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| 1 | Effect of ultrasound-guided acupotomy vs electro-acupuncture on knee osteoarthritis:a randomized controlled study显示文摘OBJECTIVE:To investigate the effect of acupotomy on knee osteoarthritis(KOA),compared to electro-acupuncture(EA).METHODS:Sixty KOA patients were randomly divided into 2 groups:ultrasound-guided acupotomy group and EA group;each had 3 weeks' therapy.After the treatment,by contrast before and after therapy,by comparing curative effects among groups,we looked into disease improvement degree through activities of daily living score(ADL),hospital for special surgery index(HSS),visual analogue scales score(VAS) and knee joint's infrared thermal imaging detection.RESULTS:Graded by ADL,the excellent rate in acupotomy group was much higher than EA group;both acupotomy group and EA group had obviouschanges in HSS index before and after the therapy(P < 0.01).And there was remarkable difference in HSS index variation between the groups(P < 0.01).Acupotomy group and EA group showed big difference in pain index before and after treatment(P <0.01).Apparent difference also existed in the comparison among groups(P < 0.01).Both acupotomy group and EA group had apparent changes in infrared thermal imaging detection before and after the treatment(P < 0.01).CONCLUSION:Acupotomy and EA both have significant effects in KOA treatment;the former is better than the latter in relieving pain and improving knee functions. | Ding Yu Wang Yuexiang Shi Xian Luo Yun Gao Yuhong Pan Jingkun | 2016 | Journal of Traditional Chinese Medicine2016，36，4： | 21 |
| 2 | Hygroscopicity of particles generated from photooxidation of α-pinene under diferent oxidation conditions in the presence of sulfate seed aerosols显示文摘Smog chamber experiments were conducted to investigate the hygroscopicity of particles generated from photooxidation of α-pinene/NOx with diferent sulfate seed aerosols or oxidation conditions. Hygroscopicity of particles was measured by a tandem diferential mobility analyzer(TDMA) in terms of hygroscopic growth factor(Gf), with a relative humidity of 85%. With sulfate seed aerosols present, Gf of the aerosols decreased very fast before notable secondary organic aerosols(SOA) formation was observed, indicating a heterogeneous process between inorganic seeds and organic products might take place as soon as oxidation begins, rather than only happening after gas-aerosol partition of organic products starts. The final SOA-coated sulfate particles had similar or lower Gf than seed-free SOA. The hygroscopicity of the final particles was not dependent on the thickness but on the hygroscopicity properties of the SOA, which were influenced by the initial sulfate seed particles. In the two designed aging processes, Gf of the particles increased more significantly with introduction of OH radical than with ozone. However, the hygroscopicity of SOA was very low even after a long time of aging, implying that either SOA aging in the chamber was very slow or the Gf of SOA did not change significantly in aging. Using an aerosol composition speciation monitor(ACSM) and matrix factorization(PMF) method, two factors for the components of SOA were identified, but the correlation between SOA hygroscopicity and the proportion of the more highly oxidized factor could be either positive or negative depending on the speciation of seed aerosols present. | Biwu Chu Kun Wang Hideto Takekawa Junhua Li Wei Zhou Jingkun Jiang Qinxing Ma Hong He Jiming Hao | 2014 | Journal of Environmental Sciences2014，26，1： | 6 |
| 3 | Innovative development path of ethnomedicines: an overview of ethnomedicines in China显示文摘疾病预防和治疗的长历史上,世界范围的祖先的人口在传统的药获得了知识和经验。例如,中国种族少数的 ethnomedicines 组成传统的药的重要部分。在我们的学习,我们第一澄清了 ethnomedicines 的概念和 ethnopharmacology 的涵义。ethnomedicine 研究的个性然后被总结,并且中国种族少数的 ethnomedicines 的发展侧面被调查当前的地位和存在问题讨论。在这个基础上,我们第一次提炼了 ethnomedicines 的创新发展路径,它为国际化被发现成就和努力的标准化发展研究工业化到 follows:resource 学习。我们发现站台建立并且队训练是完成创新开发的关键。因此,这研究为 ethnomedicine 开发提供了一个基础。 | Zhaoyun Zhu Ting Wang Dehuan Fu Yali Gui Jingkun Wang Tao Cui | 2016 | Frontiers of Medicine2016，10，2： | 4 |
