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| 1 | Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function显示文摘在肿瘤和免疫系统之间的相互作用仍然糟糕被理解。重要临床的回答在对 CTLA4 和 PD-1/PD-L1 检查点与抗体对待的癌症病人被完成了;然而,仅仅病人的小部分对治疗作出回应,显示需要探索为癌症治疗的另外的 co 禁止的分子。B7-H3, B7 总科的一个成员,被我们以前显示出禁止 T 房间激活和 autoimmunity。在这研究,我们在肿瘤免疫分析了 B7-H3 的功能。B7-H3 的表示在多重肿瘤线,渗入肿瘤的树枝状的房间,和巨噬细胞被发现。与对抗抗体对待到 B7-H3 的 B7-H3-deficient 老鼠或老鼠显示出多重肿瘤的减少的生长,它取决于 NK 和 CD8 + T 房间。与细胞毒素的淋巴细胞表示的通常认为的受体, B7-H3 禁止了他们的激活,并且它的缺乏在忍受肿瘤的鼠标导致了增加的细胞毒素的淋巴细胞功能。B7-H3 和 PD-1 的联合封锁导致了迟了阶段的肿瘤的进一步提高的治疗学的控制。一起拿,我们的结果显示 B7-H3 检查点可以对癌症为免疫疗法用作一个新奇目标。 | Young-hee Lee Natalia Martin-Orozco Peilin Zheng Jing Li Peng Zhang Haidong Tan Hyun Jung Park Mira Jeong Seon Hee Chang Byung-Seok Kim Wei Xiong Wenjuan Zang Li Guo Yang Liu Zhong-jun Dong Willem W Overwijk Patrick Hwu Qing Yi Larry Kwak Zhiying Yang Tak W Mak Wei-Li Laszlo G Radvanyi Ling Ni Dongfang Liu Chen Dong | 2017 | Cell Research2017，27，8： | 29 |
| 2 | Colonic stenting versus emergency surgery for acute left-sided malignant colonic obstruction: a multicentre randomised trial显示文摘 | Jeanin E van Hooft Willem A Bemelman Bas Oldenburg Andreas W Marinelli Martijn F Lutke Holzik Marina J Grubben Mirjam A Sprangers Marcel G Dijkgraaf Paul Fockens | 2011 | Lancet Oncology2011，，4： | 3 |
| 3 | Coronary artery disease in congenital single coronary artery in adults:A Dutch case series显示文摘AIM:To assess the current diagnostic and therapeutic management and the clinical implications of congenital single coronary artery(SCA) in adults.METHODS:We identified 15 patients with a SCA detected from four Dutch angiography centers in the period between 2010 and 2013.Symptomatic patients who underwent routine diagnostic coronary angiography(CAG) for suspected coronary artery disease and who incidentally were found to have isolated SCA were analyzed.RESULTS:Fifteen(7 females) with a mean age of 58.5 ± 13.78 years(range 43-86) had a SCA.ConventionalCAG demonstrated congenital isolated SCA originating as a single ostium from the right sinus of Valsalva in 6 patients and originating from the left in 9 patients.Minimal to moderate coronary atherosclerotic changes were found in 4,and severe stenotic lesions in another 4 patients.Seven patients were free of coronary atherosclerosis.Runs of non-sustained ventricular tachycardia were documented in 2 patients,one of whom demonstrated transmural ischemic changes on presentation.Myocardial perfusion scintigraphic evidence of transmural myocardial ischemia was found in 1 patient due to kinking and squeezing of the SCA with an interarterial course between the aorta and pulmonary artery.Multi-slice computed tomography(MSCT) was helpful to delineate the course of the anomalous artery relative to the aorta and pulmonary artery.Percutaneous coronary intervention was successfully performed in 3 patients.Eight patients were managed medically.Arterial bypass graft was performed in 4 patients with the squeezed SCA.CONCLUSION:SCA may be associated with transient transmural myocardial ischemia and aborted sudden death in the absence of coronary atherosclerosis.The availability and sophistication of MSCT facilitates the delineation of the course of a SCA.We present a Dutch case series and review of the literature. | Salah AM Said Willem G de Voogt Suat Bulut Jacques Han Peter Polak Rogier LG Nijhuis Jeroen W op den Akker Andries Slootweg | 2014 | World Journal of Cardiology2014，6，4： | 3 |
