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| 1 | Palaeogeothermal response and record of the effusing of Emeishan basalts in the Sichuan basin显示文摘Thermal history of the Sichuan basin is reconstructed based on vitrinite reflectance from boreholes in the basin using a paleo-heat flow method.The results show that the Sichuan basin experienced a relatively low heat flow period in the Early Paleozoic,and an elevated paleo-heat flow,ranging 60-80 mW/m2 with a maximum as high as 100 mW/m2 around 259 Ma,from the beginning of the Late Paleozoic to the end of the early Permian,and a decreased paleo-heat flow from the late Permian to the late Triassic,and then maintained nearly stable to the present.The Late Paleozoic paleo-heat flow was quite high where there were extensive Emeishan flood basalts or concealed basalts which erupted between the early and the late Permian,such as the southwestern and northeastern areas of the Sichuan basin.According to the distribution of paleo-heat flow,it can be inferred that,the northeastern Sichuan basin was also influenced by the Emeishan magmatic activity during the Dongwu movement though there was lack of Emeishan flood basalts.In addition,the results of thermal history reconstruction of the Sichuan basin provide paleogeothermal evidence for the existence and onset of the Emaishan mantle plume. | ZHU ChuanQing XU Ming YUAN YuSon ZHAO YongQing SHAN JingNan HE ZhiGuo TIAN YunTao HU ShengBiao | 2010 | Chinese Science Bulletin2010，55，10： | 30 |
| 2 | Recent advances in friction and lubrication of graphene and other 2D materials:Mechanisms and applications显示文摘Two-dimensional materials having a layered structure comprise a monolayer or multilayers of atomic thickness and ultra-low shear strength.Their high specific surface area,in-plane strength,weak layer-layer interaction,and surface chemical stability result in remarkably low friction and wear-resisting properties.Thus,2D materials have attracted considerable attention.In recent years,great advances have been made in the scientific research and industrial applications of anti-friction,anti-wear,and lubrication of 2D materials.In this article,the basic nanoscale friction mechanisms of 2D materials including interfacial friction and surface friction mechanisms are summarized.This paper also includes a review of reports on lubrication mechanisms based on the film-formation,self-healing,and ball bearing mechanisms and applications based on lubricant additives,nanoscale lubricating films,and space lubrication materials of 2D materials in detail.Finally,the challenges and potential applications of 2D materials in the field of lubrication were also presented. | Lincong LIU Ming ZHOU Long JIN Liangchuan LI Youtang MO Guoshi SU Xiao LI Hongwei ZHU Yu TIAN | 2019 | Friction2019，7，3： | 29 |
| 3 | Relationship between depth of anesthesia and effect-site concentration of propofol during induction with the target-controlled infusion technique in elderly patients显示文摘在那里的背景是很少研究估计 propofol 的效果地点集中是否能在控制目标的注入(TCI ) 期间预言麻药深度在 eldedy 病人感应。这研究试图在 eldedy patients.Methods 在 TCI 正式就职期间评估在 propofol 的效果地点集中和麻醉的深度之间的关系有麻醉学者( ASA )的一个美国社会的 90 个病人( 60-80 年) 1-3 的物理地位,经历在一般麻醉下面安排了腹、胸的外科随机被分配进三个组,组 S1 , S2 和 S3 (在每个组的 30 个病人)之一。在组 S1 的病人与 4.0 g/ml 的目标血浆集中收到了 propofol;在组 S2 的病人与起始的目标血浆收到了 propofol 3 分钟以后被提起到 4.0 g/ml 的 2.0 g/ml 的集中;在组 S3 的病人收到了 3 步的一个灌输的计划;从是的 2.0 g/ml 的目标血浆集中开始由 1 g/ml 增加了 stepwised 直到 4.0 g/ml 的目标血浆集中被完成,在二步之间的间隔是 3 分钟。当一个观察员对 1 的机警 / 镇静(OAA/S ) 分数的评价被完成时, remifentanil (4.0 ng/ml 的效果地点集中(Ce )) 和 rocuronium 0.9 mg/kg 被管理。气管的 intubation 被开始在 rocuronium 以后的 2 分钟注射。propofol Ce,血压(BP ) ,心率(HR ) ,和 bispectral 索引(二度) 的变化被记录。结果当 1 的一个 OAA/S 分数被完成时, propofol 的 Ce 是(1.7ed .Results 八个病人((3.1 ?? 肀?? | LIU Shao-hua WEI Wei DING Guan-nan KE Jing-dong HONG Fang-xiao TIAN Ming | 2009 | Chinese Medical Journal2009，，8： | 24 |
