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| 1 | Downstaging and resection of hepatocellular carcinoma in patients with extrahepatic metastases after stereotactic therapy显示文摘Background:A combination of tyrosine kinase inhibitors(TKIs)and anti-PD-1 antibodies with local regional therapy has elicited yield substantial clinical benefits in patients who have hepatocellular carcinoma(HCC)with extrahepatic metastases.Using this treatment strategy to convert HCC patients with extrahepatic metastases from unresectable to resectable has not yet been reported.Methods:Consecutive hepatocellular carcinoma patients with extrahepatic metastases who received first-line therapy with a combination of TKIs and anti-PD-1 antibodies and at least one local regional therapy were analysed.Results:Nine patients with localized disease who received first-line systemic therapy were enrolled.At baseline,all of them had oligometastatic disease,namely,Barcelona Clinic Liver Cancer stage C(or Chinese Liver Cancer stage IIIB).The most common treatment administered was lenvatinib plus anti-PD-1 antibody and transarterial chemoembolization,and the median time span from systemic therapy to surgery was 3.2(IQR,2.8-6.2)months.Three patients achieved a pathological complete response.Six patients underwent laparoscopic surgery,and the other 3 patients underwent open surgery.After a median follow-up of 10.2(IQR,8.6-20.0)months,7 patients survived without disease recurrence,and 2 experienced tumour recurrence.All patients had any-grade AEs,and 55.6%of the patients experienced grade 3 AEs.Fatigue was the most common AE,followed by elevated aminotransferase levels and hypertension.Conclusions:Stereotactic therapy is a feasible conversion therapy for HCC patients with extrahepatic metastases to become resectable.This is the first study to analyse therapeutic outcomes of patients receiving these therapies for HCC with extrahepatic metastases. | Xiaobo Yang Haifeng Xu Bangyou Zuo Xu Yang Jin Bian Junyu Long Dongxu Wang Junwei Zhang Cong Ning Yanyu Wang Ziyu Xun Yunchao Wang Xin Lu Yilei Mao Xinting Sang Haitao Zhao | 2021 | Hepatobiliary Surgery and Nutrition2021，10，4： | 17 |
| 2 | Balance between facilitation and competition determines spatial patterns in a plant population显示文摘A considerable challenge in plant ecology is to understand how interactions,such as competition or facilitation,shape the spatial distribution of plants.The‘‘stress gradient hypothesis’’predicts that facilitation and competition will vary inversely across gradients of abiotic stress or consumer pressure.Surprisingly,few previous studies have explored how the balance between facilitation and competition affects spatial patterns along gradients of stress in a plant population based on field experiments.In order to investigate the effects of consumer pressure,facilitation,and competition on the spatial pattern of plant populations,we conducted a restoration succession series field experiment in the Inner Mongolian steppe in which sample sites of graded consumer pressure,specifically grazing stress,were established.We chose to examine the spatial patterns of Leymus chinensis,a dominant species in our experimental site.In order to test the‘‘stress gradient hypothesis,’’we applied the univariate O-ring statistic to analyze local neighborhood density at different spatial scales.We used the pair-correlation function to detect the characteristics of point patterns using complete spatial randomness,the Poisson cluster process,and the nested double-cluster process.We found that the local densities of L.chinensis were higher under high stress than lower stress environments.This demonstrated the‘‘stress gradient hypothesis’’in that facilitation and competition varied inversely across gradients of consumer pressure.However,we found nodifferences in the spatial patterns of L.chinensis based on complete spatial randomness when interactions shifted from facilitation to competition along gradients of consumer pressure.Furthermore,we detected the characteristics of point patterns using the Poisson cluster and nested doublecluster processes.The results showed the