| 4 | Response of turbine flow meters to acoustic per- turbations显示文摘 | STOLTENKAMP P W BERGERVOET J T M WILLEMS J F H | 2008 | Journal of Sound Vibration2008，315，12： | 1 |
| 5 | Homoelinic orbit for a class of Hamiltonian systems显示文摘 | Omaha W Willem M | 1992 | Diff lnt Eqns1992，5，5： | 1 |
| 6 | Homoclinic orbits for a class of Hamiltonian systems显示文摘 | Omana W Willem M | | 0，，： | 1 |
| 7 | An integrated approachfor visual analysis of a multisource moving objectsknowledge base 显示文摘 | Willems N van Hage W R de Vries G | 2010 | International Journal of Geographical InformationScience2010，24，10： | 1 |
| 8 | Novel peptides with tyrosinase inhibitory activity 显示文摘 | Marloes S Willem J H van Berkel Harry J W | 2007 | Peptides2007，28，3： | 1 |
| 9 | The mito- chondrial prohibitin complex is essential for embryonic viability and germline function in Caenorhabditis elegans显示文摘 | ARTAK S M TSAND W Y WILLEMS E M | 2003 | J Biol Chem2003，278，32： | 1 |
| 10 | Brain shift estimation in imageguided neurosurgery using 3- D uhrasound 显示文摘 | Letteboer M M Willems P W Viergever M A | 2005 | IEEE Trans Biomed Eng2005，52，2： | 1 |
| 11 | Immunological biomark- ers of tuberculosis显示文摘 | Gerhard W Katharina R Willem H | 2011 | Nat Rev Immunol2011，5，11： | 1 |
| 12 | Systematic review of anterior inter body fusion techniques for single-and bdouble-level cervical degenerative disc disease显示文摘 | Jacobs W Willems PC Kruyt M | 2011 | Spine2011，36，14： | 1 |
| 13 | Ford和PSA公司轻型商用车新型柴油机燃烧系统的开发显示文摘Ford公司和PSA Peugeot Citroon公司首次合作专门为轻型商用车开发柴油机系列。在继承以往发动机基本结构的基础上,引入了一系列新技术,再次提高了商用车领域的技术水平。重点介绍了在德国Aachen的Ford研究中心领导下所进行的燃烧系统开发。该发动机满足轻型商用车的欧4排放法规,同时达到很低的燃油消耗率。 | Heuvel B | 2007 | 国外内燃机2007，39，6： | 1 |
| 14 | Lumbar discography:should we use prophylactic antibiotics?A study of 435 consecutive discograms and a systematic review of the literature显示文摘 | Willems PC Jacobs W Duinkerke ES | 2004 | J Spinal Disord Tech2004，17，： | 1 |
| 15 | Systematic review of anterior interbody fusion techniques for single- and double- level cervical degenerative disc disease 显示文摘 | Jacobs W Willems PC Kruyt M | 2011 | Spine2011，36，14： | 1 |
| 16 | Role of the Bordetella pertussis minor fimbrial subunit, fimd, in colonization of the mouse respiratory tract显示文摘 | GEUIJEN C A W WILLEMS R J L BONGAERTS M | 1997 | Infection and Immunity1997，65，10： | 1 |
| 17 | Luger Dissolution ofammonium paratungstate tetrahydrate in agueous ammonia before and after low temperatuercalcination显示文摘 | 13,John W van Put Willem P CDuyvesteyn and Floris G J | 1991 | Hydrometallurgy1991，26，： | 1 |
| 18 | Atrial fibrillation after radiofrequency ablation of atrial flutter: preventive effect of angiotensin converting enzyme inhibitors, angiotensin Ⅱ receptor blockers, and diuretics显示文摘 | ANNE W WILLEMS R VAN DER MERWE N | 2004 | Heart2004，90，： | 1 |
| 19 | Lumbar discography: should we use prophylactic antibiotics? A study of 435 consecutive discograms and a systematic review of the literature 显示文摘 | Willems PC Jacobs W Duinkerke ES | 2004 | J Spinal Disord Tech2004，17，3： | 1 |
| 20 | Matrix metalloproteinases and atrial remodeling in patients with mitral valve disease and atrial fibrillation显示文摘 | Anné W Willems R Roskams T | 2005 | Cardiovasc Res2005，67，4： | 1 |
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