| 4 | Continuous and comprehensive atmospheric observations in Beijing:a station to understand the complex urban atmospheric environment显示文摘Due to profound impact on climate and human health,air quality has attracted attention from all levels of the civil society.The key step in the provision of required tools for the society to tackle the complex air quality problem is to characterize it in a comprehensive manner with a long-term perspective.Here,we describe a continuous and comprehensive observation station and its accompanying state-ofthe-art instrumentation that was established to investigate the complex urban atmospheric environment in a rapidly developing Chinese Megacity.The station,located in downtown Beijing,aims to study air quality by identifying the major atmospheric pollutants and key processes determining their formation and loss mechanisms.A few hundreds of parameters are continuously measured with the state-of-the-art instruments,including trace gas concentrations,aerosol particle size distributions,and mass concentrations,covering aerosol particle chemical composition from molecules to micrometer-sized aerosol particles.This produced long-term,comprehensive big data with around 1�10^(11)bytes per year.In this paper,we provide an overview on the facilities of the station,the instrumentation used,the workflow of continuous observations and examples of results from 2018 to 2019 and a basis for establishing a modern long-term,comprehensive atmospheric urban observation station in other megacities. | Yongchun Liu Chao Yan Zemin Feng Feixue Zheng Xiaolong Fan Yusheng Zhang Chang Li Ying Zhou Zhuohui Lin Yishou Guo Ying Zhang Li Ma Wenshuo Zhou Zhikun Liu Lubna Dada Kaspar Dallenbach Jenni Kontkanen Runlong Cai Tommy Chan Biwu Chu Wei Du Lei Yao Yonghong Wang Jing Cai Juha Kangasluoma Tom Kokkonen Joni Kujansuu Anton Rusanen Chenjuan Deng Yueyun Fu Rujing Yin Xiaoxiao Li Yiqun Lu Yiliang Liu Chaofan Lian Dongsen Yang Weigang Wang Maofa Ge Yuesi Wang Douglas R.Worsnop Heikki Junninen Hong He Veli-Matti Kerminen Jun Zheng Lin Wang Jingkun Jiang Tuukka Petaja Federico Bianchi Markku Kulmala | 2020 | Big Earth Data2020，4，3： | 3 |
| 5 | Electron-phonon coupling-assisted universal red luminescence of o-phenylenediamine-based carbon dots显示文摘Due to the complex core-shell structure and variety of surface functional groups,the photoluminescence(PL)mechanism of carbon dots(CDs)remain unclear.o-Phenylenediamine(oPD),as one of the most common precursors for preparing red emissive CDs,has been extensively studied.Interestingly,most of the red emission CDs based on oPD have similar PL emission characteristics.Herein,we prepared six different oPD-based CDs and found that they had almost the same PL emission and absorption spectra after purifiication.Structural and spectral characterization indicated that they had similar carbon core structures but diffferent surface polymer shells.Furthermore,single-molecule PL spectroscopy confirmed that the multi-modal emission of those CDs originated from the transitions of different vibrational energy levels of the same PL center in the carbon core.In addition,the phenomenon of'spectral splitting'of single-particle CDs was observed at low temperature,which confirmed these oPD-based CDs were unique materials with properties of both organic molecules and quantum dots.Finally,theoretical calculations revealed their potential polymerization mode and carbon core structure.Moreover,we proposed the PL mechanism of red-emitting CDs based on oPD precursors;that is,the carbon core regulates the PL emission,and the polymer shell regulates the PL intensity.Our work resolves the controversy on the PL mechanism of oPD-based red CDs.These findings provide a general guide for the mechanism exploration and structural analysis of other types of CDs. | Boyang Wang Zhihong Wei Laizhi Sui Jingkun Yu Baowei Zhang Xiaoyong Wang Shengnan Feng Haoqiang Song Xue Yong Yuxi Tian Bai Yang Siyu Lu | 2022 | Light(Science & Applications)2022，11，7： | 2 |
