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| 1 | Non-canonical regulation of SPL transcription factors by a human OTUBl-like deubiquitinase defines a new plant type rice associated with higher grain yield显示文摘完成增加的谷物生产率长是引起节目的谷物的制服的焦点。ideotype 途径被用来在国际瑞斯研究院并且在中国改进米饭收益潜力。然而,在米饭的收益相关的特点的基因基础仍然保持不清楚。这里,我们显示出那一个主要量的特点地点, qNPT1,通过建筑学由更少 tillers 描绘了的一种新植物类型(NPT ) 的决心的行为,更坚定的灰煤杆和更大的圆锥花序,并且它与相同编码 deubiquitinating 酶到人的 OTUB1。OsOTUB1 的 Downregulation 提高 meristematic 活动,导致在谷物产量的减少的 tiller 数字,增加的谷物数字,提高的谷物重量和米饭的作为结果的增加。不同于人的 OTUB1, OsOTUB1 能劈开连接 K48 、连接 K63 的 polyubiquitin。OsOTUB1 与 E2 结合 ubiquitin 蛋白质 OsUBC13 和 squamosa 倡导者绑定交往像蛋白质的抄写因素 OsSPL14。OsOTUB1 和 OsSPL14 分享普通目标基因,和他们的物理相互作用限制 OsSPL14 的连接 K63 的 ubiquitination (K63Ub ) ,它接着支持 OsSPL14 的 K48Ub 依赖的 proteasomal 降级。相反地, OsOTUB1 的 loss-of-function 与 OsSPL14 的高水平的累积被相关,导致 NPT 建筑学。我们也证明 high-yielding npt1 和 dep1-1 等位基因节节上升为增加在当前是可完成的的上面的米饭收益潜力提供新策略。 | Shuansuo Wang Kun Wu Qian Qian Qian Liu Qi Li Yajun Pan Yafeng Ye Xueying Liu Jing Wang Jianqing Zhang Shan Li Yuejin Wu Xiangdong Fu | 2017 | Cell Research2017，27，9： | 33 |
| 2 | Occurrence of perfluoroalkyl substances in matched human serum,urine,hair and nail显示文摘The purpose of this study was to determine perfluoroalkyl substances(PFASs) in human serum, urine, hair and nail from general populations, and to investigate the possibility for human urine, hair and nail used as the biomonitoring sample for PFASs exposure. We detected the concentrations of PFHx A, PFOA, PFNA, PFDA, PFUn DA, PFDo A, PFHx S and PFOS in 39 matched human serum, urine, hair and nail samples from Shenzhen in China. The detection frequency and the median level of PFOS were all higher than that of the other PFASs in four matrices. The median concentration of PFOS in serum, urine, hair, and nail were 9.24 ng/mL, 13.96 ng/L, 0.58 ng/g and 0.63 ng/g, respectively. The results of spearman correlation test indicated that nail was an ideal matrix for biomonitoring PFOS rather than human urine and hair in general populations for the non-invasive sampling. | Yuxin Wang Yuxin Zhong Jingguang Li Jianqing Zhang Bing Lyu Yunfeng Zhao Yongning Wu | 2018 | Journal of Environmental Sciences2018，30，5： | 17 |
| 3 | ^(40)Ar/^(39)Ar isochron ages of lawsonite blueschists from Jiuquan in the northern Qilian Mountain,NW China,and their tectonic implications显示文摘Using laser 40Ar/39Ar dating method,we have gotten the metamorphic ages of lawsonite blueschist and epidote blueschist from Jiuquan,northern Qilian Mountain,NW China.The high quality laser 40Ar/39Ar dating of glaucophane from lawsonite blueschist gives an isochron age of 413±5 Ma.The isochron age obtained from phengite in epidote blueschist is 415±7 Ma.These data,combining with peak metamorphic P-T conditions and regional geological setting,allow us to infer that the lower limit of the ages of the prograde subduction metamorphism from lawsonite blueschist facies to epidote blueschist facies occurred at ca.413-415 Ma,which also suggests that the formation of lawsonite blueschist in the northern Qilian Mountain maybe resulted from the corner flow in the cold subduction zone.This study shows that the final closing time of the northern Qilian remnant oceanic basin is about 413-415 Ma,which also represents the convergent age between the North China Craton and the Qaidam block. | LIN YiHui ZHANG LiFei JI JianQing WANG QianJie SONG ShuGuang | 2010 | Chinese Science Bulletin2010，55，19： | 15 |
