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| 1 | Osteoarthritis:toward a comprehensive understanding of pathological mechanism显示文摘Osteoarthritis(OA) is the most common degenerative joint disease and a major cause of pain and disability in adult individuals. The etiology of OA includes joint injury, obesity, aging, and heredity. However, the detailed molecular mechanisms of OA initiation and progression remain poorly understood and, currently,there are no interventions available to restore degraded cartilage or decelerate disease progression. The diathrodial joint is a complicated organ and its function is to bear weight, perform physical activity and exhibit a joint-specific range of motion during movement. During OA development, the entire joint organ is affected, including articular cartilage, subchondral bone, synovial tissue and meniscus. A full understanding of the pathological mechanism of OA development relies on the discovery of the interplaying mechanisms among different OA symptoms, including articular cartilage degradation, osteophyte formation, subchondral sclerosis and synovial hyperplasia, and the signaling pathway(s) controlling these pathological processes. | Di Chen Jie Shen Weiwei Zhao Tingyu Wang Lin Han John L Hamilton Hee-Jeong Im | 2017 | Bone Research2017，5，1： | 121 |
| 2 | Stable classi?cation with limited sample: transferring a 30-m resolution sample set collected in 2015 to mapping 10-m resolution global land cover in 2017显示文摘As the world strives to reduce the impact of population growth, urbanization, agricultural expansion, and climate change on food security, energy and water shortage, resource over-exploration, biodiversity loss, environmental pollution, and ultimately human health, timely and higher resolution land cover information is urgently needed to achieve the sustainable development goals of the United Nations. | Peng Gong Han Liu Meinan Zhang Congcong Li Jie Wang Huabing Huang Nicholas Clinton Luyan Ji Wenyu Li Yuqi Bai Bin Chen Bing Xu Zhiliang Zhu Cui Yuan Hoi Ping Suen Jing Guo Nan Xu Weijia Li Yuanyuan Zhao Jun Yang Chaoqing Yu Xi Wang Haohuan Fu Le Yu Iryna Dronova Fengming Hui Xiao Cheng Xueli Shi Fengjin Xiao Qiufeng Liu Lianchun Song | 2019 | Science Bulletin2019，64，6： | 166 |
| 3 | Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection显示文摘It has been known that,the novel coronavirus,2019-nCoV,which is considered similar to SARS-CoV,invades human cells via the receptor angiotensin converting enzyme II(ACE2).Moreover,lung cells that have ACE2 expression may be the main target cells during 2019-nCoV infection.However,some patients also exhibit non-respiratory symptoms,such as kidney failure,implying that 2019-nCoV could also invade other organs.To construct a risk map of different human organs,we analyzed the single-cell RNA sequencing(scRNA-seq)datasets derived from major human physiological systems,including the respiratory,cardiovascular,digestive,and urinary systems.Through scRNA-seq data analyses,we identified the organs at risk,such as lung,heart,esophagus,kidney,bladder,and ileum,and located specific cell types(i.e.,type II alveolar cells(AT2),myocardial cells,proximal tubule cells of the kidney,ileum and esophagus epithelial cells,and bladder urothelial cells),which are vulnerable to 2019-nCoV infection.Based on the findings,we constructed a risk map indicating the vulnerability of different organs to 2019-nCoV infection.This study may provide potential clues for further investigation of the pathogenesis and route of 2019-nCoV infection. | Xin Zou Ke Chen Jiawei Zou Peiyi Han Jie Hao Zeguang Han | 2020 | Frontiers of Medicine2020，14，2： | 193 |