spatial patterns of L.chinensis to fit well with the nested double-cluster model under highly stressful conditions,while in lower stress environments they were best approximated by the Thomas process.Our results illustrate that a shift in interactions from facilitation to competition along gradients of consumer pressure can shape spatial patterns and that a combination of the Poisson cluster process and nested doublecluster process can detect spatial pattern characteristics which cannot be detected by complete spatial randomness. | Xinting Wang Cunzhu Liang Wei Wang | 2014 | Chinese Science Bulletin2014，59，13： | 16 |
| 3 | Nab-paclitaxel(abraxane)-based chemotherapy to treat elderly patients with advanced non-small-cell lung cancer:a single center,randomized and open-label clinical trial显示文摘Background:The purpose of this study is to evaluate the clinical efficacy and safety of abraxane-based chemotherapy with/without nedaplatin in elderly patients with non-small-cell lung cancer(NSCLC).Materials and methods:From October 2009 to January 2013,48 elderly patients(>65 years) with NSCLC were investigated in this clinical trial.The patients were randomized and equally allocated into arms A and AP:(A) abraxane(130 mg/m^2,days 1,8);(B) abraxane + nedaplatin(20 mg/m^2 days 1-3,q3w).The parameters of objective response rate(ORR),disease control rate(DCR),progression-free survival(PFS),overall survival(OS) and side effects were evaluated between two arms.Results:Over 80%of the patients completed four cycles of chemotherapy.The total ORR was 21.3%,DCR was 55.3%,PFS 4.5 months and OS 12.6 months.No significant difference was found between arms A and AP in terms of ORR(16.7%vs.26.1%,P=0.665) or DCR(55.3%vs.56.5%,P=0.871).The median PFS in arm A was 3.3 months[25-75%confidence interval(CI):3.1-7.2]and 5.5 months(25-75%CI:3.2-7.0) in arm AP with no statistical significance(P=0.640).The median OS in arm A was 12.6 months(25-75%CI:5.7-26.2) and 15.1 months(25-75%CI:6.4-35.3) in arm AP with no statistical significance(P=0.770).The side effects were mainly grade 1-2.The incidence of grade 3-4 toxicities was 29.1%in arm A and 62.5%in arm AP with a statistical significance(P=0.020).Conclusions:Compared with combined therapy,abraxane alone chemotherapy was beneficial for elderly NSCLC patients with better tolerability and less adverse events,whereas did not significantly differ in terms of ORR,DCR,PFS or OS. | Hanrui Chen Xuewu Huang Shutang Wang Xinting Zheng Jietao Lin Peng Li Lizhu Lin | 2015 | Chinese Journal of Cancer Research2015，27，2： | 12 |
| 4 | Design,methodology,and baseline of whole city‑million scale children and adolescents myopia survey(CAMS)in Wenzhou,China显示文摘Background:Myopia is the most common visual impairment in children and adolescents worldwide.This study described an economical and effective population-based screening pipeline and performed the project of a million scale children and adolescents myopia survey(CAMS),which will shed light on the further study of myopia from the level of epidemiology and precision medicine.Methods:We developed a novel population-based screening pattern,an intelligent screening process and internetbased information transmission and analysis system to carry out the survey consisting of school children in Wenzhou,China.The examination items include unaided distance visual acuity,presenting distance visual acuity,and noncycloplegic autorefraction.Myopia and high myopia were defined as spherical equivalent(SE)≤−1.00 diopters(D)and SE≤−6.00 D,respectively.Next,the reports of the vision checking were automatically sent to parents and the related departments.The CAMS project will be done two to four times annually with the support of the government.An online eyesight status information management system(OESIMS)was developed to construct comprehensive and efficient electronic vision health records(EVHRs)for myopia information inquiry,risk pre-warning,and further study.Results:The CAMS completed the first-round of screening within 30 days for 99.41%of Wenzhou students from districts and counties,in June 2019.A total of 1,060,925 participants were eligible for