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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | 膳食中钠(盐)与血压的关系及其他膳食因素可能的调节作用显示文摘现有资料表明,膳食钠(盐)与血压直接相关。以往大多数研究结果来自缺乏膳食数据的研究;因此,这种钠-血压关系是否受其他膳食因素调节尚不清楚。国际宏量/微量营养素和血压研究(international study on macro/micronutrients and blood pressure,INTERMAP)结果显示,在控制多种非膳食因素情况下,年龄40~59岁的男性和女性4680人(中国、日本、英国和美国的17个人口样本)的血压与24h尿钠排泄和尿钠/钾直接相关。 | 刘莉 叶鹏 Stamler J Chan Q Daviglus ML Dyer AR Van Horn L Garside DB Miura K Wu Y Ueshima H Zhao L Elliott P INTERMAP Research Group | 2018 | 中华高血压杂志2018，26，4： | 8 |
| 3 | Integrated photonic systems based on transformation optics enabled gradient index devices显示文摘Integrated photonics is expected to play an increasingly important role in optical communications,imaging,computing and sensing with the promise for significant reduction in the cost and weight of these systems.Future advancement of this technology is critically dependent on an ability to develop compact and reliable optical components and facilitate their integration on a common substrate.Here we reveal,with the utility of the emerging transformation optics technique,that functional components composed of planar gradient index materials can be designed and readily integrated into photonic circuits.The unprecedented design flexibility of transformation optics allows for the creation of a number of novel devices,such as a light source collimator,waveguide adapters and a waveguide crossing,which have broad applications in integrated photonic chips and are compatible with current fabrication technology.Using the finite-difference time-domain method,we perform full-wave numerical simulations to demonstrate their superior optical performance and efficient integration with other components in an on-chip photonic system.These components only require spatially-varying dielectric materials with no magnetic properties,facilitating low-loss,broadband operation in an integrated photonic environment. | Qi Wu Jeremiah P Turpin Douglas H Werner | 2012 | Light(Science & Applications)2012，1，1： | 6 |
| 4 | Fen1 mutations that specifically disrupt its interaction ~vith PCNA cause aneuploidy-associated cancer显示文摘 | Li Zheng Huifang Dai Muralidhar L Hegde Mian Zhou Zhigang Guo Xiwei Wu Jun Wu Lei Su Xueyan Zhong Sankar Mitra Qin Huang Kemp H Kernstine Gerd P Pfeifer Binghui Shen | 2011 | Cell Research2011，21，7： | 3 |
| 5 | Evaluation of a locked nucleic acid form of antisense oligo targeting HIF-1α in advanced hepatocellular carcinoma显示文摘BACKGROUND Hypoxia-inducible factor 1α(HIF-1α) is a gene that regulates tumor survival,neovascularization and invasion. Overexpression of HIF-1α correlates with poor prognosis in hepatocellular carcinoma(HCC). RO7070179 is a HIF-1α inhibitor that decreases HIF-1α mRNA and its downstream targets, it could be a potential treatment in HCC.AIM To evaluate safety and preliminary activity of RO7070179 in patients with previously treated HCC, with focus on a patient with prolonged response to RO7070179.METHODS In the preclinical study of RO7070179 in a HCC xenograft model, the mice wereseparated into 4 groups with each group received doses of 0, 3, 10 and 30 mg/kg for total 10 doses. HCC patients who failed at least one line of systemic treatment,received RO7070179 as a weekly infusion, each cycle is 6 wk. We evaluated the safety and HIF-1α mRNA levels of RO7070179.RESULTS Preclinical evaluation of RO7070179 in orthotopic HCC xenograft model showed no significant differences in HCC tumor weight between the 3 and 10 mg/kg groups. However, dose of 10 mg/kg of RO7070179, has shown 76% reduction of the amount of HIF-1α mRNA in HCC tissue. In the phase 1 b study of RO7070179 in previously treated HCC patients, 8 out of 9 were evaluable: 1 achieved PR and1 SD. The patient with PR responded after 2 cycles treatments, which has been maintained for 12 cycles. This patient also showed reduction in perfusion of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI) after 1 cycle