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| 1 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 2 | Effect of potential HONO sources on peroxyacetyl nitrate(PAN)formation in eastern China in winter显示文摘As an important secondary photochemical pollutant,peroxyacetyl nitrate(PAN)has been studied over decades,yet its simulations usually underestimate the corresponding observations,especially in polluted areas.Recent observations in north China found unusually high concentrations of PAN during wintertime heavy haze events,but the current model still cannot reproduce the observations,and researchers speculated that nitrous acid(HONO)played a key role in PAN formation.For the first time we systematically assessed the impact of potential HONO sources on PAN formation mechanisms in eastern China using the Weather Research and Forecasting/Chemistry(WRF-Chem)model in February of 2017.The results showed that the potential HONO sources significantly improved the PAN simulations,remarkably accelerated the RO x(sum of hydroxyl,hydroperoxyl,and organic peroxy radicals)cycles,and resulted in 80%–150%enhancements of PAN near the ground in the coastal areas of eastern China and 10%–50%enhancements in the areas around 35–40°N within 3 km during a heavy haze period.The direct precursors of PAN were aldehyde and methylglyoxal,and the primary precursors of PAN were alkenes with C>3,xylenes,propene and toluene.The above results suggest that the potential HONO sources should be considered in regional and global chemical transport models when conducting PAN studies. | Jingwei Zhang Yitian Guo Yu Qu Yong Chen Ruipeng Yu Chaoyang Xue Rui Yang Qiang Zhang Xingang Liu Yujing Mu Jing Wang Can Ye Haihan Zhao Qiangqiang Sun Ziwen Wang Junling An | 2020 | Journal of Environmental Sciences2020，32，8： | 3 |
| 3 | Effect of co-existing organic compounds on adsorption of perfluorinated compounds onto carbon nanotubes显示文摘共存的有机化合物可以在水的环境影响 perfluorinated 混合物(陆军) 和碳 nanotubes 的吸附。 perfluorooctane sulfonate ( PFOS )的吸附, perfluorooctane 酸( PFOA ), perfluorobutane sulfonate ( PFBS ),和 perfluorohexane sulfonate ( PFH x S )在太古的多围的碳 nanotubes ( MWCNTs-Pri )上, carboxyl functionalized MWCNT ( MWCTNs-COOH ),并且氢氧根 functionalized MWCNT ( MWCNT --哦)面对腐殖的酸,1萘粉,酚,和安息香的酸被学习。PFOS 的吸附动力学被 pseudo-second-order 模型描述很好,吸着平衡几乎在 24 h 以内被到达。PFOS 吸附上的共存的有机化合物的效果跟随了腐殖的酸的减少的顺序 >1 萘粉 > 安息香的酸 > 酚。PFOS 的吸附的数量面对共存显著地减少了或预装腐殖的酸,和两个吸附精力,导致 PFOS 的减少并且三 MWCNT 上的有效吸附地点减少了吸附。与增加 pH,由三 MWCNT 的 PFOS 移动面对腐殖的酸和酚减少了。MWCNT 上的不同陆军的吸附的数量在 PFBS x S < PFOA < PFOS。起始的集中的增加和共存的有机化合物的芳香的戒指的数字在 MWCNT 上压制了 PFOS 吸附。 | Shubo DENG Yue BEI Xinyu LU Ziwen DU Bin WANG Yujue WANG Jun HUANG Gang YU | 2015 | Frontiers of Environmental Science & Engineering2015，9，5： | 3 |
| 4 | Particle Image Velocimetry Experimental and Computational Investigation of a Blood Pump显示文摘Blood pumps have been adopted to treat heart failure over the past decades.A novel blood pump adopting the ro-tor with splitter blades and tandem cascade stator was developed recently.A particle image velocimetry (PIV) experiment was carried out to verify the design of the blood pump based on computational fluid dynamics (CFD) and further analyze the flow properties in the rotor and stator.The original sized pump model with an acrylic housing and an experiment loop were constructed to perform the optical measurement.The PIV testing was car-ried out at the rotational speed of 6952±50 r/min with the flow rate of 3.1 l/min and at 8186±50 r/min with 3.5 l/min,respectively.The velocity and the Reynolds shear stress distributions were investigated by PIV and CFD,and the comparisons between them will be helpful for the future blood pump design. | Xiaochen Yang Xingmin Gui Hui Huang Yongbin Shen Ziwen Yu Yan Zhang | 2012 | Journal of Thermal Science2012，21，3： | 2 |