CAMS and 1,054,251(99.37%participation rate)were selected through data quality control,which comprised 1305 schools,and 580,609,251,050 and 170,967 elementary,middle,and high school students.The mean age of participants was 12.21±3.32 years(6-20 years),the female-to-male ratio was 0.82.The prevalence of myopia in elementary,middle,and high school students was 38.16%,77.52%,and 84.00%,respectively,and the high myopia incidence was 0.95%,6.90%,and 12.98%.Conclusions:The CAMS standardized myopia screening model involves automating large-scale information collection,data transmission,data analysis and early warning,thereby supporting myopia prevention and control.The entire survey reduced 90%of staff,cost,and time consumption compared with previous surveys.This will provide new insights for decision support for public health intervention. | Liangde Xu Youyuan Zhuang Guosi Zhang Yunlong Ma Jian Yuan Changseng Tu MiaoMiao Li Wencan Wang Yaru Zhang Xiaoyan Lu Jing Li Xinting Liu Zhengbo Xue Meng Zhou Jie Sun Jinhua Bao Ming Li Fan Lu Hong Wang Jianzhong Su Jia Qu | 2021 | Eye and Vision2021，8，1： | 7 |
| 5 | Feed intake prediction model for group fish using the MEA-BP neural network in intensive aquaculture显示文摘In aquaculture,the accurate prediction of feed intake for group fish is considered to be crucial to any feeding system.Previous studies mainly used mathematical statistics to establish the mapping relationship between feed intake and influencing factors.The result was easily influenced by subjective experience.To solve the above issues,this paper proposed a feed intake prediction model for group fish using the back-propagation neural network(BPNN)and mind evolutionary algorithm(MEA).Firstly,four factors,including water temperature,dissolved oxygen,the average fish weight and the number of fish were selected as the input of the BPNN model.Secondly,the initial weight and threshold of the BPNN were optimized by the MEA to improve the matching precision.Finally,the prediction model was achieved after training.Experimental results showed that the correlation coefficient between the predicted and measured values reached 0.96.And the root mean squared error,mean square error,mean absolute error,mean absolute percent error of the model was 6.89,47.53,6.17 and 0.04,respectively.In addition,the proposed method also had the better nonlinear fitting ability than BPNN and GA-BP.By using an intelligent optimization algorithm,the mapping relationship between fish intake and environmental factors was automatically established,thus avoiding the subjectivity of traditional methods.Therefore,it can lay a theoretical foundation for the development of intelligent feeding equipment and meet the needs of the smart fishery. | Lan Chen Xinting Yang Chuanheng Sun Yizhong Wang Daming Xu Chao Zhou | 2020 | Information Processing in Agriculture2020，7，2： | 5 |
| 6 | Identification of p100 target promoters by chromatin immunoprecipitation-guided ligation and selection (ChIP-GLAS)显示文摘The multifunctional protein p100 is a vital transcriptional regulator that increases gene transcription by forming a physical bridge between promoter-specific transcription factors and the basal transcription machinery.To identify potential signal transduction pathways in which human p100 acts as a coregulator and to find target promoter regions that may interact with p100,we performed a promoter microarray assay called chromatin immunoprecipitation-guided ligation and selection(ChIP-GLAS).From this assay,we determined that a set of promoter fragments,including several factors in the transforming growth factor beta(TGF-β)signaling pathway,exhibited interaction with p100.The ChIP-GLAS data were validated by RT-PCR assessing the mRNA expression of various factors in the TGF-b signaling pathway in cell lines. | Xin Liu Lijie Dong Xuejun Zhang Baoya Wang Xinting Wang Hu Li Jinyan He Lin Ge Xiang Jing Zhi Yao Jie Yang | 2011 | Cellular & Molecular Immunology2011，8，1： | 3 |