| 4 | Evidences of rapid erosion driven by climate in the Yarlung Zangbo (Tsangpo) Great Canyon,the eastern Himalayan syntaxis显示文摘Climate and tectonism are both particularly intense in the Yarlung Zangbo (Tsangpo) Great Canyon in the eastern Himalayan syntaxis,which is characterized by the most rapid landscape evolution of anywhere in the world.Thus,the eastern Himalayan syntaxis is one of the best locations to study the interactions between climate and tectonics.This paper investigates the cooling ages of the Doxong La-Baibung profile using apatite fission track (AFT) dating on 11 bedrock samples at elevations ranging from 4210 to 710 m.There are topographic,climatic,metamorphic,and thermochronological gradients in the profile,providing good conditions to study interactions between climate and tectonics.AFT ages ranged from 4.6±0.6 Ma to 1.7±0.3 Ma,and the mean fission track lengths ranged from 11.0 to 12.4 μm.It was found that the cooling rates revealed by AFT ages increased with decreasing elevation.However,the tendency of the cooling rates revealed by the 40 Ar-39 Ar ages was different from that indicated by the AFT ages.Moreover,for most districts of the eastern Himalayan syntaxis,the compiled AFT age distribution correlates well with the annual average precipitation,indicating the coupling of the cooling and erosion rates of the near-surface rock and precipitation.The geothermal history modeling results indicate an obvious increase in the cooling and erosion rate between 1.0 and 0.5 Ma.This age is consistent with other research findings for this time,when the vapor channel of the Yarlung Zangbo Great Canyon began to take effect.These evidences suggest that climate,especially precipitation,has acting as a key factor influencing the rapid cooling and erosion in the Yarlung Zangbo Great Canyon since 1-0.5 Ma. | YU XiangJiang JI JianQing GONG JunFeng SUN DongXia QING JianChun WANG LiNing ZHONG DaLai ZHANG ZhiCheng | 2011 | Chinese Science Bulletin2011，56，11： | 11 |
| 5 | Changes in Extreme Maximum Temperature Events and Population Exposure in China under Global Warming Scenarios of 1.5 and 2.0°C: Analysis Using the Regional Climate Model COSMO-CLM显示文摘We used daily maximum temperature data(1986–2100) from the COSMO-CLM(COnsortium for Small-scale MOdeling in CLimate Mode) regional climate model and the population statistics for China in 2010 to determine the frequency, intensity, coverage, and population exposure of extreme maximum temperature events(EMTEs) with the intensity–area–duration method. Between 1986 and 2005(reference period), the frequency, intensity, and coverage of EMTEs are 1330–1680 times yr^(–1), 31.4–33.3°C, and 1.76–3.88 million km^2, respectively. The center of the most severe EMTEs is located in central China and 179.5–392.8 million people are exposed to EMTEs annually. Relative to 1986–2005, the frequency, intensity, and coverage of EMTEs increase by 1.13–6.84, 0.32–1.50, and15.98%–30.68%, respectively, under 1.5°C warming; under 2.0°C warming, the increases are 1.73–12.48, 0.64–2.76,and 31.96%–50.00%, respectively. It is possible that both the intensity and coverage of future EMTEs could exceed the most severe EMTEs currently observed. Two new centers of EMTEs are projected to develop under 1.5°C warming, one in North China and the other in Southwest China. Under 2.0°C warming, a fourth EMTE center is projected to develop in Northwest China. Under 1.5 and 2.0°C warming, population exposure is projected to increase by23.2%–39.2% and 26.6%–48%, respectively. From a regional perspective, population exposure is expected to increase most rapidly in Southwest China. A greater proportion of the population in North, Northeast, and Northwest China will be exposed to EMTEs under 2.0°C warming. The results show that a warming world will lead to increases in the intensity, frequency, and coverage of EMTEs. Warming of 2.0°C will lead to both more severe EMTEs and the exposure of more people to EMTEs. Given the probability of the increased occurrence of more severe EMTEs than in the past, it is vitally important to China that the global temperature increase is limited within 1.5°C. | Mingjin ZHAN Xiucang LI Hemin SUN Jianqing ZHAI Tong JIANG Yanjun WANG | 2018 | Journal of Meteorological Research2018，32，1： | 11 |