| 4 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 5 | Research Progress in Occupational Health Risk Assessment Methods in China显示文摘Traditional occupational disease control and prevention has remained prevalent in China over recent decades.There are appropriately 30,000 new case reports of occupational diseases annually.Although China has already established a series of occupational disease prevention programs,occupational health risk assessment(OHRA)strategies continue to be a limitation.OHRA is a tool for controlling the health | ZHOU Li Fang TIAN Fang ZOU Hua YUAN Wei Ming HAO Mo ZHANG Mei Bian | 2017 | Biomedical and Environmental Sciences2017，30，8： | 20 |
| 6 | Identification of coastal wetlands of international importance for waterbirds:a review of China Coastal Waterbird Surveys 2005–2013显示文摘Background:China's coastal wetlands belong to some of the most threatened ecosystems worldwide.The loss and degradation of these wetlands seriously threaten waterbirds that depend on wetlands.Methods:The China Coastal Waterbird Census was organized by volunteer birdwatchers in China's coastal region.Waterbirds were surveyed synchronously once every month at 14 sites,as well as irregularly at a further 18 sites,between September 2005 and December 2013.Results:A total of 75 species of waterbirds met the 1 % population level Ramsar listing criterion at least once at one site.The number of birds of the following species accounted for over 20 % of the total flyway populations at a single site:Mute Swan(Cygnus olor),Siberia Crane(Grus leucogeranus),Far Eastern Oystercatcher(Haematopus osculans),Bar-tailed Godwit(Limosa lapponica),Spotted Greenshank(Tringa guttifer),Great Knot(Calidris tenuirostris),Spoon-billed Sandpiper(Calidris pygmeus),Saunders' s Gull(Larus saundersi),Relict Gull(Larus relictus),Great Cormorant(Phalacrocorax carbo),Eurasian Spoonbill(Platalea leucorodia),Black-faced Spoonbill(Platalea minor) and Dalmatian Pelican(Pelecanus crispus).A total of 26 sites supported at least one species of which their number met the1 % criterion.Forty-two species met the 1 % criterion in the Yellow River Delta,Shandong;29 at the Cangzhou coast,Hebei and 26 species at the Lianyungang coast,Jiangsu.Conclusions:The results highlight the international importance of China's coastal wetlands for waterbirds.This study also demonstrates that participation of local birdwatchers in waterbird surveys results in data that are invaluable not only for understanding the current status of waterbirds in China's coastal regions but also for waterbird conservation and management. | Qingquan Bai Jianzhong Chen Zhihong Chen Guotai Dong Jiangtian Dong Wenxiao Dong Vivian Wing Kan Fu Yongxiang Han Gang Lu Jing Li Yang Liu Zhi Lin Derong Meng Jonathan Martinez Guanghui Ni Kai Shan Renjie Sun Suixing Tian Fengqin Wang Zhiwei Xu Yat-tung Yu Jin Yang Zhidong Yang Lin Zhang Ming Zhang Xiangwu Zeng | 2015 | Chinese Birds2015，，3： | 20 |