| 7 | Choroidal thickness and choriocapillaris vascular density in myopic anisometropia显示文摘Background:This study aims to examine interocular differences in the choroidal thickness and vascular density of the choriocapillaris in anisometropic myopes and to further explore the relationship between choroidal blood flow and myopia.Methods:The sample comprised 44 participants with anisometropic myopia,aged 9 to 18 years,with normal bestcorrected visual acuity.All participants underwent a series of examinations,including spherical equivalent refraction(SER)and axial length(AL),measured by a Lenstar optical biometer and optical coherence tomography angiography(OCTA)scanner.OCT measured the choroidal thickness,vascular density,and flow voids of the choriocapillaris,and a customized algorithm was implemented in MATLAB R2017a with the post-correction of AL.The choroidal thickness was measured at the fovea and 0.5,1.0,1.5,2.0,2.5,and 3.0 mm nasally,temporally,inferiorly,and superiorly to the fovea.The vascular density and the flow voids of the choriocapillaris were measured at a 0.6-mm-diameter central circle,and the 0.6-2.5 mm diameter circle in the nasal,temporal,inferior,and superior regions.Repeated-measured ANOVAs were used to analyze the interocular differences.Partial correlations with the K value and age adjustments were used to study the relationships between the choroidal thickness,the choriocapillaris vascular density and flow voids,the SER and AL.Results:The choroidal thickness of the more myopic eyes was significantly thinner than less myopic eyes(P≤0.001),and the flow voids in the more myopic eyes were more than less myopic eyes(P=0.002).There was no significant difference in the vascular density of the choriocapillaris between the more and less myopic eyes(P=0.525).However,when anisometropia was more than 1.50 D,the vascular density of choriocapillaris in the more myopic eyes was significantly less than the less myopic eyes(P=0.026).The interocular difference of the choroidal thickness was significantly correlated with the interocular difference in SER and AL in the center,superior,and inferior regions but not in the nasal or temporal regions.The interocular differences of the vascular density and the flow voids of the choriocapillaris were not correlated with the interocular difference of SER and AL.Conclusions:The choroidal thickness is thinner in the more myopic eyes.The flow void is increased,and the vascular density of the choriocapillaris is reduced in the more myopic eyes of children with anisometropia exceeding 1.50 D. | Xinting Liu Zhiyi Lin Feifu Wang Xiaoyi Peng Wenwen He Dan Chen Meixiao Shen Fan Lu Jun Jiang | 2021 | Eye and Vision2021，8，1： | 3 |
| 8 | Development and test verification of air temperature model for Chinese solar and Spainish Almeria-type greenhouses显示文摘Growth can be defined as an increment in biomass or an increment in weight or height of the organs of the plant influenced by physiological processes.Many of these processes have their limits genetically determined,but climate and irrigation play an important role.Because of its importance,microclimate has been extensively studied in the modeling as a surrounding condition which is imposed by the exterior climate.The main objective of this work was to develop a temperature model based on the energy balance dynamics at two different greenhouse locations-South-eastern Spain and Northern China,and the traditional structures of Chinese solar greenhouse and Almería-type multi-span greenhouse were taken into account.The final model was developed by combining the external conditions,the actuator influence and the crop growth,where the temperature is influenced by soil,crop,cover,actuators,back wall and greenhouse geometry.The model took into account the energy lost by convective and conductive fluxes,as well as the energy supplied by solar radiation and heating systems.The soil and the back wall are the main media for energy storage.The temperature dynamic was determined by a physical model,which considered the energy balance from a holistic point of view-as a sub-model for a customizable interface among the external climate,the plant and the greenhouse system.The influences of different subsystems included in the temperature model were analyzed and evaluated.The results showed a high R^(2)value of 0.94 for Beijing and 0.95 for Almeria,and the average error was low,of which the MAE and RMSE were 0.71 and 1.365 for Almeria and 0.62 and 1.102 for Beijing,respectively.Thus,the model can be considered as a powerful tool for control design purposes in microclimate systems. | Jorge Antonio Sanchez-Molina Li Ming Francisco Rodriguez Jose Luis Guzman Wang Hui Yang Xinting | 2017 | International Journal of Agricultural and Biological Engineering2017，10，4： | 2 |