| 6 | Identification of potential cross-protective epitope between a new type of coronavirus(2019-nCoV)and severe acute respiratory syndrome virus显示文摘Recently,a new type of unknown virus causing severe acute res-piratory infection was reported in Wuhan city,Hubei province,China(WHO,2020b).Infection of this virus was first reported in December 2019,and origin of the virus was traced back to a large seafood/wide animal market in Wuhan city.The serious clinical symptoms of the viral infection,including fever,dry cough,dys-pnea,and pneumonia,may result in progressive respiratory failure and even death.Moreover,the quick spread of the virus has caused an epidemic in China,as well as infection cases worldwide.The whole-genome sequence of Wuhan new virus(WH-Human_.1)was first released on January 10,2020(Zhang,2020),followed by additional ones released in Global Initiative on Sharing All Influ-enza Data(GISAID)(Shu and McCauley,2017).Later,this new virus was determined and announced as a new type of coronavirus(CoV;2019-nCoV)by the World Health Organization(WHO,2020a). | Tianyi Qiu Tiantian Mao Yuan Wang Mengdi Zhou Jingxuan Qiu Jianwei Wang Jianqing Xu Zhiwei Cao | 2020 | Journal of Genetics and Genomics2020，47，2： | 11 |
| 7 | Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2显示文摘Host cellular receptors play key roles in the determination of virus tropism and pathogenesis.However,little is known about SARS-CoV-2 host receptors with the exception of ACE2.Furthermore,ACE2 alone cannot explain the multi-organ tropism of SARS-CoV-2 nor the clinical differences between SARS-CoV-2 and SARS-CoV,suggesting the involvement of other receptor(s).Here,we performed genomic receptor profiling to screen 5054 human membrane proteins individually for interaction with the SARS-CoV-2 capsid spike(S)protein.Twelve proteins,including ACE2,ASGR1,and KREMEN1,were identified with diverse S-binding affinities and patterns.ASGR1 or KREMEN1 is sufficient for the entry of SARS-CoV-2 but not SARS-CoV in vitro and in vivo.SARS-CoV-2 utilizes distinct ACE2/ASGR1/KREMEN1(ASK)receptor combinations to enter different cell types,and the expression of ASK together displays a markedly stronger correlation with virus susceptibility than that of any individual receptor at both the cell and tissue levels.The cocktail of ASK-related neutralizing antibodies provides the most substantial blockage of SARS-CoV-2 infection in human lung organoids when compared to individual antibodies.Our study revealed an interacting host receptome of SARS-CoV-2,and identified ASGR1 and KREMEN1 as alternative functional receptors that play essential roles in ACE2-independent virus entry,providing insight into SARS-CoV-2 tropism and pathogenesis,as well as a community resource and potential therapeutic strategies for further COVID-19 investigations. | Yunqing Gu Jun Cao Xinyu Zhang Hai Gao Yuyan Wang Jia Wang Juan He Xiaoyi Jiang Jinlan Zhang Guanghui Shen Jie Yang Xichen Zheng Gaowei Hu Yuanfei Zhu Shujuan Du Yunkai Zhu Rong Zhang Jianqing Xu Fei Lan Di Qu Guoliang Xu Yun Zhao Dong Gao Youhua Xie Min Luo Zhigang Lu | 2022 | Cell Research2022，32，1： | 8 |
| 8 | Comparative genomic and transcriptomic analyses uncover the molecular basis of high nitrogen-use efficiency in the wheat cultivar Kenong 9204显示文摘Studying the regulatory mechanisms that drive nitrogen-use efficiency(NUE)in crops is important for sustainable agriculture and environmental protection.In this study,we generated a high-quality genome assembly for the high-NUE wheat cultivar Kenong 9204 and systematically analyzed genes related to nitrogen uptake and metabolism.By comparative analyses,we found that the high-affinity nitrate transporter gene family had expanded in Triticeae.Further studies showed that subsequent functional differentiation endowed the expanded family members with saline inducibility,providing a genetic basis for improving the adaptability of wheat to nitrogen