the increase in autophagosomes was sufficient to elicit ER stress-mediated apoptosis.Furthermore,ECON,as an autophagy inhibitor,exhibited synergistic effects with trametinib on PDAC.This study provides direct preclinical and experimental evidence for the therapeutic efficacy of ECON in PDAC treatment and reveals a mechanism whereby ECON inhibits PDAC growth. | Ningna Weng Siyuan Qin Jiayang Liu Xing Huang Jingwen Jiang Li Zhou Zhe Zhang Na Xie Kui Wang Ping Jin Maochao Luo Liyuan Peng Edouard C.Nice Ajay Goel Suxia Han Canhua Huang Qing Zhu | 2022 | Acta Pharmaceutica Sinica B2022，12，7： | 2 |
| 6 | Structural analysis of network traffic matrix via relaxed principal component pursuit 显示文摘 | WENG Zhe HU Kai | 2012 | SCI2012，56，7： | 1 |
| 7 | Magnetic nanomaterial derived from graphene oxide / layered double hydroxide hybrid for efficient removal of methyl orange from aqueous solution显示文摘 | Zhe Yang Shanshan Ji Wei Gao Chao Zhang Lulu Ren Weng Weei Tjiu Zheng Zhang Jisheng Pan Tianxi Liu | 2013 | Journal of Colloid And Interface Science2013，，： | 1 |
| 8 | Somatic mutation contributing to clonal haematopoiesis is a risk factor of recurrent stroke in first-ever acute ischaemic stroke:a prospective cohort study显示文摘Background Somatic mutation contributes to clonal haematopoiesis of indeterminate potential(CHIP)is related to age and associated with a higher risk of stroke and atherosclerotic cardiovascular disease.Here,we investigated the prognostic significance of CHIP in a large first-ever acute ischaemic stroke(AIS)cohort and explored the underlying mechanisms.Methods We studied a prospective cohort of 6016 patients who had a first-ever AIS in China.Whole-genome sequencing was performed to identify CHIP.High-sensitivity C reactive protein(hs-CRP)levels above 3 mg/L at baseline were defined as hyperinflammation.Recurrent stroke during the 3-month follow-up was the primary outcome.Results Among the 6016 patients who had a first-ever AIS,with a median age was 62 years(IQR,54.0‒70.0),3.70%were identified as CHIP carriers.The most common mutations occurred in the DNMT3A(30.0%)and TET2(11.4%)genes.During a follow-up of 3 months,the presence of CHIP was associated with recurrent stroke(HR 1.62,95%CI 1.04 to 2.51,p=0.03),recurrent ischaemic stroke(HR 1.64,95%CI 1.04 to 2.58,p=0.03)and combined vascular events(HR 1.58,95%CI 1.02 to 2.44,p=0.04)after adjusting for hsCRP levels at baseline in patients who had a first-ever AIS.Subgroup analysis demonstrated that CHIP was only associated with recurrent stroke when patients under hyperinflammation(OR 3.10,95%CI 1.92 to 5.00,p<0.001)but not in those without hyperinflammation(OR 0.18,95%CI 0.03 to 1.04,p=0.06,Pinteraction=0.002).Conclusion Our results suggest that somatic mutations contributing to CHIP increase the risk of short-term recurrent stroke in patients who had a first-ever AIS.Hyperinflammation may be important in the relationship between CHIP and recurrent stroke. | Xin Qiu Yalun Dai Si Cheng Hong-Qiu Gu Yong Jiang Xia Meng Yilong Wang Xingquan Zhao Yingyu Jiang Zhe Xu Xinying Huang Meng Wang Tian Jie Lyu Yubo Wang Jiaxu Weng Lingyun Cui Yi Shangguan Hao Li Yongjun Wang Zixiao Li | 2023 | Stroke & Vascular Neurology2023，8，2： | 1 |
| 9 | Supercritical Carbon Dioxide Extraction of Volatile Compounds from Antarctic Krill (Euphausia superba)显示文摘 | Weng Ting Tao Ning Ping Wang Xi Chang Jin Yin Zhe | 2012 | 2012 (396)2012，，396： | 1 |
| 10 | Rational Manipulation of Intermediates on Copper for CO_(2)Electroreduction Toward Multicarbon Products显示文摘Excess greenhouse gas emissions,primarily carbon dioxide(CO_(2)),have caused major environmental concerns worldwide.The electroreduction of CO_(2)into valuable chemicals using renewable energy is an ecofriendly approach to achieve carbon neutrality.In this regard,copper(Cu)has attracted considerable attention as the only known metallic catalyst available for converting CO_(2)to high-value multicarbon(C_(2+))products.The production of C_(2+)involves complicated C-C coupling steps and thus imposes high demands on intermediate regulation.In this review,we discuss multiple strategies for modulating intermediates to facilitate C_(2+)formation on Cu-based catalysts.Furthermore,several sophisticated in situ characterization techniques are outlined for elucidating the mechanism of C-C coupling.Lastly,the challenges and future directions of CO_(2)electroreduction to C_(2+)are envisioned. | Guangyi Jiang Daliang Han Zishan Han Jiachen Gao Xinyu Wang Zhe Weng Quan-Hong Yang | 2022 | Transactions of Tianjin University2022，28，4： | 0 |
| 11 | MECHANISM FOR THE EFFECTS OF MONO-VALENT CATIONS ON ^(23)Na NMR显示文摘The effects of mono-valent cations, Li+, K+, Rb+, Cs+ and NH4+, on 23Na NMR were investigated. It was found that the chemical shifts for Na+ signal shifted downfield with the increase in the relative amounts of monovalent cations. It was suggested that mono-valent cations had competition coordination with Na+ for Dy(PPP)27-. | Zhe ZHOU~*, Rong Juan CONG, Dong Hai LIN, Weng Xiu WANG, Qin Yi WU Department of Chemistry, Xiamen University, Xiamen 361005 | 1993 | Chinese Chemical Letters1993，4，5： | 0 |
| 12 | Altered Retinal Dopamine Levels in a Melatonin-proficient Mouse Model of Form-deprivation Myopia显示文摘Reduced levels of retinal dopamine,a key regulator of eye development,are associated with experimental myopia in various species,but are not seen in the myopic eyes of C57BL/6 mice,which are deficient in melatonin,a neurohormone having extensive interactions with dopamine.Here,we examined the relationship between form-deprivation myopia(FDM)and retinal dopamine levels in melatonin-proficient CBA/CaJ mice.We found that these mice exhibited a myopic refractive shift in form-deprived eyes,which was accompanied by altered retinal dopamine levels.When melatonin receptors were pharmacologically blocked,FDM could still be induced,but its magnitude was reduced,and retinal dopamine levels were no longer altered in FDM animals,indicating that melatonin-related changes in retinal dopamine levels contribute to FDM.Thus,FDM is mediated by both dopamine level-independent and melatonin-related dopamine level-dependent mechanisms in CBA/CaJ mice.The previously reported unaltered retinal dopamine levels in myopic C57BL/6 mice may be attributed to melatonin deficiency. | Kang-Wei Qian Yun-Yun Li Xiao-Hua Wu Xue Gong Ai-Lin Liu Wen-Hao Chen Zhe Yang Ling-Jie Cui Yun-Feng Liu Yuan-Yuan Ma Chen-Xi Yu Furong Huang Qiongsi Wang Xiangtian Zhou Jia Qu Yong-Mei Zhong Xiong-Li Yang Shi-Jun Weng | 2022 | Neuroscience Bulletin2022，38，9： | 0 |
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