| 9 | Combined contributions of over-secreted glueagon-like peptide 1 and suppressed insulin secretion to hyperglycemia induced by gatifloxacin in rats显示文摘 | Yu YunLi Wang XinTing Liu Can | 2013 | Toxicol Appl Pharmacol2013，266，3： | 1 |
| 10 | Residues of enrofloxacin,furazolidone and their metabolites in Nile tilapia (Oreochromis niloticus)显示文摘 | Xu WeiHai Zhu XiaoBin Wang XinTing | 2006 | Aquaculture2006，254，14： | 1 |
| 11 | Text segmentation of health examination item based on character statistics and information measurement显示文摘 | Hui An Dahui Wang Zhigeng Pan Meiling Chen Xinting Wang | 2018 | CAAI Transactions on Intelligence Technology2018，3，1： | 1 |
| 12 | Injury severity analysis of electric bike crashes in Changsha, Hunan Province: taking different lighting conditions into consideration显示文摘With the increasing use of electric bikes, electric bike crashes occur frequently. Analysing the influencing factors of electric bikecrashes is an effective way to reduce mortality and improve road safety. In this paper, spatial analysis is performed by geographicinformation system (GIS) to present the hot spots of electric bike crashes during daylight and darkness in Changsha, Hunan Province,China. Based on the Ordered Probit (OP) model, we studied the risk factors that led to different severities of electric bike crashes.The results show that the main influencing variables include age, illegal behaviour, collision type and road factors. During daylightand darkness, elderly electric bike riders over the age of 65 years have a higher probability of fatal crashes. Not following trafficsignals and reverse driving are significantly related to the severity of riders’ injuries. In darkness, frontal collisions are significantfactors causing rider injury. In daylight, more serious crashes will be caused in bend and slope road segments. In darkness, roadswith no physically separated bicycle lanes increases the risk of riders being injured. Electric bike crashes are mainly concentratedin the commercial, public service and residential areas in the main urban area. In suburbs at darkness, electric bike riders are morelikely to be seriously injured. Adding protectionmeasures, such as improved lighting, non-motorized lane facilities and interventionstargeting illegal behaviour in the hot spot areas can effectively reduce the number of electric bike crashes in complex traffic. | Lin Hu Xiaotong Wu Xinting Hu Fang Wang Ning Wu | 2022 | Transportation Safety and Environment2022，4，3： | 1 |
| 13 | Biosorption of copper(Ⅱ) from aqueous solutions by green alga Cladophora fascicularis显示文摘 | Liping Deng Xiaobin Zhu Xinting Wang | 2007 | Biodegradation2007，18，： | 1 |
| 14 | Asian,regional,and national burdens of respiratory tract cancers and associated risk factors from 1990 to 2019:A systematic analysis for the global burden of disease study 2019显示文摘Background:Respiratory cancer is the leading cause of cancer-related deaths worldwide,but its statistics vary between the East and West.This study aimed to estimate the burdens of tracheal,bronchus,and lung(TBL)cancer and larynx cancer and their attributable risks from 1990 to 2019 in Asia,and at regional and national levels.Methods:This research evaluated the incidence,mortality,years lived with disability,years of life lost,and disability-adjusted life years(DALYs)for respiratory tract cancers using the Global Burden of Diseases,Injuries,and Risk Factors Study(GBD)2019 database.Age-standardized rates were calculated for TBL cancer from 1990 to 2019,adjusted for smoking and socio-demographic index(SDI).Deaths from TBL cancer and larynx cancer attributable to each risk factor were estimated