deficiency in various habitats.To explore the genetic and molecular mechanisms of high NUE,we compared genomic and transcriptomic data from the high-NUE cultivar Kenong 9204(KN9204)and the low-NUE cultivar Jing 411 and quantified their nitrogen accumulation under high-and low-nitrogen conditions.Compared with Jing 411,KN9204 absorbed significantly more nitrogen at the reproductive stage after shooting and accumulated it in the shoots and seeds.Transcriptome data analysis revealed that nitrogen deficiency clearly suppressed the expression of genes related to cell division in the young spike of Jing 411,whereas this suppression of gene expression was much lower in KN9204.In addition,KN9204 maintained relatively high expression of NPF genes for a longer time than Jing 411 during seed maturity.Physiological and transcriptome data revealed that KN9204 was more tolerant of nitrogen deficiency than Jing 411,especially at the reproductive stage.The high NUE of KN9204 is an integrated effect controlled at different levels.Taken together,our data provide new insights into the molecular mechanisms of NUE and important gene resources for improving wheat cultivars with a higher NUE trait. | Xiaoli Shi Fa Cui Xinyin Han Yilin He Long Zhao Na Zhang Hao Zhang Haidong Zhu Zhexin Liu Bin Ma Shusong Zheng Wei Zhang Jiajia Liu Xiaoli Fan Yaoqi Si Shuiquan Tian Jianqing Niu Huilan Wu Xuemei Liu Zhuo Chen Deyuan Meng Xiaoyan Wang Liqiang Song Lijing Sun Jie Han Hui Zhao Jun Ji Zhiguo Wang Xiaoyu He Ruilin Li Xuebin Chi Chengzhi Liang Beifang Niu Jun Xiao Junming Li Hong-Qing Ling | 2022 | Molecular Plant2022，15，9： | 6 |
| 9 | Graphene/phosphorene nano-heterojunction:facile synthesis, nonlinear optics, and ultrafast photonics applications with enhanced performance显示文摘Owing to its thickness-modulated direct energy band gap, relatively strong light–matter interaction, and unique nonlinear optical response at a long wavelength, few-layer black phosphorus, or phosphorene, becomes very attractive in ultrafast photonics applications. Herein, we synthesized a graphene/phosphorene nano-heterojunction using a liquid phase-stripping method. Tiny lattice distortions in graphene and phosphorene suggest the formation of a nano-heterojunction between graphene and phosphorene nanosheets. In addition, we systematically investigate their nonlinear optical responses at different wavelength regimes. Our experiments indicate that the combined advantages of ultrafast relaxation, broadband response in graphene, and the strong light–matter interaction in phosphorene can be combined together by nano-heterojunction. We have further fabricated two-dimensional(2D) nano-heterojunction based optical saturable absorbers and integrated them into an erbium-doped fiber laser to demonstrate the generation of a stable ultrashort pulse down to 148 fs. Our results indicate that a graphene/phosphorene nano-heterojunction can operate as a promising saturable absorber for ultrafast laser systems with ultrahigh pulse energy and ultranarrow pulse duration. We believe this work opens up a new approach to designing 2D heterointerfaces for applications in ultrafast photonics and other research.The fabrication of a 2D nano-heterojunction assembled from stacking different 2D materials, via this facile and scalable growth approach, paves the way for the formation and tuning of new 2D materials with desirable photonic properties and applications. | SHUNXIANG LIU ZHONGJUN LI YANQI GE HUIDE WANG RUI YUE XIANTAO JIANG JIANQING LI QIAO WEN HAN ZHANG | 2017 | Photonics Research2017，5，6： | 6 |