of treatment. After 1 cycle of treatment, both patients with PR and SD showed decrease in HIF-1α mRNA at the root of biopsies(each biopsy was divided into 2 specimens, the tip and the root).CONCLUSION RO7070179 can reduce HIF-1α mRNA level in HCC patients with SD or PR. It is well tolerated at 10 mg/kg, with transaminitis as the dose of increased toxicity.This study indicates that RO7070179 might benefit HCC patients, and an early signal for clinical benefit can potentially be predicted through changes in either m RNA level or DCE-MRI within 1 cycle of therapy. | Jennifer Wu Merly Contratto Krishna P Shanbhogue Gulam A Manji Bert H O'Neil Anne Noonan Robert Tudor Ray Lee | 2019 | World Journal of Clinical Oncology2019，10，3： | 2 |
| 6 | Influence of deposition parameters on the internal stress in a-C:H films显示文摘 | Cheng Y H Wu Y P Chen J G | 1999 | Surface and Coating Technol1999，111，： | 2 |
| 7 | The Integrator complex controls the termination of transcription at diverse classes of gene targets显示文摘包含 INTS3 和 NABP1 或 NABP2 的建筑群开始在 DNA 损坏回答被描绘,但是他们的生物化学的功能仍然保持未知。用亲密关系纯化和 HIV 集成定序目标(HIT-Seq ) ,我们发现这些建筑群是综合者建筑群的部分,它绑 RNA 聚合酶 II 并且调整特定的目标基因。综合者作为他们在亲密地被结合的机制处理到他们的成熟形式的部分劈开 snRNAs 抄写结束。然而, HIT-Seq 表明那个综合者也绑在 3 ′以 polyadenylated 抄本复制依赖者 histones 和倡导者结束基因的近似区域。综合者子单元的弄空导致抄写结束失败, histone mRNA 处理的混乱,和 snRNAs 和 histone mRNAs 的 polyadenylation。而且,倡导者综合者的近似绑定否定地通常调整其抄本是的基因的表示 polyadenylated。到所有三个基因类的综合者招募是 DSIF 依赖的,建议那个综合者作为在 DSIF 依赖的 RNA 聚合酶 II 的结束建筑群工作暂停地点。 | Jeffrey R Skaar Andrea L Ferris Xiaolin Wu Anita Saraf Kum Kum Khanna Laurence Florens Michael P Washburn Stephen H Hughes Michele Pagano | 2015 | Cell Research2015，25，3： | 2 |
| 8 | New directions in management accounting research 显示文摘 | Atkinson A A Balakrishnan P B Cote J M Grout T M Roberts H Ulan E Wu A | | Journal of Management Accounting Research0，997，： | 1 |
| 9 | A simple method for cryopreservation of Ginkgo biloba callus显示文摘 | Elena V P Lee E J Wu C H | 2009 | Plant Cell Tissue and Organ Culture2009，97，3： | 1 |
| 10 | The prevalence of iron deficiency anemia and its clinical implications in patients with colorectal carcinoma显示文摘 | Ho C H Yu Y B Wu P H | 2008 | J Chin Med Assoc2008，71，3： | 1 |
| 11 | Numerical solution of time-varying functional differential equations via Haar wavelet显示文摘 | HSIAO C H WU S P | 2007 | Applied Mathematics and Computation2007，188，1： | 1 |
| 12 | P6 aeupoint injec- tion reduce postoperative nausea and vomiting显示文摘 | Shyr M H Hsu J C Wu Y W Hui Y L Tan P P | 1990 | Ma Tsui Hsueh Tsa Chi Anaesthesiol Sinica1990，28，6： | 1 |
| 13 | Chin Tradit Pat Med 显示文摘 | Liu Z Q Lai X P Wu Y H | 2001 | 23(8): 550-5522001，23，8： | 1 |
| 14 | Chemical Characterization of Auricularia Auricula Polysaccharides and Its Pharmacological Effect on Heart Antioxidant Enzyme Activities and Left Ventricular Function in Aged Mice 显示文摘 | Wu Q Tan Z P Liu H D | 2010 | International Journal of Biological Max:romolecules2010，46，4： | 1 |
| 15 | Energy Gradient Line For Drip Irrigation Laterals显示文摘 | Wu I P Gitlin H M | 1975 | Journal of The Irrigation and Drainage Division ASCE1975，101，4： | 1 |
| 16 | Effect of different protein and limiting amino acid levels coupled with a supplement of chromium picolinate on lipid metabolism and carcass characteristics of pigs显示文摘 | Lien T F Wu C P Lin B H | 1998 | Animal Science1998，67，： | 1 |
| 17 | Multifractal analysis of Hang Seng index in Hong Kong stock market显示文摘 | Sun X Chen H P Wu Z Q | 2001 | Physica A2001，291，14： | 1 |
| 18 | A novel approach to high performance elastomer by using clay显示文摘 | Wang Y Q Wu Y P Zhang H F | 2004 | Macromolecular Rapid Communications2004，25，19： | 1 |
| 19 | Heating of ions by Alfvén waves via nonresonant interactions显示文摘 | Wang C B Wu C S Yoon P H | 2006 | Physical Review Letters2006，96，12： | 1 |
| 20 | In-situ test of soil-root systems显示文摘 | Wu T H Beal P E Lan C | 1988 | Journal of Geotechnical Engineering ASCE1988，114，12： | 1 |
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