for 33 Asian countries.Results:The age-standardized incidence and death rates for TBL cancer in Asia declined from 2010 to 2019,while the incidence rate of larynx cancer increased.Smoking was the leading specific risk factor for deaths from both TBL and larynx cancers.The burden of TBL cancer in Asian countries was influenced by SDI and smoking,particularly among males in Central Asia.Deaths,DALYs,and incidences of larynx cancer in East Asia had not changed significantly over the past 30 years,but showed slight downward trends in males and both sexes combined,and an upward trend in females in recent years.Conclusions:The past decade saw increases in numbers of incident cases and deaths from TBL cancer and larynx cancer in Asia.SDI and smoking were the main factors influencing the disease burden of TBL cancer in Asian countries.This study highlights the need for tailored cancer control programs to address the burden of respiratory tract cancers in different Asian countries. | Ran Zhong Xiuyu Cai Jianfu Li Peiling Chen Runchen Wang Xinting Li Feng Li Shan Xiong Caichen Li Huiting Wang Yang Xiang Shuting Zhan Ziwen Yu Haixuan Wang Chunyan Li Lixuan Lin Wenhai Fu Xin Zheng Shen Zhao Kang Zhang Jianxing He | 2023 | Chinese Medical Journal Pulmonary and Critical Care Medicine2023，1，4： | 1 |
| 15 | Residues of enrofloxacin, furazolidone and their metabolites in Nile tilapia( Oreochromis niloticus) 显示文摘 | Xu Weihai Zhu Xiaobin Wang Xinting | 2006 | Aquaculture2006，254，14： | 1 |
| 16 | Residues of en-rofloxacin,furazolidone and their metabolites in nile tilapia (ore-ochromis niloticus)显示文摘 | XU Weihai ZHU Xiaobin Wang Xinting | | 0，，04： | 1 |
| 17 | Genetic abnormalities assist in pathological diagnosis and EBVpositive cell density impact survival in Chinese angioimmunoblastic T-cell lymphoma patients显示文摘Objective:To explore the application of genetic abnormalities in the diagnosis of angioimmunoblastic T-cell lymphoma(AITL)and the reliable pathological prognostic factors.Methods:This study included 53 AITL cases,which were reviewed for morphological patterns,immunophenotypes,presence of Hodgkin and Reed-Sternberg(HRS)-like cells,and co-occurrence of B cell proliferation.The Epstein-Barr virus(EBV)-positive cells in tissues were counted,and cases were classified into“EBV encoded RNA(EBER)high-density”group if>50/HPF.Targeted exome sequencing was performed.Results:Mutation data can assist AITL diagnosis:1)with considerable HRS-like cells(20 cases):RHOA mutated in 14 cases(IDH2 co-mutated in 3 cases,4 cases with rare RHOA mutation),TET2 was mutated in 5 cases(1 case comutated with DNMT3A),and DNMT3A mutated in 1 case;2)accompanied with B cell lymphoma(7 cases):RHOA mutated in 4 cases(1 case had IDH2 mutation),TET2 mutated in 2 cases and DNMT3A mutated in 1 case;3)mimic peripheral T cell lymphoma,not otherwise specified(5 cases):RHOA mutated in 2 cases(IDH2 co-mutated in 1 case),TET2 mutated in 3 cases,and DNMT3A mutated in 1 case;4)pattern 1(1 case),RHOA and TET2 co-mutated.Besides RHOAG17V(30/35),rare variant included RHOAK18N,RHOAR68H,RHOAC83Y,RHOAD120G and RHOAG17del,IDH2R172 co-mutated with IDH2M397V in one case.There were recurrent mutations of FAT3,PCLO and PIEZO1 and genes of epigenetic remodeling,T-cell activation,APC and PI3K/AKT pathway.EBER high-density independently indicated adverse overall survival and progression-free survival(P=0.046 and P=0.008,KaplanMeier/log-rank).Conclusions:Over half AITL cases might be confused in diagnosis for certain conditions without mutation data.Targeted exome sequencing with a comprehensive panel is crucial to detect both hot-spot and rare mutation variants for RHOA and IDH2 and other recurrent mutated genes in addition to TET2 and DNMT3A.EBER highdensity independently indicated adverse survival. | Yunfei Shi Haojie Wang Yanfei Liu Mengping Long Ning Ding Lan Mi Yumei Lai Lixin Zhou Xinting Diao Xianghong Li Weiping Liu Jun Zhu | 2023 | Chinese Journal of Cancer Research2023，35，5： | 0 |
