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| 1 | Role of nitric oxide in the genotoxic response to chronic microcystin-LR exposure in human–hamster hybrid cells显示文摘Microcystin-LR(MC-LR) is the most abundant and toxic microcystin congener and has been classified as a potential human carcinogen(Group 2B) by the International Agency for Research on Cancer. However, the mechanisms underlying the genotoxic effects of MC-LR during chronic exposure are still poorly understood. In the present study, human–hamster hybrid(AL) cells were exposed to MC-LR for varying lengths of time to investigate the role of nitrogen radicals in MC-LR-induced genotoxicity. The mutagenic potential at the CD59 locus was more than 2-fold higher(p < 0.01) in ALcells exposed to a cytotoxic concentration(1 μmol/L) of MC-LR for 30 days than in untreated control cells, which was consistent with the formation of micronucleus. MC-LR caused a dose-dependent increase in nitric oxide(NO) production in treated cells. Moreover, this was blocked by concurrent treatment with the NO synthase inhibitor NG-methyl-L-arginine(L-NMMA), which suppressed MC-LRinduced mutations as well. The survival of mitochondrial DNA-depleted(ρ0) ALcells was markedly decreased by MC-LR treatment compared to that in ALcells, while the CD59 mutant fraction was unaltered. These results provided clear evidence that the genotoxicity associated with chronic MC-LR exposure in mammalian cells was mediated by NO and might be considered as a basis for the development of therapeutics that prevent carcinogenesis. | Xiaofei Wang Pei Huang Yun Liu Hua Du Xinan Wang Meimei Wang Yichen Wang Tom K.Hei Lijun Wu An Xu | 2015 | Journal of Environmental Sciences2015，27，3： | 6 |
| 2 | Experimental investigation on dilatancy behavior of water-saturated sandstone显示文摘It is important to study the dilatancy property of water-saturated rock for understanding the engineering behavior of loaded rock mass. This study carried out the uniaxial and triaxial compressive experiments on the water-saturated red sandstone, analyzed the influences of confining pressure and pore pressure on dilatancy property of water-saturated rock, and discussed the reasonable basis of the stress of dilatancy onset as a strength design parameter of rock engineering, finally established the prediction model of the stress of dilatancy onset under the impacts of confining pressure and pore pressure. The results show that the strength parameters(the stress of dilatancy onset and peak strength) and deformation parameters(axial strain and circumferential strain) of water-saturated sandstone increase with the confining pressure, and the relations can be fitted with a positive linear function. The cohesion and internal friction angle obtained from the stress of dilatancy onset decrease by 11.57% and 7.33%, respectively, when compared with those obtained from the peak strength. The strength parameters and deformation parameters of water-saturated sandstone decrease basically with the increase of pore pressure, in which the relations between strength parameters or axial strain and pore pressure can be fitted with a negative linear function. However, the relation between the peak circumferential strain and the pore pressure should be characterized by a negative exponential function, and the circumferential strain at dilatancy onset isn't affected by the pore pressure. | Jiangyu Wu Meimei Feng Bangyong Yu Wenli Zhang Xiaoyan Ni Guansheng Han | 2018 | International Journal of Mining Science and Technology2018，28，2： | 4 |
