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| 1 | Experimental study on the effect of granular backfill with various gradations on the mechanical behavior of rock显示文摘Backfilling is a common practice in the mining industry and the backfilling performance plays a significant role in supporting the surrounding rock mass.To evaluate the backfilling performance,an experimental apparatus has been developed to understand how backfill affects the compressive strength of sandstone specimens in the laboratory.Pebbles were selected to model the backfill and divided into six groups with different particle sizes using a set of standard sieves.The backfilling pebbles with three types of particle size compositions were then produced,i.e.single gradation,two adjacent gradations,and increasingly widening gradations.A series of compressive tests were carried out to study the mechanical behavior of the sandstone specimens confined by these pebbles.The effects of the gradations of the filled pebbles on the peak and residual compressive strengths were analyzed.It is found that the increasing amount of the compressive strength is over 10%in most cases,even up to 20%.Based on the experiment data,the increasing amount was also estimated theoretically under some assumptions and it further confirmed the experimental results.The effects are closely related to the gradations of the filled pebbles except for their dense degree. | Zhihua Le Qinglei Yu Wancheng Zhu Hongyuan Liu Tianhong Yang | 2021 | International Journal of Mining Science and Technology2021，31，5： | 2 |
| 2 | The effect of oxygen on the epitaxial growth of diamond显示文摘We studied the effect of oxygen on the growth quality of diamond epitaxial layers. After oxygen is added during the growth of the diamond epitaxial layer, as the thickness of the epitaxial layer increases, the full width at half maximum of the rocking curve of the(004) plane of diamond epitaxial layer increases continuously, and, in addition, the intensities of both the Raman peaks and the free exciton emission peaks of the diamond epitaxial layer decrease continuously. These experimental results demonstrate that as the thickness of the diamond epitaxial layer increases, the quality of the diamond epitaxial layer degrades. The strong etching effect of the OH radical groups in the plasma on the diamond epilayers leads to the degradation of their crystallinity. | Meng Gong Yanan Chen Wancheng Yu Peng Jin Zhanguo Wang Zhimin Wang Shenjin Zhang Feng Yang Fengfeng Zhang Qinjun Peng Zuyan Xu | 2018 | Journal of Semiconductors2018，39，12： | 1 |
| 3 | Highly dispersed Mn_2O_3 microspheres:Facile solvothermal synthesis and their application as Li-ion battery anodes显示文摘Nanostructured transition metal oxides are promising alternative anodes for lithium ion batteries.Li-ion storage performance is expected to improve if high packing density energy particles are available.Herein,Mn_2O_3 microspheres with a ca.18 μm diameter and a tapped density of 1.33 g/cm^3 were synthesized by a facile solvothermal-thermal coversion route.Spherical MnCO_3 precursors were obtained through solvothermal treatment and they decomposed and converted into Mn_2O_3 microspheres at an annealing temperature of 700 C.The Mn_2O_3 microspheres consisted of Mn_2O_3 nanoparticles with an average 40 nm diameter.These porous Mn_2O_3 microspheres allow good electrolyte penetration and provide an ion buffer reservoir to ensure a constant electrolyte supply.The Mn_2O_3 microspheres have reversible capacities of590 and 320 mAh/g at 50 and 400 mA/g,respectively.We thus report an efficient route for the fabrication of energy particles for advanced energy storage. | Jianfei Yu Lin Zhu Cheng Fan Cheng Zan Ling Hu Shuhui Yang Qiang Zhang Wancheng Zhu Lin Shi Fei Wei | 2015 | Particuology2015，13，5： | 1 |