| 5 | PC4 serves as a negative regulator of skin wound healing in mice显示文摘Background:Human positive cofactor 4(PC4)was initially characterized as a multifunctional transcriptional cofactor,but its role in skin wound healing is still unclear.The purpose of this study was to explore the role of PC4 in skin wound healing through PC4 knock-in mouse model.Methods:A PC4 knock-in mouse model(PC4^(+/+))with a dorsal full-thickness wound was used to investigate the biological functions of PC4 in skin wound healing.Quantitative PCR,Western blot analysis and immunohistochemistry were performed to evaluate the expression of PC4;Sirius red staining and immunofluorescence were performed to explore the change of collagen deposition and angiogenesis.Proliferation and apoptosis were detected using Ki67 staining and TUNEL assay.Primary dermal fibroblasts were isolated from mouse skin to perform cell scratch experiments,cck-8 assay and colony formation assay.Results:The PC4^(+/+)mice were fertile and did not display overt abnormalities but showed an obvious delay in cutaneous healing of dorsal skin.Histological staining showed insufficient re-epithelialization,decreased angiogenesis and collagen deposition,increased apoptosis and decreased cell proliferation in PC4^(+/+)skin.Our data also showed decreased migration rate and proliferation ability in cultured primary fibroblasts from PC4^(+/+)mice in vitro.Conclusions:This study suggests that PC4 might serve as a negative regulator of skin wound healing in mice. | Fengying Liao Long Chen Peng Luo Zhongyong Jiang Zelin Chen Ziwen Wang Chi Zhang Yu Wang JintaoHe Qing Wang Yawei Wang Lang Liu Yu Huang Huilan Wang Qingzhi Jiang Min Luo YiboGan Yunsheng Liu Yang Wang Jie Wu Wentao Xie Zhuo Cheng Yali Dai Jialun Li Zujuan Liu Fan Yang Chunmeng Shi | 2020 | Burns & Trauma2020，8，1： | 1 |
| 6 | Strain effect on the orientation-dependent harmonic spectrum of monolayer aluminum nitride显示文摘In this study, we theoretically investigate the strain effect on the orientation-dependent high-order harmonic generation(HHG) of monolayer aluminum nitride(Al N) by solving the multiband semiconductor Bloch equations in strong laser fields. Our simulations denote that the efficiency of the orientation-dependent HHG is considerably enhanced when a 15% biaxial tensile strain is applied to Al N, which is attributed to the downshifting energy level of the conduction band. Furthermore, the odd-even feature in the orientation-dependent high harmonic spectra owing to the strain is considerably different when compared with that in the case without strain. The enhanced quantum interference between different energy bands in strained Al N around the Γ-M direction is responsible for the observed odd-even distributions of the orientation-dependent HHG. This study helps to better understand the HHG in solids by tuning their electronic structures. | ZiWen Wang ShiCheng Jiang GuangLu Yuan Tong Wu Cheng Li Chen Qian Cheng Jin Chao Yu WeiJie Hua RuiFeng Lu | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，5： | 1 |
| 7 | Analysis of Clinicopathologic Features and Prognostic Factors in Hepatoid Adenocarcinoma of the Stomach显示文摘 | Xiaowen Liu Yufan Cheng Weiqi Sheng Hongfen Lu Xiaoli Xu Yu Xu Ziwen Long Huiyan Zhu Yanong Wang | 2010 | The American Journal of Surgical Pathology2010，，10： | 1 |
| 8 | Specific Regulation of m^(6)A by SRSF7 Promotes the Progression of Glioblastoma显示文摘Serine/arginine-rich splicing factor 7(SRSF7),a known splicing factor,has been revealed to play oncogenic roles in multiple cancers.However,the mechanisms underlying its oncogenic roles have not been well addressed.Here,based on N6-methyladenosine(m^(6)A)co-methylation network analysis across diverse cell lines,we find that the gene expression of SRSF7 is positively correlated with glioblastoma(GBM)cell-specific m^(6)A methylation.We then indicate that SRSF7 is a novel m^(6)A regulator,which specifically facilitates the m^(6)A methylation near its binding sites on the mRNAs involved in cell proliferation and migration,through recruiting the methyltransferase complex.Moreover,SRSF7 promotes the proliferation and migration of GBM cells largely dependent on the presence of the m^(6)A methyltransferase.The two m^(6)A sites on the mRNA for PDZ-binding kinase(PBK)are regulated by SRSF7 and partially mediate the effects of SRSF7 in GBM cells through recognition by insulin-like growth factor 2 mRNA-binding protein 2(IGF2BP2).Together,our discovery reveals a novel role of SRSF7 in regulating m^(6)A and validates the presence and functional importance of temporal-and spatial-specific regulation of m^(6)A mediated by RNA-binding proteins(RBPs). | Yixian Cun Sanqi An Haiqing Zheng Jing Lan Wenfang Chen Wanjun Luo Chengguo Yao Xincheng Li Xiang Huang Xiang Sun Zehong Wu Yameng Hu Ziwen Li Shuxia Zhang Geyan Wu Meisongzhu Yang Miaoling Tang Ruyuan Yu Xinyi Liao Guicheng Gao Wei Zhao Jinkai Wang Jun Li | 2023 | Genomics, Proteomics & Bioinformatics2023，21，4： | 1 |