| 4 | Towards 6G wireless communication networks:vision,enabling technologies,and new paradigm shifts显示文摘The fifth generation(5G)wireless communication networks are being deployed worldwide from 2020 and more capabilities are in the process of being standardized,such as mass connectivity,ultra-reliability,and guaranteed low latency.However,5G will not meet all requirements of the future in 2030 and beyond,and sixth generation(6G)wireless communication networks are expected to provide global coverage,enhanced spectral/energy/cost efficiency,better intelligence level and security,etc.To meet these requirements,6G networks will rely on new enabling technologies,i.e.,air interface and transmission technologies and novel network architecture,such as waveform design,multiple access,channel coding schemes,multi-antenna technologies,network slicing,cell-free architecture,and cloud/fog/edge computing.Our vision on 6G is that it will have four new paradigm shifts.First,to satisfy the requirement of global coverage,6G will not be limited to terrestrial communication networks,which will need to be complemented with non-terrestrial networks such as satellite and unmanned aerial vehicle(UAV)communication networks,thus achieving a space-airground-sea integrated communication network.Second,all spectra will be fully explored to further increase data rates and connection density,including the sub-6GHz,millimeter wave(mmWave),terahertz(THz),and optical frequency bands.Third,facing the big datasets generated by the use of extremely heterogeneous networks,diverse communication scenarios,large numbers of antennas,wide bandwidths,and new service requirements,6G networks will enable a new range of smart applications with the aid of artificial intelligence(AI)and big data technologies.Fourth,network security will have to be strengthened when developing 6G networks.This article provides a comprehensive survey of recent advances and future trends in these four aspects.Clearly,6G with additional technical requirements beyond those of 5G will enable faster and further communications to the extent that the boundary between physical and cyber worlds disappears. | Xiaohu YOU Cheng-Xiang WANG Jie HUANG Xiqi GAO Zaichen ZHANG Mao WANG Yongming HUANG Chuan ZHANG Yanxiang JIANG Jiaheng WANG Min ZHU Bin SHENG Dongming WANG Zhiwen PAN Pengcheng ZHU Yang YANG Zening LIU Ping ZHANG Xiaofeng TAO Shaoqian LI Zhi CHEN Xinying MA Chih-Lin I Shuangfeng HAN Ke LI Chengkang PAN Zhimin ZHENG Lajos HANZO Xuemin(Sherman)SHEN Yingjie Jay GUO Zhiguo DING Harald HAAS Wen TONG Peiying ZHU Ganghua YANG Jun WANG Erik GLARSSON Hien Quoc NGO Wei HONG Haiming WANG Debin HOU Jixin CHEN Zhe CHEN Zhangcheng HAO Geoffrey Ye LI Rahim TAFAZOLLI Yue GAO HVincent POOR Gerhard P.FETTWEIS Ying-Chang LIANG | 2021 | Science China(Information Sciences)2021，64，1： | 122 |