| 7 | Gravity Flow on Slope and Abyssal Systems in the Qiongdongnan Basin,Northern South China Sea显示文摘新地震数据的学习在架并且在 Qiongdongnan 盆(QDNB ) 的深渊的设定上以内部建筑学和分发允许沉积严肃流动的鉴定。六种严肃流动类型被认出:(1 ) 有基础、一致的 truncational 的 turbidite 隧道压垂沿着架边和斜坡的关系,包括旁边地转移、使河床升高得垂直地的隧道建筑群;(2 ) 有塑造汤勺的形态学的滑坡在架裂缝上滑动步并且从变丑产生了糟糕巩固并且高水位线内容沉积;(3 ) 商业萧条在架斜坡上被限制,由一个异常斜坡坡度或由差错活动被触发;(4 ) turbidite 表建筑群(TSC ) 被归功于到盆地板扇子和斜坡扇子起源,偶尔由混浊水流喂深海洋的存款;(5 ) 沉积飘动在更低的斜坡盆地板发生,并且盖住约 400 km2 的一个区域,在越过海床流动的水流下面被产生;并且(6 ) 在深水区域的中央峡谷表示严肃流动的一种例外的类型碎片流动, turbidite 隧道,和 TSC 的一个协会创作了。它介绍平面 multisegment 和垂直多相的特征。在峡谷与好 petrophysical 性质联系的 Turbidite 能在 QDNB 被当作一个潜在的探索目标。 | SU Ming XIE Xinong LI Junliang JIANG Tao ZHANG Cheng HE Yunlong TIAN Shanshan ZHANG Cuimei | 2011 | Acta Geologica Sinica(English Edition)2011，85，1： | 19 |
| 8 | Effectiveness of Different Waist Circumference Cut-off Values in Predicting Metabolic Syndrome Prevalence and Risk Factors in Adults in China显示文摘Objective To study the effectiveness of waist circumference cut-off values in predicting the prevalence of metabolic syndrome(MetS) and risk factors in adults in China. Methods A cross-sectional survey was condcuted in 14 provinces(autonomous region, municipality) in China. A total of 47 325 adults aged ≥20 years were selected by multistage stratified sampling, and questionnaire survey and physical and clinical examination were conducted among them. MetS was defined according to the International Diabetes Federation(IDF) criteria and modified IDF criteria.Results The age-standardized prevalence of MetS was 24.2%(22.1% in men and 25.8% in women) and 19.5%(22.1% in men and 18.0% in women) according to the IDF criteria and modified IDF criteria respectively. The age-standardized prevalence of pre-MetS was 8.1%(8.6% in men and 7.8% in women) according to the modified IDF criteria. The prevalence of MetS was higher in urban residents than rural residents and in northern China residents than in southern China residents. The prevalence of central obesity was about 30% in both men and women according to the ethnicity-specific cut-off values of waist circumference for central obesity(90 cm for men and 85 cm for women). Multivariate regression analysis revealed no significant difference in risk factors between the two MetS definitions. Conclusion Using both the modified IDF criteria and ethnicity-specific cut-off values of waist circumference can provide more useful information about the prevalence of MetS in China. | ZHOU Hai Cheng LAI Ya Xin SHAN Zhong Yan JIA Wei Ping YANG Wen Ying LU Ju Ming WENG Jian Ping JI Li Nong LIU Jie TIAN Hao Ming JI Qiu He ZHU Da Long CHEN Li GUO Xiao Hui ZHAO Zhi Gang Li Qiang ZHOU Zhi Guang GE Jia Pu SHAN Guang Liang | 2014 | Biomedical and Environmental Sciences2014，27，5： | 17 |
| 9 | Fuzzy Synthetic Evaluation of Wetland Soil Quality Degradation:A Case Study on the Sanjiang Plain,Northeast China显示文摘Wetland soil quality degradation caused by large-scale agricultural reclamation on the Sanjiang Plain of Northeast China has been widely reported. A relative soil quality evaluation (RSQE) model and a projection pursuit evaluation (PPE) model based on real-coded accelerating genetic algorithm were introduced to evaluate quality variations in top layers of the main wetland soils on the Sanjiang Plain in 1999 and 2003, respectively. As soil quality degradation boundaries were vague, this study established two fuzzy synthetic evaluation (FSE) models based on the original data and criteria used in the RSQE and PPE models. The outputs of the two FSE models were obtained by choosing two fuzzy composite operators M(∧, ∨) and M(·, ⊕). Statistical analysis showed that the results of the FSE, RSQE, and PPE models were correlated. In particular, outputs of the FSE model using M(·, ⊕) were significantly