| 4 | Enhanced mechanical and microwave-absorption properties of SiC f /AlPO 4 composite with PIP–SiC interphase and the MWCNTs filler显示文摘 | Feng Wan Fa Luo Yang Mu Zhiyin Zeng Wancheng Zhou | 2015 | Ceramics International2015，，8： | 1 |
| 5 | Improvement of mechanical and dielectric properties of PIP-SiCf/SiC corn posites by using TiaSiCz as inert filler显示文摘 | Mu Yang Zhou Wancheng Hu Yang | 2015 | Ceramics Inter- national2015，41，2： | 1 |
| 6 | The effects of CVD SiC interphase on mechanical properties of KD-1 SiC fiber reinforced aluminum phosphate composites显示文摘 | Donghai Ding Wancheng Zhou Fa Luo Yang Mu Dongmei Zhu | 2011 | Materials Science & Engineering A2011，，： | 1 |
| 7 | Preparation and properties of barium aluminosilicate glass-ceramics显示文摘 | Wancheng Zhou Litong Zhang Jueming Yang | 1997 | Journal of Materials Science1997，，18： | 1 |
| 8 | Enhancing the HSV-1-mediated antitumor immune response by suppressing Bach1显示文摘Background In 2015,herpes simplex virus 1(HSV-1)-derived talimogene laherparepvec(T-VEC)was the first oncolytic virus approved by the US Food and Drug Administration as a therapeutic agent for cancer treatment.However,its antitumor application is limited to local treatment of melanoma,and there is a lack of understanding of the mechanisms underlying the regulation of HSV-1 replication in cancer cells and the associated antitumor immunity.We hypothesized that increasing the replication capacity of HSV-1 in tumor cells would enhance the antitumor effect of this virus.Methods We systematically identified IFN-stimulated genes induced by HSV-1 by performing functional screens and clarified the mechanism by which BACH1 acts against HSV-1.Then,we tested the effect of BACH1 deficiency on immunogenic cell death induced by HSV-1.Furthermore,we investigated the antitumor effect of BACH1 deficiency on HSV-1 in MCA205 and B16 murine tumor models.Results We identified eight IFN-stimulated genes(ISGs)controlling HSV-1 replication,among which BTB and CNC homology 1(BACH1)suppressed HSV-1 replication by inhibiting the transcription of ICP4,ICP27,and UL39.Loss of Bach1 function not only increased HSV-1 proliferation but also promoted HSV-1-induced cell apoptosis,HMGB1 secretion,and calreticulin exposure in tumor cells.More importantly,hemin,an FDA-approved drug known to downregulate BACH1,significantly enhanced HSV-1-mediated antitumor activity with increased T lymphocyte infiltration at the tumor site.Conclusions Our studies uncovered a novel antiviral activity of BACH1 and provided a new strategy for improving the clinical efficiency of the oncolytic virus HSV-1. | Chaohu Pan Qiaomei Cai Xiaorong Li Lili Li Liping Yang Yu Chen Junxiao Liu Wancheng Liu Meiling Gao Tianqi Sui Xiaoyang Wang Huiming Fan Jiayin Ruan Yueyue Shi Saihua Chen Lucy S.Cheng Jiayong Liu Heng Yang Genhong Cheng | 2022 | Cellular & Molecular Immunology2022，19，4： | 0 |
| 9 | Breathable Electronic Skins for Daily Physiological Signal Monitoring显示文摘With the aging of society and the increase in people’s concern for personal health,long-term physiological signal monitoring in daily life is in demand.In recent years,electronic skin(e-skin)for daily health monitoring applications has achieved rapid development due to its advantages in high-quality physiological signals monitoring and suitability for system integrations.Among them,the breathable e-skin has developed rapidly in recent years because it adapts to the long-term and high-comfort wear requirements of monitoring physiological signals in daily life.In this review,the recent achievements of breathable e-skins for daily physiological monitoring are systematically introduced and discussed.By dividing them into breathable e-skin electrodes,breathable e-skin sensors,and breathable e-skin systems,we sort out their design ideas,manufacturing processes,performances,and applications and show their advantages in long-term physiological signal monitoring in daily life.In addition,the development directions and challenges of the breathable e-skin are discussed and prospected. | Yi Yang Tianrui Cui Ding Li Shourui Ji Zhikang Chen Wancheng Shao Houfang Liu Tian-Ling Ren | 2022 | Nano-Micro Letters2022，14，10： | 0 |