| 6 | Protective effects of baicalin on amyloid beta 25-35-induced apoptosis in human neuroblastoma SH-SY5Y cells显示文摘Baicalin,a type of flavanoid,effectively prevents cellular apoptosis induced by various factors.However,little evidence is available regarding its role on amyloid β(Aβ)-induced neuronal apoptosis.The present study investigated the protective mechanisms of baicalin on Aβ-induced neuronal apoptosis.Flow cytometry and cation dye 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethyl-benzimidazoly lcarbocyanine iodide(JC-1) were employed to measure mitochondrial membrane potential,and nitric oxide secretion and apoptotic-related factors,such as caspase-3,were comprehensively analyzed.Results demonstrated a protective effect of baicalin on Aβ-treated SH-SY5Y cell viability;the rate of apoptosis decreased,nitric oxide generation and expression of caspase-3 were effectively inhibited,and mitochondrial membrane potential was effectively protected.Baicalin inhibited Aβ-induced neuronal apoptosis via multiple targets and multiple pathways,such as the inhibition of free radical damage,reduction of caspase-3 expression,and protection of normal mitochondrial functions. | Miao Geng Hongyan Chen Jianhua Wang Yazhuo Hu Jianwei Liu Jing Liu Jingkun Pan Yuhong Gao | 2010 | Neural Regeneration Research2010，5，22： | 2 |
| 7 | Curcumin inhibits the invasion of lung cancer cells by modulating thePKCα/Nox-2/ROS/ATF-2/MMP-9 signaling pathway显示文摘 | Zhigang Fan Xiaoyi Duan Hui Cai Li Wang Min Li Jingkun Qu Wanjun Li Yongheng Wang Jiansheng Wang | 2015 | Oncology Reports2015，，2： | 2 |
| 8 | Single-cell Transcriptomic Analysis Reveals the Cellular Heterogeneity of Mesenchymal Stem Cells显示文摘Ex vivo-expanded mesenchymal stem cells(MSCs)have been demonstrated to be a heterogeneous mixture of cells exhibiting varying proliferative,multipotential,and immunomodulatory capacities.However,the exact characteristics of MSCs remain largely unknown.By singlecell RNA sequencing of 61,296 MSCs derived from bone marrow and Wharton’s jelly,we revealed five distinct subpopulations.The developmental trajectory of these five MSC subpopulations was mapped,revealing a differentiation path from stem-like active proliferative cells(APCs)to multipotent progenitor cells,followed by branching into two paths:1)unipotent preadipocytes or 2)bipotent prechondro-osteoblasts that were subsequently differentiated into unipotent prechondrocytes.The stem-like APCs,expressing the perivascular mesodermal progenitor markers CSPG4/MCAM/NES,uniquely exhibited strong proliferation and stemness signatures.Remarkably,the prechondrocyte subpopulation specifically expressed immunomodulatory genes and was able to suppress activated CD3^(+T) cell proliferation in vitro,supporting the role of this population in immunoregulation.In summary,our analysis mapped the heterogeneous subpopulations of MSCs and identified two subpopulations with potential functions in self-renewal and immunoregulation.Our findings advance the definition of MSCs by identifying the specific functions of their heterogeneous cellular composition,allowing for more specific and effective MSC application through the purification of their functional subpopulations. | Chen Zhang Xueshuai Han Jingkun Liu Lei Chen Ying Lei Kunying Chen Jia Si Tian-yi Wang Hui Zhou Xiaoyun Zhao Xiaohui Zhang Yihua An Yueying Li Qian-Fei Wang | 2022 | Genomics, Proteomics & Bioinformatics2022，20，1： | 2 |