correlated with those of the RSQE model with r = 0.989 at P < 0.01. Compared with RSQE and PPE models, the FSE model may be more objective in showing soil quality variations and was closer to the natural situation, showing the feasibility and applicability of the FSE model in evaluating soil quality degradation. However, the choice of composite operator was of critical importance. The study of wetland soil quality degradation on the Sanjiang Plain was of scientific and practical significance for protection and management of soils and for sustainable development of agriculture in this area in the future. | WANG Jian-Hua LU Xian-Guo JIANG Ming LI Xiao-Yan TIAN Jing-Han | 2009 | Pedosphere2009，19，6： | 15 |
| 10 | A Duplex Real-Time PCR Assay for the Simultaneous Detection of Porcine Circovirus 2 and Circovirus 3显示文摘Porcine circoviruses(PCV) include PCV1, PCV2, and the new-emerging PCV3. PCV2 is pathogenic to pigs, but the pathogenicity of PCV3 in pigs is debatable. Recently, there have been frequent reports of PCV2 and PCV3 co-infections in clinical samples. Thus, it would be practical to develop a duplex PCR method to detect PCV2 and PCV3 simultaneously. In this study, specific primers and probes were designed to target PCV2 cap and PCV3 rep genes. A duplex real-time PCR method was then developed to detect the two viruses. The assay was found to be highly specific, sensitive, and reproducible for PCV2/3 without cross-reactions with other swine pathogens. The sensitivity of this assay was 2.9 copies for the PCV2 plasmid and 22.5 copies for the PCV3 plasmid. The established assay was then used to detect PCV2/3 infection in 340 clinical samples collected in the first half of 2017. The results showed that the co-infection rate of PCV2/3 in the samples was 27.6%. Our study provides an important tool that can be used to perform urgently needed surveys for the two porcine circoviruses to evaluate their impact on the swine industry. | Xiangdong Li Mingming Qiao Ming Sun Kegong Tian | 2018 | Virologica Sinica2018，33，2： | 15 |
| 11 | Effects of the novel 6 % hydroxyethyl starch 130/0.4 on renal function of recipients in living-related kidney transplantation显示文摘背景为使用的最佳的胶体不在肾移植期间是清楚的。经历生活相关的肾移植(LRKT ) 的病人被用来比较 6% hydroxyethyl 淀粉 130/0.4 (HES 130/0.4 ) 和 4% succinylated 胶的保护的效果,作为施主肾获得,局部缺血时间和外科的条件是可比较的。击卷变化(SVV ) 被用来监视 intravascular 体积避免肾的 allograft hypoperfusion.Methods 经历 LRKT 的八十个病人被划分成二个组:组 H 收到了 6% HES 130/0.4,组 G 收到了 4% succinylated 胶。所有施主和接受者在外科期间收到了相关胶体的 15-25 ml/kg。动脉的血压(ABP ) ,心率(HR ) ,中央静脉的压力(CVP ) , SVV 和心脏的索引(CI ) , electrocardiography (ECG ) 和 SpO2 连续地被监视。SVV 在 100-130 mmHg 在 6%-13% 和吝啬的动脉的压力之间被保留。静脉的血和尿的样品被获得 30 在 unclamping 以后并且在手术后的天(邮政部门) 的早上纪录 1-4 测量浆液和尿 2-microglobulin,尿 1-microglobulin, microalbumin 和 N 乙酰 -- D-glucosaminidase。血脲氮(甜面包) 和肌酸是坚定的操作前(到) ,在外科(t1 ) 以后并且在豆荚上的 3 个小时 1 (t2 ) , 2 (t3 ) , 4 (t4 ) , 7 (t5 ) 并且 10 (t6 ) 。尿输出在 t1, t2, t5, t6.Results 年龄,身体重量,身体表面区域(BSA ) ,操作时间,尿输出和灌输的胶体卷被记录在这些组之间是可比较的, hemodynamics 在外科期间是稳定的。在在相对 baseline.BUN 的两个组的外科在 t1, t2 和 t4 与组 G 相比在组 H 显著地减少了以后,甜面包,浆液肌酸,浆液 2-microglobulin 和尿 2-microglobulin 显著地减少了。尿 microalbumin 在与组 G 相比的邮政部门 4 上在组 H 显著地减少了。尿 1-microglobulin 不两个都在二 groups.Conclusion 之间是显著地不同的胶体能安全地为 LRKT 被使用,但是 HES130/0.4 与肾的功能的更快速的恢复被联系。 | WU Yan WU An-shi WANG Jun TIAN Ming JIA Xin-yuan RUI Yan YUE Yun | 2010 | Chinese Medical Journal2010，，21： | 14 |