| 10 | Correction to:Enhancing the HSV-1-mediated antitumor immune response by suppressing Bach1显示文摘In the version of this article initially published,a grant name and the acknowledgment information were missing.The grant name and acknowledgment information have been added at the end of Acknowledgments:J.L.is supported by WU Jieping Medical Foundation(320.6750.2021-17-12).We thank Dr.Chunfu Zheng for providing the HSV-1 BAC plasmid.The results and conclusions were not affected. | Chaohu Pan Qiaomei Cai Xiaorong Li Lili Li Liping Yang Yu Chen Junxiao Liu Wancheng Liu Meiling Gao Tianqi Sui Xiaoyang Wang Huiming Fan Jiayin Ruan Yueyue Shi Saihua Chen Lucy SCheng Jiayong Liu Heng Yang Genhong Cheng | 2022 | Cellular & Molecular Immunology2022，19，6： | 0 |
| 11 | Homeoprotein SIX1 compromises antitumor immunity through TGF-β-mediated regulation of collagens显示文摘The tumor microenvironment(TME),including infiltrated immune cells,is known to play an important role in tumor growth;however,the mechanisms underlying tumor immunogenicity have not been fully elucidated.Here,we discovered an unexpected role for the transcription factor SIX1 in regulating the tumor immune microenvironment.Based on analyses of patient datasets,we found that SIX1 was upregulated in human tumor tissues and that its expression levels were negatively correlated with immune cell infiltration in the TME and the overall survival rates of cancer patients.Deletion of Six1 in cancer cells significantly reduced tumor growth in an immune-dependent manner with enhanced antitumor immunity in the TME.Mechanistically,SIX1 was required for the expression of multiple collagen genes via the TGFBR2-dependent Smad2/3 activation pathway,and collagen deposition in the TME hampered immune cell infiltration and activation.Thus,our study uncovers a crucial role for SIX1 in modulating tumor immunogenicity and provides proof-of-concept evidence for targeting SIX1 in cancer immunotherapy. | Wancheng Liu Meiling Gao Lili Li Yu Chen Huimin Fan Qiaomei Cai Yueyue Shi Chaohu Pan Junxiao Liu Lucy S.Cheng Heng Yang Genhong Cheng | 2021 | Cellular & Molecular Immunology2021，18，12： | 0 |
| 12 | Strategies for Project-oriented Teaching Design of Automobile Inspection and Maintenance Course显示文摘Automobile Inspection and Maintenance Course is relatively practical and professional.Therefore,teachers need to provide students with opportunities for practice as much as possible,so that students can realize the integration of theory and practice,improve teaching efficiency.Project-oriented teaching design can enable students to participate in the practical training and maintenance of automotive engines,which helps students understand the theories in the book.This article mainly analyzes the strategies for teaching design of project-oriented Automobile Inspection and Maintenance Course. | Huimin Zhao Jianmin Mei Wancheng Yang | 2020 | Journal of Contemporary Educational Research2020，4，4： | 0 |
| 13 | 野生型p53通过激活PUMA抑制氧化磷酸化而促进肿瘤代谢显示文摘文章简介在一半的人类癌症中,肿瘤抑制因子p53发生了基因突变。然而令人困惑的是,在某些人类癌症如肝癌(HCC)中常常保留有野生型p53。本研究最新研究发现,野生型p53可通过诱导PUMA来抑制丙酮酸驱动的氧化磷酸化,从而产生致癌作用。IκB激酶介导PUMA在位点Ser96/106磷酸化,与线粒体丙酮酸载体(MPC)发生相互作用,进而破坏MPC寡聚化和功能,以抑制线粒体丙酮酸的摄取。 | Jinchul Kim Lili Yu Wancheng Chen Yanxia Xu Meng Wu Dilyana Todorova Qingshuang Tang Bingbing Feng Lei Jiang Jingjin He Guihua Chen 付雪梅 Yang Xu | 2020 | 科学新闻2020，，2： | 0 |
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