| 9 | Effects of two transition metal sulfate salts on secondary organic aerosol formation in toluene/NOx photooxidation显示文摘Aerosol phase reactions play a very important role on secondary organic aerosol (SOA) formation, and metal-containing aerosols are important components in the atmosphere. In this study, we tested the effects of two transition metal sulfate salts, manganese sulfate (MnSO4) and zinc sulfate (ZnSO4), on the photochemical reactions of a toluene/NOx photooxidation system in a 2 m3 smog chamber. By comparing photochemical reaction products of experiments with and without transition metal sulfate seed aerosols, we evaluated the effects of transition metal sulfate seed aerosols on toluene consumption, NOx conversion and the formation of ozone and SOA. MnSO4 and ZnSO4 seed aerosols were found to have similar effects on photochemical reactions, both enhance the SOA production, while showing negligible effects on the gas phase compounds. These observations are consistent when varying metal sulfate aerosol concentrations. This is attributed to the catalytic effects of MnSO4 and ZnSO4 seed aerosols which may enhance the formation of condensable semivolatile compounds. Their subsequent partitioning into the aerosol phase leads to the observed SOA formation enhancement. | Biwu CHU Jiming HAO Junhua LI Hideto TAKEKAWA Kun WANG Jingkun JIANG | 2013 | Frontiers of Environmental Science & Engineering2013，7，1： | 2 |
| 10 | Effect of po- rosity on carbonation and hydration resistance of CaO ma- terials 显示文摘 | Chen Min Wang Nan Yu Jingkun | 2007 | Journal of the European Ceramic Society2007，，27： | 1 |
| 11 | Single stain hyperspectral imaging for accurate fungal pathogens identification and quantification显示文摘The most widely used method of identification of microbial morphology and structure is microscopy,but it can be difficult to distinguish between pathogens with a similar appearance.Existing fluorescent staining methods require a combination of a variety of fluorescent materials to meet this demand.In this study,unique concentration-dependent fluorescent carbon dots(CDs)were synthesized for the identification and quantification of pathogens.The emission wavelength of the CDs could be tuned spanning the full visible region by virtue of aggregation-induced narrowing of bandgaps.This tunable emission wavelength of the specific concentration response to diverse microbes can be used to distinguish microorganisms with a similar appearance,even in a same genus.A hyperspectral microscopy system was demonstrated to distinguish Aspergillus flavus and A.fumigatus based on the results above.The identification accuracy of the two similar-looking pathogens can be close to 100%,and the relative proportions and spatial distributions can also be profiled from the mixture of the pathogens.This technique can provide a solution to the fast detection of microorganisms and is potentially applicable to a wide range of problems in areas such as healthcare,food preparation,biotechnology,and health emergency. | Yongqiang Zhang Kunxing Liu Jingkun Yu Haifeng Chen Rui Fu Siqi Zhu Zhenqiang Chen Shuangpeng Wang Siyu Lu | 2022 | Nano Research2022，15，7： | 1 |
| 12 | Effect of addition of poly-(ethylene glycol) on electrical conductivity of poly(3,4- ethylenedioxythiophene)- poly(styrenesulfonate) hybrid显示文摘By mixing various concentrations of poly (ethylene glycol), a series of poly(3,4-ethylenedioxythiophene)- poly(styrenesulfonate) composite thin films were prepared. The electrical conductivity of the PEDOT-PSS/PEG thin films was measured by the four-probe method. Experimental results showed that the inclusion of poly(ethylene glycol) influenced the electrical conductivity of PEDOT-PSS film significantly. With the increase of PEG concentrations, the electrical conductivity sharply increased to reach a maximum and then slowly decreased down. Furthermore, the PEG molecular weight and environment temperature also played important roles on the electrical conductivity of PEDOT-PSS/PEG thin films. A good linear relationship was found between ln sDC and T -1/2 within the entire temperature range detected. | WANG Tiejun, QI Yingqun, XU Jingkun, HU Xiujie & CHEN Ping Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100101, China Correspondence should be addressed to Chen Ping (e-mail:chenlab@ mail.ipc. ac.cn) | 2003 | Chinese Science Bulletin2003，48，22： | 1 |
| 13 | Effect of porosity on carbonation and hydration resistance of CaO materials显示文摘 | Chen Min Wang Nan Yu Jingkun | | 0，，： | 1 |
