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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | 男性迟发性性腺功能减退症的检查、治疗和监测:国际男科学会(ISA)、国际老年男性研究会(ISSAM)、欧洲泌尿外科学会(EAU)、欧洲泌尿外科学院(EAA)和美国男科学会(ASA)联合推荐显示文摘简介
人口学资料明确显示:老年人口占总人口的百分率正逐年增加。当前,有关老年男性雄激素缺乏的问题逐渐成为令人感兴趣、但又充满争议的世界性话题。已经有横向和纵向的研究资料表明,随着年龄增大,成年男子的雄激素水平逐渐降低, | Wang C Nieschlage E Swerdloff R Behre HM Hellstrom WJ Gooren LJ Kaufman JM Legros JJ Lunenfeld B Morales A Morley JE Schulman C Thompson IM Weidner W Wu FCW 伍学焱(翻译) | 2011 | 国际生殖健康/计划生育杂志2011，30，1： | 8 |
| 3 | RTOG 0211:a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients显示文摘PURPOSE: To determine the safety and efficacy of gefitinib,an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor,in combination with radiation for newly diagnosed glioblastoma(GBM) patients.METHODS AND MATERIALS: Between March 21,2002,and May 3,2004,Radiation Therapy Oncology Group(RTOG) 0211 enrolled 31 and 147GBM patients in the phase 1 and 2 arms,respectively.Treatment consisted of daily oral gefinitnib started at the time of conventional cranial radiation therapy(RT) and continued post RT for 18 months or until progression.Tissue microarrays from 68 cases were analyzed for EGFR expression.RESULTS: The maximum tolerated dose(MTD) of gefitinib was determined to be 500 mg in patients on non-enzyme-inducing anticonvulsant drugs(non-EIAEDs).All patients in the phase 2 component were treated at a gefitinib dose of 500 mg;patients receiving EIADSs could be escalated to 750 mg.The most common side effects of gefitinib in combination with radiation were dermatologic and gastrointestinal.Median survival was 11.5 months for patients treated per protocol.There was no overall survival benefit for patients treated with gefitinib + RT when compared with a historical cohort of patients treated with RT alone,matched by RTOG recursive partitioning analysis(RPA) class distribution.Younger age was significantly associated with better outcome.Per protocol stratification,EGFR expression was not found to be of prognostic value for gefitinib + RT-treated patients.CONCLUSIONS: The addition of gefitinib to RT is well tolerated.Median survival of RTOG 0211 patients treated with RT with concurrent and adjuvant gefitinib was similar to that in a historical control cohort treated with radiation alone. | Chakravarti A Wang M Robins HI Lautenschlaeger T Curran WJ Brachman DG Schultz CJ Choucair A Dolled-Filhart M Christiansen J Gustavson M Molinaro A Mischel P Dicker AP Bredel M Mehta M | 2013 | 中国神经肿瘤杂志2013，11，1： | 8 |
| 4 | Giant magneto-impedance effects in nanocrystalline soft magnetic alloy ribbons显示文摘SINCE the discovery of the giant magneto-impedance (GMI) effects in amorphous wire (or rib-bon) of CoFeSiB and nanocrystalline wire (or film) of FeCuNbSiB, it has attracted greatattention due to its promising potential applications in industry. Amorphous (and nanocrys-talline) soft magnetic alloys have very large magnetic permeability, when an ac driving currentand an external magnetic field (EMF) are applied, the EMF will damp the magnetic fluxchange caused by the ac driving current, thus the magnetic permeability will decrease; as a re- | Ku, WJ Ge, FD Yan, G Wang, XY Zhu, J | 1997 | Chinese Science Bulletin1997，42，12： | 5 |