| 5 | Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells显示文摘人的导致的 pluripotent 茎(iPS ) 房间类似于胚胎的茎(ES ) 房间,和罐头强烈地增殖并且区分进许多房间类型。然而,人的 iPS 房间的肝的区别还没被报导了。在这份报告,人的 iPS 房间被导致由一个逐步的协议区分进肝的房间。肝房间标记的表达式和人的 iPS 的肝相关的函数导出房间的房间被监视并且与区分的人的 ES 房间和主要人的 hepatocytes 的相比。在白天 7 点的约 60% 区分的人的 iPS 房间表示了肝的标记 alpha fetoprotein 和白长袍的。在白天 21 点的区分的房间包括白朊 Asecretion,肝糖合成,脲生产和可诱导的细胞色素 P450 活动展出了肝房间功能。肝的标记的表示和 iPS 的肝相关的功能导出房间的肝的房间比得上人的 ES 导出房间的肝的房间的。这些结果证明人的 iPS 房间,类似于人的 ES 房间,能高效地被导致区分房间进象 hepatocyte 一样。 | Zhihua Song Jun Cai Yanxia Liu Dongxin Zhao Jun Yong Shuguang Duo Xijun Song Yushan Guo Yang Zhao Han Qin Xiaolei Yin Chen Wu Jie Che Shichun Lu Mingxiao Ding Hongkui Deng | 2009 | Cell Research2009，19，11： | 63 |
| 6 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 7 | Ideal cardiovascular health and incidence of atherosclerotic cardiovascular disease among Chinese adults:the China-PAR project显示文摘Existing evidence on the relationship between cardiovascular health(CVH) metrics and cardiovascular disease(CVD) was primarily derived from western populations. We aimed to evaluate the benefits of ideal CVH metrics on preventing incident atherosclerotic CVD(ASCVD) in Chinese population. This study was conducted among 93,987 adults from the China-PAR project(Prediction for ASCVD Risk in China) who were followed up until 2015. Cox proportional hazard regression models were used to estimate the hazard ratios(HRs) and their corresponding 95% confidence intervals(CIs) of CVH metrics for the risk of ASCVD, including coronary heart disease(CHD), stroke and ASCVD death. We further estimated the population-attributable risk percentage(PAR%) of these metrics in relation to each outcome. We observed gradient inverse associations between the number of ideal CVH metrics and ASCVD incidence. Compared with participants having ≤2 ideal CVH metrics, the multivariable-adjusted HRs(95% CIs) of ASCVD for those with 3, 4, 5, 6 and 7 ideal CVH metrics were 0.83(0.74–0.93), 0.66(0.59–0.74), 0.55(0.48–0.61), 0.44(0.38–0.50) and 0.24(0.18–0.31), respectively(P for trend <0.0001). Approximately 62.1% of total ASCVD, 38.7% of CHD, 66.4% of stroke, and 60.5% of ASCVD death were attributable to not achieving all the seven ideal CVH metrics. After adjusting effects of ideal health factors, having four ideal health behaviors could independently bring adults health benefits in preventing 17.4% of ASCVD, 18.0% of CHD, 16.7% of stroke, and 10.1% of ASCVD death. Among all the seven CVH metrics, to keep with ideal blood pressure(BP) implied the largest public health gains against various ASCVD events(PAR% between 33.0% and 47.2%), while ideal diet was the metric most difficult to be achieved in the long term. Our study indicates that the more ideal CVH metrics adults have, the less ASCVD burden there is in China. Special efforts of health education and behavior modification should be made on keeping ideal BP and dietary habits in general Chinese population to prevent the epidemic of ASCVD. | Chao Han Fangchao Liu Xueli Yang Jichun Chen Jianxin Li Jie Cao Ying Li Chong Shen Ling Yu Zhendong Liu Xianping Wu Liancheng Zhao Dongshen Hu Xiangfeng Lu Xigui Wu Dongfeng Gu | 2018 | Science China(Life Sciences)2018，61，5： | 60 |