| 3 | Additive-free non-fullerene organic solar cells with random copolymers as donors over 9% power conversion efficiency显示文摘In this study, a series of random conjugated polymers (PBDB-TBTn) as donors were designed and synthesized. In these polymers, benzodithiophene unit with thiophene conjugated side chains (BDT) are donor part, and two different content of benzo[1,2-c:4,5-c']dithiophene-4,8-dione (BDD) and difluorobenzothiadizole (BT) linked alkylthiophene are acceptor unit. Polymer solar cells (PSCs) were fabricated with ITIC as an acceptor, and over the power conversion efficiency (PCE) of 9%was obtained, with open circuit voltage (Voc) of 0.86 V, short-circuit current density (Jsc) of 16.84 mA/cm^2, and fill factor (FF) of 62.5%. These random conjugated polymers based solar cells are insensitive to solvent additives and thermal annealing. The performance of the device decreases gradually with the increasing of the proportion of fluorinated acceptor unit. The declining efficiency is due to the excessive fluorinated acceptor unit, which leads to over aggregated topography, destroys the effective charge transport pathways, and affects phase separation domain size between the donor and the acceptor. The phenomena are explained by the charge carrier recombination, atomic force microscope (AFM), and transmission electron microscope (TEM). These results indicate that proper addition of fluorinated acceptor units to build random copolymers can enhance the efficiency of organic photovoltaics toward additive-free and thermal annealing-free PSCs. | Meimei Wu Laitao Shi Yu Hu Lie Chen Ting Hu Youdi Zhang Zhongyi Yuan Yiwang Chen | 2019 | Chinese Chemical Letters2019，30，6： | 3 |
| 4 | Optimization of a doxycycline hydroxypropyl-β-cyclodextrin inclusion complex based on computational modeling显示文摘To prepare a stable complex of doxycycline(Doxy)and hydroxypropy-β-cyclodextrin(HP-β-CD)for ophthalmic delivery,the optimum formulation and preparation conditions were investigated using response surface methodology(RSM),artificial neural network(ANN)and support vector machine(SVM)modeling.The molar ratios of HP-β-CD/Doxy and Mg^(2+)/Doxy,inclusion time and temperature were selected as independent variables (X_(1)-X_(4)) and inclusion efficiency and stability of the Doxy-HP-β-CD complex were selected as dependent(response)variables(Y_(1) and Y_(2)).The optimal formulation predicted by genetic algorithm(GA)combined with the models was characterized by microscopy and nuclear magnetic resonance spectrometry,and the stability of Doxy in the complex was evaluated.The highest values of Y_(1) and Y_(2) were obtained using an ANN model combined with GA which predicted the values of X_(1)-X_(4) to be 4,10.8,12 h and 25℃,respectively.The modeling and optimization results indicated that a feed-forward back-propagation ANN with one hidden layer and 10 hidden units showed better fitting to both responses compared to the RSM and SVM models.GA proved to be an efficient tool in multiobjective optimization of a pharmaceutical formulation. | Zhouhua Wang Zixin He Lei Zhang Haohao Zhang Meimei Zhang Xinguo Wen Guilan Quan Xintian Huang Xin Pan Chuanbin Wu | 2013 | Acta Pharmaceutica Sinica B2013，3，2： | 2 |
| 5 | Fuzzy reasoning Petri nets 显示文摘 | Meimei Gao MengChu Zhou Xiaoguang Huang Zhiming Wu | 2003 | IEEE Transactions on Systems Man and Cybernetics-Part A: Systems and Hu- mans2003，33，3： | 1 |
| 6 | A Petri Net-based Formal Reasoning Algorithm for Fuzzy Production Rule-based System 显示文摘 | Gao Meimei Wu Zhiming Zhou Mengc-hu | 2000 | IEEE International Conference on System Man and Cybernetics2000，，： | 1 |