| 12 | Fuzzy Synthetic Evaluation of Water Quality of Naoli River Using Parameter Correlation Analysis显示文摘In order to improve the effectiveness of Fuzzy Synthetic Evaluation (FSE) models, a Parameter Correlation Analysis (PCA) was introduced into the FSE and a case study was carried out in the Naoli River in the Sanjiang Plain, Northeast China. The basic principle of the PCA is that the pairs of parameters which are highly correlated and linear with each other would contribute the same information to an assessment and one of them should be eliminated. The method of the PCA is that a correlation relationship among candidate parameters is examined before the FSE. If there is an apparent nonlinear or curvilinear relationship between two parameters, then both will be retained; if the correlation is significant (p<0.01), and the scatter plot suggests a linear relationship, then one of them will be deleted. However, which one will be deleted? For solving this problem, a sensitivity test was conducted and the higher sensitivity parameters remained. The results indicate that the original data should be preprocessed through the PCA for redundancy and variability. The study shows that introducing the PCA into the FSE can simplify the FSE calculation process greatly, while the results have not been changed much. | WANG Jianhua LU Xianguo TIAN Jinghan JIANG Ming | 2008 | Chinese Geographical Science2008，18，4： | 14 |
| 13 | Lobaplatin inhibits growth of gastric cancer cells by inducing apoptosis显示文摘AIM:To assess the anti-cancer effect of lobaplatin on human gastric cancer cells,and to explore the underlying molecular mechanisms.METHODS:The human gastric cancer cell lines MKN-28,AGS and MKN-45 were used.The cytotoxicity of lobaplatin was detected using an MTS cell proliferation assay.Flow cytometry was used to detect cell apoptosis using Annexin V-FITC Apoptosis Detection Kit.The expression of apoptosis-regulated genes was examined at the protein level using Western blot.RESULTS:Lobaplatin inhibited the proliferation of human gastric cancer cells and induced apoptosis,which may be associated with the up-regulation of Bax expression,poly(ADP-ribose)polymerase(PARP)cleavage,p53 expression and the reduction of Bcl-2 expression.CONCLUSION:The cytotoxicity of lobaplatin may be due to its ability of inducing apoptosis of gastric cancer cells,which would support the potential use of lobaplatin for the therapy of gastric cancer. | Chu-Yang Yin Xiao-Lin Lin Lei Tian Ming Ye Xin-Ying Yang Xiu-Ying Xiao | 2014 | World Journal of Gastroenterology2014，20，46： | 13 |
| 14 | A Single-institution Experience with Open Irreversible Electroporation for Locally Advanced Pancreatic Carcinoma显示文摘 | Li Yan Yong-Liang Chen Ming Su Tian Liu Kai Xu Feng Liang Wan-Qing Gu Shi-Chun Lu | 2016 | Chinese Medical Journal2016，，24： | 13 |
| 15 | Molecular Typing of Leptospira interrogans Strains Isolated from Rattus tanezumi in Guizhou Province,Southwest of China显示文摘Objective To identify and type three leptospires isolated from Rattus tanezumi in Guizhou Province by using three molecular techniques (PFGE, MLVA, and MLST), reveal the molecular characteristic of causative agents of local leptospirosis and evaluate these three molecular methods based on their detection resolution and efficiency. Methods Three Leptospira strains were isolated from the kidney of Rattus tanezumi and cultured with EMJH medium. PFGE, MLVA, and MLST assays were applied to type the three strains isolated from Rattus tanezumi in Guizhou Province. Results PFGE, MLVA, and MLST typing showed that the three leptospiral isolates matched with leptospiral serogroup Icterohaemorrhagiae serovar Lai. The findings of