| 10 | Upregulation of miR-489-3p and miR-630 inhibits oxaliplatin uptake in renal cell carcinoma by targeting OCT2显示文摘Renal cell carcinoma(RCC) is one of the most common malignant tumors affecting the urogenital system, accounting for 90% of renal malignancies. Traditional chemotherapy options are often the front-line choice of regimen in the treatment of patients with RCC, but responses may be modest or limited due to resistance of the tumor to anticarcinogen. Downregulated expression of organic cation transporter OCT2 is a possible mechanism underlying oxaliplatin resistance in RCC treatment. In this study, we observed that mi R-489-3 p and mi R-630 suppress OCT2 expression by directly binding to the OCT2 30-UTR. Meanwhile, via 786-O-OCT2-mi RNAs stable expression cell models, we found that mi RNAs could repress the classic substrate 1-methyl-4-phenylpyridinium(MPP+), fluorogenic substrate N,N-dimethyl-4-(2-pyridin-4-ylethenyl) aniline(ASP+), and oxaliplatin uptake by OCT2 both in vitro and in xenografts. In 33 clinical samples, mi R-489-3 p and mi R-630 were significantly upregulated in RCC, negatively correlating with the OCT2 expression level compared to that in adjacent normal tissues, using tissue microarray analysis and q PCR validation. The increased binding of c-Myc to the promoter of pri-mi R-630, responsible for the upregulation of mi R-630 in RCC, was further evidenced by chromatin immunoprecipitation and dual-luciferase reporter assay. Overall, this study indicated that mi R-489-3 p and mi R-630 function as oncotherapy-obstructing micro RNAs by directly targeting OCT2 in RCC. | Lu Chen Le Chen Zhiyuan Qin Jinxiu Lei Sheng Ye Kui Zeng Hua Wang Meidan Ying Jianqing Gao Su Zeng Lushan Yu | 2019 | Acta Pharmaceutica Sinica B2019，9，5： | 5 |
| 11 | Transgenic 4-1BBL-engineered vaccine stimulates potent Gag-specific therapeutic and long-term immunity via increased priming of CD44+CD62Lhigh IL-7R+ CTLs with up- and downregulation of anti- and pro-apoptosis genes显示文摘 | Rong Wang Andrew Freywald Yue Chen Jianqing Xu Xin Tan Jim Xiang | 2015 | Cellular & Molecular Immunology2015，12，4： | 4 |
| 12 | Recent advances in anisotropic two-dimensional materials and device applications显示文摘Two-dimensional(2D)materials,such as transition metal dichalcogenides(TMDs),black phosphorus(BP),MXene and borophene,have aroused extensive attention since the discovery of graphene in 2004.They have wide range of applications in many research fields,such as optoelectronic devices,energy storage,catalysis,owing to their striking physical and chemical properties.Among them,anisotropic 2D material is one kind of 2D materials that possess different properties along different directions caused by the intrinsic anisotropic atoms5 arrangement of the 2D materials,mainly including BP,borophene,low-symmetry TMDs(ReSe2 and ReSa)and group IV monochalcogenides(SnS,SnSe,GeS,and GeSe).Recently,a series of new devices has been fabricated based on these anisotropic 2D materials.In this review,we start from a brief introduction of the classifications,crystal structures,preparation techniques,stability,as well as the strategy to discriminate the anisotropic characteristics of 2D materials.Then,the recent advanced applications including electronic devices,optoelectronic devices,thermoelectric devices and nanomechanical devices based on the anisotropic 2D materials both in experiment and theory have been summarized.Finally,the current challenges and prospects in device designs,integration,mechanical analysis,and micro-/nano-fabrication techniques related to anisotropic 2D materials have been discussed.This review is aimed to give a generalized knowledge of anisotropic 2D materials and their current devices applications,and thus inspiring the exploration and development of other kinds of new anisotropic 2D materials and various novel device applications. | Jinlai Zhao Dingtao Ma Cong Wang Zhinan Guo Bin Zhang Jianqing Li Guohui Nie Ni Xie Han Zhang | 2021 | Nano Research2021，14，4： | 4 |