| 7 | Anti-oxidant anti-inflammatory and antibacterial tannin-crosslinked citrate-based mussel-inspired bioadhesives facilitate scarless wound healing显示文摘The revolutionary role of tissue adhesives in wound closure,tissue sealing,and bleeding control necessitates the development of multifunctional materials capable of effective and scarless healing.In contrast to the use of traditionally utilized toxic oxidative crosslinking initiators(exemplified by sodium periodate and silver nitrate),herein,the natural polyphenolic compound tannic acid(TA)was used to achieve near instantaneous(<25s),hydrogen bond mediated gelation of citrate-based mussel-inspired bioadhesives combining anti-oxidant,anti-inflammatory,and antimicrobial activities(3A-TCMBAs).The resulting materials were self-healing and possessed low swelling ratios(<60%)as well as considerable mechanical strength(up to~1.0 MPa),elasticity(elongation~2700%),and adhesion(up to 40 kPa).The 3A-TCMBAs showed strong in vitro and in vivo anti-oxidant ability,favorable cytocompatibility and cell migration,as well as photothermal antimicrobial activity against both Staphylococcus aureus and Escherichia coli(>90%bacterial death upon near-infrared(NIR)irradiation).In vivo evaluation in both an infected full-thickness skin wound model and a rat skin incision model demonstrated that 3A-TCMBAs+NIR treatment could promote wound closure and collagen deposition and improve the collagen Ⅰ/Ⅲ ratio on wound sites while simultaneously inhibiting the expression of pro-inflammatory cytokines.Further,phased angiogenesis was observed via promotion in the early wound closure phases followed by inhibition and triggering of degradation&remodeling of the extracellular matrix(ECM)in the late stage(supported by phased CD31(platelet endothelial cell adhesion molecule-1)PDGF(platelet-derived growth factor)and VEGF(vascular endothelial growth factor)expression as well as elevated matrix metalloprotein-9(MMP-9)expression on day 21),resulting in scarless wound healing.The significant convergence of material and bioactive properties elucidated above warrant further exploration of 3A-TCMBAs as a significant,new class of bioadhesive. | Keke Wu Meimei Fu Yitao Zhao Ethan Gerhard Yue Li Jian Yang Jinshan Guo | 2023 | Bioactive Materials2023，，2： | 1 |
| 8 | A Petri Net-based Formal Reasoning Algorithm for Fuzzy Production Rule-base Systems显示文摘 | Gao Meimei Wu Zhiming Zhou Mengchu | 2003 | IEEEInternational conference on Systems Man and Cybernetics-PART A:Systems and Humans2003，33，： | 1 |
| 9 | A fuzzy reasoning Petri net model and its reasoning algorithm 显示文摘 | Gao Meimei Wu Zhiming | 1999 | Journal of Shanghai Jiaotong University (English Edition)1999，4，2： | 1 |
| 10 | miR-21 and miR-101 regulate PLAP-1 expression in periodontal ligamentcells显示文摘 | Changxia Li Chunlei Li Jing Yue Xin Huang Meimei Chen Jie Gao Buling Wu | 2012 | Molecular Medicine Reports2012，，5： | 1 |
| 11 | A Petri Net - based Formal Reasoning Algorithm for Fuzzy Production Rule - based System显示文摘 | Gao Meimei Wu Zhiming Zhou Mengc - hu | 2000 | IEEE International Conference on System Man and Cybernetics2000，4，： | 1 |
| 12 | Dietary supplementation with l-arginine or N-carbamylglutamate enhances intestinal growth and heat shock protein-70 expression in weanling pigs fed a corn- and soybean meal-based diet显示文摘 | Xin Wu Zheng Ruan Yunling Gao Yulong Yin Xihong Zhou Lei Wang Meimei Geng Yongqing Hou Guoyao Wu | 2010 | Amino Acids2010，，3： | 1 |
| 13 | Potentiation of synaptic strength and intrinsic excitability in the nucleus accumbens after 10 days of morphine withdrawal显示文摘 | Xiaobo Wu Meimei Shi Chunling Wei | | 0，，： | 1 |