| 9 | The Application of PSO-LSSVM in Fault Diagnosis of Subway Auxiliary Inverter显示文摘 | Gao Junwei Yu Jinpeng Leng Ziwen | 2013 | ICICExpress Letters2013，4，3： | 1 |
| 10 | Numerical simulation of turbulent flow around helicopter ducted tail rotor显示文摘 | Cao Yihua Yu Ziwen | 2005 | Aerospace Science and Technology2005，9，4： | 1 |
| 11 | Asian,regional,and national burdens of respiratory tract cancers and associated risk factors from 1990 to 2019:A systematic analysis for the global burden of disease study 2019显示文摘Background:Respiratory cancer is the leading cause of cancer-related deaths worldwide,but its statistics vary between the East and West.This study aimed to estimate the burdens of tracheal,bronchus,and lung(TBL)cancer and larynx cancer and their attributable risks from 1990 to 2019 in Asia,and at regional and national levels.Methods:This research evaluated the incidence,mortality,years lived with disability,years of life lost,and disability-adjusted life years(DALYs)for respiratory tract cancers using the Global Burden of Diseases,Injuries,and Risk Factors Study(GBD)2019 database.Age-standardized rates were calculated for TBL cancer from 1990 to 2019,adjusted for smoking and socio-demographic index(SDI).Deaths from TBL cancer and larynx cancer attributable to each risk factor were estimated for 33 Asian countries.Results:The age-standardized incidence and death rates for TBL cancer in Asia declined from 2010 to 2019,while the incidence rate of larynx cancer increased.Smoking was the leading specific risk factor for deaths from both TBL and larynx cancers.The burden of TBL cancer in Asian countries was influenced by SDI and smoking,particularly among males in Central Asia.Deaths,DALYs,and incidences of larynx cancer in East Asia had not changed significantly over the past 30 years,but showed slight downward trends in males and both sexes combined,and an upward trend in females in recent years.Conclusions:The past decade saw increases in numbers of incident cases and deaths from TBL cancer and larynx cancer in Asia.SDI and smoking were the main factors influencing the disease burden of TBL cancer in Asian countries.This study highlights the need for tailored cancer control programs to address the burden of respiratory tract cancers in different Asian countries. | Ran Zhong Xiuyu Cai Jianfu Li Peiling Chen Runchen Wang Xinting Li Feng Li Shan Xiong Caichen Li Huiting Wang Yang Xiang Shuting Zhan Ziwen Yu Haixuan Wang Chunyan Li Lixuan Lin Wenhai Fu Xin Zheng Shen Zhao Kang Zhang Jianxing He | 2023 | Chinese Medical Journal Pulmonary and Critical Care Medicine2023，1，4： | 1 |
| 12 | Author Correction: 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘In the initial published version of this article, there was a mistake in the P value for the correlation between gene-expression changes and 5 hmC changes in tumors. The correct P value should be same as the P value shown in Fig. S6A: 9.8?×?10?6 (mistakenly shown as “9.8?×?106” in the main text). This correction does not affect the description of results or the conclusions of this study, since the range of P value is between 0 and 1. | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2019 | Cell Research2019，29，7： | 1 |
| 13 | Life cycle implications of urban green infrastructure显示文摘 | SPATARI S YU Ziwen MONTALTO F A | 2011 | Environmental Pollution2011，159，89： | 1 |