| 14 | Acidic degradation and enhanced antioxidant activities of exopolysaccharides from Cordyceps sinensis mycelial culture显示文摘 | YAN Jingkun LI Lin WANG Zhaomei | 2009 | Food Chem2009，117，4： | 1 |
| 15 | Effect of porosity on carbon- ation and hydration resistance of CaO materials 显示文摘 | Chen Min Wang Nan Yu Jingkun | 2007 | J Eur Ceram Soe2007，27，4： | 1 |
| 16 | Formation of Al2O3 grains with different sizes and morphologies during the pulse electric current sintering process显示文摘 | S W WANG L D CHEN JINGKUN GUO | 2001 | J Mat Res2001，16，12： | 1 |
| 17 | A USB-based software CNC system 显示文摘 | Zhang Chengrui Wang Heng Wang Jingkun | 2003 | Journal of Materials Processing Technology2003，139，13： | 1 |
| 18 | Long- term trend of haze pollution and impact of particulate matter in the Yangtze River Delta, China显示文摘 | CHENG Zhen WANG Shuxiao JIANG Jingkun | 2013 | Environmental Pollution2013，182，： | 1 |
| 19 | Soft,stretchable,wireless intelligent three-lead electrocardiograph monitors with feedback functions for warning of potential heart attack显示文摘Cardiovascular diseases(CVDs)are fatal chronic diseases,where electrocardiography(ECG)monitoring could be a prominent solution for early diagnosis.In spite of available commercialized,multilead ECG devices,bulky formats,discontinuous monitoring,and no safety alarm system significantly limit their practical applications.Herein,we present a soft,and stretchable,three-lead ECG device allowing continuous monitoring and wireless transmission of ECG signals.A newly developed organohydrogel patch with a strong adhesive ability(~9.9 kPa)and higher conductivity(~6.5 kΩ)is applied for high-quality ECG signals collection.With a long operation duration(6.5 h)and wireless transmission distance(20.9 m),it could fulfill most of the daily applications.Machine learning algorithms and the graphical user interface are used for real-time ECG monitoring and cardiac abnormalities diagnosis.The vibratory flexible actuator,which is triggered by cardiac abnormalities that need immediate medical treatment,is also integrated as a warning system for the user.As a newly reported stretchable multi-lead ECG device for long-term ECG signal monitoring,there is a high potential for improving users'life quality with the high-risk population of CVDs. | Chunki Yiu Yiming Liu Chao Zhang Jingkun Zhou Huiling Jia Tsz H.Wong Xingcan Huang Jian Li Kuanming Yao Ming K.Yau Ling Zhao Hu Li Binbin Zhang Wooyoung Park Yuanting Zhang Zuankai Wang Xinge Yu | 2022 | SmartMat2022，3，4： | 1 |
| 20 | Cross-linking enhanced room-temperature phosphorescence of carbon dots显示文摘Currently,there is a strong drive to discover alternative materials that exhibit room-temperature phosphorescence(RTP)for displays,bioimaging,and data security.Ideally,these materials should be nontoxic,cheap,and possess controllable photoluminescent properties.Carbon dots(CDs)possess each of these characteristics,but to date,less attention has been paid to their RTP mechanism.Herein,we synthesized a series of CDs by self-crosslinking and carbonization of precursor.The resultant CDs were luminescent and exhibited a bright,micro-second afterglow lifetime.To increase the RTP,a second microwave processing step was used to coat the CDs with polyvinyl alcohol(PVA),polyacrylamide(PAM),or tetraethyl orthosilicate(TEOS),producing CDs@PVA,CDs@PAM,and CDs@TEOS composites.The core-shell structure acted to enhance crosslinking at the surface of the CDs to boost the RTP,creating abundant energy levels for intersystem crossover.In situ X-ray photoelectron spectroscopy verified electron transfer during luminescence.Finally,we present a design rule that can be used to tune the quantum yields and RTP lifetime of CDs,based on the effective stabilization of triplet excited states through the extent and strength of cross-linking.This simple strategy provides a flexible route for guiding the further development of CDs with tailored RTP properties for various applications. | Boyang Wang Zhen Sun Jingkun Yu Geoffrey I.N.Waterhouse Siyu Lu Bai Yang | 2022 | SmartMat2022，3，2： | 1 |
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