| 14 | Crystal structures and thermal expansion properties of Y_(2-x)Er_xMo_4O_(15) (x=0.0-2.0) solid solutions显示文摘A new series of rare earth compounds,Y2-xErxMo4O15 (x=0.0-2.0),were synthesized and their structures were determined by powder X-ray diffraction (XRD). Rietveld analysis of XRD patterns reveals that the compounds of this series crystallize in monoclinic system with space group P21/c. The lattice parameters a,b,c,β and the unit cell volume V de-crease linearly with increasing Er content. The thermal expansion properties of these compounds were studied under high-temperature XRD. Positive thermal expansions of compounds Y2-xErxMo4O15 are found to be anisotropic along the three crystallographic directions where a and c axes expand while b axis contracts in the whole temperature range. By analysis of data,the expansion of weak band Mo2-O14 with rising temperature should be responsible for positive thermal expansion. | YU Zhouxiang CHEN Dongfeng WANG Hui PENG Jie CHENG Yingzhi WU Meimei HU Zhongbo | 2007 | Rare Metals2007，26，5： | 0 |
| 15 | Progress of Research on Key Technologies and Frontier Applications of Neutron Scattering显示文摘The key project of National Key R&D Program of China'Research on Key Technologies and Frontier Applications of Neutron Scattering'(2017YFA0403700)was approved by Ministry of Science and Technology.Four topics are covered including the key components of neutron scattering optics,two-dimensional high resolution and large area GEM neutron detector,neutron spin echo and total scattering technique,and neutron nondestructive analysis of advanced engineering materials. | WU Meimei HAO Lijie SUN Kai LIU Yuntao | 2018 | 中国原子能科学研究院年报2018，，1： | 0 |
| 16 | Facile ultrafine copper seed-mediated approach for fabricating quasi-two-dimensional palladium-copper bimetallic trigonal hierarchical nanoframes显示文摘有高度分叉的形态学的各向异性的 Pd nanoparticles 着急地由于他们的新奇结构和唯一的物理化学的性质为 nanoscale 设备,催化剂,和察觉到的材料作为积木被需要。然而,为这些材料认识到尺寸控制和分支操作是很挑战性的。在这研究,我们在水的阶段开发一条灵巧的极其细小的 Cu 调停种子的途径生产新奇 Pd-Cu 三角的层次 nanoframes (THNF ) 。大多数获得的 nanocrystals 的主要分支是像三脚架的,与沿着象有自我类似的框架单位的手臂的先进分支。在这个方法, Pd-Cu THNF 的尺寸能被操作包含 sub-3 nm Cu 种子的成核灵活地控制。这些 Pd-Cu THNF 关于他们的乙醇氧化表演超过 Pd 黑色,举办 9.7 和 6.6 分别地更高预定的一项特定的活动和集体活动。这研究为生产控制尺寸的各向异性的二金属的 nanoframes 提供一条万用的极其细小的调停种子的途径。 | Min Shen Yuanbiao Huang Dongshuang Wu Jian Lv Minna Cao Meimei Liu Yinglong Yang Hongfang Li Binbin Guo Rong Cao | 2017 | Nano Research2017，10，8： | 0 |
| 17 | Study on Optimization of Passenger Flow at a Metro Station Based on AnyLogic-Case Study of Youfangqiao Station of Nanjing Metro Line 2显示文摘In this study,simulation software AnyLogic was used to establish a station simulation model for a metro line.First,a basic model of the environment of the metro station was drawn,and accordingly,reasonable assumptions and simplifications were proposed.Then,a diagram of the passenger walking path was created and the simulation variables and functions for passenger flow management were designed.Considering Youfangqiao Station of Nanjing Metro Line 2 in China as an example,the real passenger flow data of this station were statistically analyzed.To simulate the station passenger flow management,input parameters such as the passenger space diameter,passenger flow generation rate,delay rate of automatic fare collection equipment and security check machine,and the number of gates were considered.Passenger flow management was optimized for the morning and evening peak periods,and reasonable suggestions were proposed based on the optimization results,providing a theoretical basis for the construction planning and pre-evaluation of station operation capacities of urban rail transit systems. | Weihong Ni Jiahao Yu Hong Cai Meimei Bai Bin Wu | 2021 | Complex System Modeling and Simulation2021，1，3： | 0 |
| 18 | Recent Progress of Neutron Computed Tomography Device for Radioactive Sample at CARR显示文摘This neutron computed tomography(CT)system(nCT)will be used as a powerful nondestructive tool to study the radioactive samples,in particular the spent nuclear fuel element,which is able to comprehensively discern some defects inside the fuel elements,analyze the distribution and concentration of the inflammable components,detect the hydrogen concentration distribution and geometry change of zirconium alloy cladding,and also the welding state and welding tightness. | LI Zhengyao HE Linfeng WU Meimei HAN Songbai | 2018 | 中国原子能科学研究院年报2018，，1： | 0 |