| 14 | Degradable nanocatalyst enables antitumor/antibacterial therapy and promotion of wound healing for diabetes via self-enhanced cascading reaction显示文摘Diabetic patients often have problems such as residual tumor and wound infection after tumor resection,causing severe clinical problems.It is urgent to develop effective therapies to reach oncotherapy/antiinfection/promotion of wound healing combined treatment.Herein,we propose CS/MnO_(2)-GO_x (CMGO_x)nanocatalysts for the specific catalytic generation of ~·OH to inhibit tumors and bacteria in a hyperglycemic environment.The good biocompatible chitosan (CS),as a carrier for the catalyst,exhibits excellent antibacterial effect as well as promotes wound healing.Glucose oxidase (GO_x) is loaded on the surface of CS nanoparticles to generate H_(2)O_(2) and gluconic acid by consuming glucose (starvation therapy,ST) and O_(2).The MnO_(2) depletes glutathione (GSH) to produce Mn^(2+),amplifying oxidative stress and further promoting the activity of Mn^(2+)-mediated Fenton-like reaction to produce~·OH (chemodynamic therapy,CDT)in weak acidic environment.Moreover,the produced gluconic acid lowers the p H of the environment,enhancing chemodynamic therapy (ECDT).The tumor cells and bacteria are efficiently eliminated by the synergistic effect of ST and ECDT.The MnO_(2) nanoparticles at neutral environment decomposes H_(2)O_(2) into O_(2),which cooperate with CS to promote healing.The self-enhanced cascade reaction of CMGO_x in situ exhibits excellent effects of antitumor/antibacterial therapy and promotion of wound healing,offering a promising integrated treatment for diabetic patients after tumor surgical resection. | Xiang Wang Cheng Ding Ziwen Zhang Chunlin Li Dongmiao Cao Linjing Zhao Guoying Deng Yu Luo Chunping Yuan Jie Lu Xijian Liu | 2023 | Chinese Chemical Letters2023，34，7： | 0 |
| 15 | Construction of ternary heterojunction Agl/C-MoS_(2) nanosheets with enhanced visible-light photocatalytic property and self-cleaning performance显示文摘Carbon-molybdenum disulfide(C-MoS_(2))ultrathin nanosheets were prepared by a hydrothermal process,and then Agl/C-MoS_(2) were synthesized via an/n-situ deposition method.This ternary heterojunction composite exhibited better photo-catalytic activity compared with those of one-component(pristine MoS_(2))and bicomponent(Agl/MoS_(2) and C-MoS_(2))materials for the degradation of organic dyes under the visible-light irradiation.In particular,by comparing with Agl/MoS_(2),the significant role of conductive amorphous carbon in Agl/C-MoS_(2) in enhancing the charge transfer during the photocatalytic degradation of dyes was first confirmed by photocurrent response and electrochemical impedance spectroscopy(EIS).A possible photocatalytic mechanism was proposed based on the capture experiment results.Furthermore,a straightforward and interesting way had been applied to test the recycled/newly-prepared Agl/C-MoS_(2) composite for revealing its distinctive self-cleaning performance and recyclability characteristic besides its good photocatalytic activity.This work could provide a reference for the design of other new ternary heterojunction composite materials with special structures and properties. | Yan DU Ziwen NIU Tingjiang YAN Kunlei ZHU Yang YU Zhihong JING | 2021 | Frontiers of Materials Science2021，15，2： | 0 |
| 16 | High-performance Fe-N-C electrocatalysts with a 'chain mail' protective shield显示文摘Nitrogen-coordinated iron atoms on carbon supports(Fe-N-C)are among the most promising noble-metal-free electrocatalysts for oxygen reduction reaction(ORR).However,their unsatisfactory stability limits their prac-tical application.Herein,we demonstrate a dual-shell Fe-N-C electrocatalyst with excellent catalytic activity and long-term stability.Pyrrole and dopamine are sequentially polymerized on a fumed silica nanoparticle template.Metal precursor(FeCl_(3))and pore formation agent(ZnCl_(2))were loaded on the inner polypyrrole shell.During carbonization,the Zn evaporation creates abundant mesopores in the polydopamine-derived outer carbon shell,forming a 'chain mail'like outer shell that protects Fe-N-C active sites loaded on the inner carbon shell and enables efficient mass transfer.Systematical tuning of the shield thickness and porosity affords the optimal electrocatalyst with a large surface area of 934 m^(2)g^(-1) and a high Fe loading of 2.04 wt%.This electrocatalyst delivers excellent ORR activity and superior stability in both acidic and alkaline electrolytes.Primary Zn-air batteries fabricated from this electrocatalyst delivers a high-power density of 257 mW cm^(-2) and impressive durability of continuous discharging over 250 h.Creating a graphitic and porous carbon protective shell can be further extended to other electrocatalysts to enable their practical applications in energy conversion and storage. | Zixun Yu Chang Liu Junsheng Chen Ziwen Yuan Yuan Chen Li Wei | 2021 | Nano Materials Science2021，3，4： | 0 |
