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| 1 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 2 | Genetic transformation of wheat mediated by Agrobacterium tumefaciens显示文摘 | Cheng M Fry J E Pang S Zhou H Hironaka C M Duncan D R Conner T W Wan Y | 1997 | Plant Physiol1997，，： | 2 |
| 3 | 新生儿继发于筛窦炎的眼眶脓肿(英文)显示文摘骨膜下脓肿是眼眶蜂窝织炎的一种,以脓和渗出液汇集在眼眶内骨膜下为特点。对于新生儿,眼眶脓肿非常罕见。我们报告1例年龄为26d的右眼患有严重眼眶蜂窝织炎的女患儿。眼眶和副鼻窦CT扫描显示右眼眶蜂窝织炎并内侧骨膜下和眼眶后部脓肿。眼分泌物培养见葡萄球菌生长,经用先锋霉素和甲硝唑静脉注射和经内窥镜鼻窦手术行急诊脓肿引流,恢复良好。通过内窥镜的鼻窦引流手术是预防更严重的并发症的首选治疗。 | C D Che Mahiran K Wan Mariny J Alagaratnam W H Wan Hazabbah | 2008 | 国际眼科杂志2008，8，4： | 2 |
| 4 | Clinical measures of disease severity and outcome in psoriasis:a critical appraisal of their quality显示文摘 | ASHCROFT D M WAN PO A L WILLIAMS H C | 1999 | Br J Dermatol1999，141，2： | 1 |
| 5 | Acclimatization of soil respiration to warming in a tall grass prairie显示文摘 | Luo Y Wan S H ui D | 2001 | Nature2001，413，： | 1 |
| 6 | Telangiectatic osteosarcoma:radiologic-pathologic comparison显示文摘 | Mark D M Suphanee wan Jaovisidha H Thomas T | 2003 | Radiology2003，229，： | 1 |
| 7 | Effect of drip irrigation with saline water on tomato ( Lycopersicon esculentum Mill) yield and water use in semi-humid area显示文摘 | Wan S Q Kang Y H Wang D | 2007 | Agricultural Water Management2007，90，： | 1 |
| 8 | Study of a combined sulfur autotrophic with proton-exchange membraneelectrodialyticdeni- trification technology: Sulfate control and pH balance显示文摘 | Wan D J Liu H J Liu R P | 2011 | Bioresource Technology2011，102，10： | 1 |
| 9 | Anionic surfactant induced mesophase transformation to synthesize highly ordered large-pore mesoporous silica structures显示文摘 | Chen D H Li Z Wan Y | 2006 | J Mater Chem2006，16，： | 1 |
| 10 | Preparation and characterization of rare earth orthovanadates for propane oxidative dehydrogenation 显示文摘 | Au C T Zhang W D Wan H L | 1996 | Catal Lett1996，37，： | 1 |
| 11 | Cryptic invasion of the exotic Bemisia tabaci biotype Q occurred widespread in Shandong Province of China显示文摘 | Chu D Zhang Y J Wan F H | 2010 | Florida Entomologist2010，93，： | 1 |
| 12 | A onepass thinning algorithm and its parallel implementation显示文摘 | CHIN R T WAN G H K Stover D L | 1987 | Computer Vision Graphics Image Process-ing1987，40，1： | 1 |
| 13 | Absorption Rate into a MDEA Aqueous Solution Blended with Piperazine under a High CO_2 Partial Pressure显示文摘 | Zhang X Wan H L Weng W Z Yi X D | | 0，，1： | 1 |
| 14 | Synthesis and properties of polyfor proton conducting membranes in fuel cells显示文摘 | Guan Y Pu H Wan D | 2011 | Polymer Chemistry Articles2011，39，2： | 1 |
| 15 | Combination of mean platelet volume and the GRACE risk score better predicts future cardiovascular events in patients with acute coronary syndrome 显示文摘 | WAN Z F ZHOU D XUE J H | 2014 | Platelets2014，25，6： | 1 |
| 16 | Study on microstructure and ther-modynamics of nacre in mussel shell 显示文摘 | Ren F Z Wan X D Ma Z H | 2009 | Materials Chemistry andPhysics2009，114，1： | 1 |
| 17 | An effective feature selection method forhyperspectral image classification based on genetic algorithm and sup-port vector machine显示文摘 | Li S J Wu H Wan D | 2011 | Knowledge - Based Systems2011，24，1： | 1 |
| 18 | VOCs decomposition via modified ferroelectric packed bed dielectric barrier discharge plasma 显示文摘 | Zhu T Wan Y D Li H R | 2011 | IEEE Transactions on P/asma Science2011，39，8： | 1 |
| 19 | 查看详情显示文摘 | Qian X F Wan Y Wen Y L Jia N Q Li H X Zhao D Y | | 0，，： | 1 |
| 20 | Catalpol increases brain angiogenesis and up-regulates VEGF and EPO in the rat after permanent middle cerebral artery occlusion 显示文摘 | Zhu H F Wan D Luo Y | 2010 | Int J Biol Sci2010，6，5： | 1 |
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