| 8 | Effect of Microstructure Refinement on the Strength and Toughness of Low Alloy Martensitic Steel显示文摘马氏体的微观结构在熄灭,有从 6 亩 m 到 199 亩 m 的优先的奥氏体谷物尺寸的 tempered 17CrNiMo6 钢被光金属组织学( OM )描绘了,与各种各样的优先的奥氏体谷物尺寸扫描电子显微镜学( SEM )和传动电子显微镜学( TEM ) .Theyield 强度和钢的坚韧被测试并且与微观结构特征相关。结果证明在 17CrNiMo6 钢的优先的奥氏体谷物尺寸和马氏体的包尺寸与收益强度跟随一种 Hall-Petch 关系。当优先的奥氏体谷物尺寸从 199 亩 m 被精制到 6 亩 m 时,收益强度由 235 MPa 增加了,当在 77 K 的 Charpy U槽口冲击能多于 8times 改善了时,显示那微观结构精炼在比在增加强度改进抵抗到劈开骨折是更有效的。破裂表面暗示为劈开骨折的联合起来的裂缝路径作为是包被识别。 | Chunfang WANG Maoqiu WANG Jie SHI Weijun HUI Han DONG | 2007 | Journal of Materials Science & Technology2007，23，5： | 50 |
| 9 | Future changes in thermal comfort conditions over China based on multi-RegCM4 simulations显示文摘使用4个不同全球模式模拟结果,驱动RegCM4区域气候模式,进行了RCP4.5中等温室气体排放情景下东亚地区21世纪气候变化的高分辨率(25 km)模拟。本文基于此套模拟集合,使用综合考虑了气温、相对湿度和风速因素的人体热感受指数有效温度(ET),给出了未来中国区域热舒适条件的变化。分析中同时考虑了未来人口数量和分布情景所引起的暴露度变化。研究发现,未来中国区域的ET的普遍升高引起炎热天气的人口暴露度大幅度增加(到21世纪末相对于当代全国平均将增加6倍‘人-天’(person–days),凉、冷和寒冷天气的暴露度则减少。同时尽管舒适日数有所增加,但相应的人-天数目则有22%的减少。不同因素(气候、人口和两者的相互作用)对于上述变化的贡献分析表明,在舒适度的热端,气候因素的作用更重要,而人口因素则在冷端起着主导作用。总体而言,即使是在中等水平温室气体排放情景下,中国区域未来的热强度也将增加,尽管结果表现出很强的地理依赖特征。相对使用单纯气候因素的结果,人口暴露度的引入对变化信号有着强烈的调制作用,从而更加强调了在与气候变化相关的风险评估分析中,考虑社会-经济因素的重要性。 | GAO Xue-Jie WU Jie SHI Ying WU Jia HAN Zhen-Yu ZHANG Dong-Feng TONG Yao LI Rou-Ke XU Ying GIORGI Filippo | 2018 | Atmospheric and Oceanic Science Letters2018，11，4： | 30 |
| 10 | MATHEMATICAL MODEL FOR THE FLOW WITH SUBMERGED AND EMERGED RIGID VEGETATION显示文摘The article summarizes previous studies on the flow in open channels with rigid vegetation, and constructs a mathematical model for submerged and emerged rigid vegetation. The model involves the forces balance in the control volume in one-dimensional steady uniform flow. For submerged vegetation, the whole flow is divided into four regions: external region, upper vegetated region, transition region and viscous region. According to the Karman similarity theory, the article improves the mixing length expression, and then gives an analytical solution to predict the vertical distribution of stream-wise velocity in the external region. For emerged vegetation, the flow is divided into two region: outer region and viscous region. In the two circumstances, the thicknesses of each region are determined respectively. The comparison between the calculated results and our experimental data and other researchers' data proves that the proposed model is effective. | HUAI Wen-xin CHEN Zheng-bing HAN Jie ZHANG Li-xiang ZENG Yu-hong | 2009 | Journal of Hydrodynamics2009，21，5： | 26 |
| 11 | Differences in microstructure and properties between selective laser melting and traditional manufacturing for fabrication of metal parts: A review显示文摘(直线波松) 作为生产技术的添加剂之一,选择激光融化广泛地被调查制作金属部分。在直线波松,部分以一种 layer-by-layer 方式从粉末直接被生产;直线波松也提供几个优点,例如有高三维的精确性的复杂部分的生产,与生产技术的另外的添加剂相比。因此,直线波松能在航空学被使用,航天学,药,并且死并且铸造工业。然而,这种技术不同于传统的方法,例如扔并且前进;例如,前者极大地以产品的微观结构和性质不同。这份报纸通过直线波松在金属材料制造上总结相关研究。基于在 Huazhong 大学 Sci 技术完成的一个工作,快速的 Manuf。中心(HUST-RMC ) 并且与在其它描述的特征相比,直线波松的报导研究,微观结构,性质,维的精确性,和应用被介绍。 | Bo SONG Xiao ZHAO Shuai LI Changjun HAN Qingsong WEI Shifeng WEN Jie LIU Yusheng SHI | 2015 | Frontiers of Mechanical Engineering2015，10，2： | 26 |