| 5 | 声音通过皮质丘脑环路缓解疼痛显示文摘声音(包括音乐和噪音)可以减轻人类的疼痛,但潜在的神经机制仍然未知。该研究发现高于环境噪音5-dB的声音可以缓解疼痛。病毒追踪、显微内镜钙成像和在体多通道记录表明,低信噪比(SNR)声音抑制了从听觉皮质(ACx)到丘脑后核(PO)和丘脑腹后核(VP)的谷氨酸能输入。光遗传学或化学遗传学抑制ACx^(Glu)→PO和ACx^(Glu)→VP环路分别模拟了低SNR声音对炎症痛模型小鼠后爪和前爪的镇痛作用,而激活这些环路可反转声音诱导的镇痛作用。该研究通过解读听觉系统在疼痛处理中的作用,揭示声音促进镇痛作用背后的皮质丘脑环路机制。 | Zhou WJ Ye CH Wang HT 胡丹丹(译) 张玲(校) | 2022 | 中国疼痛医学杂志2022，28，12： | 4 |
| 6 | Desorption corona beam ionization source for mass spectrometry显示文摘 | Wang H Sun WJ Zhang JS | | Analyst0，，： | 2 |
| 7 | Laparoseopie Roux-en-Y versus mini-gastric bypass for the treatment of morbid obesity : a prospective randomized controlled clinical trial显示文摘 | Lee WJ Yu PJ Wang W | 2005 | Ann Surg2005，242，1： | 1 |
| 8 | Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon ougrowth显示文摘 | Wang SW Mu X Bowers WJ | 2002 | Development2002，129，： | 1 |
| 9 | Stenting of symptomatic M1 stenosis of middle cerebral artery: an initial experience of 40 patients显示文摘 | Jiang WJ Wang Y J Du B | 2004 | Stroke2004，35，6： | 1 |
| 10 | Stenting of Symptomatic M1 Stenosis of Middle Cerebral Artery : An Initial Experience of 40 Patients 显示文摘 | Jiang WJ Wang YJ Du B | 2004 | Stroke2004，35，： | 1 |
| 11 | Stenting of symptomatic M1 stenosis of middle cerebral artery:an initial experience of 40 patients显示文摘 | Jiang WJ Wang YJ Du B | 2004 | Stroke2004，35，： | 1 |
| 12 | Transactivation,dimerization,and DNA-binding activity of white spot syndrome virus immediate early protein IE1显示文摘 | Liu WJ Chang YS Wang HC | 2008 | J Virol2008，82，11： | 1 |
| 13 | Role of I1-imidazoline receptors within the caudal ventrolateral medulla in cardiovascular responses to clonidine in rats显示文摘 | Wang WZ Yuan WJ Yang J | 2003 | J Cardiovasc Pharmacol2003，42，1： | 1 |
| 14 | Evaluation of antiseptic -impregnated central venous catheters for prevention of catheter -related infection in intensive care unit patients显示文摘 | Sheng WH Ko WJ Wang JT | 2000 | Diagn Microbiol Infect Dis2000，38，1： | 1 |
| 15 | Adrenal gland volume after spinal cord injury 显示文摘 | Lee WJ Wang YH Su CT | 2002 | Phys Med Rehabil Am2002，7，： | 1 |
| 16 | Therapeutic efficacy of bipolar plasmakinetic technique compared with transurethral resection on benign prostate hyperplasia 显示文摘 | Wu WJ Wang XH Wang HP | 2005 | Zhonghua Yi Xue Za Zhi2005，85，47： | 1 |
| 17 | Differential activations of PKC/PKA related to microvasculopathy in diabetic GK rats 显示文摘 | Wang H Jiang YW Zhang WJ | 2012 | Am J Physiol Endocrinol Metab2012，302，： | 1 |
| 18 | Synthesis,Characterization,and Property of Amphiphilic Fluorinated ABC-Type Triblock Copolymers显示文摘 | Guo WJ Tang XD Xu J Wang X | | 0，，： | 1 |
| 19 | DPP-4 inhibitor attenu- ates toxic effects of indoxyl sulfate on kidney tubular cells显示文摘 | Wang WJ Chang CH Sun MF | 2014 | PLoS One2014，9，4： | 1 |
| 20 | Adjunctive GnRHa treatment attenuates depletion of ovarian reserve associat- ed with cyclophosphamide therapy in pre-menopausal SLE patients 显示文摘 | Marder W McCune WJ Wang L | 2012 | Gynecology Endocrinol2012，28，8： | 1 |
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