| 13 | Novel exosome-targeted T-cell-based vaccine counteracts T-cell anergy and converts CTL exhaustion in chronic infection via CD40L signaling through the mTORC1 pathway显示文摘CD8 + 细胞毒素的 T 淋巴细胞(CTL ) 疲劳是为在长期的传染疾病的无效病毒消除的一个主要问题。我们产生了新奇 ovalbumin (卵) 特定的 OVA-Texo 和导致治疗学的免疫的 HIV 特定的 Gag-Texo 疫苗。在长期的感染估计他们的治疗学的效果,我们由与表示卵的侵入人体气管粘膜的病菌 AdVova 感染 C57BL/6 老鼠的 i.v 开发了一个新长期的感染模型。在长期的 AdVova 感染期间,老鼠 CTL 被发现房间死亡 protein-1 (PD-1 ) 和淋巴细胞激活 gene-3 (LAG-3 ) 到禁止的分子规划了的快车,证明在 T 房间增长, IFN- 生产和 cytolytic 的重要缺乏完成机能上地精疲力尽并且。天真的 CD8 + T 房间 upregulated 禁止的 PD-ligand 1 (PD-L1 ) , B 淋巴细胞和 T 淋巴细胞衰减器和 T 房间联系变应力缺乏的分子(圣盘和痒) 当时下面调整在在有长期的感染的老鼠的刺激之上的 proliferative 反应。显著地, OVA-Texo 疫苗抵抗了 T 房间变应力缺乏并且变换了 CTL 疲劳。后者与(i) 被联系为 CTL 功能的一个标记的 upregulation, diacetylated histone-H3 (diAcH3 ) ,(ii ) CTL,宿主 DC 的发生独立人士或 CD4 + T 细胞的四折的增加,并且(iii ) CTL IFN- 生产和 cytotoxicity 的恢复。在 vivo OVA-Texo-stimulated CTL upregulated mTORC1 的活动小径相关的分子 Akt, S6, eIF4E 和 T 赌注,和有一个 mTORC1 禁止者的 CTL 的处理, rapamycin,显著地在 CTL 减少了 OVA-Texo-induced 增加。有趣地,发信号的 OVA-Texo-mediated CD40L 在观察免疫学的效果起了一个关键作用。重要地, Gag-Texo 疫苗在长期的感染导致了作呕特定的治疗学的免疫。因此,这研究应该为人的免疫不全在新治疗学的疫苗的发展有严肃的影响病毒(HIV-1 ) 感染。 | Rong Wang Aizhang Xu Xueying Zhang Jie Wu Andrew Freywald Jianqing Xu Jim Xiang | 2017 | Cellular & Molecular Immunology2017，14，6： | 4 |
| 14 | Trajectory prediction of cyclist based on dynamic Bayesian network and long short-term memory model at unsignalized intersections显示文摘Cyclist trajectory prediction is of great significance for both active collision avoidance and path planning of intelligent vehicles.This paper presents a trajectory prediction method for the motion intention of cyclists in real traffic scenarios.This method is based on dynamic Bayesian network(DBN)and long short-term memory(LSTM).The motion intention of cyclists is hard to predict owing to potential large uncertainties.The DBN is used to infer the distribution of cyclists’intentions at intersections to improve the prediction time.The LSTM with encoder-decoder is used to predict the cyclists’trajectories to improve the accuracy of prediction.Therefore,the DBN and LSTM are adopted to guarantee prediction accuracy and improve the prediction time.The experiment results are presented to show the effectiveness of the predict strategies. | Hongbo GAO Hang SU Yingfeng CAI Renfei WU Zhengyuan HAO Yongneng XU Wei WU Jianqing WANG Zhijun LI Zhen KAN | 2021 | Science China(Information Sciences)2021，64，7： | 4 |
| 15 | Structure,Timing,and Mechanism of the Pliocene and Late Miocene Uplift Process of the Ailao Shan-Diancang Shan,SE Tibet,China显示文摘The uplift of the Ailao Shan-Diancang Shan(ASDS) along the Ailao Shan-Red River(ASRR) shear zone is an important geological event in the southeastern margin of Qinghai-Tibet Plateau tectonic domain in the Late Cenozoic,and it preserves important information on the structures,exhumational history and tectonic evolution of the ASRR shear zone.The uplift structural mode and uplift timing of the ASDS is currently an important scientific topic for understanding the ASDS formation and late stage movements and evolution of the ASRR shear zone.The formation of the ASDS has been widely considered to be the consequence of the strike-slip movements of the ASRR shear zone.However,the shaping of geomorphic units is generally direct results of the latest tectonic activities.In this study,we investigated the timing and uplift structural mechanism of the ASDS and provided the following lines of supportive evidence.Firstly,the primary tectonic foliation of the ASDS shows significant characteristic variations,with steeply dipping tectonic foliation developed on the east side of the ASDS and the relatively horizontal foliation on the west side.Secondly,from northeast to southwest direction,the deformation and metamorphism gradually weakened and this zone can be further divided into three different metamorphic degree belts.Thirdly,the contact relationship between the ASDS and the Chuxiong basin-Erhai lake is a normal fault contact which can be found on the east side of the ASDS.40Ar/39 Argeochronology suggests that the Diancang Shan had