| 12 | Acute kidney injury in acute-on-chronic liver failure is different from in decompensated cirrhosis显示文摘AIM To evaluate the differences in acute kidney injury(AKI) between acute-on-chronic liver failure(ACLF) and decompensated cirrhosis(DC) patients. METHODS During the period from December 2015 to July 2017, 280 patients with hepatitis B virus(HBV)-related ACLF(HBV-ACLF) and 132 patients with HBV-related DC(HBV-DC) who were admitted to our center were recruited consecutively into an observational study. Urine specimens were collected from all subjects and the levels of five urinary tubular injury biomarkers were detected,including neutrophil gelatinase-associated lipocalin(NGAL), interleukin-18(IL-18), liver-type fatty acid binding protein(L-FABP), cystatin C(CysC), and kidney injury molecule-1(KIM-1). Simultaneously, the patient demographics, occurrence and progression of AKI, and response to terlipressin therapy were recorded. All patients were followed up for 3 mo or until death after enrollment. RESULTS AKI occurred in 71 and 28 of HBV-ACLF and HBV-DC patients, respectively(25.4% vs 21.2%, P = 0.358). Among all patients, the levels of four urinary biomarkers(NGAL, CysC, L-FABP, IL-18) were significantly elevated in patients with HBV-ACLF and AKI(ACLF-AKI), compared with that in patients with HBV-DC and AKI(DC-AKI) or those without AKI. There was a higher proportion of patients with AKI progression in ACLF-AKI patients than in DC-AKI patients(49.3% vs 17.9%, P = 0.013). Fortythree patients with ACLF-AKI and 19 patients with DC-AKI were treated with terlipressin. The response rate of ACLFAKI patients was significantly lower than that of patients with DC-AKI(32.6% vs 57.9%, P = 0.018). Furthermore, patients with ACLF-AKI had the lowest 90 d survival rates among all groups(P < 0.001).CONCLUSION AKI in ACLF patients is more likely associated with structural kidney injury, and is more progressive, with a poorer response to terlipressin treatment and a worse prognosis than that in DC patients. | Qun-Qun Jiang Mei-Fang Han Ke Ma Guang Chen Xiao-Yang Wan Semvua Bukheti Kilonzo Wen-Yu Wu Yong-Li Wang Jie You Qin Ning | 2018 | World Journal of Gastroenterology2018，24，21： | 25 |
| 13 | Multicenter case-control study of the risk factors for ulcerative colitis in China显示文摘AIM:To evaluate potential risk factors in the development of ulcerative colitis(UC) in China.METHODS:A total of 1308 patients with UC and 1308 age-matched and sex-matched controls were prospectively studied in China.The UC cases were collected from 17 hospitals in China from April 2007 to April 2010.Uniform questionnaires were designed to investigate risk factors including smoking,appendectomy,stress,socio-economic conditions,nonsteroidal antiinflammatory drugs(NSAIDs),oral contraceptives,diet,breastfeeding,infections and family sanitary conditions.Group comparisons by each factor were done using simple logistic regression analysis.Conditional logistic regression was used for multivariate analysis.RESULTS:By univariate analysis,the variables predictive of UC included feeling stress,light and heavy alcoholic drinking,spicy food,sugar consumption and infectious diarrhea,while heavy tea intake and tap water consumption were protective against UC.On multivariate analysis,the protective factor for UC was tap water consumption [odds ratios(OR) = 0.424,95%CI:0.302-0.594,P < 0.001];while the potential risk factors for UC were heavy sugar consumption(OR = 