the genotyping methods were consistent. MLVA and MLST defined genotypes, whereas PFGE allowed the recognition of additional subgroups within the genotypes, and the findings of molecular typing were also consistent with those of traditional techniques. Conclusion Three leptospiral isolates from Guizhou Province matched with leptospiral serogroup Icterohaemorrhagiae serovar Lai, and PFGE, MLVA, and MLST, as reliable molecular techniques for identifying and typing of Leptospira interrogans, would contribute to the active surveillance, outbreak investigation and source tracking for leptospirosis in Guizhou Province. | LI Shi Jun ZHANG Cui Cai LI Xiu Wen TIAN Ke Cheng TANG Guang Peng WANG Ding Ming LIU Ying NIE Yi Xin JIANG Xiu Gao | 2012 | Biomedical and Environmental Sciences2012，25，5： | 12 |
| 16 | C-reactive Protein Level,Apolipoprotein B-to-apolipoprotein A-1 Ratio,and Risks of Ischemic Stroke and Coronary Heart Disease among Inner Mongolians in China显示文摘Objective We aimed to investigate the cumulative effect of high CRP level and apolipoprotein B-to-apolipoprotein A-1(ApoB/ApoA-1) ratio on the incidence of ischemic stroke(IS) or coronary heart disease(CHD) in a Mongolian population in China.Methods From June 2003 to July 2012,2589 Mongolian participants were followed up for IS and CHD events based on baseline investigation.All the participants were divided into four subgroups according to C-reactive protein(CRP) level and ApoB/ApoA-1 ratio.Cox proportional hazard models were used to estimate the hazard ratios(HRs) and 95% confidence intervals(CIs) for the IS and CHD events in all the subgroups.Results The HRs(95% CI) for IS and CHD were 1.33(0.84-2.12),1.14(0.69-1.88),and 1.91(1.17-3.11) in the ‘low CRP level with high ApoB/ApoA-1',‘high CRP level with low ApoB/ApoA-1',and ‘high CRP level with high ApoB/ApoA-1' subgroups,respectively,in comparison with the ‘low CRP level with low ApoB/ApoA-1' subgroup.The risks of IS and CHD events was highest in the ‘high CRP level with high ApoB/ApoA-1' subgroup,with statistical significance.Conclusion High CRP level with high ApoB/ApoA-1 ratio was associated with the highest risks of IS and CHD in the Mongolian population.This study suggests that the combination of high CRP and ApoB/ApoA-1 ratio may improve the assessment of future risk of developing IS and CHD in the general population. | TIAN Yun Fan ZHOU Yi Peng ZHONG Chong Ke BUREN Batu XU Tian LI Hong Mei ZHANG Ming Zhi WANG Ai Li ZHANG Yong Hong | 2016 | Biomedical and Environmental Sciences2016，29，7： | 12 |
| 17 | Antagonistic Potential against Pathogenic Microorganisms and Hydrogen Peroxide Production of Indigenous Lactobacilli Isolated from Vagina of Chinese Pregnant Women显示文摘Objective To investigate the indigenous lactobacilli from the vagina of pregnant women and to screen the isolates with antagonistic potential against pathogenic microorganisms.Methods The strains were isolated from pregnant women's vagina and identified using the API50CH system.The ability of the isolates to produce hydrogen peroxide was analyzed semi-quantitatively using the TMB-HRP-MRS agar.The antagonistic effects of the isolates on pathogenic microorganisms were determined with a double layer agar plate.Results One hundred and three lactobacilli strains were isolated from 60 samples of vaginal secretion from healthy pregnant women.Among them,78 strains could produce hydrogen peroxide,in which 68%,80%,80%,and 88% had antagonistic effects against Candida albicans CMCC98001,Staphylococcus aureus