| 17 | Design of a Web Crawler for Water Quality Monitoring Data and Data Visualization显示文摘Many countries are paying more and more attention to the protection of water resources at present,and how to protect water resources has received extensive attention from society.Water quality monitoring is the key work to water resources protection.How to efficiently collect and analyze water quality monitoring data is an important aspect of water resources protection.In this paper,python programming tools and regular expressions were used to design a web crawler for the acquisition of water quality monitoring data from Global Freshwater Quality Database(GEMStat)sites,and the multi-thread parallelism was added to improve the efficiency in the process of downloading and parsing.In order to analyze and process the crawled water quality data,Pandas and Pyecharts are used to visualize the water quality data to show the intrinsic correlation and spatiotemporal relationship of the data. | Ziwen Yu Jianjun Zhang Wenwu Tan Ziyi Xiong Peilun Li Liangqing Meng Haijun Lin Guang Sun Peng Guo | 2022 | Journal on Big Data2022，4，2： | 0 |
| 18 | Identification and expression analysis of chlorogenic acid biosynthesis key gene PpHCT in peach显示文摘Shikimic acid/quinic acid hydroxy cinnamyl transferase(HCT)is one of the key enzymes in the phenylpropanoid pathway.However,the role of the HCT gene in chlorogenic acid(CGA)biosynthesis in peach fruit remains unclear.For this,we identified the accumulation pattern of CGA in four peach cultivars,cloned and characterized 11 PpHCT gene members,and further analyzed the expression patterns of these PpHCT genes during fruit development.The contents of CGAs in the four peach cultivars all exhibited a trend of increasing and then decreasing during the fruit growth and development.Moreover,the contents of CGAs in the peel and flesh were tissue-specific.Gene structure analysis indicated that the PpHCT genes were highly conserved,containing two exons and one intron.The protein structure analysis demonstrated that the PpHCT proteins contained two conserved motifs(HXXXD,DFGWG)and a transferase domain(PF02458),which belonged to the BAHD acyltransferase family.The cis-acting element analysis suggested that the promoters of PpHCT genes contained many light-related,hormone-related,stress-related,tissue-specific,and circadian-related elements,and they could participate in a variety of biological processes.Phylogenetic analysis showed that the HCT proteins of peach were closely related to the HCT proteins of plum and had a close evolutionary relationship.The qRT-PCR analysis indicated that the expression levels of PpHCT1 and PpHCT2 showed an opposite trend to the accumulation of CGA,whereas the expression levels of PpHCT4,PpHCT5,PpHCT7,PpHCT8,and PpHCT11 demonstrated the same trend as CGA accumulation.It was worth noting that only PpHCT4 and PpHCT5 were highly expressed in the two high-CGA cultivars but showed low levels of expression in the two low-CGA cultivars.Therefore,it was hypothesized that these two genes might be key genes to the synthesis of CGA in peach fruit.Those findings provide a theoretical basis for further study on the biological functions of the HCT gene and help to reveal the molecular mechanism of CGA. | Ziwen Su Meng Sun Zhixiang Cai Shaolei Guo Jiyao Li Bintao Zhao Zhijun Shen Ruijuan Ma Juan Yan Mingliang Yu | 2023 | Horticultural Plant Journal2023，9，4： | 0 |