| 18 | Efficacy and safety of subsequent radiotherapy in patients with advanced-stage hepatocellular carcinoma treated with immune checkpoint inhibitors显示文摘Background:The development of immunotherapy resistance is associated with a poor prognosis in patients diagnosed with hepatocellular carcinoma(HCC)who are undergoing treatment with immune checkpoint inhibitors(ICI).This study aimed to evaluate the efficacy and safety of subsequent radiotherapy(RT)for patients with advanced-stage HCC who had lesion enlargement or new lesions(NLs)during ICI therapy.Methods:This retrospective observational study enrolled 36 patients with advanced-stage HCC who underwent subsequent RT for lesion enlargement or NLs during ICI therapy from two centers.The primary endpoints were progression-free survival(PFS)and overall survival(OS).The secondary endpoints included objective response rate(ORR),disease control rate(DCR),1-and 2-year local control(LC)rates,in-field PFS(IFPFS),out-field PFS(OFPFS),and safety.Results:The median follow-up time was 15.3 months.The median PFS was 7.4 months[95%confidence interval(CI):3.1-11.7 months],and the median OS was 18.8 months(95%CI:17.1-20.5 months).ORR and DCR were 38.9%and 72.2%,respectively.In addition,the median IFPFS was 17.8 months(95%CI:11.5-24.2 months),median OFPFS was 7.9 months(95%CI:3.4-12.5 months),and estimated 1-and 2-year LC rates were 67.1%and 31.9%,respectively.The most common treatment-related adverse events(all grades)were diarrhea(33.3%),rash(30.6%),and malaise(27.8%);a total of 14(38.9%)patients developed grade 3-4 AEs.Conclusions:Subsequent RT showed reliable antitumor effects and an acceptable safety profile in patients with advanced-stage HCC who had unsatisfactory response to ICI therapy;therefore,it could serve as an optional salvage strategy. | Cong Ning Jun Jia Xinmu Zhang Jing Sun Yunchao Wang Jingnan Xue Longhao Zhang Xiaorong Hou Xiaobo Yang Xinting Sang Xuezhang Duan Haitao Zhao | 2023 | Hepatobiliary Surgery and Nutrition2023，12，6： | 0 |
| 19 | Conversion therapy of stage IVb unresectable gallbladder carcinoma显示文摘Gallbladder carcinoma(GBC)is a highly malignant tumor of the digestive system,and the 5-year survival rate of stage IVb is only 2%(1).For unresectable GBC,although the guidelines published by the National Comprehensive Cancer Network(NCCN)in 2019 recommended radiotherapy combined with chemotherapy as the first-line treatment,no promising prognosis has been reported(2).Conversion therapy refers to the achievement of long-term survival by radical surgery in some patients with advanced cancer on the premise that systemic therapy will be effective(3,4).Herein,we reported the case of a 61-year-old male patient with stage IVb GBC who was diagnosed with multiple abdominal,retroperitoneal,mediastinal,and bilateral hilar lymph nodes.The results of follow-up showed that the patient achieved a disease-free survival(DFS)of 11.3 months and overall survival(OS)of 18.1 months after conversion therapy. | Cong Ning Xinmu Zhang Xiaobo Yang Xinting Sang Haitao Zhao Hanping Wang | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 0 |
| 20 | A method for threshold selection in load extrapolation based on multiple criteria decision-making technology显示文摘In order to establish an accurate peak over threshold(POT)model for reasonable load extrapolation,a new threshold selection method based on multiple criteria decision making(MCDM)technology is proposed.The fitting test criterion is taken into consideration in the method.For each candidate threshold,the fitting values of several fitting test criteria are integrated into a comprehensive evaluation value through entropy method and MCDM technology.The threshold corresponding to the minimum comprehensive evaluation value is assumed as the optimal threshold.A random simulation study is carried out to evaluate the performance of the method and to compare them with other literature methods.Genuine load data are applied the proposed method.Both the results shown that the proposed method could be seen as an additional method that complements existing threshold selection methods. | Jixin Wang Qingsong Liu Xinting Zhai | 2017 | International Journal of Modeling, Simulation, and Scientific Computing2017，8，3： | 0 |
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