1.632,95%CI:1.156-2.305,P < 0.001),spicy food(light intake:OR = 3.329,95%CI:2.282-4.857,P < 0.001;heavy intake:OR = 3.979,95%CI:2.700-5.863,P < 0.001),and often feeling stress(OR = 1.981,95%CI:1.447-2.711,P < 0.001).Other factors,such as smoking habit,appendectomy,breastfeeding,a history of measles,rural or urban residence,education,oral contraceptives,and NSAID use have not been found to have a significant association with the development of UC in the present study.CONCLUSION:Our study showed tap water consumption was a protective factor for UC,while spicy food,heavy sugar consumption and often feeling stress were risk factors for UC in this Chinese population. | Yu-Fang Wang Qin Ou-yang Bing Xia Li-Na Liu Fang Gu Kai-Fang Zhou Qiao Mei Rui-Hua Shi Zhi-Hua Ran Xiao-Di Wang Pin-Jin Hu Kai-Chun Wu Xin-Guang Liu Ying-Lei Miao Ying Han Xiao-Ping Wu Guo-Bing He Jie Zhong Guan-Jian Liu | 2013 | World Journal of Gastroenterology2013，19，11： | 24 |
| 14 | Antisense telomerase RNA induced human gastric cancer cell apoptosis显示文摘INTRODUCTION Human tissue homeostasis is precisely regulated bycellular division,differentiation and death.Normalhuman somatic cells progressively lose telomererestriction fragment(TRF)length with eachsuccessive cell division,eventually leading tocellular quiescence,chromosomal end-degradationand apoptosis.On the contrary,stabilization oftelomere lengths by expressing telomerase,an RNA-dependent DNA polymerase,may be involved incellular immortality and carcinogenesis. | Fang Xin Zhang Xue Yong Zhang Dai Ming Fan Zi Yun Deng Yan Yan Han Ping Wu Jun Jie Fan | 2000 | World Journal of Gastroenterology2000，6，3： | 24 |
| 15 | Effect of ursodeoxycholic acid on TGF betal/Smad signaling pathway in rat hepatic stellate cells显示文摘背景肝的纤维变性到 cirrhosis.Ursodeoxycholic 酸( UDCA )的从肝的损害的病理学的进步的关键阶段作为在研究试图在转变生长因素 beta1 ( TGF1 ) /Smad 的发信号的小径上学习 UDCA 的效果并且讨论的长期的肝 diseases.Our 上有重要临床的治疗学的效果被知道了它禁止肝的 fibrosis.Methods 的可能的分子的机制老鼠肝的星形的房间在 vitro 是有教养的并且随机把 gr 分到 4 组 A 是控制组,与仅仅文化媒介使用了的 DMEM,并且组织 B, C, D 是试验性的组,与 UDCA 的不同剂量(1.0 mmol/L, 0.5 mmol/L 和 0.25 mmol/L 分别地) 增加了进他们 24 个小时和 48 个小时的进一步的文化的 DMEM 文化媒介。TGF1 的蛋白质表情, TGF 类型我受体, Smad3, Smad4 和 Smad7 被西方的弄污,以及 TGF1, Smad3, Smad7 和营地反应元素(CREB ) 的表情测量由即时 PCR 的有约束力的蛋白质(CBP ) mRNA。社会科学统计套装软体 11.5 统计包裹与控制组,相比为数据 analyses.Results 被采用在为 24 个小时和 48 个小时的高、中间的 UDCA 剂量组的 TGF1 的 mRNA 表达式显著地减少了( P < 0.05 ),在为 48 个小时的二个上面的组并且在为 24 个小时的高剂量组的 TGF1 的蛋白质表达式显著地减少了( P < 0.05 )。在为 24 个小时和 48 个小时的每个 UDCA 剂量组的 Smad3 的蛋白质和 mRNA 表情显著地减少了,与在不同 UDCA 亲密的组之中的重要差别,在 24 的之间,小时和 48 个小时观察了(P < 0.05 ) 。在高、中间的 UDCA 的 Smad7 的蛋白质和 mRNA 表情关上组显著地增加的 24 个小时和 48 个小时。在为 24 个小时和 48 个小时的每个 UDCA 剂量组的 CBP mRNA 表示显著地减少了( P < 0.05 ),与在不同 UDCA 之中的重要差别,剂量组观察了( P < 0.05 ) .Conclusion UDCA 能通过由禁止 TGF1 , Smad3 和 CBP 的表情并且增加 Smad7 的表示影响 TGF1/Smad 的发信号的小径限制肝的纤维变性的发展。 | LIANG Tie-jun YUAN Jun-hua TAN Yan-rong REN Wan-hua HAN Guo-qing ZHANG Jie WANG Lai-cheng QIN Cheng-yong | 2009 | Chinese Medical Journal2009，，10： | 23 |
| 16 | Estimating In-pulse Characteristics of Radar Signal Based on Multi-index显示文摘 | HAN Jun HE Minghao TANG Zhikai WANG Jie | 2011 | Chinese Journal of Electronics2011，20，1： | 23 |