| 19 | Functional requirement of terminal inverted repeats for efficient ProtoRAG activity reveals the early evolution of V(D)J recombination显示文摘The discovery of ProtoRAG in amphioxus indicated that vertebrate RAG recombinases originated from an ancient transposon. However, the sequences of ProtoRAG terminal inverted repeats(TIRs) were obviously dissimilar to the consensus sequence of mouse 12/23 RSS and recombination mediated by Proto RAG or RAG made them incompatible with each other. Thus, it is difficult to determine whether or how 12/23 RSS persisted in the vertebrate RAG system that evolved from the TIRs of ancient RAG transposons. Here, we found that the activity of ProtoRAG is highly dependent on its asymmetric 5 TIR and 3 TIR, which are composed of conserved TR1 and TR5 elements and a partially conserved TRsp element of 27/31 bp to separate them. Similar to the requirements for the recombination signal sequences(RSSs) of RAG recombinase, the first CAC in TR1, the three dinucleotides in TR5 and the specific length of the partially conserved TRsp are important for the efficient recombination activity of ProtoRAG. In addition, the homologous sequences flanking the signal sequences facilitate Proto RAG-but not RAG-mediated recombination. In addition to the diverged TIRs, two differentiated functional domains in Bb RAG1 L were defined to coordinate with the divergence between TIRs and RSSs. One of these is the CTT^*domain, which facilitates the specific TIR recognition of the Bb RAGL complex, and the other is NBD^*, which is responsible for DNA binding and the protein stabilization of the Bb RAGL complex. Thus, our findings reveal that the functional requirement for ProtoRAG TIRs is similar to that for RSS in RAG-mediated recombination, which not only supports the common origin of ProtoRAG TIRs and RSSs from the asymmetric TIRs of ancient RAG transposons, but also reveals the development of RAG and RAG-like machineries during chordate evolution. | Xin Tao Shaochun Yuan Fan Chen Xiaoman Gao Xinli Wang Wenjuan Yu Song Liu Ziwen Huang Shangwu Chen Anlong Xu | 2020 | National Science Review2020，7，2： | 0 |
| 20 | A Randomized Controlled Trial of a Biodegradable Polymer,Microcrystalline Sirolimus-Eluting Stent(MiStent)versus Another Biodegradable Polymer Sirolimus-Eluting Stent(TIVOLI):The DESSOLVE-C Trial显示文摘Objective::Data comparing the outcomes of MiStent(Micell Technologies,Durham,North Carolina,USA)microcrystalline biodegradable polymer(BP)drug-eluting stent(DES)and those of another post-marketing BP-DES,TIVOLI(EssenTech,Beijing,China)are rare.This study sought to compare the angiographic efficacy and clinical outcomes of the microcrystalline BP sirolimus-eluting stent(SES)system MiStent and those of TIVOLI BP-SES.Methods::The DESSOLVE-C trial was a prospective,single-blinded,multicenter,randomized trial(NCT02448524),which randomly assigned patients with de novo coronary lesions to receive MiStent or TIVOLI BP-SES by a 1:1 ratio.The primary endpoint was a non-inferiority comparison of in-stent late lumen loss(LLL)by quantitative coronary angiography at 9 months.The secondary endpoint was device-related clinical cardiovascular composite events(target lesion failure(TLF),composite of cardiac death,target vessel myocardial infarction(MI),and clinically driven target lesion revascularization)and 1-year outcomes.Results::A total of 428 patients(216 patients in the MiStent group and 212 patients in the TIVOLI group)were enrolled and included in an intention-to-treat analysis.MiStent was not only non-inferior but superior to TIVOLI for in-stent LLL at 9 months((0.23±0.37)mm vs.(0.34±0.48)mm,P for non-inferiority<0.001,P for superiority=0.02).Although without significant difference,the rate of TLF in MiStent was quantitatively lower than that in TIVOLI(3.70%vs.6.60%;P=0.17).Conclusion::Compared with TIVOLI BP-SES,the MiStent system was superior in in-stent LLL at 9 months and had a comparable clinical benefit at 1 year in de novo coronary lesions. | Bin Wang Sicong Ma Zhiyong Wang Li Zhang Hanjun Pei Yang Zheng Yuejin Yang Zheng Zhang Xinqun Hu Ziwen Ren Feng Zhang Changqian Wang Renqiang Yang Zhiming Yang Yuexi Wang Guosheng Fu Yu Cao Zuyi Yuan Kai Xu Xin Zhao Bo Xu Miaohan Qiu Quanmin Jing | 2023 | Cardiology Discovery2023，3，1： | 0 |
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