experienced a fast cooling event during 3–4 Ma.The apatite fission track testing method gives the age of 6.6–10.7 Ma in the Diancang Shan and 4.6–8.4 Ma in the Ailao Shan,respectively.Therefore the uplift of the ASDS can be explained by tilted block mode in which the east side was uplifted much higher than the west side,and it is not main reason of the shearing movements of the ASRR shear zone.The most recent uplift stages of the ASDS happened in the Pliocene(3–4 Ma) and Late Miocene(6–10 Ma). | LI Baolong WANG Dandan JI Jianqing | 2014 | Acta Geologica Sinica(English Edition)2014，88，4： | 3 |
| 16 | Novel C-17 spirost protostane-type triterpenoids from Alisma plantago-aquatica with antiinflammatory activity in Caco-2 cells显示文摘Twenty-one protostane-type triterpenoids with diverse structures, including nine new compounds(1 e9), were isolated from the of Alisma plantago-aquatica Linn. Structurally, alisolides A-F(1 e6), composed of an oxole group coupled to a five-membered ring, represent unusual C-17 spirost protostane-type triterpenoids. Alisolide H(8) is a novel triterpenoid with an unreported endoperoxide bridge. Alisolide I(9) represents the first example of 23,24-acetal triterpenoid. Their structures were elucidated based on spectroscopic analysis, wherein the absolute configurations of 4-6, 8 were further confirmed by the Mo2(OAc)4-induced ECD method. Furthermore, all isolates were evaluated for their inhibitory effects on LPS-induced NO production in Caco-2 cells, and all the compounds showed remarkable inhibitory activities, with IC50 values in the range of 0.76 e38.20 mmol/L. | Qinghao Jin Jianqing Zhang Jinjun Hou Min Lei Chen Liu Xia Wang Yong Huang Shuai Yao Bang Yeon Hwang Wanying Wu Dean Guo | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 3 |
| 17 | Fabrication of cellular Zn–Mg alloy foam by gas release reaction via powder metallurgical approach显示文摘By using CaCO_3 as the 'blowing agent', Zn–(10–50) wt% Mg alloy foams with close-pore structure were fabricated by the powder metallurgical route. The key of successful foaming is Mg addition and the proper sintering treatment, which lead to the formation of intermetallic compounds and can make the gas release reaction between Mg melt and CaCO_3 happen the during foaming process. | Donghui Yang Jianqing Chen Weiping Chen Lei Wang Hui Wang Jinghua Jiang Aibin Ma | 2017 | Journal of Materials Science & Technology2017，33，10： | 3 |
| 18 | Microbiota analysis revealed vertical transmission and microbial adjusting function of symbiotic fungus in the attelabid weevil fungiculture显示文摘Dear Editor,Microbial symbionts are crucial participants in the life history of fungus-farming insects (Mueller et al., 2005;Youngsteadt, 2008). The attelabid weevil (Euops chinensis)feeding on Fallopia japonica in southern China, has evolved a special proto-farming bipartite symbiosis with the fungus(Penicillium herquei), which produces antibiotic (+)-scleroderolide in the leaf-rolls ('cradle' for offspring development) to protect the offspring from potential microbial parasites and pathogens (Sakurai, 1985;Wang et al., 2015). | Bin Lin Lin Wang Muzammi Hussain Xiaoling Zhang Jianqing Tian Sha Qi Xingzhong Liu Meichun Xiang | 2019 | Science China(Life Sciences)2019，62，12： | 3 |
| 19 | Ore-forming Fluid Characteristics of the Saishitang Cu-polymetallic Deposit in Qinghai Province,China显示文摘Saishitang Cu-polymetallic deposit is located in the southeast section of Late Paleozoic arcfold in the southeastern margin of Qaidam platform. Accoring to the geological process of the deposit,four mineralization episodes were identified: melt/fluid coexisting period(O),skarn period(A),first sulfide period(B) and second sulfide period(C),and 10 stages were finally subdivided. Three types of inclusions were classified in seven stages,namely crystal bearing inclusions(type I),aqueous inclusions(type II) and