| 17 | Collagen scaffolds modified with collagen-binding bFGF promotes the neural regeneration in a rat hemisected spinal cord injury model显示文摘Nerve conduit is one of strategies for spine cord injury(SCI)treatment.Recently,studies showed that biomaterials could guide the neurite growth and promote axon regeneration at the injury site.However,the scaffold by itself was difficult to meet the need of SCI functional recovery.The basic fibroblast growth factor(bFGF)administration significantly promotes functional recovery after organ injuries.Here,using a rat model of T9 hemisected SCI,we aimed at assessing the repair capacity of implantation of collagen scaffold(CS)modified by collagen binding bFGF(CBD-bFGF).The results showed that CS combined with CBD-bFGF treatment improved survival rates after the lateral hemisection SCI.The CS/CBD-bFGF group showed more significant improvements in motor than the simply CS-implanted and untreated control group,when evaluated by the 21-point Basso-Beattie-Bresnahan(BBB)score and footprint analysis.Both hematoxylin and eosin(H&E)and immunohistochemical staining of neurofilament(NF)and glial fibrillary acidic protein(GFAP)demonstrated that fibers were guided to grow through the implants.These findings indicated that administration of CS modified with CBD-bFGF could promote spinal cord regeneration and functional recovery. | SHI Qin GAO Wei HAN XingLong ZHU XueSong SUN Jie XIE Fang HOU XiangLin YANG HuiLin DAI JianWu CHEN Liang | 2014 | Science China(Life Sciences)2014，57，2： | 23 |
| 18 | Differential expression of serum miR-126,miR-141 and miR-21 as novel biomarkers for early detection of liver metastasis in colorectal cancer显示文摘Objective:MicroRNAs(miRNAs) have potential as diagnostic biomarkers in cancer.Evaluation of the association between miRNA expression patterns and early detection of liver metastasis in colorectal cancer(CRC) has not been reported.Methods:We investigated the expression of metastasis-associated miRs-31,335,206,141,126,200b,200c,21,Let7a,Let7b and Let7c in localized,liver-metastatic and other organ-metastatic CRC(OM-CRC).Expressions of target miRNAs in serum were evaluated in 116 consecutive localized CRC(L-CRC),72 synchronous liver-metastatic CRC(SLM-CRC) and 36 other OM-CRC by quantitative real-time PCR.Results:Seven of 11 tested miRNAs could be detected from serum.Four miRNAs,miR-126,Let-7a,miR-141 and miR-21 were identified as metastasis-associated miRNAs.Compared with L-CRC,significant upregulated expression was observed for miR-141 and miR-21 in SLM-CRC and OM-CRC,down-regulated expression was observed for miR-126 in SLM-CRC and OM-CRC,and up-regulated expression of Let-7a in OM-CRC.The receiver operating characteristic(ROC) curve showed serum miR-126 had a cut-off [log 10 relative quantity(log 10 RQ)=–0.2005] with 77.78% sensitivity and 68.97% specificity with an area under curve(AUC) of 0.7564,miR-141 had a cut-off(log 10 RQ=–0.2285) with 86.11% sensitivity and 76.11% specificity with an AUC of 0.8279,and miR-21 had a cut-off(log 10 RQ=–0.1310) with 73.61% sensitivity and 66.38% specificity with an AUC of 0.7479.Conclusions:We identified liver metastasis-associated miRNAs,suggesting serum miR-126,miR-141 and miR-21 may be novel biomarkers for clinical diagnosis of early stage liver-metastatic CRC. | Jie Yin Zhigang Bai Jianning Song Yun Yang Jin Wang Wei Han Jun Zhang Hua Meng Xuemei Ma Yao Yang Tingting Wang Weirong Li Zhongtao Zhang | 2014 | Chinese Journal of Cancer Research2014，26，1： | 22 |