CMCC26003,Escherichia coli CMCC44113,and Pseudomonas aeruginosa CMCC10110,respectively.Conclusion The recovery of hydrogen peroxide-producing lactobacilli decreases with the increasing pregnant age and time.The most commonly isolated species from vagina of Chinese pregnant women are Lactobacillus acidophilus and Lactobacillus crispatus.Most of L.acidophilus and L.crispatus produce a high H2O2 level. | HENG-YI XU WAN-HONG TIAN CUI-XIANG WAN LI-JUN JIA LAN-YIN WANG JING YUAN CHUN-MEI LIU MING ZENG HUA WEI | 2008 | Biomedical and Environmental Sciences2008，21，5： | 12 |
| 18 | Recent advances in gecko adhesion and friction mechanisms and development of gecko-inspired dry adhesive surfaces显示文摘The remarkable ability of geckos to climb and run rapidly on walls and ceilings has recently received considerable interest from many researchers.Significant progress has been made in understanding the attachment and detachment mechanisms and the fabrication of articulated gecko-inspired adhesives and structured surfaces.This article reviews the direct experiments that have investigated the properties of gecko hierarchical structures,i.e.,the feet,toes,setae,and spatulae,and the corresponding models to ascertain the mechanical principles involved.Included in this review are reports on gecko-inspired surfaces and structures with strong adhesion forces,high ratios of adhesion and friction forces,anisotropic hierarchical structures that give rise to directional adhesion and friction,and“intelligent”attachment and detachment motions. | Ming ZHOU Noshir PESIKA Hongbo ZENG Yu TIAN Jacob ISRAELACHVILI | 2013 | Friction2013，1，2： | 12 |
| 19 | Ginsenoside-Rg_6, a Novel Triterpenoid Saponin from the Stem-Leaves of Panax ginseng C. A. Mey.显示文摘A novel dammarane-type triterpene oligoglycoside, named ginsenoside-Rg6 3, was isolated from the stem-leaves of Panax ginseng C. A. Mey., together with two known ones, 20(S)-ginsenoside-Rg2 1 and 20(R)-ginsenoside-Rg2 2. On the basis of chemical and physicochemical evidence , the structure of ginsenoside-Rg6 have been elucidated as 6-O-(-L-rhamnosyl-(1?2)-(-D-glucopyranosyl-dammarane-(E)-20(22), 24-diene-3(, 6(, 12(-triol. | Xiu Wei YANG, Long Yun LI, Jian Ming TIAN, Zhi Wei ZHANG, Jin Mei YE, Wei Fang Gu (National Research Laboratory of Natural & Biomimetic Drugs, Peking University, Beijing 100083) (Academy of Chinese Traditional Medicine and Materia Medica of Jilin Provinc | 2000 | Chinese Chemical Letters2000，11，10： | 12 |
| 20 | Imaging superoxide flash and metabolism-coupled mitochondrial permeability transition in living animals显示文摘线粒体为精力新陈代谢和反应的氧种类(ROS ) 的生产是必要的。在未经触动的房间,呼吸线粒体展览自发的 “ superoxide flashes”,对短暂 mitochondrial 渗透转变(tMPT ) 结果的 quantal 生产 ROS 事件。这里,我们在表示 superoxide 生物传感器 mt-cpYFP 的生活老鼠在 mitochondrial superoxide 闪光和 tMPT 活动的 vivo 成像执行第一,并且表明他们联合到整个身体的葡萄糖新陈代谢。柔韧的 tMPT/superoxide 闪光活动发生在骨胳的肌肉和 anesthetized 的臀部的神经转基因的老鼠。在骨胳的肌肉,成像 tMPT/superoxide 闪光揭示了线粒体的迷宫的三维的网络同时地操作。tMPT/superoxide 闪光活动响应全身的葡萄糖挑战或胰岛素刺激澎湃,以一种显然调制频率的方式并且也在 tMPT 的 gating 模式包含移动。因此,在 tMPT 依赖的 mitochondrial ROS 的 vivo 成像,信号和 metabolism-tMPT-superoxide 的发现闪光联合标记为 mitochondrial 功能并且 ROS 处于健康和疾病发信号的学习的重要工艺、概念的进展。 | Huaqiang Fang Min Chen Yi Ding Wei Shang Jiejia Xu Xing Zhang Wanrui Zhang Kaitao Li Yao Xiao Feng Gao Shujiang Shang Jing-Chao Li Xiao-Li Tian Shi-Qiang Wang Jingsong Zhou Noah Weisleder Jianjie Ma Kunfu Ouyang Ju Chen Xianhua Wang Ming Zheng Wang Wang Xiuqin Zhang Heping Cheng | 2011 | Cell Research2011，21，9： | 11 |
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