pure liquid inclusions(type III). Type I and II inclusions were observed in stage O1,having homogenization temperature from 252 to 431°C,and salinities ranging from 24.3% to 48.0%. Type I inclusion was present in stage A1,having homogenization temperature from 506 to 548°C,and salinities ranging from 39.4% to 44.6%. In stage B1,type II and III inclusions were observed,with homogenization temperature concentrating between 300–400°C,and salinities from 0.4% to 4.3%. Type II inclusions were present in stage B2,with homogenization temperature varying from 403 to 550°C. In stage C1,type I and II inclusion commonly coexisted,and constituted a boiling inclusion group,having homogenization temperatures at 187–463°C,and salinities in a range of 29.4%–46.8% and 2.2%–11.0%. Type II and III inclusions were developed in stage C2,having homogenization temperature at 124–350°C,and salinities ranging between 1.6% and 15.4%. In stage C3,type II and III inclusions were presented,with a homogenization temperature range of 164–360°C,and salinities varying from 4.0% to 11.0%. The results of micro-thermal analysis show that fluids are characterized by high temperature and high salinity in stage O1 and A1,and experienced slight decrease in temperature and dramatic decrease in salinity in stage B1 and B2. In stage C1,the salinity of fluid increased greatly and a further decrease of temperature and salinity occurred in stage C2 and C3. Fluids boiled in stage C1. With calculated pressure of 22 MPa from the trapping temperature of 284–289°C,a mineralization depth of 2.2 km was inferred. Results of Laser Raman Spectroscopy show high density of H2 O,CH4 and CO2 were found as gas composition. H-O isotope study indicates the oreforming fluids were the mixture of magmatic water and meteoric water. Physicochemical parameters of fluids show oxygen and sulfur fugacity experienced a decrease,and redox state is weakly reducing. Along with fluid evolution,oxidation has increased slightly. Comprehensive analysis shows that melt exsolution occurred during the formation of quartz diorite and that metal elements existed and migrated in the form of chlorine complex. Immiscible fluid separation and boiling widely occurred after addition of new fluids,bringing about dissociation of chlorine-complex,resulting in a great deal of copper precipitation. In conclusion,Saishitang deposit,controlled by regional tectonics,is formed by metasomatism between highly fractionated mineralization rock body and wall rock,and belongs to banded skarn Cu-polymetallic deposit. | LAI Jianqing JU Peijiao MAO Yin AN Jianghua WANG Xiongjun | 2015 | Acta Geologica Sinica(English Edition)2015，89，2： | 2 |
| 20 | Generation of liver bipotential organoids with a small-molecule cocktail显示文摘Understanding the mechanism of how cholangiocytes(liver ductal cells)are activated upon liver injury and specified to hepatocytes would permit liver regenerative medicine.Here we achieved long-term in vitro expansion of mouse liver organoids by modulating signaling pathways with a combination of three small-molecule compounds.CHIR-99021,blebbistatin,and forskolin together maintained the liver organoids in bipotential stage with both cholangiocyte-and hepatocyte-specific gene expression profiles and enhanced capacity for further hepatocyte differentiation.By employing a chemical approach,we demonstrated that Wnt/β-catenin,NMII-Rac,and PKA-ERK are core signaling pathways essential and sufficient for mouse liver progenitor expansion.Moreover,the advanced small-molecule culture of bipotential organoids facilitates the ex vivo investigation of liver cell fate determination and the application of organoids in liver regenerative medicine. | Xin Wang Chao Ni Ning Jiang Jinsong Wei Jianqing Liang Bing Zhao Xinhua Lin | 2020 | Journal of Molecular Cell Biology2020，12，8： | 2 |
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