| 19 | The final collision of the CAOB:Constraint from the zircon U-Pb dating of the Linxi Formation,Inner Mongolia显示文摘The Linxi Formation occupies an extensive area in the eastern Inner Mongolia in the Central Asian Orogenic Belt(CAOB).The Linxi Formation is composed of slate,siltstone,sandstone and plant,lamellibranch microfossils in the associated strata.Major and trace element data(including REE) for sandstones from the formation indicate that these rocks have a greywacke protolith and have been deposited during a strong tectonic activity.LA-ICPMS U—Pb dating of detrital zircons yield ages of 1801 to 238 Ma for four samples from the Linxi Formation.425—585 Ma,together with the ~500 Ma age for the metamorphism event previously determined for Northeast China,indicates that their provenance is the metamorphic rocks of Pan-African age that have a tectonic affinity to NE China.A few older zircons with U-Pb ages at 1689-1801 Ma,1307-1414 Ma,593-978 Ma are also present,revealing the Neoproterozoic history of NE China.The youngest population shows a peak at ca.252 Ma,suggesting that the main deposition of the Linxi Formation was at late Permain.Moreover,the ca.250 Ma zircon grains of all four samples yield weighted mean ^(206)Pb/^(238)U ages of 250 ± 3 Ma,248 ± 3 Ma,249 ± 3 Ma,and 250 ± 2 Ma,respectively.These ages,together with the youngest zircon age in the sample ZJB-28(ca.238 Ma),suggest that the deposition of the Linxi Formation extended to the early Triassic.Combining with previous results,we suggest that the final collision of the Central Asian Orogenic Belt(CAOB) in the southern of Linxi Formation,which located in the Solonker-Xra Moron-Changchun suture,and the timing for final collision should be at early Triassic. | Jie Han Jian-Bo Zhou Bin Wang Jia-Lin Cao | 2015 | Geoscience Frontiers2015，6，2： | 22 |
| 20 | Activation of aldehyde dehydrogenase 2 slows down the progression of atherosclerosis via attenuation of ER stress and apoptosis in smooth muscle cells显示文摘(ALDH2 ) 醛脱氢酶 2 是在醛的新陈代谢的关键 mitochondrial 酶并且可以为象心脏的肥大,心失败,心肌的 I/R 损害,灌注,心律不齐,冠的心疾病和动脉粥样硬化那样的条件有有益的心血管的效果。在这研究,我们在动脉粥样硬化和内在的机制的前进调查了 ALDH2 的角色,与 endoplasmic 蜂窝胃的一个焦点(嗯) 应力。临床的研究与冠的心疾病在 248 个病人被执行。病人根据他们的 ALDH2 遗传型被划分成二个组。基线临床的特征和冠的 angiography 被记录,并且冠的动脉 Gensini 分数是计算的。4-hydroxy-2-nonenal (4-HNE ) 的浆液层次被检测。临床的学习表明变异的 ALDH2 遗传型是为冠的心疾病的一个独立风险因素。ALDH2 基因多型性仔细与动脉粥样硬化和冠的动脉狭窄的严厉被联系。4-HNE 的浆液层次比在有野类型的 ALDH2 遗传型的病人在有变异的 ALDH2 遗传型的病人是显著地更高的。作为一在里面动脉粥样硬化的 vitro 模型,老鼠光滑的肌肉房间( SMC )与 oxygenized 被对待低密度的脂蛋白( ox-LDL )它显著地提高了层次嗯标记调整葡萄糖的 protein78 ( GRP78 ),蛋白质 kinase 象R一样嗯 kinase (津贴), phosphorylated 真核细胞的翻译开始因素子单元( p-eIF2 ),激活的抄写 factor-4 ( ATF-4 ), CEBP 相应蛋白质(砍)和在房间的 4-HNE 。所有 ox-LDL-induced 回答显著地面对 Alda-1 (激活代理人的 ALDH2 ) 被稀释,并且面对 daidzin (一个 ALDH2 禁止者) 加重了。而且,有 ALDH2 使活跃之物 Alda-1 的预告的处理显著地减少了 ox-LDL-induced apoptosis。同样, ALDH2 的 overexpression 保护了 SMC 免于 ox-LDL-induced 嗯应力象一样嗯导致压力的 apoptosis。这些调查结果建议 ALDH2 可以经由变细减缓动脉粥样硬化的前进嗯在光滑的肌肉房间的应力和 apoptosis。 | Mei-yan YANG Ya-bin WANG Bo HAN Bo YANG Yu-wei QIANG Yan ZHANG Zhao WANG Xu HUANG Jie LIU Yun-dai CHEN Jun REN Feng CAO Yong XU | 2018 | Acta Pharmacologica Sinica2018，39，1： | 22 |
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