| 19 | Safety and activity of WX-0593(Iruplinalkib)in patients with ALK-or ROS1-rearranged advanced non-small cell lung cancer:a phase 1 dose-escalation and dose-expansion trial显示文摘WX-0593(Iruplinalkib)is a novel,highly selective oral ALK and ROS1 tyrosine kinase inhibitor(TKI).In this study,the safety,antitumor activity,and pharmacokinetics of WX-0593 were evaluated in advanced non-small cell lung cancer(NSCLC)patients with ALK or ROS1 rearrangement.In the dose-escalation phase and dose-expansion phase,patients were treated with WX-0593 until disease progression,unacceptable toxicity,or subject withdrawal.In the dose-escalation phase,the primary endpoints were maximum tolerated dose(MTD),dose-limiting toxicity(DLT),and safety assessed by investigators.In the dose-expansion phase,the primary endpoint was objective response rate(ORR)assessed by investigators.Between September 25,2017 and October 15,2018,a total of 153 patients received WX-0593 treatment.Two dose-limiting toxicities(DLTs)including one grade 3 QT interval prolonged and one grade 2 chronic heart failure were reported at the dose of 300 mg in one patient.MTD was not reached.Overall,140 of the 152(92%)patients experienced treatment-related adverse events(TRAEs)and 35 of the 152(23%)patients had TRAEs≥grade 3.The overall ORR was 59.3%(32 of 54)for the dose-escalation phase and 56.6%(56 of 99)for the dose-expansion phase.For patients who were ALK-rearranged and ALK TKI naive,the ORR were 81.0%(17 of 21)in the dose-escalation phase and 76.3%(29 of 38)in the dose-expansion phase,and for patients who previously received crizotinib as the only ALK TKI,the ORR were 38.1%(8 of 21)and 45.7%(21 of 46)for the two phases,respectively.For patients who were ROS1-rearranged,the ORR were 30.0%(3 of 10)in the dose-escalation phase and 44.4%(4 of 9)in the dose-expansion phase.WX-0593 showed favorable safety and promising antitumor activity in advanced NSCLC patients with ALK or ROS1 rearrangement. | Yuankai Shi Jian Fang Xuezhi Hao Shucai Zhang Yunpeng Liu Lin Wang Jianhua Chen Yi Hu Xiaosheng Hang Juan Li Chunling Liu Yiping Zhang Zhehai Wang Yanping Hu Kangsheng Gu Jian’an Huang Liangming Zhang Jinlu Shan Weiwei Ouyang Yanqiu Zhao Wu Zhuang Yan Yu Jun Zhao Helong Zhang Pei Lu Weidong Li Meimei Si Mingjing Ge Huaize Geng | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 0 |
| 20 | MODELING OF FMS BASED ON UML AND OPNS显示文摘As the main component of computer integrated manufacturing system (CIMS), flexible manufacturing system (FMS) should be an open system with reusability and extenchaility. Moreover, as FMS is a complex asynchronous concurrent system, its model also should have the abilities to express the concurrency in the system and to analyze the behavior of the system. It is difficult to use any one method to model such a complex system as FMS. A modeling method using Object-oriented modeling language-unified modeling language (UML) and object-Oriented Petri nets (OPNs) is proposed. Class diagram in UML is used to represent the static relations among the objects in FMS. OPNs are used to model the dynamic behavior of the objects and conduct performance analysis. OPNs also can be used to identify the attributes and operations of the objects. The model can describe the system integrally and can be used to design FMS control software naturally. | Gao Meimei Wu Zhiming (Department of Automation, Shanghai Jiaotong University) | 2000 | Chinese Journal of Mechanical Engineering2000，13，2： | 0 |
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